公开(公告)号：US20110060197A1

公开(公告)日：2011-03-10

申请号：US12832603

申请日：2010-07-08

申请人： Wei ZHANG ,  Shih-Ping Wang ,  Shuoming Zhou ,  Zengpin Yu

发明人： Wei ZHANG ,  Shih-Ping Wang ,  Shuoming Zhou ,  Zengpin Yu

IPC分类号： A61B5/1455

CPC分类号： A61B5/14553 ,  A61B5/6814 ,  A61B5/7239

摘要： Methods, systems, and related computer program products for the non-invasive spectrophotometric monitoring of an optical property of a tissue volume are described. Multiple optical signals having different modulation frequencies are introduced into the tissue volume simultaneously and on a continuous basis throughout the monitoring session. Multiple optical signal portions incident upon each of a plurality of optical detectors are detected and separated based on their modulation frequency. Amplitude and phase signals corresponding to each optical signal portion are extracted and processed to determine the optical property of the tissue volume. In one preferred embodiment, a first optical detector includes an aperture having a central area, a first edge positioned nearer to a first optical source than the central area, and a second edge positioned farther from the first optical source than the central area. The first and second edges are each curved concavely toward the first optical source.

摘要翻译： 描述了用于非侵入性分光光度监测组织体积的光学性质的方法，系统和相关的计算机程序产品。 具有不同调制频率的多个光信号在整个监视会话中同时并连续地引入到组织体积中。 入射到多个光学检测器中的每一个的多个光信号部分基于它们的调制频率被检测和分离。 提取和处理对应于每个光信号部分的幅度和相位信号，以确定组织体积的光学特性。 在一个优选实施例中，第一光学检测器包括具有中心区域的第一边缘，比中心区域更靠近第一光源的第一边缘以及比中心区域更远离第一光源的第二边缘。 第一和第二边缘各自朝向第一光源凹入弯曲。

公开(公告)号：US20100198029A1

公开(公告)日：2010-08-05

申请号：US12701274

申请日：2010-02-05

申请人： Shih-Ping WANG

发明人： Shih-Ping WANG

IPC分类号： A61B5/1455

CPC分类号： A61B5/14553 ,  A61B5/14552 ,  A61B5/6814

摘要： Non-invasive spectrophotometric monitoring of oxygen saturation levels based on a combination of continuous wave spectrophotometry (CWS) and phase modulation spectrophotometry (PMS) is described. First information representative of absolute oxygen saturation levels in relatively shallow regions of a patient tissue volume are acquired from PMS-based monitoring thereof during a reference interval. Second information representative of non-absolute oxygen saturation levels in relatively deep regions of the tissue volume are acquired from CWS-based monitoring thereof during the reference interval. Based on the first and second information acquired during the reference interval, a mapping is automatically determined between the second information and estimated absolute oxygen saturation metrics for the relatively deep regions. On a continuing basis during a monitoring interval subsequent to the reference interval, the second information continuously acquired from CWS-based monitoring of the tissue volume are continuously mapped into estimated absolute oxygen saturation metrics, which are continuously displayed on a display output.

摘要翻译： 描述了基于连续波分光光度法（CWS）和相位调制分光光度法（PMS）的组合的无创分光光度法监测氧饱和度水平。 在参考间隔期间，从基于PMS的监视中获取代表患者组织体积的较浅区域中绝对氧饱和度水平的第一信息。 在参考间隔期间，从其基于CWS的监测中获取代表组织体积的相对较深区域中的非绝对氧饱和度水平的第二信息。 基于在参考间隔期间获取的第一和第二信息，在相对较深的区域的第二信息和估计的绝对氧饱和度度量之间自动确定映射。 在参考间隔之后的监视间隔期间，连续地基于从组织体积的基于CWS的监视连续获取的第二信息被连续地映射到在显示输出上连续显示的估计的绝对氧饱和度度量。

