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    ANTIBODY HAVING AN IMMUNE-ENHANCEMENT FUNCTION
    1.
    发明申请
    ANTIBODY HAVING AN IMMUNE-ENHANCEMENT FUNCTION 审中-公开
    具有免疫增强功能的抗体

    公开(公告)号：US20110059471A1

    公开(公告)日：2011-03-10

    申请号：US12922304

    申请日：2009-03-13

    申请人： Hiromichi Yamashiro ,  Toshimasa Tadaki

    发明人： Hiromichi Yamashiro ,  Toshimasa Tadaki

    IPC分类号： G01N33/53 ,  C07K16/18 ,  C07K14/00

    CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K2317/73 ,  C07K2317/74 ,  G01N33/56972 ,  G01N2333/705

    摘要： The present invention provides a monoclonal antibody against FLJ32028, which binds specifically to the surfaces of regulatory T-cells (Treg) and especially to the surfaces of induced Treg. This monoclonal antibody can be used for a Treg-removal method or a Treg-removal apparatus. This monoclonal antibody can also be used as a drug that improves cell-proliferation function, an immune-enhancement function, or especially for cancer treatment.

    摘要翻译： 本发明提供了针对FLJ32028的单克隆抗体，其特异性结合于调节性T细胞（Treg）的表面，特别是与诱导的Treg的表面结合。 该单克隆抗体可用于除去Treg的方法或Treg去除装置。 该单克隆抗体也可以用作改善细胞增殖功能，免疫增强功能或特别用于癌症治疗的药物。

    Dendritic cells, pharmaceutical composition comprising said dendritic cells, therapeutic method and yo t-cell culture method utilizing said dendritic cells
    5.
    发明申请
    Dendritic cells, pharmaceutical composition comprising said dendritic cells, therapeutic method and yo t-cell culture method utilizing said dendritic cells 有权
    树突细胞，包含所述树突状细胞的药物组合物，利用所述树突状细胞的治疗方法和转运细胞培养方法

    公开(公告)号：US20070190169A1

    公开(公告)日：2007-08-16

    申请号：US11631660

    申请日：2005-07-07

    申请人： Mie Nieda ,  Manami Isogai ,  Kazuhiro Kakimi

    发明人： Mie Nieda ,  Manami Isogai ,  Kazuhiro Kakimi

    IPC分类号： A61K35/32 ,  C12N5/08

    CPC分类号： A61K35/15 ,  A61K2035/122 ,  C12N5/0639 ,  C12N2501/999

    摘要： The present invention provides dendritic cells capable of efficiently activating and/or proliferating γδ T-cells in vivo and/or in vitro, pharmaceutical compositions comprising said dendritic cells, therapeutic methods and γδ T-cell culture methods utilizing said dendritic cells. By pulsing immature dendritic cells derived from peripheral blood monocytes with a bisphosphonate-based bone metabolism improving drug to enable the cells to activate γδ T-cells, and cultivating them with a cell subset containing γδ T-cells, γδ T-cells can be activated and/or proliferated. This allows for easy proliferation of γδ T-cells without burdening a patient, leading to practical applications of immune cell therapies that utilize γδ T-cells.

    摘要翻译： 本发明提供能够在体内和/或体外有效活化和/或增殖Gammadelta T细胞的树突状细胞，包含所述树突状细胞的药物组合物，利用所述树突状细胞的治疗方法和Gammadelta T细胞培养方法。 通过用来自外周血单核细胞的未成熟树突状细胞用基于二膦酸盐的骨代谢改善药物进行脉冲激活，以使细胞能够激活Gammadelta T细胞，并用含有Gammadelta T细胞的细胞亚群进行培养，可以激活Gammadelta T细胞 和/或增殖。 这允许Gammadelta T细胞的容易增殖而不会使患者负担，导致利用Gammadelta T细胞的免疫细胞疗法的实际应用。

    Fluid delivery system
    6.
    发明授权
    Fluid delivery system 有权

    公开(公告)号：US09605240B2

    公开(公告)日：2017-03-28

    申请号：US14915681

    申请日：2014-09-02

    申请人： MEDINET CO., LTD.

