公开(公告)号：US20230000890A1

公开(公告)日：2023-01-05

申请号：US17841193

申请日：2022-06-15

申请人： ZOGENIX MDS, INC.

发明人： Daniel DiPIETRO

IPC分类号： A61K31/708 ,  A61K31/7068 ,  A61K9/00 ,  A61P43/00

摘要： Deoxynucleotide prodrugs and methods of their use for treatment of diseases characterized by unbalanced nucleotide pools such as MPV17 and deoxyguanosine kinase deficiency are provided herein.

公开(公告)号：US20100237236A1

公开(公告)日：2010-09-23

申请号：US12408026

申请日：2009-03-20

申请人： Bruce Thomson ,  Bruce Collings

发明人： Bruce Thomson ,  Bruce Collings

IPC分类号： B01D59/44

CPC分类号： H01J49/0045 ,  H01J49/4225 ,  H01J49/427

摘要： A method of processing multiple precursor ions in a tandem mass spectrometer includes generating a plurality of precursor ions with an ion source. At least some of the plurality of precursor ions is trapped in an ion trap. At least two precursor ions of interest are isolated from the plurality of precursor ions with a filtered noise field. Precursor ions of interest are sequentially ejected toward a collision cell. The sequentially ejected precursor ions of interest are fragmented in a collision cell. The mass-to-charge ratio spectra of the fragmented ions are then determined with a mass spectrometer.

摘要翻译： 在串联质谱仪中处理多种前体离子的方法包括用离子源生成多个前体离子。 多个前体离子中的至少一些被捕获在离子阱中。 感兴趣的至少两个前体离子与多个前体离子与已滤波的噪声场分离。 感兴趣的前体离子顺序地朝向碰撞池排出。 感兴趣的顺序排出的前体离子在碰撞池中碎裂。 然后用质谱仪测定碎片离子的质荷比谱。

公开(公告)号：US20100078551A1

公开(公告)日：2010-04-01

申请号：US12569357

申请日：2009-09-29

申请人： Alexandre Loboda

发明人： Alexandre Loboda

IPC分类号： H01J49/26

CPC分类号： H01J49/004 ,  H01J49/0031

摘要： A method and apparatus for multiplexing ions in an MSn mass spectrometer is provided. Ion are filtered to produce a group of ions of interest, the group of ions below a space charge limit of the MSn mass spectrometer. At least a portion of the group of ions are fragmented to form a fragmented group of ions. At least a portion of the fragmented group are stored such that a plurality of portions of the fragmented group can be sequentially selected for mass spectrometry analysis. Each of the plurality of portions of the fragmented group are sequentially selected and re-fragmented prior to mass spectrometry analysis. Each of the plurality of portions of the fragmented group are analyzed, via mass spectrometry, once each of the plurality of portions of the fragmented group has been fragmented.

摘要翻译： 提供了一种用于在MSn质谱仪中复用离子的方法和装置。 离子被过滤以产生一组感兴趣的离子，这组离子低于MSn质谱仪的空间电荷极限。 离子组中的至少一部分被碎裂以形成一组离散的碎片。 存储片段的至少一部分，使得能够依次选择多个片段的部分进行质谱分析。 碎片组的多个部分中的每一个在质谱分析之前依次选择并再分段。 通过质谱分析碎片组的多个部分中的每一个，一旦碎片组的多个部分中的每一个已经被分段。

公开(公告)号：US20090294648A1

公开(公告)日：2009-12-03

申请号：US12472980

申请日：2009-05-27

申请人： Bradley Schneider ,  Thomas Covey

发明人： Bradley Schneider ,  Thomas Covey

IPC分类号： B01D59/44 ,  H01J49/00

CPC分类号： H01J49/004 ,  G01N27/624

摘要： A system including a differential mobility spectrometer is described as is a method of operating the system including the differential mobility spectrometer. The method and system involve a) providing ions to the differential mobility spectrometer; b) providing a drift gas to an inlet of the differential mobility spectrometer; c) adjusting a meter to define a selected volumetric flow rate for supplying a modifier liquid to the drift gas; and, d) supplying an actual volumetric flow rate of the modifier liquid to the drift gas, wherein the actual volumetric flow rate is within a percentage deviation from the selected volumetric flow rate

