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公开(公告)号:US20240325437A1
公开(公告)日:2024-10-03
申请号:US18619343
申请日:2024-03-28
发明人: Noga RON-HAREL , David EZUZ
CPC分类号: A61K33/26 , A61K31/49 , A61K38/385 , A61K39/39 , A61P37/04
摘要: A method of increasing proliferation of adaptive immune cells of a subject at least 65 years old is provided. The method comprising contacting the immune cells with an agent which increases the level of labile iron in the immune cells and/or reduces toxicity of hemoglobin, heme or a degradation product thereof, thereby increasing the proliferation of the adaptive immune cells of the subject.
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公开(公告)号:US12084523B2
公开(公告)日:2024-09-10
申请号:US17982883
申请日:2022-11-08
发明人: Ashraf Brik , Mickal Nawatha , Hiroaki Suga , Joseph Rogers
摘要: The present invention is directed to a cyclic polypeptide having ubiquitin binding affinity (KD) of 0.1-100 nM. Further provided are methods for reducing deubiquitination activity of a cell, and for treating cancer in a subject in need thereof.
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公开(公告)号:US20240269318A1
公开(公告)日:2024-08-15
申请号:US18626620
申请日:2024-04-04
发明人: Avi SCHROEDER , Mor SELA
CPC分类号: A61K47/6911 , A61P25/16 , B82Y5/00
摘要: In one aspect of the invention, there is provided a nanoparticle comprising a core and a shell, wherein the core comprises a bioactive compound, and the shell comprises a lipid layer comprising a first modified lipid and a additional lipid, wherein the first modified lipid is bound to a targeted moiety via a spacer, and wherein the additional lipid comprises a polymer-bound lipid. The present invention further provides pharmaceutical compositions and methods for therapeutic and/or diagnostic use.
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公开(公告)号:US12060575B2
公开(公告)日:2024-08-13
申请号:US17178279
申请日:2021-02-18
IPC分类号: C12N5/0735 , C12N5/00
CPC分类号: C12N5/0606 , C12N5/0031 , C12N5/0037 , C12N5/0043 , C12N2501/115 , C12N2501/15 , C12N2501/2306 , C12N2501/235 , C12N2533/12 , C12N2533/90
摘要: A method of expanding and maintaining human embryonic stem cells (ESCs) in an undifferentiated state by culturing the ESCs in a suspension culture under culturing conditions devoid of substrate adherence is provided. Also provided are a method of deriving ESC lines in the suspension culture and methods of generating lineage-specific cells from ESCs which were expanded in the suspension culture of the present invention.
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公开(公告)号:US12047494B2
公开(公告)日:2024-07-23
申请号:US17543979
申请日:2021-12-07
发明人: Eli Biham , Sara Bitan-Erlich , Alon Dankner
CPC分类号: H04L9/0825 , H04L9/3213 , H04L9/3228 , H04L9/3242
摘要: One of the main obstacles of securing industrial control systems is the lack of an appropriate security model that is both implementable by vendors and addresses the inherent security and usability issues needed by organizations. Current solutions such as device passwords and IPSec lack scalable key management infrastructure and fine granularity access control mechanisms. A security model for industrial control systems that supports organizational level authorizations and authentication requirements, while hiding the low-level details (e.g., keys and passwords) from the users is disclosed. It also enables easy addition and removal of PLCs, engineering station, HMI devices and users, and assigning permission to them. A major advantage is its support for hybrid ICS systems, characterized by co-existence of legacy devices and new devices, while using the same protocol. Devices may communicate therein either natively, or by a connected converter. This co-existence allows organizations to gradually switch from a fully-legacy ICS to ICS natively supporting the disclosed security model, by replacing a single (or a few) devices at a time, incurring little or no system downtime. An exemplary protocol supporting the disclosed security model, namely K7, is based on the Siemens S7 protocol, and enhances it with new cryptographic features to support the extra functionality. Similar enhancements may be applied to other protocols. A ticket-based system, (e.g., Kerberos with LDAP server) used to support the exchange of permissions and keys, is incorporated into the disclosed protocol. K7 may be implemented as a protocol converter add-on to standard Siemens clients and PLCs that transform them into augmented devices that use K7. Siemens and other vendors may add direct support for K7 on their ICS systems, devices, and the like in the future.