公开(公告)号：US20090326345A1

公开(公告)日：2009-12-31

申请号：US12146754

申请日：2008-06-26

申请人： Richard A. Jaffe ,  Jaime R. Lopez ,  Xuefeng Cheng

发明人： Richard A. Jaffe ,  Jaime R. Lopez ,  Xuefeng Cheng

IPC分类号： A61B5/1455

CPC分类号： A61B5/6814 ,  A61B5/14553

摘要： Methods, systems, and related computer program products for optically monitoring a chromophore level in a body part of a patient are described. An optical source introduces optical radiation into the body part, and an optical detector receives optical radiation that has propagated through at least a portion of the body part and produces a first signal representative of the received optical radiation. The first signal is processed to produce a chromophore level metric, which is output on a user display, and is further processed to produce a second signal known to exhibit measurably significant timewise fluctuations corresponding to at least one intrinsic physiological oscillation of the patient when the optical source and the optical detector are in proper optical coupling with the body part. An error condition indication is provided if the measurably significant timewise fluctuations are not present in the second signal.

摘要翻译： 描述用于光学监测患者身体部位中的发色团水平的方法，系统和相关的计算机程序产品。 光源将光辐射引入身体部位，并且光学检测器接收已经传播通过身体部分的至少一部分的光辐射并且产生表示所接收的光辐射的第一信号。 第一信号被处理以产生在用户显示器上输出的生色团电平度量，并且被进一步处理以产生已知具有对应于患者的至少一个固有生理振荡的可测量显着的时间波动的第二信号，当光学 光源和光学检测器与身体部位正确的光耦合。 如果在第二信号中不存在可测量的显着的时间波动，则提供错误状况指示。

公开(公告)号：US20110190613A1

公开(公告)日：2011-08-04

申请号：US13004393

申请日：2011-01-11

申请人： Wei ZHANG ,  Zengpin Yu ,  Shih-Ping Wang

发明人： Wei ZHANG ,  Zengpin Yu ,  Shih-Ping Wang

IPC分类号： A61B5/1455

CPC分类号： A61B5/1455

摘要： Systems, methods, and related computer program products for non-invasive NIR spectrophotometric (NIRS) monitoring of total blood hemoglobin levels and/or other blood constituent levels based on a hybrid combination of phase modulation spectrophotometry (PMS) and continuous wave spectrophotometry (CWS) are described. PMS-based measurements including both amplitude and phase information used in the determination of a non-pulsatile component of an absorption property for each of at least three distinct wavelengths are processed to compute PMS-derived intermediate information at least partially representative of a scattering characteristic. CWS-based measurements including amplitude information is processed in conjunction with the PMS-derived intermediate information to compute a pulsatile component of the absorption property. A metric representative of at least one chromophore level, such as the total blood hemoglobin level, is computed from the pulsatile component of the absorption property at the at least three wavelengths and displayed on an output display.

摘要翻译： 基于相位调制分光光度法（PMS）和连续波分光光度法（CWS）的混合组合，用于非侵入式近红外分光光度计（NIRS）监测总血红蛋白水平和/或其他血液成分水平的系统，方法和相关计算机程序产品， 被描述。 处理包括用于确定至少三个不同波长中的每一个的吸收特性的非脉动分量的幅度和相位信息的基于PMS的测量，以计算至少部分代表散射特性的PMS衍生的中间信息。 结合PMS派生的中间信息来处理包括振幅信息的基于CWS的测量，以计算吸收特性的脉冲分量。 代表至少一个生色团水平的度量，例如总血液血红蛋白水平，是根据至少三个波长的吸收特性的脉动分量来计算的，并显示在输出显示器上。

公开(公告)号：US20110046459A1

公开(公告)日：2011-02-24

申请号：US12826218

申请日：2010-06-29

申请人： Wei ZHANG ,  Zengpin YU ,  Thomas P. NEFF ,  Shih-Ping WANG

发明人： Wei ZHANG ,  Zengpin YU ,  Thomas P. NEFF ,  Shih-Ping WANG

IPC分类号： A61B5/00

CPC分类号： A61B5/14553

摘要： Methods, systems, and related computer program products for non-invasive spectrophotometric monitoring of an optical property of a medium are described. Respective light portions are propagated through respective at least partially non-overlapping subregions of the medium during each of a calibration interval and a subsequent monitoring interval. Detections of the light portions acquired during the calibration interval are processed to compute at least one algorithm compensation that causes a first result related to the optical property for the first subregion to be substantially equal to a second result related to the optical property for the second subregion. Subsequently, detections of respective light portions acquired during the monitoring interval are processed in conjunction with the at least one algorithm compensation to compute a monitoring result for the optical property. Advantages can include a reduction in the number of sources/detectors required and/or an obviation of symmetry requirements in source/detector layout.

