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公开(公告)号：US08785202B2
公开(公告)日：2014-07-22
申请号：US12708326
申请日：2010-02-18
CPC分类号： C07K14/525 , A61K38/191 , A61K38/39 , A61K39/39 , A61K47/60 , A61K47/6923 , A61K49/0013 , A61K49/0017 , A61K49/0056 , A61K49/0065 , A61K51/1244 , A61K2039/55505 , A61K2039/55516 , A61K2039/55522 , C07K16/241
摘要： The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, these vector compositions comprise a colloidal metal, derivatized PEG (polyethylene glycol) and an agent. The invention also comprises methods and compositions for making such colloidal metal compositions and for treatment of cancer.
摘要翻译： 本发明包括用于药物递送系统的组合物和方法，包括治疗化合物，药剂，药物，检测剂，核酸序列和生物因子。 通常，这些载体组合物包含胶态金属，衍生化PEG（聚乙二醇）和试剂。 本发明还包括制备这种胶体金属组合物和治疗癌症的方法和组合物。
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公开(公告)号：US08435801B2
公开(公告)日：2013-05-07
申请号：US13090751
申请日：2011-04-20
IPC分类号： G01N33/553 , C12N5/00 , C12N5/02
CPC分类号： A61K33/24 , A61K31/28 , A61K33/06 , A61K33/26 , A61K33/38 , A61K45/06 , A61K47/646 , A61K47/6923 , A61K47/6929 , B82Y5/00 , C07K16/241 , Y10S530/811
摘要： The present invention comprises compositions and methods for making monoclonal antibodies. The present invention further comprises vectors that replicate the immune system components, particularly an antigen-presenting cell (APC) element of the immune synapse. Additionally, the present invention may further comprise synthetic T-cells.
摘要翻译： 本发明包括用于制备单克隆抗体的组合物和方法。 本发明还包括复制免疫系统组分，特别是免疫突触的抗原呈递细胞（APC）元件的载体。 另外，本发明还可以包括合成的T细胞。
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3.发明授权Thiolated paclitaxels for reaction with gold nanoparticles as drug delivery agents 有权硫化紫杉醇与金纳米粒子作为药物递送剂反应公开(公告)号：US08558019B2
公开(公告)日：2013-10-15
申请号：US12373135
申请日：2008-11-10
IPC分类号： C07D305/14
CPC分类号： C07D305/14 , A61K47/6923 , B82Y5/00
摘要： Thioloated taxane derivatives are linked to colloidal metal particles such as gold nanoparticles for use as antitumor agents. The antitumor agents may be targeted to tumors.
摘要翻译： 透射紫杉烷衍生物与胶体金属颗粒如金纳米颗粒连接，用作抗肿瘤剂。 抗肿瘤剂可以靶向肿瘤。
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公开(公告)号：USRE42524E1
公开(公告)日：2011-07-05
申请号：US11923344
申请日：2007-10-24
IPC分类号： G01N33/553
CPC分类号： C07K14/525 , A61K38/191 , A61K38/39 , A61K39/39 , A61K47/60 , A61K47/6923 , A61K49/0013 , A61K49/0017 , A61K49/0056 , A61K49/0065 , A61K51/1244 , A61K2039/55505 , A61K2039/55516 , A61K2039/55522 , C07K16/241
摘要： The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, these vector compositions comprise a colloidal metal, derivatized PEG (polyethylene glycol) and an agent. The invention also comprises methods and compositions for making such colloidal metal compositions and for treatment of cancer.
摘要翻译： 本发明包括用于药物递送系统的组合物和方法，包括治疗化合物，药剂，药物，检测剂，核酸序列和生物因子。 通常，这些载体组合物包含胶态金属，衍生化PEG（聚乙二醇）和试剂。 本发明还包括制备这种胶体金属组合物和治疗癌症的方法和组合物。
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公开(公告)号：US07960145B2
公开(公告)日：2011-06-14
申请号：US12267847
申请日：2008-11-10
IPC分类号： C12P21/08 , C12N5/02 , C12N5/18 , C12N5/0781
CPC分类号： C07K16/241 , C07K16/1282 , C07K16/22 , C07K16/2866 , C07K2317/21
摘要： The compositions and methods of the present invention comprise the efficient and effective presentation of antigens to the appropriate components of the immune system resulting in the production of species-specific antibodies in vitro. In general, these compositions comprise one or more antigenic components together with a colloidal metal, optionally combined with derivatized PEG (polyethylene glycol) or other agents. The invention also comprises novel cytokine cocktails for generating desired antibodies.
摘要翻译： 本发明的组合物和方法包括有效和有效地将抗原呈递给免疫系统的合适组分，导致体外物种特异性抗体的产生。 通常，这些组合物包含一种或多种抗原成分以及胶体金属，任选地与衍生化的PEG（聚乙二醇）或其它试剂组合。 本发明还包括用于产生所需抗体的新型细胞因子鸡尾酒。
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公开(公告)号：US20090104114A1
公开(公告)日：2009-04-23
申请号：US12235342
申请日：2008-09-22
IPC分类号： A61K51/00 , A61K9/00 , A61K9/14 , A61K9/127 , A61K49/00 , A61K39/395 , A61K31/437 , A61K31/7076 , A61K31/426 , A61P37/00 , A61P35/00 , A61K31/473 , A61K31/505 , A61K31/19 , A61K31/7064 , A61K33/24 , A61K31/704 , A61K31/337 , A61K38/16 , A61K31/7052 , A61K31/70 , A61K35/76
CPC分类号： B82Y5/00 , A61K47/6923
摘要： The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, the nanotherapeutic compositions of the present invention comprise a platform comprising a colloidal metal, a targeting ligand such a tumor necrosis factor, a stealth agent such as polyethylene glycol, and one or more diagnostic or therapeutic agents for delivery. The invention also comprises methods and compositions for making such nanotherapeutic compositions and for the treatment of cancer.
