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公开(公告)号：US20080091370A1
公开(公告)日：2008-04-17
申请号：US11548311
申请日：2006-10-11
申请人： Stephen C. Gabeler
发明人： Stephen C. Gabeler
IPC分类号： G01D18/00
CPC分类号： H01J49/40 , H01J49/0009
摘要： Disclosed is a method of determining when to calibrate a time-of-flight mass spectrometer. In various embodiments, the method comprises storing within a controller a set of parameters for the mass spectrometer; providing an updated set of parameters while retaining at least one set of previously stored parameters; computing at least one rate of change of the updated set of parameters with respect to the at least one set of previously stored parameters; and determining when to calibrate the mass spectrometer from the results of computing the rate of change of at least one of the parameters. In various embodiments, a parameter stored can be a set of temperatures derived from obtaining system temperature measurements of those components whose changing temperature is an indication of mass drift. In various embodiments, the controller can store a history of calibration factors and temperatures over time, can calculate the time rate of change of the calibration factors and the temperature to estimate the mass drift rate of the instrument and compare the drift rate to a predetermined mass error limit for determining when re-calibration can be scheduled.
摘要翻译： 公开了一种确定何时校准飞行时间质谱仪的方法。 在各种实施例中，该方法包括在控制器内存储用于质谱仪的一组参数; 提供更新的参数集合，同时保留至少一组先前存储的参数; 相对于所述至少一组先前存储的参数来计算更新的参数集合的至少一个变化率; 以及从计算至少一个参数的变化率的结果确定何时校准质谱仪。 在各种实施例中，存储的参数可以是从获得其变化温度是质量漂移的指示的那些组件的系统温度测量得到的一组温度。 在各种实施例中，控制器可以存储校准因子和温度随时间变化的历史，可以计算校准因子和温度的时间变化率，以估计仪器的质量漂移率，并将漂移率与预定质量 确定何时可以安排重新校准的错误限制。
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公开(公告)号：US06512225B2
公开(公告)日：2003-01-28
申请号：US10178631
申请日：2002-06-24
IPC分类号： H01J4900
CPC分类号： H01J49/40 , H01J49/004
摘要： A tandem time-of-flight mass spectrometer is described. The spectrometer includes a pulsed source of ions that focuses a packet of ions substantially within a predetermined mass-to-charge ratio range onto a focal plane in a flight path of the ions. An ion selector receives the focused packet of ions and selects ions substantially within the predetermined mass-to-charge ratio range and rejects substantially all other ions. An ion fragmentor that fragments a fraction of the selected ions is positioned in the flight path of the selected ions. A pulsed ion accelerator that accelerates the selected ions and fragments thereof is positioned in a flight path of the selected ions and fragments thereof after the ion fragmentor. An electrode is positioned in the flight path of the accelerated selected ions and fragments thereof after the pulsed ion accelerator. In operation, the electrode is biased with a time varying bias voltage that increases the energy of the fragments relative to the selected ions.
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公开(公告)号：US5917184A
公开(公告)日：1999-06-29
申请号：US797088
申请日：1997-02-07
申请人： William W. Carson , Stephen C. Gabeler , Yin Liang F. Hsieh , Stephen A. Martin , Michael J. Tomany , Anotoli Verentchikov
发明人： William W. Carson , Stephen C. Gabeler , Yin Liang F. Hsieh , Stephen A. Martin , Michael J. Tomany , Anotoli Verentchikov
CPC分类号： H01J49/044 , H01J49/165
摘要： An interface apparatus for introducing a sample for analysis from a liquid flow into a mass spectrometer as a plurality of charged droplets is disclosed. The interface apparatus includes interface body which defines a spray chamber and an orifice, a spray means defining a liquid-flow inlet channel and an excess-sample-flow exit channel and having an open end disposed inside the spray chamber, and a voltage device for applying a voltage to the sample to form a plurality of charged droplets. The charged droplets pass through the orifice in the interface body and are introduced into a mass spectrometer for analysis. The interface includes a valve for regulating the flow of sample into the sample inlet channel and a device for imposing a pressure gradient on the sample at the open end which induces the sample to flow from the sample inlet channel through the excess sample outlet channel.
摘要翻译： 公开了一种用于将用于分析的样品从液体流引入质谱仪作为多个带电液滴的界面装置。 接口装置包括限定喷雾室和孔口的界面体，限定液流入口通道的喷射装置和多余样品流出口通道，并且具有设置在喷雾室内部的开口端;以及电压装置， 向样品施加电压以形成多个带电液滴。 带电液滴通过界面体中的孔口，并引入质谱仪进行分析。 该界面包括用于调节样品流入样品入口通道的阀和用于在开口端施加样品上的压力梯度的装置，其引起样品从样品入口通道流过多余的样品出口通道。
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公开(公告)号：US4920255A
公开(公告)日：1990-04-24
申请号：US264872
申请日：1988-10-31
申请人： Stephen C. Gabeler
发明人： Stephen C. Gabeler
IPC分类号： G06K7/10
CPC分类号： G06K7/10831 , G06K7/10801 , G06K7/10861 , G06K2207/1012 , G06K2207/1013
摘要： An automatic incremental focusing scanner system which optically reads a code pattern on an object. The system includes a scanner which directs a beam of radiation onto the object at one of a number of focal lengths. The system further includes a range determining unit for measuring the range of the object relative to the scanner, and a mechanism for alternating the focal length of the radiation beam to selectively focus it as commanded by a control module. The focal length of the beam is adjusted based on the measured range to enable accurate reading of the code pattern.
