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公开(公告)号：US20130224231A1
公开(公告)日：2013-08-29
申请号：US13360163
申请日：2012-01-27
申请人： Oreola Donini , Annett Rozek , Shannon Wayne Lentz
发明人： Oreola Donini , Annett Rozek , Shannon Wayne Lentz
IPC分类号： C07K7/00
CPC分类号： C07K7/00 , A61K38/00 , C07K7/06 , C07K7/08 , C07K7/64 , C12Q1/37 , G01N33/569 , G01N2800/52 , Y02A50/473 , Y02A50/481 , Y02A50/491
摘要： In one aspect, the present invention provides isolated novel peptides that can be used to modulate innate immunity in a subject and/or for the treatment of an immune-related disorder, including treating and preventing infection by modulating innate immunity. Also provided are an agent reactive with the peptide, a pharmaceutical composition that includes the peptide, an isolated nucleic acid molecule encoding the peptide, a recombinant nucleic acid construct that includes the nucleic acid molecule, at least one host cell comprising the recombinant nucleic acid construct, and a method of producing the peptide using the host cell. The present invention further provides a method for treating and/or preventing infection in a subject by administering the peptide of the invention to the subject, thereby modulating innate immunity in the subject. Additionally, the present invention provides a method for predicting whether a subject would be responsive to treatment with a peptide of the invention.
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2.发明申请Novel Peptides for Treating and Preventing Immune-Related Disorders, Including Treating and Preventing Infection by Modulating Innate Immunity 有权用于治疗和预防免疫相关疾病的新型肽，包括通过调节先天免疫治疗和预防感染公开(公告)号：US20090246217A1
公开(公告)日：2009-10-01
申请号：US12083086
申请日：2006-10-04
申请人： Oreola Donini , Annett Rozek , Shannon Wayne Lentz
发明人： Oreola Donini , Annett Rozek , Shannon Wayne Lentz
IPC分类号： A61K39/21 , C07K7/00 , C07K5/00 , C07K16/18 , A61K38/10 , A61K38/08 , A61K38/07 , A61K38/06 , A61K39/00 , A61K39/12 , A61K39/02 , A61K39/002 , C12Q1/02
CPC分类号： C07K7/00 , A61K38/00 , C07K7/06 , C07K7/08 , C07K7/64 , C12Q1/37 , G01N33/569 , G01N2800/52 , Y02A50/473 , Y02A50/481 , Y02A50/491
摘要： In one aspect, the present invention provides isolated novel peptides that can be used to modulate innate immunity in a subject, and/or for the treatment of an immune-related disorder, including treating and preventing infection by modulating innate immunity. Also provided are an agent reactive with this peptide, a pharmaceutical composition that includes the peptide, an isolated nucleic acid molecule encoding the peptide, a recombinant nucleic acid construct that includes the nucleic acid molecule, at least one host cell comprising the recombinant nucleic acid construct, and a method of producing the peptide using the host cell. The present invention further provides a method for treating and/or preventing infection in a subject by administering the peptide of the invention to the subject, thereby modulating innate immunity in the subject. Additionally, the present invention provides a method for predicting whether a subject would be responsive to treatment with a peptide of the invention.
