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    Fenofibrate tablets
    4.
    发明授权
    Fenofibrate tablets 失效
    非诺贝特片

    公开(公告)号：US07976869B2

    公开(公告)日：2011-07-12

    申请号：US12603341

    申请日：2009-10-21

    申请人： Pascale Blouquin ,  Philippe Reginault

    发明人： Pascale Blouquin ,  Philippe Reginault

    IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K9/14

    CPC分类号： A61K9/145 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2866 ,  A61K31/216

    摘要： The present invention relates to a novel galenic formulation of fenofibrate for oral administration and to the process for its preparation. According to the invention, the formulation is a tablet obtained by compressing a mixture comprising: a) granules containing: 1 to 5% of a surfactant; micronized fenofibrate; and at least one solid excipient selected from starch, cellulose and derivatives thereof, with the exception of C12 disaccharides, said granules being obtained by granulating the mixture with the aid of an aqueous solution of polyvinylpyrrolidone; b) crosslinked polyvinylpyrrolidone; and c) optionally flow aids or lubricants, the amount of fenofibrate being greater than 50% by weight, expressed relative to the weight of the tablet.

    摘要翻译： 本发明涉及用于口服给药的非诺贝特的新颖盖仑制剂及其制备方法。 根据本发明，制剂是通过压缩混合物获得的片剂，其包含：a）含有1至5％表面活性剂的颗粒; 微粉化非诺贝特; 和至少一种选自淀粉，纤维素及其衍生物的固体赋形剂，除了C12二糖之外，所述颗粒是通过聚乙烯吡咯烷酮水溶液的混合物造粒得到的; b）交联聚乙烯吡咯烷酮; 和c）任选的助流剂或润滑剂，相对于片剂的重量，非诺贝特的量大于50重量％。

    5-Thioxylopyranose Compounds
    5.
    发明申请
    5-Thioxylopyranose Compounds 失效
    5-噻吩基吡喃糖化合物

    公开(公告)号：US20090186840A1

    公开(公告)日：2009-07-23

    申请号：US12411765

    申请日：2009-03-26

    申请人： Veronique BARBEROUSSE ,  Didier Thomas ,  Michel Bondoux

    发明人： Veronique BARBEROUSSE ,  Didier Thomas ,  Michel Bondoux

    IPC分类号： C07H15/20 ,  A61K31/7034 ,  A61P9/00

    CPC分类号： C07H15/203

    摘要： Compounds of 5-thioxylopyranose, preferably derivatives of the 5-thioxilopyranose type, a method for preparing such compounds, and the use of such compounds as an active ingredient in pharmaceutical compositions which are useful, in particular, for treating or inhibiting thrombosis or heart failure or thromboembolic disease states.

    摘要翻译： 5-硫代羟基吡喃糖的化合物，优选5-硫代吡喃葡萄糖型的衍生物，制备这些化合物的方法，以及这些化合物作为有效成分在药物组合物中的用途，其特别用于治疗或抑制血栓形成或心力衰竭 或血栓栓塞性疾病状态。

    5-Thioxylopyranose Compounds
    6.
    发明申请
    5-Thioxylopyranose Compounds 有权
    5-噻吩基吡喃糖化合物

