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    Rotary Sensor Assembly with Axial Switch and Redundancy Feature
    2.
    发明申请
    Rotary Sensor Assembly with Axial Switch and Redundancy Feature 审中-公开
    具有轴向开关和冗余特性的旋转传感器组件

    公开(公告)号：US20160287807A1

    公开(公告)日：2016-10-06

    申请号：US15036997

    申请日：2014-11-20

    申请人： NOVO NORDISK A/S

    发明人： John Oestergaard Madsen ,  Jesper Peter Windum

    IPC分类号： A61M5/315 ,  A61M5/24 ,  G01D5/251

    CPC分类号： A61M5/31568 ,  A61M5/24 ,  A61M5/3155 ,  A61M5/31551 ,  A61M5/31583 ,  A61M2005/2411 ,  A61M2005/3126 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  G01D5/25 ,  G01D5/251

    摘要： A sensor assembly comprising a first rotary sensor part with a plurality of individual electrically conducting axial position sensor segments arranged in a circumferential pattern, and a second rotary sensor part arranged rotationally relative to the first portion and comprising a plurality of circumferentially arranged electrically interconnected axial position contacts adapted to be arranged in contact with the axial position sensor segments. The assembly further comprises actuator means for axially moving the axial position contacts between a connected and a dis-connected position, wherein the axial position contacts and the axial position sensor segments are arranged such that for a given rotational position at least two axial position contacts each are in contact with a different axial position sensor segment.

    摘要翻译： 一种传感器组件，包括具有以圆周方式布置的多个独立的导电轴向位置传感器段的第一旋转传感器部分和相对于第一部分旋转地布置的第二旋转传感器部分，并且包括多个周向布置的电互连轴向位置 适于与轴向位置传感器段接触的触头。 组件还包括用于在连接位置和不连接位置之间轴向移动轴向位置触点的致动器装置，其中轴向位置触点和轴向位置传感器段被布置成使得对于给定的旋转位置，至少两个轴向位置接触每个 与不同的轴向位置传感器段接触。

    Drug Delivery Device with Front Loading Feature
    3.
    发明申请
    Drug Delivery Device with Front Loading Feature 审中-公开
    具有前加载功能的药物输送装置

    公开(公告)号：US20160256631A1

    公开(公告)日：2016-09-08

    申请号：US15028848

    申请日：2014-10-14

    申请人： NOVO NORDISK A/S

    发明人： Morten Soerensen ,  Knud Skifter Winther ,  Christian Plambech ,  Jesper Peter Windum

    IPC分类号： A61M5/24 ,  A61M5/32 ,  A61M5/315 ,  A61M5/34

    CPC分类号： A61M5/24 ,  A61M5/28 ,  A61M5/3155 ,  A61M5/3293 ,  A61M5/34 ,  A61M39/105 ,  A61M2005/2407 ,  A61M2005/2411

    摘要： The invention provides a drug delivery device adapted to receive a cartridge, the cartridge being adapted to receive a needle assembly. The drug delivery device comprises a front-loaded cartridge holder adapted to receive and hold a cartridge in a mounted state and being actuatable between an open loading state and a closed operational state. The drug delivery device is further provided with blocking means configured to prevent the cartridge holder from being actuated between the closed and the open state when a cartridge with a mounted needle assembly is held in a mounted position.

    摘要翻译： 本发明提供了一种适于接纳药筒的药物输送装置，所述药筒适于接收针组件。 药物输送装置包括一个前装药筒保持器，适用于将药筒接收和保持在安装状态，并可在打开负载状态和闭合操作状态之间起动。 药物输送装置还设置有阻挡装置，其被配置为当具有安装的针组件的药筒保持在安装位置时防止药筒保持器在闭合和打开状态之间被致动。

    Drug Delivery Device with Brake Mechanism
    4.
    发明申请
    Drug Delivery Device with Brake Mechanism 审中-公开
    带制动机构的药物输送装置

    公开(公告)号：US20160235924A1

    公开(公告)日：2016-08-18

    申请号：US15028867

    申请日：2014-10-14

    申请人： NOVO NORDISK A/S

    发明人： Morten Soerensen ,  Bo Kvolsbjerg ,  Kalle H. Madsen ,  Christian Plambech

    IPC分类号： A61M5/315 ,  A61M5/24

    CPC分类号： A61M5/31563 ,  A61M5/20 ,  A61M5/2033 ,  A61M5/24 ,  A61M5/31501 ,  A61M5/31528 ,  A61M5/31551 ,  A61M5/31553 ,  A61M5/31583 ,  A61M2005/2411 ,  A61M2005/3143

    摘要： A drug delivery device (1) comprises a housing and an expelling assembly adapted to expel a dose of drug from a cartridge (380). The expelling assembly comprises a drive spring (135) which in an energized state is adapted to drive the expelling assembly, a rotating component (550,650) adapted to rotate relative to an axis of rotation during expelling of a dose of drug, and user actuated release means (191, 190) for releasing the drive spring to thereby expel a dose of drug. The device is provided with a brake element (575, 675) being moveable in a plane generally perpendicular to the axis of rotation, the brake element being adapted to engage the rotating component such that during rotation thereof the brake element is moved back and forth, whereby the brake element provides a braking action on the rotating component.