摘要翻译： 一种自动增量聚焦扫描仪系统，用于光学读取物体上的码型。 该系统包括扫描器，其以多个焦距中的一个将辐射束引导到物体上。 该系统还包括用于测量物体相对于扫描器的范围的范围确定单元，以及用于交替放射线束的焦距以根据控制模块所指令选择性地聚焦的机构。 基于测量范围调整光束的焦距，以便准确读取编码图案。
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公开(公告)号：US07518107B2
公开(公告)日：2009-04-14
申请号：US11548322
申请日：2006-10-11
申请人： Stephen C. Gabeler
发明人： Stephen C. Gabeler
IPC分类号： B01D59/44
CPC分类号： H01J49/40 , H01J49/0009
摘要： Disclosed are methods and apparatus for compensating for mass error for a time-of-flight mass spectrometer. A reference flight distance for a pulse of ions corresponding to a reference temperature of one or more components of an ion flight path assembly is determined, and the temperature of one or more components of the ion flight path assembly is measured. Correlating the thermal expansion of the flight path assembly with the temperature measurement allows the measured flight times to be adjusted to correspond with the reference flight distance to thereby compensate for the thermal expansion of the flight path assembly. A mass spectrum is obtained using the adjusted flight times. In various embodiments, the temperature signal is used with pre-determined thermal expansion correction factors for the flight path assembly to calculate a correction factor to control another component of the TOF MS, such as the voltage applied to a power supply system or a signal to control clock frequencies.
摘要翻译： 公开了用于补偿飞行时间质谱仪的质量误差的方法和装置。 确定对应于离子飞行路径组件的一个或多个部件的参考温度的离子脉冲的参考飞行距离，并且测量离子飞行路径组件的一个或多个部件的温度。 将飞行路径组件的热膨胀与温度测量相关联可以将测量的飞行时间调整为与参考飞行距离相对应，从而补偿飞行路径组件的热膨胀。 使用调整的飞行时间获得质谱。 在各种实施例中，温度信号与用于飞行路径组件的预定的热膨胀校正因子一起使用以计算校正因子以控制TOF MS的另一部件，例如施加到电源系统的电压或信号 控制时钟频率。
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公开(公告)号：US5526682A
公开(公告)日：1996-06-18
申请号：US245398
申请日：1994-05-18
CPC分类号： G01N30/7246 , G01N30/7273 , G01N30/7293
摘要： A system and process for analyzing a liquid sample is disclosed which includes an ultrasonic nebulizer capable of vibrating at a frequency between about 50 Khz and 760 Khz for converting the liquid sample to a liquid aerosol. The liquid aerosol is heated at a pressure of at least atmospheric pressure to evaporate solvent in the aerosol and to form a solid aerosol. The solid aerosol is separated from the evaporate solvent and the solid aerosol is directed into an electron impact ionizer and a mass spectrometer where it is analyzed.
摘要翻译： 公开了一种用于分析液体样品的系统和方法，其包括能够以约50KHZ和760KHZ之间的频率振动的超声雾化器，用于将液体样品转换成液体气溶胶。 将液体气溶胶在至少大气压的压力下加热以蒸发气溶胶中的溶剂并形成固体气溶胶。 将固体气溶胶与蒸发溶剂分离，并将固体气溶胶引导到电子碰撞离子发生器和质谱仪中进行分析。
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公开(公告)号：US07518104B2
公开(公告)日：2009-04-14
申请号：US11548311
申请日：2006-10-11
申请人： Stephen C. Gabeler
发明人： Stephen C. Gabeler
IPC分类号： G01D18/00
CPC分类号： H01J49/40 , H01J49/0009
摘要： Disclosed is a method of determining when to calibrate a time-of-flight mass spectrometer. In various embodiments, the method comprises storing within a controller a set of parameters for the mass spectrometer; providing an updated set of parameters while retaining at least one set of previously stored parameters; computing at least one rate of change of the updated set of parameters with respect to the at least one set of previously stored parameters; and determining when to calibrate the mass spectrometer from the results of computing the rate of change of at least one of the parameters. In various embodiments, a parameter stored can be a set of temperatures derived from obtaining system temperature measurements of those components whose changing temperature is an indication of mass drift. In various embodiments, the controller can store a history of calibration factors and temperatures over time, can calculate the time rate of change of the calibration factors and the temperature to estimate the mass drift rate of the instrument and compare the drift rate to a predetermined mass error limit for determining when re-calibration can be scheduled.