    公开(公告)号：US20090118325A1

    公开(公告)日：2009-05-07

    申请号：US12352382

    申请日：2009-01-12

    申请人： Didier THOMAS ,  Michel Bondoux ,  Veronique Barberousse ,  Vincent Peyrou

    发明人： Didier THOMAS ,  Michel Bondoux ,  Veronique Barberousse ,  Vincent Peyrou

    IPC分类号： A61K31/437 ,  C07D409/02 ,  A61K31/428 ,  A61K31/423 ,  C07D471/02

    CPC分类号： C07H1/00 ,  C07H17/00

    摘要： 5-thioxylose compounds, especially 5-thioxylopyranose compounds, a process for their preparation, and their use for treating and/or inhibiting thromboses, especially venous thromboses. The compounds correspond to formula I: in which the pentapyranosyl group represents a free or substituted 5-thio-β-D-xylopyranosyl group; R′, R″ and R′″ each independently represent a hydrogen atom, a C2-C6 acyl group, or two adjacent ones of them form a 1-methylethylidene bridge; X1 and X2 each represent carbon or nitrogen; Y1 and Y2 each independently represent carbon, nitrogen, sulfur or oxygen, with the proviso that if Y2 represents oxygen or sulfur, then Y1 represents carbon or nitrogen; R1, R2, R3, R4 and R5 each independently represent hydrogen, a COOR6 group where R6 represents hydrogen or a C1-C4 alkyl group optionally substituted by a phenyl ring, a halogen atom or a —COOR6 group; a C1-C4 alkoxy group; a C1-C6 acyl group; a benzoyl group or a phenyl ring; and the addition salts and/or active metabolites of such compounds.

    摘要翻译： 5-硫代羟基化合物，特别是5-羟基吡喃糖化合物，其制备方法及其用于治疗和/或抑制血栓形成，特别是静脉血栓形成的用途。 化合物对应于式I：其中五草酰基代表游离或取代的5-硫代-β-D-吡喃木糖基; R'，R“和R”'各自独立地表示氢原子，C 2 -C 6酰基或其两个相邻的一个形成1-甲基亚乙基桥; X1和X2各自表示碳或氮; Y1和Y2各自独立地表示碳，氮，硫或氧，条件是如果Y2表示氧或硫，则Y1表示碳或氮; R 1，R 2，R 3，R 4和R 5各自独立地表示氢，COOR 6基团，其中R 6表示氢或任选被苯环，卤素原子或-COOR 6基团取代的C 1 -C 4烷基; C1-C4烷氧基; C1-C6酰基; 苯甲酰基或苯环; 和这些化合物的加成盐和/或活性代谢物。

    5-thio-β-D-xylopryanoside derivatives, preparation, method, pharmaceutical compositions containing them and their therapeutic use
    9.
    发明授权
    5-thio-β-D-xylopryanoside derivatives, preparation, method, pharmaceutical compositions containing them and their therapeutic use 失效
    5-硫代-β-D-木兰糖苷衍生物，制剂，方法，含有它们的药物组合物及其治疗用途

    公开(公告)号：US06927209B2

    公开(公告)日：2005-08-09

    申请号：US10139908

    申请日：2002-05-06

    申请人： Véronique Barberousse ,  Soth Samreth

    发明人： Véronique Barberousse ,  Soth Samreth

    IPC分类号： C07H17/04 ,  A61K31/7048 ,  A61P7/00 ,  A61P7/02 ,  A61P9/00 ,  C07H17/075 ,  A61K31/55 ,  A61K31/496 ,  A61K31/5377

    CPC分类号： C07H17/075

    摘要： The present invention relates to novel compounds of formula (I): in which: R1, R2 and R3, which are identical or different, are each independently: a (C1-C6)alkyl group, a pyridinyl group or a group —CH2—NR4R5, in which R4 and R5 are each independently a hydrogen atom or a (C1-C4)alkyl group, or alternatively R4 and R5 form, with the nitrogen atom to which they are bonded, a pyrrolidinyl, piperidinyl, hexahydroazepinyl, morpholinyl or piperazinyl group, with the proviso that at least one of the substituents R1, R2 and R3 is other than a (C1-C6)alkyl group, and their salts, solvates and hydrates, especially those which are pharmaceutically acceptable. These compounds are useful particularly for the treatment of disorders of the venous circulation.

    摘要翻译： 本发明涉及新的式（I）化合物：其中：R 1，R 2和R 3，它们是相同或 不同的，各自独立地为：（C 1 -C 6 -C 6）烷基，吡啶基或基团-CH 2 - 其中R 4和R 5各自独立地为氢原子或（C