摘要翻译： 一方面，本发明提供了分离的新型肽，其可用于调节受试者的先天免疫，和/或用于治疗免疫相关病症，包括通过调节先天免疫来治疗和预防感染。 还提供了与该肽反应的试剂，包含肽，分离的编码该肽的核酸分子的药物组合物，包含该核酸分子的重组核酸构建体，至少一个宿主细胞，其包含重组核酸构建体 ，以及使用该宿主细胞产生该肽的方法。 本发明还提供了通过将本发明的肽给予受试者来治疗和/或预防受试者感染的方法，从而调节受试者的先天免疫。 另外，本发明提供了一种用于预测受试者是否对本发明的肽的治疗有反应的方法。
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3.发明申请Novel Peptides For Treating and Preventing Immune-Related Disorders, Including Treating And Preventing Infection by Modulating Innate Immunity 有权用于治疗和预防免疫相关疾病的新型肽，包括通过调节先天免疫治疗和预防感染公开(公告)号：US20130316960A1
公开(公告)日：2013-11-28
申请号：US13457162
申请日：2012-04-26
申请人： Oreola Donini , Annett Rozek , Shannon Wayne Lentz
发明人： Oreola Donini , Annett Rozek , Shannon Wayne Lentz
IPC分类号： C07K14/81
CPC分类号： C07K14/8103 , A61K38/00 , C07K5/0806 , C07K5/081 , C07K5/0815 , C07K5/0817 , C07K5/1019 , C07K7/06 , C07K7/08 , C12Q1/37 , G01N33/569 , G01N33/6893 , G01N2800/24 , G01N2800/26 , G01N2800/52 , Y02A50/473 , Y02A50/481 , Y02A50/491
摘要： In one aspect, the present invention provides isolated novel peptides that can be used to modulate innate immunity in a subject and/or for the treatment of an immune-related disorder, including treating and preventing infection by modulating innate immunity. Also provided are an agent reactive with the peptide, a pharmaceutical composition that includes the peptide, an isolated nucleic acid molecule encoding the peptide, a recombinant nucleic acid construct that includes the nucleic acid molecule, at least one host cell comprising the recombinant nucleic acid construct, and a method of producing the peptide using the host cell. The present invention further provides a method for treating and/or preventing infection in a subject by administering the peptide of the invention to the subject, thereby modulating innate immunity in the subject. Additionally, the present invention provides a method for predicting whether a subject would be responsive to treatment with a peptide of the invention.
摘要翻译： 一方面，本发明提供分离的新型肽，其可用于调节受试者中的先天免疫和/或用于治疗免疫相关病症，包括通过调节先天免疫来治疗和预防感染。 还提供了与肽反应的试剂，包含肽，分离的编码该肽的核酸分子的药物组合物，包含该核酸分子的重组核酸构建体，至少一个宿主细胞，其包含重组核酸构建体 ，以及使用该宿主细胞产生该肽的方法。 本发明还提供了通过将本发明的肽给予受试者来治疗和/或预防受试者感染的方法，从而调节受试者的先天免疫。 另外，本发明提供了一种用于预测受试者是否对本发明的肽的治疗有反应的方法。
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4.发明申请Novel peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity 审中-公开用于治疗和预防免疫相关疾病的新型肽，包括通过调节先天免疫来治疗和预防感染公开(公告)号：US20080118525A1
公开(公告)日：2008-05-22
申请号：US11730695
申请日：2007-04-03
申请人： Oreola Donini , Annett Rozek , Shannon Wayne Lentz
发明人： Oreola Donini , Annett Rozek , Shannon Wayne Lentz
IPC分类号： A61K38/00 , A61K39/00 , A61P43/00 , C07K16/18 , C07K7/00 , C12N15/00 , C12N15/11 , C12N5/06 , C12P21/04
CPC分类号： C07K14/8103 , A61K38/00 , C07K5/0806 , C07K5/081 , C07K5/0815 , C07K5/0817 , C07K5/1019 , C07K7/06 , C07K7/08 , C12Q1/37 , G01N33/569 , G01N33/6893 , G01N2800/24 , G01N2800/26 , G01N2800/52 , Y02A50/473 , Y02A50/481 , Y02A50/49 , Y02A50/491
摘要： In one aspect, the present invention provides isolated novel peptides that can be used to modulate innate immunity in a subject and/or for the treatment of an immune-related disorder, including treating and preventing infection by modulating innate immunity. Also provided are an agent reactive with the peptide, a pharmaceutical composition that includes the peptide, an isolated nucleic acid molecule encoding the peptide, a recombinant nucleic acid construct that includes the nucleic acid molecule, at least one host cell comprising the recombinant nucleic acid construct, and a method of producing the peptide using the host cell. The present invention further provides a method for treating and/or preventing infection in a subject by administering the peptide of the invention to the subject, thereby modulating innate immunity in the subject. Additionally, the present invention provides a method for predicting whether a subject would be responsive to treatment with a peptide of the invention.
