利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.02 秒)

    PHOTONIC BLOOD TYPING
    2.
    发明申请
    PHOTONIC BLOOD TYPING 有权

    公开(公告)号：US20140315760A1

    公开(公告)日：2014-10-23

    申请号：US14234134

    申请日：2012-07-20

    申请人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

    发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

    IPC分类号： G01N33/543 ,  G01N33/80

    CPC分类号： G01N33/54373 ,  G01N21/75 ,  G01N33/80

    摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

    摘要翻译： 提供了用于检测生物溶液（例如全血）中的分析物的光子器件，系统和方法。 代表性的光子器件是具有纳米尺度特征和微米尺寸直径的光学环形谐振器。 由于这些器件的紧凑尺寸，许多谐振器可以被布置在单个衬底上并且当样品通过器件时同时测试。 典型的分析物包括血细胞，抗体和病原体，以及指示存在血细胞或病原体的化合物（例如血清学）。 在某些实施方案中，血液类型可以通过使用血细胞直接检测和血清学的组合的光子感测来确定。 通过组合多个装置的检测信号，可以确定血液的类型。

    Determination of von Willebrand Factor cleavage by ADAMTS13
    3.
    发明授权
    Determination of von Willebrand Factor cleavage by ADAMTS13 有权
    通过ADAMTS13测定von Willebrand因子切割

    公开(公告)号：US08637268B2

    公开(公告)日：2014-01-28

    申请号：US13289474

    申请日：2011-11-04

    申请人： Junmei Chen ,  Dominic W. Chung ,  Jose Aron Lopez

    发明人： Junmei Chen ,  Dominic W. Chung ,  Jose Aron Lopez

    IPC分类号： C12Q1/56

    CPC分类号： C12Q1/56 ,  G01N2800/226

    摘要： Novel methods are described for measuring the rate of ADAMTS13-mediated cleavage of von Willebrand Factor (VWF) multimers. Through the use of the reagent, ristocetin, the method can advantageously be performed in the absence of an applied shear stress or added denaturing agent. Also described are methods for diagnosing ADAMTS13-associated disorders and methods for providing improved treatment of those disorders by evaluating the efficacy of the treatment using the methods as described.

    摘要翻译： 描述了用于测量冯维勒布兰因子（VWF）多聚体的ADAMTS13介导的切割速率的新方法。 通过使用试剂瑞斯托菌素，该方法可以有利地在没有施加的剪切应力或加入的变性剂的情况下进行。 还描述了用于诊断ADAMTS13相关疾病的方法和通过使用所述方法评估治疗的功效来提供对这些疾病的改善治疗的方法。

    Photonic blood typing
    4.
    发明授权
    Photonic blood typing 有权

    公开(公告)号：US10794921B2

    公开(公告)日：2020-10-06

    申请号：US16047911

    申请日：2018-07-27

    申请人： University of Washington through its Center for Commercialization ,  Bloodworks

    发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

    IPC分类号： G01N33/80 ,  G01N33/543 ,  G01N21/77 ,  G01N21/75

    摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

    Biochemical Markers of Red Blood Cell Storage and Toxicity
    9.
    发明申请
    Biochemical Markers of Red Blood Cell Storage and Toxicity 有权
    红细胞储存和毒性的生化标志物

    公开(公告)号：US20140178904A1

    公开(公告)日：2014-06-26

    申请号：US14012885

    申请日：2013-08-28

    申请人： Puget Sound Blood Center

    发明人： James Charles Zimring

    IPC分类号： G01N33/50

    CPC分类号： G01N33/80 ,  G01N33/5005 ,  G01N33/53 ,  G01N2800/7066

    摘要： Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more markers in a red blood cell sample are provided.

    摘要翻译： 提供了通过测量红细胞样品中一种或多种标记物的水平来确定红血球的输血后存活或毒性的红血球单元用于输血的组合物和方法。

    Method of reducing immunogenicity and inducing immunologic tolerance
    10.
    发明授权
    Method of reducing immunogenicity and inducing immunologic tolerance 失效
    降低免疫原性并诱导免疫耐受的方法

    公开(公告)号：US4998931A

    公开(公告)日：1991-03-12

    申请号：US290856

    申请日：1988-12-21

    申请人： Sherrill J. Slichter ,  H. Joachim Deeg

    发明人： Sherrill J. Slichter ,  H. Joachim Deeg

    IPC分类号： A61K41/00

    CPC分类号： A61K41/0023 ,  A61K41/0019

    摘要： The immunogenicity of transfused or transplanted, allogeneic tissue is reduced by either directly exposing the tissue to ultraviolet (UV) irradiation prior to administering the tissue to the recipient or by inducing a state of tolerance in the recipient to non-UV or UV-irradiated allogeneic tissue by prior exposure to UV-irradiated allogeneic tissue.

    摘要翻译： 输血或移植的同种异体组织的免疫原性通过在将组织施用于受体之前直接暴露于紫外线（UV）照射或通过在接受者中诱导非UV或UV照射的同种异体的耐受状态来降低 组织通过先前暴露于紫外线照射的同种异体组织。