公开(公告)号：US20250032388A1

公开(公告)日：2025-01-30

申请号：US18899935

申请日：2024-09-27

Applicant: Galderma Holding SA

Inventor： Ruandro Victor KNAPIK CECCON ,  Nicolas JOLY-TONETTI ,  Virginie LE NOEL ,  Sandrine Therese Beatrice PASCAL-SUISSE ,  Nadège Maryline LACHMANN ,  Mathieu GRIVET-SEYVE ,  Hyun Dae CHO ,  Jae Yong SEO

IPC: A61K8/67 ,  A61K8/19 ,  A61K8/27 ,  A61K8/29 ,  A61K8/9789 ,  A61K8/9794 ,  A61Q17/04 ,  A61Q19/00

Abstract: Provided herein are personal care compositions for reducing the signs of aging in sensitive skin without the irritating effects associated with retinol. Such personal care compositions comprise niacinamide, Leontopodium alpinum extract, Oryza sativa lees extract, panthenol, and soy-derived glycopeptides. Use of such compositions also modulates some biochemical indicators that are associated with premature aging of skin in response to pollution.

公开(公告)号：US12202854B2

公开(公告)日：2025-01-21

申请号：US17745471

申请日：2022-05-16

Applicant: Galderma Holding SA

Inventor： Johan Olsson ,  Kristoffer Bergman

IPC: C07H3/04 ,  C07H1/00 ,  C07H1/06

Abstract: The present technology is directed to methods of producing 6,6′-diamino-6,6′-dideoxy-trehalose (“DATH”) or a salt thereof. The methods include optionally protecting one or more hydroxyl groups of D-trehalose and converting the primary hydroxyl groups of D-trehalose to produce DATH or a salt thereof through use of a halogen, azide, and/or protected amine. The present technology is also directed to intermediate products of the methods.

公开(公告)号：US20240058268A1

公开(公告)日：2024-02-22

申请号：US18237864

申请日：2023-08-24

Applicant: GALDERMA HOLDING SA

Inventor： Valerie JULIA ,  Jayendra Kumar KRISHNASWAMY

IPC: A61K9/107 ,  A61P17/10 ,  A61K31/40

CPC classification number: A61K9/107 ,  A61P17/10 ,  A61K31/40

Abstract: Disclosed herein are methods for treatment of a skin disorders using pharmaceutical compositions that reduces the expression of and/or inhibit the activity of various genes including chemokine (C-X-C motif) ligands such as CXCL13 and XCL1, and matrix-metalloproteinases such as MMP12 and MMP13. The pharmaceutical compositions effectively act on epidermal differentiation and proliferation as well as on innate and adaptive immune cells in pathogenesis of skin disorders such as acne.

公开(公告)号：US11896806B2

公开(公告)日：2024-02-13

申请号：US17979589

申请日：2022-11-02

Applicant: Galderma Holding SA

Inventor： Jonas Törnsten ,  Max Blomqvist ,  Pekka Niskala

IPC: A61M5/31 ,  A61M5/315

CPC classification number: A61M5/3137 ,  A61M5/3159 ,  A61M5/31595 ,  A61M5/3148 ,  A61M2005/3139 ,  A61M2205/581 ,  A61M2205/582

Abstract: The present invention relates to a finger grip (1) arranged to be connected to a syringe barrel having a plunger and a plunger rod for driving said plunger. The finger grip comprises a body having a lower side with finger supporting surfaces (13) for supporting fingers of a user during handling and an engagement member (5) being moveable between an inactive position where the engagement member is arranged not to engage with the plunger rod of the syringe barrel and an active position where the engagement member is arranged to engage with a grooved surface on the plunger rod of the syringe such that feedback is given to a user as the plunger is moved relative to the finger grip. An activation member (7) for moving the engagement member from said inactive position to said active position is built-in into the finger grip.

公开(公告)号：US20230049863A1

公开(公告)日：2023-02-16

申请号：US17979589

申请日：2022-11-02

Applicant: Galderma Holding SA

Inventor： Jonas TÖRNSTEN ,  Max BLOMQVIST ,  Pekka NISKALA

IPC: A61M5/31 ,  A61M5/315

Abstract: The present invention relates to a finger grip (1) arranged to be connected to a syringe barrel having a plunger and a plunger rod for driving said plunger. The finger grip comprises a body having a lower side with finger supporting surfaces (13) for supporting fingers of a user during handling and an engagement member (5) being moveable between an inactive position where the engagement member is arranged not to engage with the plunger rod of the syringe barrel and an active position where the engagement member is arranged to engage with a grooved surface on the plunger rod of the syringe such that feedback is given to a user as the plunger is moved relative to the finger grip. An activation member (7) for moving the engagement member from said inactive position to said active position is built-in into the finger grip.