摘要翻译： 一方面，本发明提供分离的新型肽，其可用于调节受试者中的先天免疫和/或用于治疗免疫相关病症，包括通过调节先天免疫来治疗和预防感染。 还提供了与肽反应的试剂，包含肽，分离的编码该肽的核酸分子的药物组合物，包含该核酸分子的重组核酸构建体，至少一个宿主细胞，其包含重组核酸构建体 ，以及使用该宿主细胞产生该肽的方法。 本发明还提供了通过将本发明的肽给予受试者来治疗和/或预防受试者感染的方法，从而调节受试者的先天免疫。 另外，本发明提供了一种用于预测受试者是否对本发明的肽的治疗有反应的方法。
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5.发明授权Peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity 有权用于治疗和预防免疫相关疾病的肽，包括通过调节先天免疫来治疗和预防感染公开(公告)号：US08791061B2
公开(公告)日：2014-07-29
申请号：US13457162
申请日：2012-04-26
申请人： Oreola Donini , Annett Rozek , Shannon Wayne Lentz
发明人： Oreola Donini , Annett Rozek , Shannon Wayne Lentz
CPC分类号： C07K14/8103 , A61K38/00 , C07K5/0806 , C07K5/081 , C07K5/0815 , C07K5/0817 , C07K5/1019 , C07K7/06 , C07K7/08 , C12Q1/37 , G01N33/569 , G01N33/6893 , G01N2800/24 , G01N2800/26 , G01N2800/52 , Y02A50/473 , Y02A50/481 , Y02A50/491
摘要： In one aspect, the present invention provides isolated novel peptides that can be used to modulate innate immunity in a subject and/or for the treatment of an immune-related disorder, including treating and preventing infection by modulating innate immunity. Also provided are an agent reactive with the peptide, a pharmaceutical composition that includes the peptide, an isolated nucleic acid molecule encoding the peptide, a recombinant nucleic acid construct that includes the nucleic acid molecule, at least one host cell comprising the recombinant nucleic acid construct, and a method of producing the peptide using the host cell. The present invention further provides a method for treating and/or preventing infection in a subject by administering the peptide of the invention to the subject, thereby modulating innate immunity in the subject. Additionally, the present invention provides a method for predicting whether a subject would be responsive to treatment with a peptide of the invention.
摘要翻译： 一方面，本发明提供分离的新型肽，其可用于调节受试者中的先天免疫和/或用于治疗免疫相关病症，包括通过调节先天免疫来治疗和预防感染。 还提供了与肽反应的试剂，包含肽，分离的编码该肽的核酸分子的药物组合物，包含该核酸分子的重组核酸构建体，至少一个宿主细胞，其包含重组核酸构建体 ，以及使用该宿主细胞产生该肽的方法。 本发明还提供了通过将本发明的肽给予受试者来治疗和/或预防受试者感染的方法，从而调节受试者的先天免疫。 另外，本发明提供了一种用于预测受试者是否对本发明的肽的治疗有反应的方法。
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6.发明授权Peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity 有权用于治疗和预防免疫相关疾病的肽，包括通过调节先天免疫来治疗和预防感染公开(公告)号：US09416157B2
公开(公告)日：2016-08-16
申请号：US13360163
申请日：2012-01-27
申请人： Oreola Donini , Annett Rozek , Shannon Wayne Lentz
发明人： Oreola Donini , Annett Rozek , Shannon Wayne Lentz
CPC分类号： C07K7/00 , A61K38/00 , C07K7/06 , C07K7/08 , C07K7/64 , C12Q1/37 , G01N33/569 , G01N2800/52 , Y02A50/473 , Y02A50/481 , Y02A50/491
摘要： In one aspect, the present invention provides isolated novel peptides that can be used to modulate innate immunity in a subject and/or for the treatment of an immune-related disorder, including treating and preventing infection by modulating innate immunity. Also provided are an agent reactive with the peptide, a pharmaceutical composition that includes the peptide, an isolated nucleic acid molecule encoding the peptide, a recombinant nucleic acid construct that includes the nucleic acid molecule, at least one host cell comprising the recombinant nucleic acid construct, and a method of producing the peptide using the host cell. The present invention further provides a method for treating and/or preventing infection in a subject by administering the peptide of the invention to the subject, thereby modulating innate immunity in the subject. Additionally, the present invention provides a method for predicting whether a subject would be responsive to treatment with a peptide of the invention.