摘要翻译： 描述了用于非侵入式分光光度监测介质的光学性质的方法，系统和相关的计算机程序产品。 在校准间隔和后续监视间隔的每一个期间，各个光部分通过介质的相应的至少部分不重叠的子区域传播。 处理在校准间隔期间获取的光部分的检测以计算至少一个算法补偿，其使得与第一子区域的光学特性相关的第一结果基本上等于与第二子区域的光学性质相关的第二结果 。 随后，结合该至少一个算法补偿来处理在监视间隔期间获取的各个光部分的检测，以计算出光学特性的监视结果。 优点可以包括减少源/检测器布局所需的源/检测器的数量和/或对称要求的消除。

公开(公告)号：US07551950B2

公开(公告)日：2009-06-23

申请号：US10877977

申请日：2004-06-29

申请人： Xuefeng Cheng

发明人： Xuefeng Cheng

IPC分类号： A61B5/1455

CPC分类号： A61B5/0073 ,  A61B5/14552

摘要： The present invention relates to a non-invasive optical system equipped with optical tomographic scanning method and algorithm for quantifying scattering and absorption properties and chromophore concentrations of highly scattering medium such as biological tissues, for 3D mapping and imaging reconstruction of the spatial and temporal variations in such properties. The invention further relates to a method and an apparatus for simultaneous measurement of concentrations of biochemical substances and blood oxygen saturation inside a biological tissue and arterial blood.

摘要翻译： 本发明涉及一种配备光学层析扫描方法和算法的非侵入性光学系统，用于量化诸如生物组织的高度散射介质的散射和吸收特性和发色团浓度，用于3D映射和成像重建的空间和时间变化 这样的属性。 本发明还涉及用于同时测量生物组织和动脉血中生化物质浓度和血氧饱和度的方法和装置。

公开(公告)号：US20120095305A1

公开(公告)日：2012-04-19

申请号：US12815696

申请日：2010-06-15

申请人： Ming Wang ,  Shih-Ping Wang ,  Zengpin Yu ,  Wei Zhang

发明人： Ming Wang ,  Shih-Ping Wang ,  Zengpin Yu ,  Wei Zhang

IPC分类号： A61B5/1455 ,  A61B6/00

CPC分类号： A61B5/0075 ,  A61B5/103 ,  A61B5/14551

摘要： Methods, systems, and related computer program products for the non-invasive spectrophotometric monitoring of a biological volume having multiple tissue layers are described. Aggregate absorption and scattering properties are measured for each of a plurality of predetermined source-detector separation distances along a surface of the biological volume, the measurement being based on a model of the biological volume as a single-layer, semi-infinite, homogeneous volume. A predetermined multi-layer tissue model is retrieved that characterizes a mathematical relationship among (a) absorption and scattering properties of each layer of a multi-layer tissue structure, and (b) aggregate absorption and scattering properties of the multi-layer tissue structure as would be measured at selected source-detector separation distances along a surface thereof. The measured aggregate absorption and scattering properties are processed in conjunction with the predetermined multi-layer tissue model to compute therefrom a deep-layer-specific absorption property corresponding to the relatively deep tissue layer.

