公开(公告)号：US20210252072A1

公开(公告)日：2021-08-19

申请号：US16973108

申请日：2019-06-13

申请人： LOMA LINDA UNIVERSITY ,  LOMA LINDA UNIVERSITY MEDICAL CENTER ,  FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE

发明人： Huynh CAO ,  Yi XU ,  Kimberly PAYNE ,  David BAYLINK

IPC分类号： A61K35/28 ,  C12N5/0789

摘要： In one aspect, engineered hematopoietic stem cells comprising a heterologous expression cassette are provided. In some embodiments, the expression cassette comprises a promoter operably linked to a polynucleotide that encodes a 1α-hydroxylase protein, wherein the 1α-hydroxylase protein is human cytochrome P450 family 27 subfamily B member 1 (CYP27B1).

公开(公告)号：US09414967B2

公开(公告)日：2016-08-16

申请号：US14991331

申请日：2016-01-08

申请人： Loma Linda University ,  Loma Linda University Medical Center ,  North Carolina State University

发明人： Wolff M. Kirsch ,  Samuel M. Hudson ,  Andrew Crofton

IPC分类号： A61L2/14 ,  B29C43/00 ,  A61F13/00 ,  A61L24/08 ,  A61L24/00 ,  B29L31/00 ,  B29C43/56

CPC分类号： A61F13/00987 ,  A61F13/00012 ,  A61F2013/00106 ,  A61K9/70 ,  A61K47/36 ,  A61L2/0035 ,  A61L2/081 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/08 ,  A61L2300/232 ,  A61L2300/404 ,  A61L2400/04 ,  A61L2400/18 ,  B29C43/003 ,  B29C2043/561 ,  B29C2793/009 ,  B29K2005/00 ,  B29L2031/7722 ,  C08L5/08

摘要： A thin chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using γ-irradiation, treated under a nitrogen plasma, or both. A thin chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using γ-irradiation, treating under a nitrogen plasma, or both.

摘要翻译： 薄壳聚糖基材料可用于生物医学应用。 壳聚糖已经在氮气田中通过施加能量来电离壳聚糖材料中和周围的氮而被处理。 可以使用单次或多次这样的治疗。 例如，可以使用γ-照射在氮气下照射壳聚糖材料，在氮等离子体下进行处理，或者两者。 通过表面改性处理可以容易地处理薄壳聚糖材料，例如使用γ照射在氮气下照射，在氮等离子体下处理，或两者均可。

公开(公告)号：US20210177908A1

公开(公告)日：2021-06-17

申请号：US17256509

申请日：2019-06-28

申请人： LOMA LINDA UNIVERSITY ,  FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE ,  THE UNITE STATES OF AMERICA AS REPRESENTED BY UNTED STATES DEPARTMENT OF VETERANS AFFAIRS

发明人： Zhang XIAOBING ,  David BAYLINK ,  Wanqui CHEN ,  Kin-Hing William LAU

IPC分类号： A61K35/28 ,  A61P19/10 ,  C07K14/49 ,  C07K14/50 ,  C07K5/09

摘要： In one aspect, anabolic agent fusion proteins and compositions comprising anabolic agent fusion proteins are provided. In some embodiments, the anabolic agent fusion protein comprises a platelet derived growth factor (PDGF) or a fibroblast growth factor (FGF) and an Asp-Ser-Ser tripeptide (DSS) repeat sequence. In another aspect, methods of promoting bone growth and methods of treating a fracture using anabolic agent fusion proteins and compositions comprising anabolic agent fusion proteins are provided.

公开(公告)号：US08998943B2

公开(公告)日：2015-04-07

申请号：US14295224

申请日：2014-06-03

申请人： Faculty Physicians and Surgeons of Loma Linda University School of Medicine ,  Loma Linda University

发明人： Dalton Duane Baldwin ,  Alexander Yeo ,  Jacob Martin

IPC分类号： A61B17/34 ,  A61B5/06

CPC分类号： A61B17/3415 ,  A61B1/00147 ,  A61B1/00154 ,  A61B1/018 ,  A61B1/063 ,  A61B1/0676 ,  A61B1/307 ,  A61B5/061 ,  A61B5/065 ,  A61B6/12 ,  A61B6/485 ,  A61B6/487 ,  A61B8/0841 ,  A61B17/00234 ,  A61B17/3403 ,  A61B17/3423 ,  A61B34/20 ,  A61B90/13 ,  A61B2017/0034 ,  A61B2017/00707 ,  A61B2017/00853 ,  A61B2017/00907 ,  A61B2017/3413 ,  A61B2034/2055 ,  A61B2090/0807 ,  A61B2090/3762 ,  A61B2090/3966 ,  A61M25/0074 ,  A61M25/0097 ,  A61M25/10

摘要： A needle access assembly and method for obtaining percutaneous needle access with little or no fluoroscopy. The method can include selecting a target for percutaneous access, directing a laser guide at a desired needle-insertion angle and in line with the selected target, aligning the needle access assembly with the laser, and inserting the needle into the target.

公开(公告)号：US09259357B2

公开(公告)日：2016-02-16

申请号：US14254827

申请日：2014-04-16

申请人： Loma Linda University ,  North Carolina State University

发明人： Wolff M. Kirsch ,  Samuel M. Hudson ,  Andrew Crofton

IPC分类号： A61L2/14 ,  B29C43/00 ,  A61F13/00 ,  A61L24/08 ,  A61L24/00 ,  A61L2/00 ,  A61L2/08 ,  C08L5/08 ,  B29C43/56

CPC分类号： A61F13/00987 ,  A61F13/00012 ,  A61F2013/00106 ,  A61K9/70 ,  A61K47/36 ,  A61L2/0035 ,  A61L2/081 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/08 ,  A61L2300/232 ,  A61L2300/404 ,  A61L2400/04 ,  A61L2400/18 ,  B29C43/003 ,  B29C2043/561 ,  B29C2793/009 ,  B29K2005/00 ,  B29L2031/7722 ,  C08L5/08

摘要： A thin chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using γ-irradiation, treated under a nitrogen plasma, or both. A thin chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using γ-irradiation, treating under a nitrogen plasma, or both.