    摘要翻译： 药物输送装置（1）包括壳体和适于从药筒（380）排出一定剂量的药物的排出组件。 排出组件包括驱动弹簧（135），其在通电状态下适于驱动排出组件，旋转部件（550,650）适于在药物剂量排出期间相对于旋转轴线旋转，并且用户致动释放 用于释放驱动弹簧以释放一剂药物的装置（191,190）。 该装置设置有可在大致垂直于旋转轴线的平面中移动的制动元件（575,675），制动元件适于接合旋转部件，使得在其旋转期间制动元件前后移动， 由此制动元件对旋转部件提供制动作用。

    Motorized Drug Delivery Device
    6.
    发明申请
    Motorized Drug Delivery Device 审中-公开

    公开(公告)号：US20170151388A1

    公开(公告)日：2017-06-01

    申请号：US15324559

    申请日：2015-07-08

    申请人： Novo Nordisk A/S

    发明人： Michael Monrad ,  Per Einar Pontus Holm ,  Jens Aage Munk

    IPC分类号： A61M5/20 ,  A61M5/315

    CPC分类号： A61M5/20 ,  A61M5/31546 ,  A61M5/31578 ,  A61M2005/3126 ,  A61M2005/31588 ,  A61M2205/3306 ,  A61M2205/332 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2205/60 ,  A61M2205/8206

    摘要： A drug delivery device comprising a piston rod adapted to engage and axially move a cartridge piston to thereby expel an amount of drug from a loaded cartridge corresponding to a set dose amount, the device comprising a motor for moving the drive member from an initial position, through a start-of-dose position, to an end-of-dose position, as well as position detection means adapted to generate output data indicative of the drive member's position relative to the piston of a loaded cartridge. An electronic controller adapted is adapted operate the motor to continuously move the drive member from the initial position, based on output data from the position detection means determine that the drive member is in engagement with the cartridge piston corresponding to the start-of-dose position, and operate the motor to move the drive member from the start-of-dose position to the an end-of-dose position corresponding to the set dose.

    GLP-1 Derivatives and Uses Thereof
    7.
    发明申请
    GLP-1 Derivatives and Uses Thereof 审中-公开

    公开(公告)号：US20180258153A1

    公开(公告)日：2018-09-13

    申请号：US15534644

    申请日：2015-12-17

    申请人： Novo Nordisk A/S

    发明人： Jacob Kofoed

    IPC分类号： C07K14/605 ,  A61P3/10 ,  A61P3/04

    CPC分类号： C07K14/605 ,  A61K38/00 ,  A61P3/04 ,  A61P3/10

    摘要： The invention relates to a derivative of a GLP-1 analogue of a general Formula I, which derivative comprises a side chain attached to a Lys residue at position 34, 35, 36, 37, 38, or 39 of the GLP-1 analogue. The side chain comprises a Branched linker, a 1st and a 2nd Protractor and a Pre-linker. The Branched linker is connected to the Lys residue of the GLP-1 analogue via the Pre-linker and to the 1st and the 2nd Protractor via a 1st and 2nd Post-linker, respectively. The Branched linker may, e.g., be a tri-radical of Lys. The 1st and the 2nd Protractor is C20 diacid. Various linker elements may be used in the Prelinker as well as the two Post-linkers. The invention also relates to novel GLP-analogues, novel side chain intermediates and their manufacture and use to prepare derivatives of biologically active peptides and proteins, as well as pharmaceutical compositions and medical uses of the analogues and derivatives. The derivatives have very long half-lives while maintaining a satisfactory potency, which makes them potentially suitable for once-monthly administration.

    A Housing for a Medical Injection Device
    10.
    发明申请
    A Housing for a Medical Injection Device 审中-公开
    医疗注射装置的住房

    公开(公告)号：US20170000953A1

    公开(公告)日：2017-01-05

    申请号：US15101730

    申请日：2014-11-27

    申请人： Novo Nordisk A/S

    发明人： Ken Hansen ,  Lee Higson ,  Imran Ghulam ,  Jesper Bach Noergaard ,  Claus Urup Gjoedesen ,  Asger Meng Larsen

    IPC分类号： A61M5/315

    CPC分类号： A61M5/31593 ,  A61M5/3129 ,  A61M5/31551 ,  A61M5/31583 ,  A61M2005/3126 ,  A61M2207/00 ,  B29C45/14 ,  B29L2031/7544

    摘要： The invention relates to a medical injection device having polymeric housing. The housing comprises a moulded outer housing element and a moulded ring-shaped unitary element. The ring-shaped unitary element carries a pointer and a thread segment in predetermined and correlated positions. The pointer points to indicia on a scale drum and the thread segments guides the scale drum. The outer housing element is moulded over the unitary element to form one single component.

    摘要翻译： 本发明涉及具有聚合物壳体的医疗注射装置。 壳体包括模制的外部壳体元件和模制的环形整体元件。 环形单体元件在预定和相关位置中携带指针和线段。 指针指向刻度盘上的标记，螺纹段引导刻度鼓。 外部壳体元件被模制在整体元件上以形成一个单一部件。