摘要翻译： 公开了一种确定何时校准飞行时间质谱仪的方法。 在各种实施例中，该方法包括在控制器内存储用于质谱仪的一组参数; 提供更新的参数集合，同时保留至少一组先前存储的参数; 相对于所述至少一组先前存储的参数来计算更新的参数集合的至少一个变化率; 以及从计算至少一个参数的变化率的结果确定何时校准质谱仪。 在各种实施例中，存储的参数可以是从获得其变化温度是质量漂移的指示的那些组件的系统温度测量得到的一组温度。 在各种实施例中，控制器可以存储校准因子和温度随时间变化的历史，可以计算校准因子和温度的时间变化率，以估计仪器的质量漂移率，并将漂移率与预定质量 确定何时可以安排重新校准的错误限制。
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公开(公告)号：US06441369B1
公开(公告)日：2002-08-27
申请号：US09712882
申请日：2000-11-15
IPC分类号： B01D5444
CPC分类号： H01J49/40 , H01J49/004
摘要： A tandem time-of-flight mass spectrometer is described. The spectrometer includes a pulsed source of ions that focuses a packet of ions substantially within a predetermined mass-to-charge ratio range onto a focal plane in a flight path of the ions. An ion selector receives the focused packet of ions and selects ions substantially within the predetermined mass-to-charge ratio range and rejects substantially all other ions. An ion fragmentor that fragments a fraction of the selected ions is positioned in the flight path of the selected ions. A pulsed ion accelerator that accelerates the selected ions and fragments thereof is positioned in a flight path of the selected ions and fragments thereof after the ion fragmentor. An electrode is positioned in the flight path of the accelerated selected ions and fragments thereof after the pulsed ion accelerator. In operation, the electrode is biased with a time varying bias voltage that increases the energy of the fragments relative to the selected ions.
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公开(公告)号：US5423661A
公开(公告)日：1995-06-13
申请号：US235007
申请日：1994-04-28
CPC分类号： F04C14/08 , F04C15/0069 , G01N30/34 , G01N30/36 , F04C2220/24 , G01N2030/324 , G01N2030/326 , G01N2030/347
摘要： A gear pump is used for the primary flow source for a low pressure, high performance separation system. The pump is controlled such that its flow and leakage characteristics are compensated by an electronic controller which results in controlled output flow rates to a variety of loads. The pump is particularly suited for use in liquid chromatography (LC) systems, especially LC systems which use membrane based separation media. A modification to the gear pump results in an efficient mixer, further enhancing its use in LC systems which involve gradient operational modes. Also disclosed are embodiments which allow the gear pump to be used in high pressure separation systems, e.g., high performance liquid chromatography (HPLC) systems.
摘要翻译： 齿轮泵用于低压，高性能分离系统的主流动源。 泵的控制使得其流量和泄漏特性由电子控制器补偿，其导致受控的输出流量到各种负载。 该泵特别适用于液相色谱（LC）系统，特别是使用基于膜的分离介质的LC系统。 对齿轮泵的修改产生了有效的混合器，进一步增强了其在涉及梯度操作模式的LC系统中的应用。 还公开了允许齿轮泵用于高压分离系统例如高效液相色谱（HPLC）系统的实施例。
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10.发明授权Power supply regulation using a feedback circuit comprising an AC and DC component 有权使用包括AC和DC分量的反馈电路的电源调节公开(公告)号：US07847241B2
公开(公告)日：2010-12-07
申请号：US12350773
申请日：2009-01-08
申请人： Stephen C. Gabeler
发明人： Stephen C. Gabeler
IPC分类号： H01J49/10
CPC分类号： H01J49/04 , H01J49/022 , H01J49/40
摘要： In various aspects, ion sources, mass spectrometer systems, and a power supply circuit coupled to a feedback circuit are provided. A power supply is provided that includes at least the power supply circuit and is operable to transfer charge to a load. The feedback circuit is responsive to a DC component of an output voltage supplied by the power supply in a first feedback loop and an AC component of the output voltage in a second feedback loop to produce a feedback signal representative of at least one of: a value of the output voltage before a charge transfer from a capacitor of the power supply to a load; the value of the output voltage during the charge transfer from the capacitor of the power supply to the load; or the value of the output voltage after the charge transfer from the capacitor of the power supply to the load.
摘要翻译： 在各个方面，提供了耦合到反馈电路的离子源，质谱仪系统和电源电路。 提供了至少包括电源电路并且可操作地将电荷传送到负载的电源。 反馈电路响应于在第一反馈回路中由电源提供的输出电压的DC分量和在第二反馈回路中的输出电压的AC分量以产生表示以下至少一个的反馈信号：值 在从电源的电容器到负载的电荷转移之前的输出电压; 在从电源的电容器到负载的电荷转移期间的输出电压的值; 或从电源的电容器到负载的电荷转移后的输出电压的值。
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