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公开(公告)号:US12070541B2
公开(公告)日:2024-08-27
申请号:US18323077
申请日:2023-05-24
申请人: Orth Consulting, LLC
发明人: Donald S. Orth , Roger W. Orth
IPC分类号: A61M1/34 , A61F2/01 , A61F2/95 , A61K8/66 , A61M1/14 , A61M1/16 , A61M1/26 , A61M1/36 , B01D63/02 , B01D63/06 , B01D69/04 , B01D69/08 , B01J31/00 , C07K16/00 , C07K16/38 , C07K16/40 , C12N9/22 , C12N11/00 , C12N11/04 , C12N11/06 , C12N11/14 , C12N11/16
CPC分类号: A61M1/3489 , A61F2/01 , A61F2/95 , A61K8/66 , A61M1/15632 , A61M1/1621 , A61M1/1678 , A61M1/267 , A61M1/36 , A61M1/3601 , A61M1/3618 , A61M1/3621 , A61M1/3679 , A61M1/3687 , A61M1/3689 , B01D63/02 , B01D63/06 , B01D69/04 , B01D69/043 , B01D69/08 , B01J31/00 , B01J31/003 , C07K16/00 , C07K16/38 , C07K16/40 , C12N9/22 , C12N11/00 , C12N11/04 , C12N11/06 , C12N11/14 , C12N11/16 , A61M2202/0445 , A61M2205/3303 , A61M2205/3368
摘要: A blood treatment method includes the steps of inducing flow of a patient's blood through a blood treatment device inlet and outlet in fluid connection to the circulatory system of the patient. Metastatic deoxyribonucleic acid (DNA) contained within patient blood is destroyed by passing a patient's blood over a bioreactor surface having attached or immobilized deoxyribonuclease 1 (DNase 1) enzyme. The blood treatment device which consists of a bioreactor containing immobilized DNase 1, enables continuous treatment of a patient's blood and increases the effective concentration of DNase 1 in a patient's bloodstream to convert metastasizing cancer DNA in blood into non-oncogenic nucleotide fragments in vivo without adding any chemicals to the blood of the patient.
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公开(公告)号:US11208178B2
公开(公告)日:2021-12-28
申请号:US17150821
申请日:2021-01-15
申请人: ORTH CONSULTING, LLC
发明人: Donald S. Orth
IPC分类号: B63B34/56 , B63B32/30 , B63B34/565 , B63B32/60 , B63B34/52
摘要: Manually propelled water skis support a person skiing on water. The water ski includes a base having a binding on an upper surface and stationary propulsion structures with uniform height on the bottom surface. The propulsion structures include a rearward facing and vertical propulsion surface and a forward facing and sloped surface such that drag is greater when the water ski is moved rearwardly. The propulsion surface may be arcuate, V-shape, U-shaped, or other shaped in a horizontal plane and may also be circularly concave in a vertical plane. Buoyancy structures may be secured to the upper surface of the base forward and rearward of the binding. Water ski poles including elliptically- or cylindrically-shaped floats at the bottom ends may be used to provide a synergistic increase in waterskiing speed. Straps on the base near the binding may be used to secure the water ski poles to the base in order to form an outrigger.
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公开(公告)号:US20210339833A1
公开(公告)日:2021-11-04
申请号:US17150821
申请日:2021-01-15
申请人: ORTH CONSULTING, LLC
发明人: Donald S. Orth
IPC分类号: B63B34/56 , B63B32/30 , B63B32/60 , B63B34/565
摘要: Manually propelled water skis support a person skiing on water. The water ski includes a base having a binding on an upper surface and stationary propulsion structures with uniform height on the bottom surface. The propulsion structures include a rearward facing and vertical propulsion surface and a forward facing and sloped surface such that drag is greater when the water ski is moved rearwardly. The propulsion surface may be arcuate, V-shape, U-shaped, or other shaped in a horizontal plane and may also be circularly concave in a vertical plane. Buoyancy structures may be secured to the upper surface of the base forward and rearward of the binding. Water ski poles including elliptically- or cylindrically-shaped floats at the bottom ends may be used to provide a synergistic increase in waterskiing speed. Straps on the base near the binding may be used to secure the water ski poles to the base in order to form an outrigger.
