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    Use of a lectin or conjugates for modulation of c-fibre activity
    3.
    发明授权
    Use of a lectin or conjugates for modulation of c-fibre activity 失效
    使用凝集素或共轭物调节c-纤维活性

    公开(公告)号：US07208466B1

    公开(公告)日：2007-04-24

    申请号：US09937484

    申请日：2000-03-31

    申请人： Keith Alan Foster ,  John Andrew Chaddock ,  Conrad Padraig Quinn

    发明人： Keith Alan Foster ,  John Andrew Chaddock ,  Conrad Padraig Quinn

    IPC分类号： A61K38/00 ,  A61K51/00 ,  A61M36/14 ,  C07K16/00 ,  C07K17/00

    CPC分类号： C07K14/42 ,  A61K38/168 ,  A61K47/6415 ,  A61K48/00

    摘要： The present invention relates to the treatment of pain and to compounds that modulate C-fibre activity. In particular, the present invention relates to the use of a lectin in the manufacture of a medicament for modulation of C-fibre neuron activity, and to lectin conjugates. The lectin conjugates comprise a lectin coupled to a peptide or protein, wherein the peptide or protein is substantially free of Clostridial neurotoxin enzyme activity. The present invention also concerns methods for manufacturing conjugates. The compounds and compositions described have particular application in the treatment of diseases of which C-fibre activity is a component. Such diseases include pain, inflamation, psoriasis and other C-fibre related conditions.

    摘要翻译： 本发明涉及疼痛的治疗以及调节C-纤维活性的化合物。 特别地，本发明涉及凝集素在制备用于调节C-纤维神经元活性的药物和凝集素缀合物中的用途。 凝集素缀合物包含与肽或蛋白质偶联的凝集素，其中肽或蛋白质基本上不含梭菌神经毒素酶活性。 本发明还涉及制造缀合物的方法。 所述的化合物和组合物特别适用于治疗其C-纤维活性为组分的疾病。 这些疾病包括疼痛，炎症，牛皮癣和其他C纤维相关病症。

    Preparation of highly pure toxin fragments
    4.
    发明授权
    Preparation of highly pure toxin fragments 有权
    制备高纯度毒素片段

    公开(公告)号：US07193066B1

    公开(公告)日：2007-03-20

    申请号：US10070764

    申请日：2000-09-13

    申请人： John Andrew Chaddock ,  Frances Celine Gail Alexander ,  Keith Alan Foster

    发明人： John Andrew Chaddock ,  Frances Celine Gail Alexander ,  Keith Alan Foster

    IPC分类号： C07K1/00 ,  G01N33/537 ,  G01N33/549

    CPC分类号： C07K16/1282 ,  A61K38/164 ,  C07K14/33 ,  Y10S530/81 ,  Y10S530/811 ,  A61K2300/00

    摘要： Toxin derivatives are prepared by proteolytic treatment of holotoxin, and their toxicity is reduced by contacting the preparation with a ligand, which can be a metal or an antibody or another ligand. This ligand selectively binds to the toxin but not to the toxin derivative. Removing the ligand and toxin bound to the ligand further reduces toxicity. A second ligand is used to remove conjugates of the toxin and the first ligand. Compositions contain the purified derivative, optionally plus the toxin and the ligand.

    摘要翻译： 通过蛋白水解处理全毒素制备毒素衍生物，并且通过使制剂与可以是金属或抗体或另一种配体的配体接触来降低它们的毒性。 该配体选择性地结合毒素，但不与毒素衍生物结合。 去除与配体结合的配体和毒素进一步降低毒性。 第二配体用于去除毒素和第一配体的缀合物。 组合物含有纯化的衍生物，任选加上毒素和配体。