公开(公告)号：US06862473B2

公开(公告)日：2005-03-01

申请号：US10085428

申请日：2002-02-28

Applicant: Preston Keusch ,  Vilambi Nrk ,  Bruce Michael Eliash

Inventor： Preston Keusch ,  Vilambi Nrk ,  Bruce Michael Eliash

IPC: A61K9/22 ,  A61N1/30

CPC classification number: A61N1/0448 ,  A61F2013/0296 ,  A61N1/0436 ,  A61N1/044

Abstract: A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

Abstract translation: 用于离子电渗药物递送装置的本发明的储存器电极组件包括位于与电极导电关系的电极和亲水性储存器。 亲水性储存器由具有第一表面和吸附在电极上的第二表面的吸水性亲水性交联聚合物材料形成。 当应用于患者皮肤区域时，聚合物材料的第一表面可剥离地粘附。 聚合物材料具有内聚强度，其形成粘合剂粘合，聚合物材料的第二表面与电极之间的粘合强度大于聚合物材料的内聚强度。 此外，聚合物材料的第一表面与患者的施用区域的粘合粘合强度小于聚合材料的内聚强度，使得当从患者的施用区域移除本发明的储器组件时， 基本上没有聚合物材料保留在施加的区域上，并且亲水性储存器保持基本上完整且粘附到电极上。

公开(公告)号：US20090312688A1

公开(公告)日：2009-12-17

申请号：US12355521

申请日：2009-01-16

Applicant: Vilambi NRK Reddy ,  Preston Keusch

Inventor： Vilambi NRK Reddy ,  Preston Keusch

IPC: A61N1/30 ,  A61M19/00

CPC classification number: A61N1/0448 ,  A61K9/0009 ,  A61N1/044 ,  A61N1/325 ,  A61N1/36021

Abstract: A shelf-stable electrically assisted transdermal drug delivery system for highly effective electrotransport of an anesthetic and a vasoconstrictor producing clinically acceptable dermal anesthesia and sensation is provided. In certain embodiments the anesthetic includes lidocaine and the vasoconstrictor includes epinephrine. Medicament delivery is affected to provide dermal anesthesia with little or no sensation during delivery, as measured by a variety of indicator tests. Methods of producing dermal anesthesia in patients are also provided.

Abstract translation: 提供了一种用于产生临床可接受的皮肤麻醉和感觉的麻醉剂和血管收缩剂的高效电运输的稳定的电辅助透皮药物递送系统。 在某些实施方案中，麻醉剂包括利多卡因，血管收缩剂包括肾上腺素。 如通过各种指标测试所测量，药物输送受影响以在输送期间提供很少或没有感觉的皮肤麻醉。 还提供了在患者体内产生真皮麻醉的方法。

公开(公告)号：US20070093743A1

公开(公告)日：2007-04-26

申请号：US11535608

申请日：2006-09-27

Applicant: Preston Keusch ,  Vilambi Reddy ,  Ashutosh Sharma ,  George Baskinger

Inventor： Preston Keusch ,  Vilambi Reddy ,  Ashutosh Sharma ,  George Baskinger

IPC: A61N1/30

CPC classification number: A61N1/30 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0448

Abstract: An electrically assisted transdermal drug delivery system for highly effective electrotransport of an anesthetic and a vasoconstrictor producing clinically acceptable depth and duration of dermal anesthesia at a treatment site. In certain embodiments, the anesthetic comprises lidocaine and the vasoconstrictor comprises epinephrine.

Abstract translation: 用于麻醉剂和血管收缩剂的高效电运输的电辅助透皮药物递送系统，其在治疗部位产生临床可接受的皮肤麻醉深度和持续时间。 在某些实施方案中，麻醉剂包含利多卡因，血管收缩剂包含肾上腺素。

公开(公告)号：US20050159698A1

公开(公告)日：2005-07-21

申请号：US11039514

申请日：2005-01-19

Applicant: Preston Keusch ,  Nrk Vilambi ,  Bruce Eliash

Inventor： Preston Keusch ,  Nrk Vilambi ,  Bruce Eliash

IPC: A61N1/30 ,  A61B17/20

CPC classification number: A61N1/0448 ,  A61N1/0436 ,  A61N1/044

Abstract: A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic crosslinked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