摘要翻译： 描述了包括差动迁移谱仪的系统是包括差动迁移谱仪的系统的操作方法。 该方法和系统包括：a）向差速迁移谱仪提供离子; b）向差动迁移谱仪的入口提供漂移气体; c）调节仪表以限定用于向漂移气体供应改性液体的选定体积流量; 以及d）将所述改性液体的实际体积流量提供给所述漂移气体，其中所述实际体积流量与所选择的体积流量的偏差百分比

公开(公告)号：US20090194683A1

公开(公告)日：2009-08-06

申请号：US12359471

申请日：2009-01-26

申请人： Mircea Guna ,  Yves Le Blanc

发明人： Mircea Guna ,  Yves Le Blanc

IPC分类号： B01D59/44

CPC分类号： H01J49/4295 ,  H01J49/0063 ,  H01J49/422

摘要： In accordance with an aspect of an embodiment of the present invention, there is provided a method for fragmenting ions in an ion trap of a mass spectrometer. The method comprises a) selecting parent ions for fragmentation; b) retaining the parent ions within the ion trap for a retention time interval, the ion trap having an operating pressure of less than about 1×10−4 Torr; c) providing a RF trapping voltage to the ion trap to provide a Mathieu stability parameter q at an excitement level during an excitement time interval within the retention time interval; d) providing a resonant excitation voltage to the ion trap during the excitement time interval to excite and fragment the parent ions; and, e) within the retention time interval and after the excitement time interval, terminating the resonant excitation voltage and changing the RF trapping voltage applied to the ion trap to reduce the Mathieu stability parameter q to a hold level less than the excitement level to retain fragments of the parent ions within the ion trap.

摘要翻译： 根据本发明的实施方案的一个方面，提供了一种用于在质谱仪的离子阱中分离离子的方法。 该方法包括：a）选择亲本离子进行碎裂; b）将母离子保留在离子阱内保持时间间隔，离子阱具有小于约1×10-4乇的操作压力; c）向离子阱提供RF捕获电压，以在保持时间间隔内的兴奋时间间隔期间以兴奋水平提供Mathieu稳定性参数q; d）在兴奋时间间隔期间向离子阱提供共振激发电压以激发和分裂母体离子; 并且e）在保持时间间隔内和在兴奋时间间隔之后，终止谐振激励电压并改变施加到离子阱的RF捕获电压，以将Mathieu稳定性参数q降低至小于保持的兴奋水平的保持水平 离子阱内母离子的碎片。

公开(公告)号：US07518104B2

公开(公告)日：2009-04-14

申请号：US11548311

申请日：2006-10-11

申请人： Stephen C. Gabeler

发明人： Stephen C. Gabeler

IPC分类号： G01D18/00

CPC分类号： H01J49/40 ,  H01J49/0009

摘要： Disclosed is a method of determining when to calibrate a time-of-flight mass spectrometer. In various embodiments, the method comprises storing within a controller a set of parameters for the mass spectrometer; providing an updated set of parameters while retaining at least one set of previously stored parameters; computing at least one rate of change of the updated set of parameters with respect to the at least one set of previously stored parameters; and determining when to calibrate the mass spectrometer from the results of computing the rate of change of at least one of the parameters. In various embodiments, a parameter stored can be a set of temperatures derived from obtaining system temperature measurements of those components whose changing temperature is an indication of mass drift. In various embodiments, the controller can store a history of calibration factors and temperatures over time, can calculate the time rate of change of the calibration factors and the temperature to estimate the mass drift rate of the instrument and compare the drift rate to a predetermined mass error limit for determining when re-calibration can be scheduled.