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6.
公开(公告)号:US12043641B2
公开(公告)日:2024-07-23
申请号:US17777684
申请日:2020-11-18
摘要: A dendrimer including a ring core moiety, a paramagnetic group, a linking moiety and a branching moiety for continuously probing and quantifying an analyte is provided together with methods, kits and devices for performing sensitive, accurate and durable measurements.
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公开(公告)号:US20240243639A1
公开(公告)日:2024-07-18
申请号:US18289474
申请日:2022-03-09
发明人: Carmel ROTSCHILD , Joseph CASSELL
CPC分类号: H02K7/1823 , B01D53/1475 , B01D53/92 , F02C6/18 , B01D2251/304 , B01D2251/306 , B01D2251/402 , B01D2251/404 , B01D2251/602 , B01D2251/606 , B01D2257/504 , B01D2258/01
摘要: An energy storage and retrieval system including an air chamber, a first air compressor operating with Heat Transfer Liquid (HTL-compressor) connected to the air chamber, a second turbine, operating with Heat Transfer Liquid (HTL-turbine) connected to the air chamber, accepting compressed air from the air chamber and producing work. Related apparatus and methods are also described.
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公开(公告)号:US12040152B2
公开(公告)日:2024-07-16
申请号:US17641987
申请日:2020-09-10
发明人: Ido Kaminer , Michael Shentcis , Raphael Dahan
IPC分类号: H01J35/10
CPC分类号: H01J35/10 , H01J2235/081 , H01J2235/086 , H01J2235/088
摘要: An energy converter unit and X-ray source system are presented. The energy converter unit comprises a multilayered crystal structure having a selected layers' arrangement comprising at least first and second of layers of at least first and second material compositions. The layers-arrangement is formed of a pattern of n1 layers of said first layer type and n2 layers of said second layer type generating a selected lattice periodicity of said layers. The lattice periodicity is selected such that said multilayered crystal structure responds to the charged particle beam of predetermined parameters by coherent emission of X-ray radiation having selected spectral content and emission direction.
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公开(公告)号:US20240218024A1
公开(公告)日:2024-07-04
申请号:US18507493
申请日:2023-11-13
发明人: Roee AMIT , Sarah GOLDBERG , Naor GRANIK , Nanami KIKUCHI , Or WILLINGER , Patricia KITCHEN
IPC分类号: C07K14/165 , A61K35/76 , C07K14/705
CPC分类号: C07K14/165 , A61K35/76 , C07K14/705 , C07K2319/30 , C07K2319/85
摘要: RNA-protein granules comprising fusion proteins and RNA are disclosed, as well as uses thereof for treating or preventing viral infection. Soluble fusion proteins comprising an extracellular domain of a human receptor or a fragment thereof and a bacteriophage coat protein, as well as synthetic microcarriers comprising a solid support conjugated to a plurality of viral proteins or fragments thereof are provided. Nucleic acid molecules and vectors encoding the soluble fusion protein, synthetic RNA-protein granules comprising a fusion protein, as well as method using the soluble fusion protein are also provided.
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公开(公告)号:US20240162367A1
公开(公告)日:2024-05-16
申请号:US18506163
申请日:2023-11-10
发明人: Elad KOREN , Debopriya DUTTA , Subhrajit MUKHERJEE
IPC分类号: H01L31/113 , H01L31/032 , H01L31/18
CPC分类号: H01L31/1136 , H01L31/032 , H01L31/18
摘要: A heterostructure system comprises a two-dimensional ferroelectric material on a dielectric substrate, and a two-dimensional semiconductor material having a first region disposed on the ferroelectric material and a second region disposed on the dielectric substrate, wherein an edge of the ferroelectric material is between the first region and the second region of the semiconductor material.
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