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公开(公告)号：US11199476B2
公开(公告)日：2021-12-14
申请号：US16470668
申请日：2017-12-21
IPC分类号： G01N1/02 , C12Q1/24 , C12Q1/6806 , G01N1/40
摘要： Biological specimen recovery materials include cellulose acetate nanofibers that are capable of dissolution upon contact with a liquid comprising a dissolution effective amount (e.g., between about 1 to about 10M) guanidinium isothiocyanate (GITC). Kits containing the materials (e.g., in the form of a swab, filtration media or surface wipe) and a dissolution liquid containing the dissolution effective amount of guanidinium isothiocyanate (GITC) are also provided.
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公开(公告)号：US11022717B2
公开(公告)日：2021-06-01
申请号：US16114376
申请日：2018-08-28
摘要： A system for performing distributed measurements of in-situ stress includes an expandable element with at least one fiber optic sensor. The expandable element can be positioned at various depths in a hole in a substrate. A pressurizing device expands (and contracts) the expandable element when the expandable element is inserted in the hole in the substrate to exert pressure on the hole wall. A pressure sensor provides a sensor output indicative of a pressure applied to the hole wall by the expandable element. The fiber optic sensor and an optical interrogator measure strain along a length of the sensor in a continuous, high spatial resolution manner Based on the measured strain and pressure sensor output, the system determines various properties of the substrate such as, minimum principal stress, maximum principal stress, and/or principal stress direction associated with one or more fractures in the substrate, as well as substrate modulus.
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公开(公告)号：US10161768B2
公开(公告)日：2018-12-25
申请号：US15500243
申请日：2015-07-28
摘要： A high-speed interrogation system is provided for interferometric sensors, one example of which is an EFPI sensor, that operates based on spectral interference. The system uses a two mode operation that includes a lower speed, accurate absolute measurement mode and a higher speed, relative measurement mode. The system achieves greater overall measurement accuracy and speed than known sensor interrogation approaches.
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公开(公告)号：US09244011B2
公开(公告)日：2016-01-26
申请号：US14358951
申请日：2012-11-05
发明人： Mark E. Froggatt
CPC分类号： G01N21/53 , B01D57/02 , G01N21/45 , G01N27/44721 , G01N2030/746
摘要： An optical interrogation system, e.g., an OFDR-based system, measures local changes of index of refraction of a medium contained within a light guiding tube and includes an optical interferometric interrogator, optical detection circuitry, and a data processor. The data processor initiates a sweep of the light source and guide light from an interrogating light source into a medium contained by a tube which restricts movement of particles provided into the tube, where the medium is subjected to a driving force that overcomes resistance to movement of particles through the medium in the tube. The optical interferometric interrogator provides an optical interference pattern associated with a group of particles having moved in the tube as a result of the driving force. Based on the optical interference pattern, the data processor identifies a current location of the group of particles in the tube.
摘要翻译： 光学询问系统，例如基于OFDR的系统，测量包含在导光管内的介质的折射率的局部变化，并且包括光学干涉询问器，光学检测电路和数据处理器。 数据处理器启动光源的扫描并将光从询问光源引导到由管包含的介质中，该介质限制了设置在管中的颗粒的移动，其中介质受到驱动力，该驱动力克服 颗粒通过管中的介质。 光学干涉询问器提供与由于驱动力而在管中移动的一组颗粒相关联的光学干涉图案。 基于光学干涉图案，数据处理器识别管中的一组颗粒的当前位置。
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5.发明申请BIOMARKER-TARGETING CONTRAST AGENTS AND THEIR USE IN MAGNETIC RESONANCE IMAGING FOR DETECTION OF ATHEROSCLEROTIC PLAQUE 审中-公开生物标志物对照试剂及其在磁共振成像中的用途，用于检测甲状腺素公开(公告)号：US20140161733A1
公开(公告)日：2014-06-12
申请号：US14007649
申请日：2012-03-29
CPC分类号： A61K49/1812 , A61K45/00 , A61K49/1839 , A61K49/189 , B82Y5/00
摘要： A composition comprising: a liposome having a bilayer structure, a gadofullerene having a high relaxivity, and an amphiphilic receptor ligand. In the composition, the gadofullerene is embedded in the bilayer structure of the liposome. In addition, a method for detecting atherosclerotic plaque in an animal using the composition is described.
摘要翻译： 一种组合物，其包含：具有双层结构的脂质体，具有高弛豫力的多余富勒烯和两亲性受体配体。 在该组合物中，天然富勒烯被包埋在脂质体的双层结构中。 另外，描述了使用该组合物检测动物的动脉粥样硬化斑块的方法。
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公开(公告)号：US08563585B2
公开(公告)日：2013-10-22
申请号：US12921049
申请日：2009-03-03
申请人： Christopher L. Kepley , Robert P. Lenk , Stephen R. Wilson , Zhiguo Zhou , Darren K. MacFarland
发明人： Christopher L. Kepley , Robert P. Lenk , Stephen R. Wilson , Zhiguo Zhou , Darren K. MacFarland
IPC分类号： A61K31/41 , A61K31/235 , C07D403/00 , C07C67/48
摘要： Described herein are methods for treating inflammatory disorders. The methods comprise administering to a subject in need thereof a therapeutically effective amount of a synthetically modified fullerene.