公开(公告)号：US11406769B2

公开(公告)日：2022-08-09

申请号：US15114598

申请日：2015-01-30

Applicant: Galderma Holding SA

Inventor： Jonas Törnsten

IPC: A61L31/02 ,  A61L31/14 ,  A61M5/32 ,  A61M5/42 ,  A61M5/178

Abstract: A method for lubricating an injection needle when used multiple times at a single occasion to penetrate a support, the method including the steps of: a) depositing a layer of a lubricating composition on the support; b) penetrating multiple times the layer of the lubricating composition deposited in step a) with the injection needle, thereby providing a lubricated injection needle having a deposited layer of the lubricating composition thereon.

公开(公告)号：US20220023250A1

公开(公告)日：2022-01-27

申请号：US17492320

申请日：2021-10-01

Applicant: Galderma Holding SA

Inventor： Karine Nadau-Fourcade ,  Jean-Christophe Buge

IPC: A61K31/327 ,  A61P17/10 ,  A61K47/02 ,  A61K47/10 ,  A61K47/20 ,  A61K47/32 ,  A61K47/26 ,  A61K47/18

Abstract: Described herein are compositions comprising (i) Isopropylcarbonate Benzoyl Peroxide, (ii) an opacifier, and (iii) and a preserving agent that have good physical, chemical and microbiological stability and corresponding methods of use.

公开(公告)号：US11154565B2

公开(公告)日：2021-10-26

申请号：US15766746

申请日：2016-10-13

Applicant: GALDERMA HOLDING SA

Inventor： Claire Mallard ,  Richard Dugat ,  Elodie Roger ,  Ricardo Diaz

IPC: A61K9/107 ,  A61K31/7048 ,  A01N43/90 ,  A61K47/10 ,  A61P17/10 ,  A61P17/08 ,  A61P17/04 ,  A01N25/04

Abstract: A process is described for preparing a stable emulsion that includes at least one avermectin. Also described, is the emulsion thus obtained, especially for use in the treatment of dermatological disorders such as rosacea.

公开(公告)号：US20210155763A1

公开(公告)日：2021-05-27

申请号：US17166909

申请日：2021-02-03

Applicant: Galderma Holding SA

Inventor： Morgan KARLSSON

IPC: C08J3/24 ,  C08B37/08 ,  C08L5/08 ,  A61K8/73 ,  A61K31/728 ,  A61K47/36 ,  A61K9/06 ,  A61Q19/08 ,  A61L27/20 ,  C08J3/075

Abstract: A process for manufacturing a cross-linked hyaluronic acid (HA) gel product is comprising the steps of: (a) preparing an aqueous mixture of HA and a cross-linking agent selected from multiepoxides and diepoxides; wherein the HA is dissolved in an aqueous solution containing 1-10% (w/w) inorganic hydroxide; and wherein the dissolved HA constitutes more than 10% (w/w) of the final mixture; and (b) subjecting the aqueous mixture to cross-linking conditions to allow the dissolved HA to react with the cross-linking agent so as to obtain a cross-linked HA gel product.

公开(公告)号：US10982016B2

公开(公告)日：2021-04-20

申请号：US16781264

申请日：2020-02-04

Applicant: Galderma Holding SA

Inventor： Morgan Karlsson ,  Anne Helander Kenne ,  Åke Öhrlund

IPC: C08B37/08 ,  A61K8/04 ,  A61K8/73 ,  A61K31/728 ,  A61Q19/00 ,  D01F9/00 ,  A61Q19/08 ,  A61K9/00

Abstract: A method for manufacturing a shaped cross-linked hyaluronic acid product including the step of subjecting a non-cross-linked precipitated hyaluronic acid substrate in a desired shape to a single cross-linking reaction in a liquid medium having a pH of 11.5 or higher and including one or more polyfunctional cross-linking agent(s) and an amount of one or more organic solvent(s) giving precipitating conditions for hyaluronic acid, under suitable conditions to obtain a precipitated, shaped cross-linked hyaluronic acid product having a degree of modification of 1-40 cross-linking agent units per 1000 disaccharide units.