公开(公告)号：US09351758B2

公开(公告)日：2016-05-31

申请号：US14678696

申请日：2015-04-03

申请人： FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE ,  LOMA LINDA UNIVERSITY

发明人： Dalton Duane Baldwin ,  Alexander Yeo ,  Jacob Martin

IPC分类号： A61B17/34 ,  A61B5/06 ,  A61B1/00 ,  A61B1/307 ,  A61B19/00 ,  A61B1/018 ,  A61B17/00 ,  A61M25/00 ,  A61B1/06 ,  A61B8/08 ,  A61B6/00 ,  A61M25/10 ,  A61B6/12

CPC分类号： A61B17/3415 ,  A61B1/00147 ,  A61B1/00154 ,  A61B1/018 ,  A61B1/063 ,  A61B1/0676 ,  A61B1/307 ,  A61B5/061 ,  A61B5/065 ,  A61B6/12 ,  A61B6/485 ,  A61B6/487 ,  A61B8/0841 ,  A61B17/00234 ,  A61B17/3403 ,  A61B17/3423 ,  A61B34/20 ,  A61B90/13 ,  A61B2017/0034 ,  A61B2017/00707 ,  A61B2017/00853 ,  A61B2017/00907 ,  A61B2017/3413 ,  A61B2034/2055 ,  A61B2090/0807 ,  A61B2090/3762 ,  A61B2090/3966 ,  A61M25/0074 ,  A61M25/0097 ,  A61M25/10

摘要： A needle access assembly and method for obtaining percutaneous needle access with little or no fluoroscopy. The method can include selecting a target for percutaneous access, directing a laser guide at a desired needle-insertion angle and in line with the selected target, aligning the needle access assembly with the laser, and inserting the needle into the target.

公开(公告)号：US20140357987A1

公开(公告)日：2014-12-04

申请号：US14295224

申请日：2014-06-03

申请人： FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE ,  LOMA LINDA UNIVERSITY

发明人： Dalton Duane Baldwin ,  Alexander Yeo ,  Jacob Martin

IPC分类号： A61B5/06

CPC分类号： A61B17/3415 ,  A61B1/00147 ,  A61B1/00154 ,  A61B1/018 ,  A61B1/063 ,  A61B1/0676 ,  A61B1/307 ,  A61B5/061 ,  A61B5/065 ,  A61B6/12 ,  A61B6/485 ,  A61B6/487 ,  A61B8/0841 ,  A61B17/00234 ,  A61B17/3403 ,  A61B17/3423 ,  A61B34/20 ,  A61B90/13 ,  A61B2017/0034 ,  A61B2017/00707 ,  A61B2017/00853 ,  A61B2017/00907 ,  A61B2017/3413 ,  A61B2034/2055 ,  A61B2090/0807 ,  A61B2090/3762 ,  A61B2090/3966 ,  A61M25/0074 ,  A61M25/0097 ,  A61M25/10

摘要： A needle access assembly and method for obtaining percutaneous needle access with little or no fluoroscopy. The method can include selecting a target for percutaneous access, directing a laser guide at a desired needle-insertion angle and in line with the selected target, aligning the needle access assembly with the laser, and inserting the needle into the target.

公开(公告)号：US20220273468A1

公开(公告)日：2022-09-01

申请号：US17753007

申请日：2020-08-11

申请人： LOMA LINDA UNIVERSITY

发明人： Michael Davidson ,  Spencer Cutting

IPC分类号： A61F2/66 ,  A61F2/74

摘要： The present disclosure relates to an anatomically aligned prosthetic ankle with a passive assist and associated methods. The prosthetic ankle includes a talus movably coupled to a tibia section by a connector about which the talus is pivotal such so during locomotion by a user of the prosthetic ankle. The passive to assist provides a selected dorsi-flexion force to aid in the push-off or pre-swing phases of gait for the user.

公开(公告)号：US20220211813A1

公开(公告)日：2022-07-07

申请号：US17594167

申请日：2020-04-13

申请人： LOMA LINDA UNIVERSITY

发明人： Salvador SORIANO ,  Dong Kyu SHIN

IPC分类号： A61K38/18 ,  A61K31/137 ,  A61K31/445 ,  A61K45/06 ,  A61P3/06

摘要： Provided here are methods of treating Niemann-Pick disease type C (NPC) in a subject or delaying the onset of NPC in a subject by administering to the subject an immunomodulator, or a modulator of amyloid precursor protein (APP) function, or a combination thereof.

公开(公告)号：US20210322386A1

公开(公告)日：2021-10-21

申请号：US17250185

申请日：2019-06-10

申请人： Loma Linda University

发明人： Salvador SORIANO ,  Dong Kyu SHIN ,  Karina MAYAGOITIA

IPC分类号： A61K31/4196 ,  A61K45/06 ,  A61P25/28

摘要： In one aspect, methods of reversing or delaying the progression of Alzheimer's disease in a subject having Alzheimer's disease or delaying the onset of Alzheimer's disease in a subject having mild cognitive impairment are provided. In some embodiments, the method comprises administering to the subject an oxysterol inhibitor.