摘要翻译： 公开了一种确定何时校准飞行时间质谱仪的方法。 在各种实施例中，该方法包括在控制器内存储用于质谱仪的一组参数; 提供更新的参数集合，同时保留至少一组先前存储的参数; 相对于所述至少一组先前存储的参数来计算更新的参数集合的至少一个变化率; 以及从计算至少一个参数的变化率的结果确定何时校准质谱仪。 在各种实施例中，存储的参数可以是从获得其变化温度是质量漂移的指示的那些组件的系统温度测量得到的一组温度。 在各种实施例中，控制器可以存储校准因子和温度随时间变化的历史，可以计算校准因子和温度的时间变化率，以估计仪器的质量漂移率，并将漂移率与预定质量 确定何时可以安排重新校准的错误限制。

公开(公告)号：US07417223B2

公开(公告)日：2008-08-26

申请号：US11260222

申请日：2005-10-28

申请人： Yves LeBlanc ,  Nic Bloomfield

发明人： Yves LeBlanc ,  Nic Bloomfield

IPC分类号： G01N27/00 ,  G01N30/72 ,  G01N37/00 ,  H01J49/02 ,  H01J49/26

CPC分类号： H01J49/0036 ,  G06F19/703 ,  H01J49/0045

摘要： A first mass spectrum and a second mass spectrum of the same ion sample can be analyzed to determine reaction pairs. These reaction pairs are determined based on a selected neutral difference by shifting the second mass spectrum by the neutral difference relative to the first mass spectrum to provide a shifted mass spectrum. Then, the shifted mass spectrum is compared with the first mass spectrum of the ion sample to determine the reaction pairs based on the neutral difference.

摘要翻译： 可以分析相同离子样品的第一质谱和第二质谱，以确定反应对。 这些反应对是通过将第二质谱相对于第一质谱转移中性差而基于所选择的中性差来确定的，以提供转移的质谱。 然后，将移位的质谱与离子样品的第一质谱进行比较，以基于中性差来确定反应对。

公开(公告)号：US20080017789A1

公开(公告)日：2008-01-24

申请号：US11778954

申请日：2007-07-17

申请人： Jim Hager ,  Bruce Thomson

发明人： Jim Hager ,  Bruce Thomson

IPC分类号： H01J49/00

CPC分类号： H01J49/4225 ,  H01J49/004 ,  H01J49/4265 ,  H01J49/4285

摘要： A method of operating a mass spectrometer having a rod set is provided. The rod set has a first end, a second end opposite to the first end, and a longitudinal axis extending between the first end and the second end. The method comprises a) admitting ions into the rod set; b) trapping at least some of the ions in the rod set by i) producing a first barrier field at a first end member adjacent to the first end of the rod set, ii) producing a second barrier field at a second end member adjacent to the second end of the rod set, and iii) providing an aggregate field comprising an RF field between the rods of the rod set; c) selecting a first selected mass to charge ratio of a first group of ions in the ions; d) determining a first excitement level of a selected characteristic of the aggregate field for the first group of ions; e) adjusting the selected characteristic of the aggregate field to the first excitement level to resonantly excite the first group of ions to mass selectively eject the first group of ions from the rod set past the barrier field; and, f) maintaining the selected characteristic of the aggregate field at the first excitement level during an excitement time interval wherein the excitation time interval is at least 1 millisecond.

摘要翻译： 提供了具有棒组的操作质谱仪的方法。 杆组具有第一端，与第一端相对的第二端和在第一端和第二端之间延伸的纵向轴线。 该方法包括：a）将离子进入棒组; b）通过以下步骤捕获所述棒组中的至少一些离子：i）在与所述棒组的第一端相邻的第一端构件处产生第一屏障场，ii）在邻近所述杆组的第二端构件处产生第二屏障场 所述杆组的第二端，以及iii）提供包括所述杆组的杆之间的RF场的聚集场; c）选择离子中的第一组离子的第一选择质量与电荷比; d）确定第一组离子的聚集场的选定特征的第一兴奋度; e）将聚集场的所选特征调整到第一兴奋水平以共振地激发第一组离子以质量选择性地从穿过屏障场的棒组中弹出第一组离子; 以及f）在所述激发时间间隔至少为1毫秒的兴奋时间间隔期间将所述聚集场的选定特性保持在所述第一兴奋度水平。