摘要翻译： 本发明包括用于药物递送系统的组合物和方法，包括治疗化合物，药剂，药物，检测剂，核酸序列和生物因子。 通常，本发明的纳米治疗组合物包含包含胶体金属，靶向配体如肿瘤坏死因子，隐形剂如聚乙二醇和用于递送的一种或多种诊断或治疗剂的平台。 本发明还包括用于制备这种纳米治疗组合物和用于治疗癌症的方法和组合物。
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公开(公告)号：US5965379A
公开(公告)日：1999-10-12
申请号：US959267
申请日：1997-10-28
IPC分类号： G01N33/533
CPC分类号： G01N33/533 , G01N2333/545 , Y10S436/808 , Y10S436/817
摘要： The present invention relates to methods for measuring endogenous cytokines in blood. The method accurately measures the cytokines in the blood in the presence of substances that bind the cytokines thereby causing the measurement of the cytokines by conventional methods to give inaccurate results. The present invention also includes the non-invasive measurement of cytokines in biological fluids such as saliva and nasal secretions. Finally, the present invention allows one to monitor the level of cytokines in the blood during treatment of a human or animal with cytokines.
摘要翻译： 本发明涉及测量血液中内源性细胞因子的方法。 该方法在结合细胞因子的物质的存在下精确地测量血液中的细胞因子，从而通过常规方法进行细胞因子的测量以给出不准确的结果。 本发明还包括生物流体如唾液和鼻分泌物中的细胞因子的非侵入性测量。 最后，本发明允许在用细胞因子治疗人或动物的过程中监测血液中细胞因子的水平。
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公开(公告)号：US20120134956A1
公开(公告)日：2012-05-31
申请号：US13282437
申请日：2011-10-26
IPC分类号： A61K38/19 , A61K47/48 , A61K47/20 , A61K38/20 , A61P37/04 , A61K39/00 , A61K39/085 , A61K38/21 , A61P35/00 , A61K47/10 , A61K39/02
CPC分类号： C07K14/525 , A61K38/191 , A61K38/39 , A61K39/39 , A61K47/60 , A61K47/6923 , A61K49/0013 , A61K49/0017 , A61K49/0056 , A61K49/0065 , A61K51/1244 , A61K2039/55505 , A61K2039/55516 , A61K2039/55522 , C07K16/241
摘要： The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, these vector compositions comprise a colloidal metal, derivatized PEG (polyethylene glycol) and an agent. The invention also comprises methods and compositions for making such colloidal metal compositions and for treatment of cancer.
摘要翻译： 本发明包括用于药物递送系统的组合物和方法，包括治疗化合物，药剂，药物，检测剂，核酸序列和生物因子。 通常，这些载体组合物包含胶态金属，衍生化PEG（聚乙二醇）和试剂。 本发明还包括制备这种胶体金属组合物和治疗癌症的方法和组合物。
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公开(公告)号：US08137989B2
公开(公告)日：2012-03-20
申请号：US10672144
申请日：2003-09-26
申请人： Lawrence Tamarkin , Giulio Paciotti
发明人： Lawrence Tamarkin , Giulio Paciotti
IPC分类号： G01N33/553 , G01N33/543
CPC分类号： A61K39/39 , A61K2039/55505 , A61K2039/55516 , A61K2039/55522 , C07K16/241 , C07K2317/77
摘要： In accordance with the present invention, a composition and method is provided that allows for the administration of a biologically-active factors to a human or animal. The present invention can be used to treat a disease with a biologically-active factor or combination of biologically-active factors, or can be used to safely vaccinate a human or animal against a biologically-active factor. It can also be used as a method for the delivery of biologically-active factors for the treatment of disease. Additionally, the present invention also includes a method of targeted drug delivery for the treatment of disease through the administration of custom complexes containing of one or more biologically active factors bound to a colloidal metal where at least one of the biologically-active factors is capable of binding a high affinity receptor on a cell surface.
摘要翻译： 根据本发明，提供了允许向人或动物施用生物活性因子的组合物和方法。 本发明可用于治疗具有生物活性因子或生物活性因子组合的疾病，或可用于安全地针对生物活性因子对人或动物进行疫苗接种。 它也可以用作递送用于治疗疾病的生物活性因子的方法。 此外，本发明还包括通过施用含有结合到胶体金属的一种或多种生物活性因子的定制复合物来治疗疾病的靶向药物递送的方法，其中至少一种生物活性因子能够 在细胞表面上结合高亲和力受体。
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公开(公告)号：US07387900B2
公开(公告)日：2008-06-17
申请号：US10135886
申请日：2002-04-30
IPC分类号： G01N33/553
CPC分类号： C07K14/525 , A61K38/191 , A61K38/39 , A61K39/39 , A61K47/60 , A61K47/6923 , A61K49/0013 , A61K49/0017 , A61K49/0056 , A61K49/0065 , A61K51/1244 , A61K2039/55505 , A61K2039/55516 , A61K2039/55522 , C07K16/241
摘要： The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, these vector compositions comprise a colloidal metal, derivatized PEG (polyethylene glycol) and an agent. The invention also comprises methods and compositions for making such colloidal metal compositions and for treatment of cancer.
摘要翻译： 本发明包括用于药物递送系统的组合物和方法，包括治疗化合物，药剂，药物，检测剂，核酸序列和生物因子。 通常，这些载体组合物包含胶态金属，衍生化PEG（聚乙二醇）和试剂。 本发明还包括制备这种胶体金属组合物和治疗癌症的方法和组合物。
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