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公开(公告)号：US08004686B2
公开(公告)日：2011-08-23
申请号：US11792082
申请日：2005-12-13
申请人： Mark Froggatt , Dawn K. Gifford
发明人： Mark Froggatt , Dawn K. Gifford
IPC分类号： G01B9/02
CPC分类号： G01M11/3172 , G01M11/083
摘要： An optical device under test (DUT) is interferometrically measured. The DUT can include one or more of an optical fiber, an optical component, or an optical system. First interference pattern data for the DUT is obtained for a first path to the DUT, and second interference pattern data for the DUT is obtained for a second somewhat longer path to the DUT. Because of that longer length, the second interference pattern data is delayed in time from the first interference pattern data. A time varying component of the DUT interference pattern data is then identified from the first and second interference pattern data. The identified time varying component is used to modify the first or the second interference pattern data to compensate for the time-varying phase caused by vibrations, etc. One or more optical characteristics of the DUT may then be determined based on the modified interference pattern data.
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8.发明授权公开(公告)号：US07948633B2
公开(公告)日：2011-05-24
申请号：US12805879
申请日：2010-08-23
申请人： Mark Froggatt , Dawn K. Gifford
发明人： Mark Froggatt , Dawn K. Gifford
IPC分类号： G01B9/02
CPC分类号： G01M11/3172 , G01M11/083
摘要： An optical device under test (DUT) is interferometrically measured. The DUT can include one or more of an optical fiber, an optical component, or an optical system. First interference pattern data for the DUT is obtained for a first path to the DUT, and second interference pattern data for the DUT is obtained for a second somewhat longer path to the DUT. Because of that longer length, the second interference pattern data is delayed in time from the first interference pattern data. A time varying component of the DUT interference pattern data is then identified from the first and second interference pattern data. The identified time varying component is used to modify the first or the second interference pattern data to compensate for the time-varying phase caused by vibrations, etc. One or more optical characteristics of the DUT may then be determined based on the modified interference pattern data.
摘要翻译： 对被测光学器件（DUT）进行干涉测量。 DUT可以包括光纤，光学部件或光学系统中的一个或多个。 对于DUT的第一路径获得DUT的第一干涉图案数据，并且获得用于DUT的第二干涉图案数据用于到DUT的第二更长的路径。 由于该长度较长，所以第二干涉图案数据在时间上与第一干涉图案数据相比延迟。 然后从第一和第二干涉图案数据识别DUT干涉图案数据的时变分量。 所识别的时变分量用于修改第一或第二干涉图案数据以补偿由振动等引起的时变相位。然后可以基于经修改的干涉图案数据来确定DUT的一个或多个光学特性 。
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9.发明申请ADDITIVE PARTICLES HAVING SUPERHYDROPHOBIC CHARACTERISTICS AND COATINGS AND METHODS OF MAKING AND USING THE SAME 失效具有超级特性和涂层的添加剂颗粒及其制备和使用方法公开(公告)号：US20090298369A1
公开(公告)日：2009-12-03
申请号：US12420618
申请日：2009-04-08
CPC分类号： B05D5/08 , B05D2601/20 , C03C17/007 , C03C2217/46 , C03C2217/76 , C08K3/22 , C08K3/36 , C08K9/06 , C08K9/12 , C09D7/62 , C09D7/68 , C09D7/69 , D06M11/45 , D06M11/46 , D06M11/79 , D06M11/83 , D06M15/263 , D06M15/564 , D06M15/643 , D06M23/08 , D06M2200/12 , Y10T428/25 , Y10T428/259 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T442/2164
摘要： Additive particles may be employed in sufficient amounts to impart superhydrophobicity to a coating system in which the additive particles are incorporated. The additive particles include carrier microparticles and a dense plurality of nanoparticles adhered to the surfaces of the carrier microparticles (e.g., preferably by electrostatic deposition or covalent bonding). The additive particles are advantageously incorporated into a coating material (e.g., a polymeric material) in amounts sufficient to render a substrate surface superhydrophobic when coated with the coating material. The substrate may be rigid (e.g., glass, ceramic or metal) or flexible (e.g., a polymeric film or sheet or a fabric). In some preferred embodiments, both the microparticle and nanoparticles are formed of silica and are surface treated with a hydrophobic treatment so as to impart superhydrophobic properties thereto. Especially preferred are particles treated with silicone fluid comprised of a polysiloxane and/or a perfluoro silane having between 1 and 40 carbon atoms.
摘要翻译： 可以以足够的量使用添加剂颗粒以赋予其中掺入添加剂颗粒的涂料体系超疏水性。 添加剂颗粒包括载体微粒和粘附到载体微粒表面的致密多个纳米颗粒（例如优选通过静电沉积或共价键合）。 添加剂颗粒有利地以足以在涂覆涂料时使基材表面超疏水的量掺入涂料（例如聚合物材料）中。 基底可以是刚性的（例如，玻璃，陶瓷或金属）或柔性的（例如，聚合物膜或片或织物）。 在一些优选的实施方案中，微粒和纳米颗粒均由二氧化硅形成，并用疏水处理进行表面处理，以赋予其超疏水性。 特别优选的是用聚硅氧烷和/或具有1至40个碳原子的全氟硅烷组成的硅氧烷流体处理的颗粒。
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公开(公告)号：US07513160B2
公开(公告)日：2009-04-07
申请号：US11806475
申请日：2007-05-31
IPC分类号： G01N29/04
CPC分类号： G01S15/003
摘要： A digital pulsed phase locked loop (DPPLL) provides exact measurements of echo phase, time, and/or position delay as well as echo amplitude. These exact measurements provide better and more reliable results that directly benefit the many real world applications for the DPPLL. The DPPLL permits simultaneous tracking of multiple echo pulses and considerably improved echo selection and sampling.
摘要翻译： 数字脉冲锁相环（DPPLL）提供回波相位，时间和/或位置延迟以及回波幅度的精确测量。 这些精确的测量提供更好和更可靠的结果，直接有益于DPPLL的许多现实世界的应用。 DPPLL允许同时跟踪多个回波脉冲，并显着改善回波选择和采样。
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