公开(公告)号：US07288761B2

公开(公告)日：2007-10-30

申请号：US11135426

申请日：2005-05-24

申请人： Bruce Andrew Collings

发明人： Bruce Andrew Collings

IPC分类号： H01J49/00

CPC分类号： H01J49/4225

摘要： The invention provides a multipole ion trap. The trap has a longitudinal axis. An oscillating on-axis potential is set up along the longitudinal axis, providing a potential well in which ions are trapped. In some embodiments, rods forming the poles are symmetrically and equidistantly positioned about the longitudinal axis and RF signal with different magnitudes are applied to the poles. In other embodiments, the rods are not positioned symmetrically about the longitudinal axis and the RF signals applied to the poles may have the same or different magnitudes. Poles used in the invention may include two or more rods. An ion trap according to the invention may include more than two poles, and in some embodiments, a third or additional pole may be added to provide the oscillating on-axis potential. The ion trap may be used mass selectively scan ions, fragment ions and to trap and separate differently charged ions, among other uses.

摘要翻译： 本发明提供一种多极离子阱。 陷阱具有纵轴。 沿纵轴设置振荡的轴上电位，提供潜在的阱，其中离子被捕获。 在一些实施例中，形成极的杆围绕纵向轴线对称和等距定位，并且具有不同幅度的RF信号施加到极。 在其他实施例中，杆不围绕纵轴对称地定位，并且施加到杆的RF信号可以具有相同或不同的量值。 本发明中使用的极可以包括两个或更多个棒。 根据本发明的离子阱可以包括多于两个极，并且在一些实施例中，可以添加第三或另外的极以提供振荡的轴上电位。 离子阱可以选择性地扫描离子，碎片离子，并捕获和分离不同电荷的离子等等。

公开(公告)号：USRE39627E1

公开(公告)日：2007-05-15

申请号：US11020088

申请日：2004-12-23

申请人： Scott D. Tanner ,  Dmitry R. Bandura ,  Vladimir I. Baranov

发明人： Scott D. Tanner ,  Dmitry R. Bandura ,  Vladimir I. Baranov

IPC分类号： H01J49/00

CPC分类号： H01J49/105 ,  H01J49/067

摘要： A mass spectrometer has an ion source for producing sample ions. The ions pass through an ion interface, to a reaction/collision cell section. An ion-neutral decoupling device is provided between the ion interface and the reaction/collision cell section, to provide substantial separation between ions and neutral particles. The supersonic jet entering the spectrometer can have sufficient energy to cause the plasma gases, such as argon, to overcome the pressure differential between the reaction/collision cell and an upstream section of the spectrometer so as to penetrate into the reaction/collision cell; the decoupling device prevents this. The decoupling device can have offset apertures provided by plates or rods or other comparable arrangements, or can comprise a quadrupolar electrostatic deflector, an electrostatic sector deflector or a magnetic sector deflector.

摘要翻译： 质谱仪具有用于产生样品离子的离子源。 离子通过离子界面到反应/碰撞电池部分。 在离子界面和反应/碰撞电池部分之间提供离子 - 中性去耦装置，以提供离子和中性粒子之间的实质分离。 进入光谱仪的超音速喷射器可以具有足够的能量来引起诸如氩气的等离子体气体克服反应/碰撞池与光谱仪的上游部分之间的压力差，从而渗入反应/碰撞池中; 去耦设备防止这种情况。 去耦装置可以具有由板或杆或其他可比较的布置提供的偏移孔，或者可以包括四极静电偏转器，静电扇形偏转器或磁性扇形偏转器。