摘要翻译： 一方面，本发明提供分离的新型肽，其可用于调节受试者中的先天免疫和/或用于治疗免疫相关病症，包括通过调节先天免疫来治疗和预防感染。 还提供了与肽反应的试剂，包含肽，分离的编码该肽的核酸分子的药物组合物，包含该核酸分子的重组核酸构建体，至少一个宿主细胞，其包含重组核酸构建体 ，以及使用该宿主细胞产生该肽的方法。 本发明还提供了通过将本发明的肽给予受试者来治疗和/或预防受试者感染的方法，从而调节受试者的先天免疫。 另外，本发明提供了一种用于预测受试者是否对本发明的肽的治疗有反应的方法。
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公开(公告)号：US08124721B2
公开(公告)日：2012-02-28
申请号：US12083086
申请日：2006-10-04
申请人： Oreola Donini , Annett Rozek , Shannon Wayne Lentz
发明人： Oreola Donini , Annett Rozek , Shannon Wayne Lentz
CPC分类号： C07K7/00 , A61K38/00 , C07K7/06 , C07K7/08 , C07K7/64 , C12Q1/37 , G01N33/569 , G01N2800/52 , Y02A50/473 , Y02A50/481 , Y02A50/491
摘要： In one aspect, the present invention provides isolated novel peptides that can be used to modulate innate immunity in a subject, and/or for the treatment of an immune-related disorder, including treating and preventing infection by modulating innate immunity. Also provided are an agent reactive with this peptide, a pharmaceutical composition that includes the peptide, an isolated nucleic acid molecule encoding the peptide, a recombinant nucleic acid construct that includes the nucleic acid molecule, at least one host cell comprising the recombinant nucleic acid construct, and a method of producing the peptide using the host cell. The present invention further provides a method for treating and/or preventing infection in a subject by administering the peptide of the invention to the subject, thereby modulating innate immunity in the subject. Additionally, the present invention provides a method for predicting whether a subject would be responsive to treatment with a peptide of the invention.
摘要翻译： 一方面，本发明提供了分离的新型肽，其可用于调节受试者的先天免疫，和/或用于治疗免疫相关病症，包括通过调节先天免疫来治疗和预防感染。 还提供了与该肽反应的试剂，包含肽，分离的编码该肽的核酸分子的药物组合物，包含该核酸分子的重组核酸构建体，至少一个宿主细胞，其包含重组核酸构建体 ，以及使用该宿主细胞产生该肽的方法。 本发明还提供了通过将本发明的肽给予受试者来治疗和/或预防受试者感染的方法，从而调节受试者的先天免疫。 另外，本发明提供了一种用于预测受试者是否对本发明的肽的治疗有反应的方法。
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公开(公告)号：US20060014136A1
公开(公告)日：2006-01-19
申请号：US11182243
申请日：2005-07-14
申请人： Monisha Scott , Danika Goosney , Annett Rozek
发明人： Monisha Scott , Danika Goosney , Annett Rozek
CPC分类号： C07K7/08 , C12Q1/18 , G01N33/5044
摘要： Screening assays that allow for the identification of agents that modulate host cell response to microbial infection. The methods of the invention provide the ability to measure the reduction in toxicity to the host cell, which is directly related to the ability of a compound to alter the cell's responses and thereby protect the cell from the consequences of infection.
摘要翻译： 筛选试验，允许鉴定调节宿主细胞对微生物感染的反应的试剂。 本发明的方法提供了测量宿主细胞毒性降低的能力，其与化合物改变细胞反应的能力直接相关，从而保护细胞免受感染的后果。
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