Abstract translation: 用于离子电渗药物递送装置的本发明的储存器电极组件包括位于与电极导电关系的电极和亲水性储存器。 亲水性储存器由具有粘附到电极的第一表面和第二表面的吸水性亲水性交联聚合物材料形成。 当应用于患者皮肤区域时，聚合物材料的第一表面可剥离地粘附。 聚合物材料具有内聚强度，其形成粘合剂粘合，聚合物材料的第二表面与电极之间的粘合强度大于聚合物材料的内聚强度。 此外，聚合物材料的第一表面与患者的施用区域的粘合粘合强度小于聚合材料的内聚强度，使得当从患者的施用区域移除本发明的储器组件时， 基本上没有聚合物材料保留在施加的区域上，并且亲水性储存器保持基本上完整且粘附到电极上。

公开(公告)号：US20070078372A1

公开(公告)日：2007-04-05

申请号：US11537141

申请日：2006-09-29

Applicant: Vilambi Reddy ,  Preston Keusch

Inventor： Vilambi Reddy ,  Preston Keusch

IPC: A61N1/30

CPC classification number: A61N1/0448 ,  A61K9/0009 ,  A61N1/044 ,  A61N1/325 ,  A61N1/36021

Abstract: A shelf-stable electrically assisted transdermal drug delivery system for highly effective electrotransport of an anesthetic and a vasoconstrictor producing clinically acceptable dermal anesthesia and sensation is provided. In certain embodiments the anesthetic includes lidocaine and the vasoconstrictor includes epinephrine. Medicament delivery is affected to provide dermal anesthesia with little or no sensation during delivery, as measured by a variety of indicator tests. Methods of producing dermal anesthesia in patients are also provided.

Abstract translation: 提供了一种用于产生临床可接受的皮肤麻醉和感觉的麻醉剂和血管收缩剂的高效电运输的稳定的电辅助透皮药物递送系统。 在某些实施方案中，麻醉剂包括利多卡因，血管收缩剂包括肾上腺素。 如通过各种指标测试所测量，药物输送受影响以在输送期间提供很少或没有感觉的皮肤麻醉。 还提供了在患者体内产生真皮麻醉的方法。

公开(公告)号：US20050159700A1

公开(公告)日：2005-07-21

申请号：US11039520

申请日：2005-01-19

Applicant: Preston Keusch ,  Nrk Vilambi ,  Bruce Eliash

Inventor： Preston Keusch ,  Nrk Vilambi ,  Bruce Eliash

IPC: A61N1/30 ,  A61B17/20

CPC classification number: A61N1/0448 ,  A61N1/0436 ,  A61N1/044

Abstract: A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

公开(公告)号：US20050159699A1

公开(公告)日：2005-07-21

申请号：US11039519

申请日：2005-01-19

Applicant: Preston Keusch ,  Nrk Vilambi ,  Bruce Eliash

Inventor： Preston Keusch ,  Nrk Vilambi ,  Bruce Eliash

IPC: A61N1/30 ,  A61B17/20

CPC classification number: A61N1/0448 ,  A61N1/0436 ,  A61N1/044

Abstract: A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material. Additionally, an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir assembly of the invention from the applied area of the patient, substantially no polymeric material remains on the applied area and the hydrophilic reservoir remains substantially intact and adhesively adherent to the electrode.

公开(公告)号：US06858018B1

公开(公告)日：2005-02-22

申请号：US09162301

申请日：1998-09-28

Applicant: Philip G. Green ,  Ronald J. Pettis ,  Michelle R. Brosnan-Cook

Inventor： Philip G. Green ,  Ronald J. Pettis ,  Michelle R. Brosnan-Cook

IPC: A61K9/00 ,  A61K9/70 ,  A61K31/445 ,  A61K31/4468 ,  A61K47/32 ,  A61N1/30 ,  A61P23/00 ,  A61P25/04 ,  C07D211/58

CPC classification number: A61K9/0009 ,  A61N1/30

Abstract: Iontophoretic devices for the delivery of N-phenyl-N-(4-piperidinyl)amide esters are provided. The N-phenyl-N-(4-piperidinyl)amide esters are compounds of the 1. A reservoir comprising a matrix material and, distributed in said matrix material, a pharmaceutically acceptable amount of at least one compound selected from compounds of the formula (I) wherein: X is a member selected from the group consisting of alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C1-2)alkoxy-(C1-2)alkoxy-carbonyl-lower alkyl; Ar is a member selected from the group consisting of phenyl, and mono-, di- and tri-substituted phenyl, wherein each substituent is independently selected from the group consisting of halo, lower alkyl, lower alkoxy and trifluoromethyl; R is a member selected from the group consisting of lower alkyl, and lower alkoxy-lower alkyl,; R1 is a member selected from the group consisting of hydrogen, lower alkoxy-carbonyl; and R2 is a member selected from the group consisting of hydrogen and methyl; and the optically active and cis-trans isomers thereof, and the acid addition salts, of said compounds and isomers.

