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1.发明授权公开(公告)号：US10561369B2
公开(公告)日：2020-02-18
申请号：US15587913
申请日：2017-05-05
申请人： Topera, Inc.
摘要： A system to generate a representation of a rhythm disorder that includes identifying remote or polar sources associated with a cardiac rhythm disorder is disclosed. The system includes generating a representation based on the cardiac information signals received from the sensors by transformation of spline-sensor locations of the catheter to x-y coordinate pairs of locations. A first offset is determined resulting from a perturbation to corresponding x-y coordinate pairs of locations associated with the representation, the first offset displacing coordinate pairs of sensor locations of the representation at least one unit of displacement in a first direction. A remote source associated with a cardiac rhythm disorder is identified when activations associated with the cardiac information signals rotate in sequence at least once, or emanate centrifugally for at least a first time period, the source being identified based on the representation as displaced.A corresponding method and computer-readable medium are also disclosed.
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公开(公告)号：US10434319B2
公开(公告)日：2019-10-08
申请号：US15585091
申请日：2017-05-02
摘要： An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element over a period of time. The selecting and determining are repeated over multiple periods of time. A source parameter of rotation activations or focal activations is determined, wherein the source parameter indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart. The determining of a source parameter is repeated for multiple regions of the heart. Thereafter, representation of the source parameter is displayed for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder.
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3.发明授权公开(公告)号：US10085655B2
公开(公告)日：2018-10-02
申请号：US14774120
申请日：2014-03-14
摘要： A system and method are provided for identifying a driver of a source associated with a heart rhythm disorder. Data are accessed from a plurality of sensors representing biological activity in the heart. A local first region of the heart that has repeating activation and determine whether the first region controls a second distant region of the heart for at least a predetermined number of beats is identified. The first local region is assigned as a driver of a source of the heart rhythm disorder, the source including the first local region and the second distant region.
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公开(公告)号：US09724009B2
公开(公告)日：2017-08-08
申请号：US14507790
申请日：2014-10-06
IPC分类号： A61B5/02 , A61B5/0468 , A61B5/00 , A61B5/044 , A61B5/046 , A61B5/042 , A61B5/04 , A61B5/0452 , A61B8/02 , A61B5/0464 , A61B5/024
CPC分类号： A61B5/0468 , A61B5/002 , A61B5/02405 , A61B5/04011 , A61B5/04012 , A61B5/042 , A61B5/0422 , A61B5/044 , A61B5/0452 , A61B5/04525 , A61B5/046 , A61B5/0464 , A61B5/7239 , A61B5/7246 , A61B5/7257 , A61B5/7425 , A61B5/743 , A61B8/02
摘要： A system and method of locating a source of a heart rhythm disorder are provided in which a first pair of cardiac signals is processed to define a first coefficient associated with variability of the first pair of signals at a first region of the heart. A second pair of cardiac signals is processed to define a second coefficient associated with variability of the second pair of signals at a second region of the heart. Thereafter, the first coefficient of variability is compared to the second coefficient of variability to determine a direction towards the source of the rhythm disorder.
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公开(公告)号：US09220427B2
公开(公告)日：2015-12-29
申请号：US14670300
申请日：2015-03-26
IPC分类号： A61B5/04 , A61B5/042 , A61B5/0452 , A61B5/00 , A61B5/0205 , A61B5/046 , A61B5/0464
CPC分类号： A61B5/04012 , A61B5/0205 , A61B5/024 , A61B5/02405 , A61B5/0245 , A61B5/0255 , A61B5/04011 , A61B5/0402 , A61B5/0422 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/0472 , A61B5/4836 , A61B5/6852 , A61B5/7203 , A61B5/7207 , A61B5/7217 , A61B5/7239 , A61B5/7246 , A61B5/7278 , A61B5/7282 , A61B5/742 , A61B2562/046
摘要： In a system and method for reconstructing cardiac activation information, an analysis cardiac signal and a reference cardiac signal are processed to determine a first point of change in a derivative of the analysis cardiac signal with respect to a derivative of the reference cardiac signal. The analysis cardiac signal and the reference cardiac signal are processed to determine a second point of change in a different derivative of the analysis cardiac signal with respect to a different derivative of the reference cardiac signal. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.
摘要翻译： 在用于重建心脏激活信息的系统和方法中，处理分析心脏信号和参考心脏信号以确定分析心脏信号的导数相对于参考心脏信号的导数的第一变化点。 处理分析心脏信号和参考心脏信号以确定分析心脏信号相对于参考心脏信号的不同导数的不同导数的第二变化点。 在基于第一变化点和第二变化点的数学关联点的点处在分析心脏信号中分配激活开始时间，以定义指示分析心脏信号中的搏动的心脏激活。
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6.发明授权System and method for reconstructing cardiac signals associated with a complex rhythm disorder 有权用于重建与复杂节律紊乱相关的心脏信号的系统和方法公开(公告)号：US09089269B2
公开(公告)日：2015-07-28
申请号：US14231600
申请日：2014-03-31
发明人： Sanjiv Narayan , Ruchir Sehra
IPC分类号： A61B5/046 , A61B5/04 , A61B5/0456 , A61B5/042 , A61B5/0472 , A61B5/0464 , A61B5/0452 , A61B5/00
CPC分类号： A61B5/0452 , A61B5/0255 , A61B5/04011 , A61B5/04012 , A61B5/0422 , A61B5/0432 , A61B5/044 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/4857 , A61B5/6852 , A61B5/7221 , A61B5/726 , A61B5/7264 , A61B5/7278
摘要： System, assembly and method are provided to facilitate reconstruction of cardiac information representing a complex rhythm disorder associated with a patient's heart to indicate a source of the heart rhythm disorder. The complex rhythm disorder can be treated by application of energy to modify the source of the rhythm disorder.