摘要翻译： 描述了用于非侵入式分光光度监测具有多个组织层的生物体积的方法，系统和相关的计算机程序产品。 测量沿着生物体积的表面的多个预定的源 - 检测器分离距离中的每一个的聚集吸收和散射性质，该测量基于生物体积的模型作为单层，半无限均质体​​积 。 检索预定的多层组织模型，其表征（a）多层组织结构的每层的吸收和散射性质之间的数学关系，以及（b）多层组织结构的聚集吸收和散射性质作为 将沿着其表面的选定的源 - 检测器间隔距离测量。 测量的聚集体吸收和散射性质与预定的多层组织模型结合进行处理，从而计算对应于相对较深的组织层的深层特异性吸收特性。

公开(公告)号：US20090234245A1

公开(公告)日：2009-09-17

申请号：US12049843

申请日：2008-03-17

申请人： Richard A. JAFFE ,  Jaime R. Lopez ,  Xuefeng Cheng ,  Paul Chan

发明人： Richard A. JAFFE ,  Jaime R. Lopez ,  Xuefeng Cheng ,  Paul Chan

IPC分类号： A61B5/00

CPC分类号： A61B5/031 ,  A61B5/0059

摘要： Methods, systems, and related computer program products for are described for non-invasive detection of intracranial pressure (ICP) variations in an intracranial compartment of a patient. Optical radiation is propagated transcranially into the intracranial compartment, and optical radiation that has migrated through at least a portion of the intracranial compartment and back out of the cranium is detected. At least one signal representative of the detected optical radiation is processed to extract therefrom at least one component signal that varies in time according to at least one of an intrinsic physiological oscillation and an externally driven oscillation in the patient. Examples of suitable intrinsic physiological oscillations include intrinsic respiratory and cardiac oscillations. Examples of suitable externally driven oscillations include ventilated respiratory oscillations and externally mechanically induced oscillations. The extracted component signal is then processed to generate an output signal representative of the ICP variations in the intracranial compartment.

摘要翻译： 描述了用于非侵入性检测患者颅内隔室中的颅内压（ICP）变化的方法，系统和相关的计算机程序产品。 光辐射经颅传播到颅内隔室中，并且已经迁移通过颅内隔室的至少一部分并且返回到颅骨的光辐射被检测到。 处理表示检测到的光辐射的至少一个信号，以从其中提取至少一个根据患者内部生理振荡和外部驱动的振荡中的至少一个在时间上变化的分量信号。 合适的内在生理振荡的实例包括固有的呼吸和心脏振荡。 合适的外部驱动振荡的示例包括通气的呼吸振荡和外部机械感应的振荡。 然后处理所提取的分量信号以产生表示颅内隔室中的ICP变化的输出信号。

公开(公告)号：US20080177163A1

公开(公告)日：2008-07-24

申请号：US12017969

申请日：2008-01-22

申请人： Shih-Ping Wang ,  Xuefeng Cheng ,  Zengpin Yu

发明人： Shih-Ping Wang ,  Xuefeng Cheng ,  Zengpin Yu

IPC分类号： A61B5/1455

CPC分类号： A61B5/0073 ,  A61B5/14553 ,  A61B5/4064 ,  A61B5/6814 ,  A61B2562/0233 ,  A61B2562/046

摘要： Methods, systems, and related computer program products for non-invasive monitoring of a biological volume, such as a human brain, are described. In one preferred embodiment, each of a plurality of optical sources emits optical radiation into the biological volume each of a plurality of optical detectors detects optical radiation impinging thereupon from the biological volume. The optical measurements are processed to compute a requisite property value associated with each source-detector pair. For each source-detector pair, a volumetric basis region corresponding thereto is weighted by the requisite property value, the volumetric basis region being predetermined and representative of an estimated subvolume of the biological volume encountered by optical radiation emitted from that source and propagating to that detector. The weighted volumetric basis regions are accumulated into a volumetric cumulative array, and a display output is generated based at least in part on the volumetric cumulative array.

摘要翻译： 描述了用于非侵入性监测生物体积的方法，系统和相关的计算机程序产品，例如人类大脑。 在一个优选实施例中，多个光源中的每一个将光辐射发射到生物体积中，多个光学检测器中的每一个检测器从生物体积检测入射的光辐射。 处理光学测量以计算与每个源 - 检测器对相关联的必要属性值。 对于每个源 - 检测器对，与其对应的体积基础区域由所需的属性值加权，体积基础区域是预定的，并且代表从该源发射并传播到该检测器的光辐射遇到的生物体积的估计子体积 。 加权体积基础区域被累积到体积累积阵列中，并且至少部分地基于体积累积阵列生成显示输出。