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公开(公告)号:US10926849B1
公开(公告)日:2021-02-23
申请号:US16864833
申请日:2020-05-01
申请人: ORTH CONSULTING, LLC
发明人: Donald S. Orth
IPC分类号: B63B34/56 , B63B34/565 , B63B34/52
摘要: Manually propelled water skis support a person skiing on water. The water ski includes a base having a binding on an upper surface and propulsion structures on the bottom surface. The propulsion structures include a rearward facing and vertical propulsion surface and a forward facing and sloped surface such that drag is greater when the water ski is moved rearwardly. The propulsion surface may be arcuate, V-shape, U-shaped, or other shaped in a horizontal plane and may also be concave in a vertical plane. Buoyancy structures may be secured to the upper surface of the base forward and rearward of the binding. Water ski poles including elliptical floats at the bottom ends may be used to provide a synergistic increase in waterskiing speed. Straps on the base near the binding may be used to secure the water ski poles to the base in order to form an outrigger.
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公开(公告)号:US11305045B2
公开(公告)日:2022-04-19
申请号:US17395267
申请日:2021-08-05
申请人: ORTH CONSULTING, LLC
发明人: Donald S. Orth
摘要: A detoxification method includes the steps of inducing flow of patient blood through an extracorporeal device inlet and outlet in fluid connection to the circulatory system of a patient. Biological agents including lipopolysaccharide (LPS) contained within patient blood can be detoxified by passing patient blood over a biochemical reactor surface having attached or immobilized Saccharomyces boulardii alkaline phosphatase enzyme, with the biochemical reactor being contained within the extracorporeal device. An acyloxyacyl hydrolase enzyme may also be used on the biochemical reactor surface.
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公开(公告)号:US20210361846A1
公开(公告)日:2021-11-25
申请号:US17395267
申请日:2021-08-05
申请人: ORTH CONSULTING, LLC
发明人: Donald S. Orth
摘要: A detoxification method includes the steps of inducing flow of patient blood through an extracorporeal device inlet and outlet in fluid connection to the circulatory system of a patient. Biological agents including lipopolysaccharide (LPS) contained within patient blood can be detoxified by passing patient blood over a biochemical reactor surface having attached or immobilized Saccharomyces boulardii alkaline phosphatase enzyme, with the biochemical reactor being contained within the extracorporeal device. An acyloxyacyl hydrolase enzyme may also be used on the biochemical reactor surface.
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公开(公告)号:US10881781B1
公开(公告)日:2021-01-05
申请号:US16862378
申请日:2020-04-29
申请人: ORTH CONSULTING, LLC
发明人: Donald S. Orth
摘要: A detoxification method includes the steps of inducing flow of patient blood through an extracorporeal device inlet and outlet in fluid connection to the circulatory system of a patient. Biological agents including lipopolysaccharide (LPS) contained within patient blood can be detoxified by passing patient blood over a biochemical reactor surface having attached or immobilized Saccharomyces boulardii alkaline phosphatase enzyme, with the biochemical reactor being contained within the extracorporeal device.
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公开(公告)号:US20230414855A1
公开(公告)日:2023-12-28
申请号:US18323055
申请日:2023-05-24
申请人: Orth Consulting, LLC
发明人: Donald S. Orth , Roger W. Orth
CPC分类号: A61M1/3687 , C12N11/18 , C12N11/14 , A61M2202/203 , A61M2202/206 , A61M2205/3303 , A61M2205/3368 , A61M2205/36 , A61M2205/103
摘要: A detoxification method for treating sepsis, microbial infections, and other inflammatory conditions includes the steps of inducing flow of patient blood through a blood treatment device consisting of a bioreactor inlet and outlet in fluid connection to the circulatory system of a patient. Biological agents including lipopolysaccharide (LPS) and extracellular adenosine triphosphate (ATP) contained within patient blood can be irreversibly detoxified by passage of patient blood over a bioreactor surface having attached or immobilized alkaline phosphatase enzymes and acyloxyacyl hydrolase enzyme, with the bioreactor being contained within the blood treatment device. The method uses continuous treatment of a patient's blood to convert LPS and extracellular ATP in blood into inhibitors of inflammation in vivo without adding any chemicals to the bloodstream of the patient.