摘要翻译： 提供系统，组装和方法以便于重建表示与患者心脏相关联的复杂节律紊乱的心脏信息，以指示心律失常的来源。 可以通过施加能量来改变节律紊乱的来源来治疗复杂的节律紊乱。
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公开(公告)号：US20130226016A1
公开(公告)日：2013-08-29
申请号：US13840334
申请日：2013-03-15
IPC分类号： A61B5/0452
CPC分类号： A61B5/04012 , A61B5/0205 , A61B5/024 , A61B5/02405 , A61B5/0245 , A61B5/0255 , A61B5/04011 , A61B5/0402 , A61B5/0422 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/0472 , A61B5/4836 , A61B5/6852 , A61B5/7203 , A61B5/7207 , A61B5/7217 , A61B5/7239 , A61B5/7246 , A61B5/7278 , A61B5/7282 , A61B5/742 , A61B2562/046
摘要： An example system and method of reconstructing cardiac activation information are disclosed. An analysis signal and a reference signal are processed to determine whether there is a first point of change in a first selected-order derivative of the analysis signal with respect to a first selected-order derivative of the reference signal above a first threshold. The analysis signal and the reference signal are processed to determine whether there is a second point of change in a second selected-order derivative of the analysis cardiac signal with respect to a second selected-order derivative of the reference cardiac signal above a second threshold. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.
摘要翻译： 公开了重建心脏激活信息的示例系统和方法。 处理分析信号和参考信号以确定相对于高于第一阈值的参考信号的第一选择阶导数，分析信号的第一选择阶导数中是否存在第一变化点。 对分析信号和参考信号进行处理，以确定相对于高于第二阈值的参考心脏信号的第二选择阶导数，分析心脏信号的第二选择阶导数中是否存在第二变化点。 在基于第一变化点和第二变化点的数学关联点的点处在分析心脏信号中分配激活开始时间，以定义指示分析心脏信号中的搏动的心脏激活。
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公开(公告)号：US20120271135A1
公开(公告)日：2012-10-25
申请号：US13409352
申请日：2012-03-01
IPC分类号： A61B5/04
CPC分类号： A61B5/0422 , A61B5/042 , A61B5/6858 , A61B5/6859 , A61B18/1492 , A61B2018/0016 , A61B2018/00267 , A61B2018/00351 , A61B2562/17 , F04C2270/0421 , Y10T29/49117
摘要： A device for insertion into a body lumen, includes: an electrode assembly strip with exposed electrodes including: a polymeric substrate having an upper surface and an opposed lower surface; one or more electrodes disposed over a portion of the upper surface of the polymeric substrate; one or more electrical traces disposed over a portion of the lower surface of the polymeric substrate in electrical communication with the one or more electrodes by way of metal plated holes through the substrate; and a flexible polymeric substrate having a substrate surface and a substrate wall; wherein the electrode assembly strip is compressingly and thermally bonded to the substrate surface of the flexible polymeric substrate to define a flexible electrode assembly strip; and wherein the electrode assembly strip has a thickness from about 0.0005 inches to about 0.008 inches.
摘要翻译： 一种用于插入体腔的装置，包括：具有暴露电极的电极组件带，包括：具有上表面和相对的下表面的聚合物基底; 设置在聚合物基材的上表面的一部分上的一个或多个电极; 一个或多个电迹线设置在所述聚合物基底的下表面的一部分上，通过穿过所述基底的金属电镀孔与所述一个或多个电极电连通; 以及具有衬底表面和衬底壁的柔性聚合物衬底; 其中所述电极组合条被压缩并热粘合到所述柔性聚合物基底的所述基底表面以限定柔性电极组合带; 并且其中所述电极组件条的厚度为约0.0005英寸至约0.008英寸。
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公开(公告)号：US11426088B2
公开(公告)日：2022-08-30
申请号：US16999583
申请日：2020-08-21
申请人： Topera, Inc.
摘要： Provided are a system and method of generating an aggregated stability map of one or more rotational sources associated with a heart rhythm disorder. In accordance therewith, a plurality of rotational area profile maps is accessed for a plurality of analysis intervals. Each of the profile maps includes rotation intensity values for a plurality of locations associated with rotation of the one or more rotational sources. An aggregated stability map is generated based on the profile maps, wherein the stability map includes a plurality of locations. Each location includes a rotation intensity value based at least on a filter number of highest rotation intensity values from corresponding locations of the profile maps, the filter number being automatically determined from a plurality of filter numbers such that the plurality of profile maps as filtered includes a predetermined number of rotation intensity values in excess of a threshold intensity value.
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公开(公告)号：US10271786B2
公开(公告)日：2019-04-30
申请号：US15204455
申请日：2016-07-07
摘要： Reconstruction of cardiac information associated with a heart rhythm disorder includes accessing a plurality of neighboring cardiac signals and eliminating far-field activations from the neighboring cardiac signals using one or more divergence criteria that define local activations, where the divergence criteria is associated with divergence among the plurality of neighboring cardiac signals. The local activations in the plurality of neighboring cardiac signals may be used to construct a clinical representation of the heart rhythm disorder.
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