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公开(公告)号：US07810166B2
公开(公告)日：2010-10-05
申请号：US11576724
申请日：2005-09-30
摘要： The invention relates to a device for scanning probe microscopy, said device comprising a scanning microscopy measuring device provided with a measuring probe for scanning microscopy measurements and a sample carrier for receiving a sample to be measured by scanning microscopy; a control device which is connected to the scanning microscopy measuring device in such a way that it is integrated into the system, and is designed in such a way as to automatically control the measuring device in order to perform a scanning microscopy measurement according to pre-defined control parameters; and/or an evaluation device that is connected to the scanning microscopy measuring device in such a way that it is integrated into the system, and is designed in such a way as to automatically evaluate measurements according to pre-defined evaluation parameters.
摘要翻译： 本发明涉及一种用于扫描探针显微镜的装置，所述装置包括具有用于扫描显微镜测量的测量探针的扫描显微镜测量装置和用于通过扫描显微镜接收待测样品的样品载体; 控制装置，以与集成在系统中的方式连接到扫描显微镜测量装置，并且被设计成以自动控制测量装置的方式进行，以便根据预先进行的扫描显微镜测量， 定义控制参数; 和/或与扫描显微镜测量装置连接的评估装置，其被集成到系统中，并且被设计成以根据预定义的评估参数自动评估测量的方式。
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公开(公告)号：US20090253589A1
公开(公告)日：2009-10-08
申请号：US12440126
申请日：2006-09-05
CPC分类号： G01N33/6803 , G01N2333/726 , G01N2500/04 , G01Q30/04 , G01Q60/42
摘要： In one aspect the invention relates to a method for testing a chemical entity for its capability to modulate a (poly)peptide that is malfunctioning by means of an interaction of said chemical entity and said (poly)peptide, the method using single-molecule force spectroscopy. In another aspect the invention relates to a method for testing a chemical or physical entity for its capability to interact with a G protein-coupled receptor (GPCR) in its natural membrane environment, the method using single-molecule force spectroscopy.
摘要翻译： 一方面，本发明涉及一种用于测试化学实体的能力，以通过所述化学实体和所述（多）肽的相互作用来调节（多）肽的功能的方法，该方法使用单分子力 光谱学。 在另一方面，本发明涉及一种用于测试化学或物理实体在其天然膜环境中与G蛋白偶联受体（GPCR）相互作用的能力的方法，该方法使用单分子力谱。
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公开(公告)号：US20100031403A1
公开(公告)日：2010-02-04
申请号：US12376160
申请日：2006-08-11
IPC分类号： G01Q60/24
CPC分类号： G01Q30/10 , F28D15/0275 , F28F13/00 , F28F2013/008
摘要： The invention concerns a heat coupling device for scanning force or atomic force microscopy, comprising a first heat conducting device (27), a second heat conducting device (28) and a coupling device (36, 38, 39, 40, 41), in which the first heat conducting device (27) is movable relative to the second heat conducting device (28) and the coupling device (36, 38, 39, 40, 41) is arranged between the first and second heat conducting device (27, 28) and designed so that it is at least partially deformable fluid-like and/or flexible and the heat can be transferred between the first and second heat conducting device (28).
摘要翻译： 本发明涉及一种用于扫描力或原子力显微镜的热耦合装置，包括第一导热装置（27），第二导热装置（28）和联接装置（36,38,39,40,41），其中 所述第一导热装置（27）相对于所述第二导热装置（28）可移动，并且所述联接装置（36,38,39,40,41）布置在所述第一和第二导热装置（27,28）之间 ），并且被设计成使得其至少部分可变形地流体状和/或柔性，并且热量可以在第一和第二导热装置（28）之间传递。
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公开(公告)号：US20080072665A1
公开(公告)日：2008-03-27
申请号：US11576724
申请日：2005-09-30
IPC分类号： G01B5/28
摘要： The invention relates to a device for scanning probe microscopy, said device comprising a scanning microscopy measuring device provided with a measuring probe for scanning microscopy measurements and a sample carrier for receiving a sample to be measured by scanning microscopy; a control device which is connected to the scanning microscopy measuring device in such a way that it is integrated into the system, and is designed in such a way as to automatically control the measuring device in order to perform a scanning microscopy measurement according to pre-defined control parameters; and/or an evaluation device that is connected to the scanning microscopy measuring device in such a way that it is integrated into the system, and is designed in such a way as to automatically evaluate measurements according to pre-defined evaluation parameters.
