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22 条记录 (耗时 0.017 秒)

    Dry powder inhaler
    1.
    发明申请
    Dry powder inhaler 审中-公开
    干粉吸入器

    公开(公告)号：US20020040713A1

    公开(公告)日：2002-04-11

    申请号：US10007617

    申请日：2001-11-07

    申请人： Dura Pharmaceuticals, Inc.

    发明人： Robert F. Eisele ,  Karen Davies ,  Nelson Holton ,  Tim Kline ,  Ian Smith

    IPC分类号： B05D007/14 ,  A61M015/00 ,  A61M016/00 ,  B65D083/06

    CPC分类号： A61M15/0045 ,  A61M15/0006 ,  A61M15/0025 ,  A61M15/0031 ,  A61M15/0033 ,  A61M15/0048 ,  A61M2016/0024 ,  A61M2202/064 ,  A61M2205/8206

    摘要： A drug powder inhaler has a cover plate pivotably attached to a lid on an inhaler housing. A lever is pivotably attached to the cover plate. A blister pack disk is rotatably mounted on the housing under the cover plate. A powder duct in the housing extends from a staging chamber underneath one end of the lever to an aerosolizing chamber. An actuator in the housing is pressed to shear open a blister on the blister pack disk and thereby deliver the drug dose contents of the blister into the staging chamber. A switch senses pressure in the mouthpiece and switches on a motor spinning an impeller within the aerosolizing chamber, when inhalation is detected.

    摘要翻译： 药物吸入器具有可枢转地附接到吸入器壳体上的盖的盖板。 杠杆可枢转地附接到盖板。 泡罩包装盘可旋转地安装在盖板下方的壳体上。 壳体中的粉末管道从杠杆的一端的分级室延伸到雾化室。 按压壳体中的致动器来剪切泡罩包装盘上的泡罩，从而将泡罩的药物剂量内容物输送到分级室中。 当检测到吸入时，开关感测接口管中的压力并打开在雾化室内旋转叶轮的电动机。

    Pulmonary delivery of pharmaceuticals
    2.
    发明授权
    Pulmonary delivery of pharmaceuticals 失效
    肺部输送药物

    公开(公告)号：US6060069A

    公开(公告)日：2000-05-09

    申请号：US71578

    申请日：1998-05-01

    申请人： Malcolm Hill ,  Peter R. Byron

    发明人： Malcolm Hill ,  Peter R. Byron

    IPC分类号： A61K9/00 ,  A61M15/00 ,  A61K9/12

    CPC分类号： A61K9/0075 ,  A61M15/0006 ,  A61M15/0016 ,  A61M15/0033 ,  A61M15/0045 ,  A61M15/0048 ,  Y10S514/826

    摘要： In a method for treating lung diseases, a drug formulation is prepared by combining micronized crystalline beclomethasone dipropionate and lactose. The drug formulation is placed into a dry powder inhaler which provides inhalable drug particles having a mass median diameter of about 0.5-5.8 microns. The inhaler is preferably largely flow rate independent. Drug and lactose particles are separated in the inhaler during inhalation, most desirably via a spinning element. Due to deep deposition, the drug particles persist in the lungs for a surprisingly long duration, increasing the therapeutic effect of each dose. The patient inhales the drug particles with an inspiratory flow rate of about 10-60 liters/minute, to produce a deep lung deposition of inhaled particles.

    摘要翻译： 在治疗肺部疾病的方法中，通过将微粉化的结晶倍氯米松二丙酸酯和乳糖组合制备药物制剂。 将药物制剂置于干粉吸入器中，其提供质量中值直径约为0.5-5.8微米的可吸入药物颗粒。 吸入器优选地大体积流量独立。 药物和乳糖颗粒在吸入过程中在吸入器中分离，最理想的是通过纺丝元件。 由于深沉积，药物颗粒在肺中持续令人惊讶的持续时间，增加了每种剂量的治疗效果。 患者以吸气流速约10-60升/分钟吸入药物颗粒，以产生吸入颗粒的深层肺沉积。

    Dry powder inhaler
    5.
    发明申请
    Dry powder inhaler 有权
    干粉吸入器

    公开(公告)号：US20010027790A1

    公开(公告)日：2001-10-11

    申请号：US09773261

    申请日：2001-01-31

    申请人： Dura Pharmaceuticals, Inc.

    发明人： Andrew W. Gieschen ,  Michael Ligotke ,  Jeffrey Chen ,  Charles F. Ganem ,  Bernard Greenspan

    IPC分类号： A61M015/00 ,  A61M013/00 ,  A61M011/00 ,  B05D007/14 ,  A61M016/00 ,  B65D083/06

    CPC分类号： A61M15/0086 ,  A61M15/0008 ,  A61M15/0031 ,  A61M15/0043 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/02 ,  A61M2202/064 ,  A61M2205/43 ,  A61M2206/16 ,  A61M2206/18

    摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from the larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater air flow and powder dispersion, without any increased effort by the patient.

    摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的空气流动和粉末分散，而不会增加患者的任何增加的努力。

    Dry powder inhaler delivery system
    6.
    发明授权
    Dry powder inhaler delivery system 失效
    干粉吸入器输送系统

    公开(公告)号：US6029663A

    公开(公告)日：2000-02-29

    申请号：US841994

    申请日：1997-04-22

    申请人： Robert F. Eisele ,  Allan Cameron ,  David Titzler ,  Leonard Porche

    发明人： Robert F. Eisele ,  Allan Cameron ,  David Titzler ,  Leonard Porche

    IPC分类号： A61M15/00 ,  A61M16/00

    CPC分类号： A61M15/0045 ,  A61M15/0006 ,  A61M15/0025 ,  A61M15/0031 ,  A61M15/0033 ,  A61M15/0048 ,  A61M2016/0024 ,  A61M2202/064 ,  A61M2205/8206

    摘要： A powder storage and delivery system for a drug powder inhaler has a carrier disk with a blister shell sealed by a shear layer. A tab is adhered to the shear layer, underneath the blister shell. The carrier disk is placed into a dry powder inhaler. An actuator pushes against the tab, causing the shear layer to tear away, releasing the powder drug contents from the blister into the dry powder inhaler. A disk carrier has bursting blisters with a brittle blister shell sealed with a foil lid, and covered by a plate. An actuator moves against the plate, causing the plate to buckle and the blister shell to burst open, releasing powdered drug into the dry powder inhaler.

    摘要翻译： 用于药物粉末吸入器的粉末储存和递送系统具有带有由剪切层密封的泡罩的载体盘。 在泡罩外面的剪切层上粘附有一个舌片。 将载体盘放入干粉吸入器中。 致动器推动突片，导致剪切层撕开，将粉末药物从泡罩释放到干粉吸入器中。 磁盘托架具有破裂的气泡，具有用箔盖密封并被板覆盖的脆性泡罩壳。 致动器抵靠板移动，导致板卡扣并且水泡壳破裂，将粉末药物释放到干粉吸入器中。