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公开(公告)号:US20240189413A1
公开(公告)日:2024-06-13
申请号:US18376177
申请日:2023-10-03
发明人: Oreola Donini , Axel Lehrer
CPC分类号: A61K39/12 , A61K39/39 , A61P31/14 , C12N7/00 , A61K2039/55566 , A61K2039/575 , A61K2039/70
摘要: Disclosed is a stable immunogenic composition capable of eliciting a robust and durable immune response, comprising at least one antigen consisting of a filovirus glycoprotein and at least one nano-emulsion adjuvant which are co-lyophilized and can be reconstituted immediately prior to use. Also disclosed is a vaccine composition comprising at least two antigens, wherein each antigen is specific to a different genus of filovirus and which also comprises at least one nano-emulsion adjuvant.
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公开(公告)号:US20240075122A1
公开(公告)日:2024-03-07
申请号:US18268032
申请日:2021-12-30
申请人: University of Hawaii
发明人: Tung HOANG , Ian A. MCMILLAN , Yun HEACOCK-KANG , Zhenxin SUN , Jan ZARZYCKI-SIEK , Michael H. NORRIS
CPC分类号: A61K39/0208 , A61P31/04 , C07K16/1203 , A61K2039/522 , C07K2317/569
摘要: Virulence factors from Burkholderia species are provided by this invention as are antibodies specifically binding the same and methods of using the virulence factors and antibodies in methods of immunizing and treating or attenuating a Burkholderia infection.
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公开(公告)号:US11912772B2
公开(公告)日:2024-02-27
申请号:US17260077
申请日:2019-07-12
申请人: University of Hawaii
发明人: Lishomwa C. Ndhlovu , Toshiro Niki
CPC分类号: C07K16/2851 , A61K45/06 , A61P35/00 , A61K2039/505
摘要: An antibody targeting Galectin-9 is provided as are methods of using the same treatment of chronic immune conditions such as infections, inflammatory diseases and cancer, in particular malignant mesothelioma.
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公开(公告)号:US11911111B2
公开(公告)日:2024-02-27
申请号:US16551001
申请日:2019-08-26
申请人: UNIVERSITY OF HAWAII
发明人: Bardia Konh , Omid Haji Maghsoudi
CPC分类号: A61B34/20 , A61B17/3478 , A61B34/32 , G06N5/01 , A61B2017/00314 , A61B2017/00323 , A61B2017/00367 , A61B2017/00867 , A61B2034/107 , A61B2034/2063 , A61B2034/2065 , A61B2034/301
摘要: An autonomous system and method for controlling the operation of a steerable surgical device includes multiple surgical device actuation elements, an imaging apparatus (e.g., ultrasound) arranged external to a mammalian body, and at least one processor. The processor(s) is/are configured to generate a transit path between an insertion point and a target point, control the surgical device actuation elements to advance the steerable surgical device along one or more segments of the transit path, identify deviation of position relative to the transit path utilizing signals from the imaging apparatus and generate an updated transit path, and control the surgical device actuation elements to advance the steerable surgical device along at least one segment of the updated transit path. Transit of the steerable surgical device between the insertion point and the target point may be controlled without human intervention.
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公开(公告)号:US11742509B2
公开(公告)日:2023-08-29
申请号:US17621891
申请日:2020-06-23
申请人: University of Hawaii
发明人: Tianwei Ma , Jian Yu
IPC分类号: H01M8/22
CPC分类号: H01M8/227
摘要: Disclosed herein is a system and method for energy generation from salinity gradients using asymmetrically porous electrodes. In certain embodiments, an energy generation system includes at least one pair of asymmetrically porous electrodes positioned within a chamber in selective fluidic communication with a freshwater source (e.g., a river) and a saltwater source (e.g., an ocean). Asymmetry between a first average percent volume per unit pore-width of a first electrode and a second average percent volume per unit pore-width of a second electrode creates differing interfacial potentials between the first electrode and the second electrode when such electrodes are immersed in freshwater and saltwater. By cyclically immersing the electrodes in freshwater and saltwater, energy is harvested from Gibbs free energy from mixing saltwater and freshwater. Such a system does not require a membrane or an external charge source. Methods of generating energy using asymmetrically porous electrodes are also provided.