摘要翻译： 本发明涉及一种用于扫描探针显微镜的装置，所述装置包括具有用于扫描显微镜测量的测量探针的扫描显微镜测量装置和用于通过扫描显微镜接收待测样品的样品载体; 控制装置，以与集成在系统中的方式连接到扫描显微镜测量装置，并且被设计成以自动控制测量装置的方式进行，以便根据预先进行的扫描显微镜测量， 定义控制参数; 和/或与扫描显微镜测量装置连接的评估装置，其被集成到系统中，并且被设计成以根据预定义的评估参数自动评估测量的方式。
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5.发明授权公开(公告)号：US08291511B2
公开(公告)日：2012-10-16
申请号：US12519568
申请日：2006-12-28
IPC分类号： G01B5/28
摘要： Proposed is a procedure for carrying out a scanning probe microscopic or atomic force spectroscopic measurement within predetermined parameters, which said procedure encompasses the following steps: a determination of a value variance of at least one of the parameters, and control of an adjustment member in relation to said variance, so that the variance is at least partially compensated for.
摘要翻译： 提出了在预定参数内执行扫描探针微观或原子力光谱测量的程序，所述方法包括以下步骤：确定至少一个参数的值方差，以及关于调节构件的控制 到所述方差，使得方差至少部分地被补偿。
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6.发明申请公开(公告)号：US20100146673A1
公开(公告)日：2010-06-10
申请号：US12519568
申请日：2006-12-28
申请人： Leif Riemenschneider , Gerd Hoffman
发明人： Leif Riemenschneider , Gerd Hoffman
摘要： Proposed is a procedure for carrying out a scanning probe microscopic or atomic force spectroscopic measurement within predetermined parameters, which said procedure encompasses the following steps: a determination of a value variance of at least one of the parameters, and control of an adjustment member in relation to said variance, so that the variance is at least partially compensated for.
摘要翻译： 提出了在预定参数内执行扫描探针微观或原子力光谱测量的程序，所述方法包括以下步骤：确定至少一个参数的值方差，以及关于调节构件的控制 到所述方差，使得方差至少部分地被补偿。
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公开(公告)号：US20080193963A1
公开(公告)日：2008-08-14
申请号：US11910634
申请日：2006-05-12
申请人： Alexej Kedrov , Daniel J. Muller
发明人： Alexej Kedrov , Daniel J. Muller
CPC分类号： G01Q60/42 , G01N33/54373 , G01N2500/04
摘要： The present invention relates to a method for determining the state of activation of a (poly)peptide, comprising the steps of: (a) immobilizing a (poly)peptide on a carrier; (b) attaching the (poly)peptide immobilized on the carrier to a force measuring device of a force spectroscope; (c) applying a pulling force to the (poly)peptide and measuring the force required for stretching and/or unfolding of the (poly)peptide attached to the carrier, wherein the measurements are carried out (i) prior to and (ii) after treatment with a known modulator of said (poly)peptide; (d) comparing the force spectra of the (poly)peptide prior to and after treatment with the modulator; and (e) concluding from a difference of the force spectra of step (d) on the state of activation of the (poly)peptide. Furthermore, the present invention relates to a method for determining whether a compound is an activator of (poly)peptide function, comprising the steps of (a) immobilizing a (poly)peptide on a carrier; (b) attaching the (poly)peptide to a force measuring device of a force spectroscope; (c) applying a pulling force to the (poly)peptide and measuring the force required for stretching and/or unfolding of the (poly)peptide attached to the carrier, wherein separate measurements are carried out in the presence of a test and a reference buffer, wherein the test buffer comprises a compound suspected of being an activator of the function of said (poly)peptide and wherein the reference buffer comprises (i) a compound known to have no effect on the activity of said (poly)peptide or (ii) a compound known to be an activator of said (poly)peptide; (d) comparing the force spectra of the (poly)peptide measured in the presence of the test and the reference buffer; and (e) concluding from a difference of the force spectra of step (d) whether the compound suspected of being an activator of said (poly)peptide is an activator of the (poly)peptide. Finally the present invention relates to a method for determining whether a compound is an inhibitor of (poly)peptide function.
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