    发明人： Daisuke Higeta ,  Tetsuya Yagura ,  Shun Ogasawara ,  Kazumi Ota ,  Takahiro Sato ,  Nao Yoshinaga ,  Hiroshi Terakawa

    IPC分类号： B01L3/00 ,  C12M1/00 ,  F04B43/12 ,  C12M1/34

    CPC分类号： C12M29/04 ,  C12M23/26 ,  C12M41/00 ,  F04B43/1269

    摘要： To avoid contamination of workspaces by splashing and the like of a waste fluid. A fluid delivery system for delivering a fluid from one container to another container includes: a delivery channel connecting between the one container to the other container; and a delivery pump which feeds the fluid into the delivery channel by compressively deforming inner diameter in the middle of the delivery channel, wherein the delivery channel is a partially elastic configuration that can be compressively deformed by the delivery pump, and also is a closed-system configuration with which the fluid flowing inside thereof is isolated from outside. As described, the delivery pump and the delivery tube or the waste-fluid container are not directly connected but are simply in contact. Therefore, it is possible to prevent splashing and the like of the waste fluid onto a work space when handling the waste fluid.

    Method for activation treatment of antigen-presenting cell
    8.
    发明授权
    Method for activation treatment of antigen-presenting cell 有权
    抗原呈递细胞的活化治疗方法

    公开(公告)号：US08609410B2

    公开(公告)日：2013-12-17

    申请号：US12066313

    申请日：2006-09-05

    申请人： Mie Nieda ,  Manami Isogai ,  Masashi Takahara ,  Andrew Nicol

    发明人： Mie Nieda ,  Manami Isogai ,  Masashi Takahara ,  Andrew Nicol

    IPC分类号： C12N5/078 ,  C12N5/0784

    CPC分类号： C12N5/0639 ,  A61K38/00 ,  A61K39/0011 ,  A61K2039/5158 ,  C12N5/0636

    摘要： Activated antigen-presenting cells that can induce immunocytes including disease antigen-specific CD8+ CTLs and/or γδ T cells efficiently in vivo and/or in vitro, a medical composition comprising the activated antigen-presenting cells, a treatment and prevention method using the activated antigen-presenting cells, and an induction method of immunocytes including disease antigen-specific CTLs and/or γδ T cells induced using the activated antigen-presenting cell, immunocytes induced by the above-noted method, a medical composition comprising the immunocytes, and a treatment and prevention method using the immunocytes are provided. By co-pulsing antigen-presenting cells with bisphosphonate in addition to the pulse with a disease antigen, the ratio of disease antigen-specific CD8+ CTLs and/or γδ T cells and the number of the disease antigen-specific CD8+ CTLs and the γδ T cells can be increased, compared with the case where the co-pulse with bisphosphonate is not carried out.

    摘要翻译： 可在体内和/或体外有效诱导包括疾病抗原特异性CD8 + CTL和/或Gammadelta T细胞的免疫细胞的活化抗原呈递细胞，包含活化的抗原呈递细胞的药物组合物，使用活化的抗原呈递细胞的治疗和预防方法 抗原呈递细胞，以及包括使用活化的抗原呈递细胞诱导的疾病抗原特异性CTL和/或Gammadelta T细胞的免疫细胞的诱导方法，由上述方法诱导的免疫细胞，包含免疫细胞的药物组合物和 提供了使用免疫细胞的治疗和预防方法。 除具有疾病抗原的脉冲之外，通过将抗原呈递细胞与双膦酸盐共脉冲，疾病抗原特异性CD8 + CTL和/或Gammadelta T细胞的比例以及疾病抗原特异性CD8 + CTL和gammadelta T的数量 与不进行与双膦酸盐的共脉冲的情况相比，可以增加细胞。

    METHOD FOR DETECTING AN ANTIGEN-SPECIFIC ANTIBODY AND REAGENT FOR USE THEREIN
    9.
    发明申请
    METHOD FOR DETECTING AN ANTIGEN-SPECIFIC ANTIBODY AND REAGENT FOR USE THEREIN 有权

    公开(公告)号：US20210032302A1

    公开(公告)日：2021-02-04

    申请号：US17029206

    申请日：2020-09-23

    申请人： Junichiro FUTAMI ,  Medinet Co., Ltd.

    发明人： Junichiro FUTAMI ,  Kazuhiro KAKIMI ,  Ryuji MAEKAWA ,  Masato SHIRAKI

    IPC分类号： C07K14/47 ,  G01N33/574 ,  G01N33/68 ,  G01N33/543 ,  C07K1/113

    摘要： A method for detecting an antigen-specific antibody detection reagent, which includes a cationized, denatured antigenic protein immobilized on a solid-phase surface of a carrier material, is provided. The cationized, denatured antigenic protein has cationized SH groups formed from reaction with a cationizing agent. The detection reagent is capable of specifically binding to an antigen-specific antibody which binds to an epitope of the antigenic protein. The method includes contacting a sample containing the antigen-specific antibody with the detection reagent to bind the antigen-specific antibody with the detection reagent. A labeled secondary antibody is then added to allow the labeled secondary antibody to bind to the antigen-specific antibody; and the detection reagent bound with the antigen-specific antibody is detected.