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公开(公告)号:US20230221180A1
公开(公告)日:2023-07-13
申请号:US17819892
申请日:2022-08-15
申请人: University of Hawaii
发明人: Paul Lucey
CPC分类号: G01J3/26 , G01J3/4531 , G01J3/14
摘要: A spatial Fourier transform spectrometer is disclosed. The Fourier transform spectrometer includes a Fabry-Perot interferometer with first and second optical surfaces. The gap between the first and second optical surfaces spatially varies in a direction that is orthogonal to the optical axis of the Fourier transform spectrometer. The Fabry-Perot interferometer creates an interference pattern from input light. An image of the interference pattern is captured by a detector, which is communicatively coupled to a processor. The processor is configured to process the interference pattern image to determine information about the spectral content of the input light.
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公开(公告)号:US11661338B2
公开(公告)日:2023-05-30
申请号:US16648661
申请日:2018-09-21
申请人: University of Hawaii
CPC分类号: C01B3/0026 , C01B35/04
摘要: Some embodiments described herein provide for methods for synthesizing magnesium borohydride from hydrogenation of magnesium boride at moderate temperature and pressure in the presence of a modifier. The modifier may be in form of hydrides, liquid hydrogen carriers, ammonia borane, metallic species, croconate anion based materials, ethers, amines or imines, metal carbides, borides, graphene, arenes, magnesium, aluminum, calcium or ionic liquids. Some embodiments provide for charging magnesium boride in presence of a modifier at high pressure hydrogen while simultaneously heating the material. The modification in some instances may lead to an improved magnesium boride product with enhanced properties for application in other hydrogen storage systems.
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公开(公告)号:US20220289720A1
公开(公告)日:2022-09-15
申请号:US17628513
申请日:2020-07-22
申请人: UNIVERSITY OF HAWAII
发明人: James TURKSON , Francisco LOPEZ-TAPIA , Marcus TIUS , Peibin YUE , Christine BROTHERTON-PLEISS , Wenzhen FU
IPC分类号: C07D403/12 , C07D401/14 , C07D401/12 , C07D205/04 , C07D213/81 , C07D403/14 , C07C317/36 , C07D237/32 , C07D405/14 , A61P35/00
摘要: The present disclosure provides pharmaceutical compositions comprising aryl sulfonamide Stat3 small molecule inhibitors and certain pharmaceutically acceptable salts thereof, and methods of their use for treating cancer.
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公开(公告)号:US20220133354A1
公开(公告)日:2022-05-05
申请号:US17516076
申请日:2021-11-01
申请人: UNIVERSITY OF HAWAII
发明人: Bardia Konh
IPC分类号: A61B17/34
摘要: A steerable surgical device includes tubular body members and at least one moveable joint, with a moveable tray member arranged to permit tissue extraction and a retractable tip member for removal of a sample while a remainder of the surgical device remains in the tissue. A method utilizes sensed SMA electrical properties and sensed compressive force to determine joint deflection that is used with a joint deflection model to map tip position in tissue. Another method for determining position of a tip of a steerable instrument within tissue utilizes transverse ultrasound probe images and image processing together with saved and predicted tip information. A method for sequentially removing a plurality of samples from tissue utilizes a steerable surgical device, without requiring complete removal of the device from the tissue
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公开(公告)号:US11219411B2
公开(公告)日:2022-01-11
申请号:US15042109
申请日:2016-02-11
申请人: University of Hawaii
IPC分类号: A61B5/0507 , A61B5/08 , A61B5/00 , G16H40/63 , A61B5/029 , A61B5/024 , A61B5/0205 , A61B5/021
摘要: A system and method for monitoring lung water content of a patient. The system may include microwave sensors and a processor. The system may transmit microwave signals into, and receive microwave signals from, the thorax of a patient using the microwave sensors. The received microwave signals may each have at least one frequency component with a magnitude and a phase. The system may analyze the phase of the received microwave signal corresponding to a first pair of the microwave signals to monitor changes in the lung water content. The system may analyze the magnitude of the received microwave signal corresponding to a second, different pair of the microwave sensors to determine whether the lung water content is increasing or decreasing. The system may also analyze the received microwave signals to determine a blood pressure indicator and to determine lung water content.
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