Abstract translation: 提供用于递送N-苯基-N-（4-哌啶基）酰胺酯的离子电渗装置。 N-苯基-N-（4-哌啶基）酰胺酯是1.含有基质材料并且在所述基质材料中分布有药学上可接受量的至少一种选自以下化合物的化合物的储库的化合物（ I）其中：X是选自烷氧基 - 羰基 - 低级烷基，低级烷基 - 羰氧基 - 低级烷基，烯氧基 - 羰基 - 低级烷基和（C1-2）烷氧基 - （C1-2）烷氧基 - 羰基 - 低级烷基; Ar是选自苯基和单 - ，二 - 和三取代的苯基的成员，其中每个取代基独立地选自卤素，低级烷基，低级烷氧基和三氟甲基 ; R是选自低级烷基和低级烷氧基 - 低级烷基的成员; R 1是选自氢，低级烷氧基 - 羰基， 和R 2是选自氢和甲基的成员; 及其光学活性和顺式 - 反式异构体，以及所述化合物和异构体的酸加成盐。

公开(公告)号：US20070078434A1

公开(公告)日：2007-04-05

申请号：US11537182

申请日：2006-09-29

Applicant: Preston Keusch ,  Vilambi Reddy ,  Richard Greene ,  George Baskinger ,  Ashutosh Sharma

Inventor： Preston Keusch ,  Vilambi Reddy ,  Richard Greene ,  George Baskinger ,  Ashutosh Sharma

IPC: A61M31/00

CPC classification number: A61N1/30 ,  A61N1/044 ,  A61N1/0448

Abstract: The use of an iontophoresis electrode assembly for delivery of a drug formulation is described. The drug formulation includes an anaesthetic and a vasoconstrictor. It is administered to a patient prior to a procedure to produce clinically acceptable depth and duration of dermal anaesthesia at the portion of skin to subject to a painful procedure or to reduce or eliminate pain. The procedure is one selected from the group consisting of venipuncture, IV cannulation, needle aspirations, body piercings, blood donations, electrolysis, tattoo removal, tattoo application, injections, dermabrasion, skin peeling, high velocity particle ablation, pace maker implantation, pace maker replacement, epidural puncture, lumbar puncture, regional nerve blocks, skin harvesting, small skin incisions, skin biopsies, circumcisions or excisions. The iontophoresis electrode assembly may also be used to reduce or temporarily eliminate neuropathic pain.

Abstract translation: 描述了用于递送药物制剂的离子电渗电极组件的使用。 药物制剂包括麻醉剂和血管收缩剂。 在手术部分之前产生临床上可接受的皮肤麻醉深度和持续时间的患者施用于患者，以忍受痛苦的过程或减轻或消除疼痛。 该方法选自静脉穿刺，IV插管，针吸，身体穿刺，献血，电解，纹身去除，纹身应用，注射，皮肤磨皮，皮肤剥离，高速颗粒消融，起搏器植入，起搏器 替代，硬膜外穿刺，腰椎穿刺，局部神经阻滞，皮肤收获，小皮肤切口，皮肤活检，切割或切除。 离子电渗电极组件也可用于减少或暂时消除神经性疼痛。

公开(公告)号：US20070078373A1

公开(公告)日：2007-04-05

申请号：US11537308

申请日：2006-09-29

Applicant: Ashutosh Sharma ,  Sonal Patel ,  Vilambi Reddy ,  Preston Keusch ,  Yogeshvar Kalia

Inventor： Ashutosh Sharma ,  Sonal Patel ,  Vilambi Reddy ,  Preston Keusch ,  Yogeshvar Kalia

IPC: A61N1/30

CPC classification number: A61N1/0448 ,  A61N1/0436 ,  A61N1/044

Abstract: Provided are various embodiments of integrated electrode devices, assemblies and systems structured for use in association with electrically assisted delivery devices configured for delivery of a composition, such as a composition comprising gonadotropin-releasing hormone and/or related analogs through a membrane. The integrated electrode devices, assemblies and systems include one or more of a variety of structural, physical, mechanical, electrical and electromechanical enhancements. Methods of administering compositions to patients with integrated electrode devices according to various embodiments described herein are also disclosed.

Abstract translation: 提供了集成电极装置，组件和系统的各种实施例，其被构造用于与被配置用于递送组合物的电辅助递送装置结合使用，所述组合物例如包含通过膜的促性腺激素释放激素和/或相关类似物的组合物。 集成电极装置，组件和系统包括各种结构，物理，机械，电和机电增强中的一种或多种。 还公开了根据本文所述的各种实施方案向具有集成电极装置的患者施用组合物的方法。