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公开(公告)号:US20230381392A1
公开(公告)日:2023-11-30
申请号:US18323077
申请日:2023-05-24
申请人: Orth Consulting, LLC
发明人: Donald S. Orth , Roger W. Orth
CPC分类号: A61M1/3489 , C12N9/22 , C07K16/40 , A61M1/15632
摘要: A blood treatment method includes the steps of inducing flow of a patient's blood through a blood treatment device inlet and outlet in fluid connection to the circulatory system of the patient. Metastatic deoxyribonucleic acid (DNA) contained within patient blood is destroyed by passing a patient's blood over a bioreactor surface having attached or immobilized deoxyribonuclease 1 (DNase 1) enzyme. The blood treatment device which consists of a bioreactor containing immobilized DNase 1, enables continuous treatment of a patient's blood and increases the effective concentration of DNase 1 in a patient's bloodstream to convert metastasizing cancer DNA in blood into non-oncogenic nucleotide fragments in vivo without adding any chemicals to the blood of the patient.
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10.
公开(公告)号:US12070543B2
公开(公告)日:2024-08-27
申请号:US18323055
申请日:2023-05-24
申请人: Orth Consulting, LLC
发明人: Donald S. Orth , Roger W. Orth
IPC分类号: A61M1/36 , A61F2/01 , A61F2/95 , A61K8/66 , A61M1/14 , A61M1/16 , A61M1/26 , A61M1/34 , B01D15/00 , B01D15/08 , B01D63/02 , B01D63/06 , B01D69/04 , B01D69/08 , B01J20/22 , B01J31/00 , C07K16/00 , C07K16/38 , C07K16/40 , C12N11/00 , C12N11/02 , C12N11/06 , C12N11/14 , C12N11/16 , C12N11/18 , A61F2/00
CPC分类号: A61M1/3687 , A61F2/01 , A61F2/95 , A61K8/66 , A61M1/15632 , A61M1/1621 , A61M1/267 , A61M1/3489 , A61M1/36 , A61M1/3621 , A61M1/3653 , A61M1/3679 , A61M1/3689 , B01D15/00 , B01D15/08 , B01D63/02 , B01D63/06 , B01D69/04 , B01D69/043 , B01D69/08 , B01J20/22 , B01J31/003 , C07K16/00 , C07K16/38 , C07K16/40 , C12N11/00 , C12N11/02 , C12N11/06 , C12N11/14 , C12N11/16 , C12N11/18 , A61F2/00 , A61M2202/0445 , A61M2202/0456 , A61M2202/046 , A61M2202/07 , A61M2202/203 , A61M2202/206 , A61M2205/3303 , B01J2220/4812 , B01J2220/4868
摘要: A detoxification method for treating sepsis, microbial infections, and other inflammatory conditions includes the steps of inducing flow of patient blood through a blood treatment device consisting of a bioreactor inlet and outlet in fluid connection to the circulatory system of a patient. Biological agents including lipopolysaccharide (LPS) and extracellular adenosine triphosphate (ATP) contained within patient blood can be irreversibly detoxified by passage of patient blood over a bioreactor surface having attached or immobilized alkaline phosphatase enzymes and acyloxyacyl hydrolase enzyme, with the bioreactor being contained within the blood treatment device. The method uses continuous treatment of a patient's blood to convert LPS and extracellular ATP in blood into inhibitors of inflammation in vivo without adding any chemicals to the bloodstream of the patient.
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