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1.发明授权Indocyanine compound, synthesis method and purification method thereof, diagnostic composition using the indocyanine compound, and device for measuring biokinetics and device for visualizing circulation using the diagnostic composition 有权吲哚菁化合物，其合成方法和纯化方法，使用吲哚菁化合物的诊断组合物，以及使用诊断组合物测量生物动力学的装置和可视化循环装置公开(公告)号：US09056131B2
公开(公告)日：2015-06-16
申请号：US13575810
申请日：2011-01-28
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61K49/00 , C08B37/16 , C09B23/01 , C09B23/08 , C09B67/00 , A61B5/0275
CPC分类号： A61K49/0054 , A61B5/0071 , A61B5/0205 , A61B5/026 , A61B5/0275 , A61B5/201 , A61B5/415 , A61B5/418 , A61B5/7275 , A61B5/7425 , A61B2576/00 , A61K49/001 , A61K49/0032 , A61K49/0034 , A61K49/0093 , A61M5/007 , C08B37/0012 , C08B37/0015 , C09B23/0066 , C09B23/086 , C09B68/41 , C09B68/485
摘要： The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.
摘要翻译： 本发明的目的在于提供一种新的吲哚菁化合物，其解决了常规使用的吲哚菁绿的问题，例如在水或生理盐水中的溶解度，其合成方法和纯化方法，以及包含新的吲哚菁化合物的诊断组合物。 此外，提供了用于评估新型吲哚菁化合物的生物动力学的方法和用于测量生物动力学的装置，以及利用诊断组合物来观察生物体中的血液等流体的循环的方法和装置。 此外，发现了一种新颖的吲哚菁化合物，其中近红外荧光靛蓝分子中的疏水部分包含在环状糖链环糊精的空腔中，以用葡萄糖覆盖靛蓝分子中的疏水部分，以及合成方法和 其纯化方法。 此外，发现了通过静脉内给药对肝脏以外的器官进行荧光成像的方法，评价新型吲哚菁化合物的生物动力学的评价方法，生物动力学测定装置以及用于使流体（例如血液）的循环可视化的方法和装置 在生物体中，利用包含新的吲哚菁化合物的诊断组合物。
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公开(公告)号：US09844606B2
公开(公告)日：2017-12-19
申请号：US14616117
申请日：2015-02-06
申请人： NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY , NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61K49/00 , C08B37/16 , C09B23/01 , C09B23/08 , A61B5/0205 , A61B5/026 , A61B5/20 , A61M5/00 , C09B67/00 , A61B5/0275
CPC分类号： A61K49/0054 , A61B5/0071 , A61B5/0205 , A61B5/026 , A61B5/0275 , A61B5/201 , A61B5/415 , A61B5/418 , A61B5/7275 , A61B5/7425 , A61B2576/00 , A61K49/001 , A61K49/0032 , A61K49/0034 , A61K49/0093 , A61M5/007 , C08B37/0012 , C08B37/0015 , C09B23/0066 , C09B23/086 , C09B68/41 , C09B68/485
摘要： The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.
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3.发明申请NOVEL INDOCYANINE COMPOUND, SYNTHESIS METHOD AND PURIFICATION METHOD THEREOF, DIAGNOSTIC COMPOSITION USING THE INDOCYANINE COMPOUND, AND DEVICE FOR MEASURING BIOKINETICS AND DEVICE FOR VISUALIZING CIRCULATION USING THE DIAGNOSTIC COMPOSITION 有权新型吲哚啉化合物，其合成方法和纯化方法，使用吲哚啉化合物的诊断组合物和用于测量生物活性的装置和用于使用诊断组合物观察循环的装置公开(公告)号：US20120302881A1
公开(公告)日：2012-11-29
申请号：US13575810
申请日：2011-01-28
CPC分类号： A61K49/0054 , A61B5/0071 , A61B5/0205 , A61B5/026 , A61B5/0275 , A61B5/201 , A61B5/415 , A61B5/418 , A61B5/7275 , A61B5/7425 , A61B2576/00 , A61K49/001 , A61K49/0032 , A61K49/0034 , A61K49/0093 , A61M5/007 , C08B37/0012 , C08B37/0015 , C09B23/0066 , C09B23/086 , C09B68/41 , C09B68/485
摘要： The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.
摘要翻译： 本发明的目的在于提供一种新颖的吲哚菁化合物，其解决常规使用的吲哚菁绿的问题，例如在水或生理盐水中的溶解度，其合成方法和纯化方法，以及包含新的吲哚菁化合物的诊断组合物。 此外，提供了用于评估新型吲哚菁化合物的生物动力学的方法和用于测量生物动力学的装置，以及利用诊断组合物来观察生物体中的血液等流体的循环的方法和装置。 此外，发现了一种新颖的吲哚菁化合物，其中近红外荧光靛蓝分子中的疏水部分包含在环状糖链环糊精的空腔中，以用葡萄糖覆盖靛蓝分子中的疏水部分，以及合成方法和 其纯化方法。 此外，发现了通过静脉内给药对肝脏以外的器官进行荧光成像的方法，评价新型吲哚菁化合物的生物动力学的评价方法，生物动力学测定装置以及用于使流体（例如血液）的循环可视化的方法和装置 在生物体中，利用包含新的吲哚菁化合物的诊断组合物。
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4.发明申请公开(公告)号：US20070012221A1
公开(公告)日：2007-01-18
申请号：US11480401
申请日：2006-07-05
申请人： Hideki Maeta , Tadahisa Sato
发明人： Hideki Maeta , Tadahisa Sato
IPC分类号： C08K5/00
CPC分类号： C08K5/0041 , C09B67/0013 , C09B67/0096 , C09B68/4253 , C09B68/44 , C09B68/463 , C09B68/485
摘要： A method of producing an organic pigment dispersion liquid, which has the steps of: providing an alkaline or acidic solution with an organic pigment dissolved therein and an aqueous medium, wherein a polymerizable compound is contained in at least one of the organic pigment solution and the aqueous medium; mixing the organic pigment solution and the aqueous medium; and thereby forming the pigment as fine particles; then polymerizing the polymerizable compound to form a polymer immobile from the pigment fine particles.
摘要翻译： 一种生产有机颜料分散液的方法，其具有以下步骤：提供溶解有有机颜料的碱性或酸性溶液和水性介质，其中在至少一种有机颜料溶液和 水介质; 混合有机颜料溶液和水性介质; 从而形成作为细颗粒的颜料; 然后聚合可聚合化合物以形成从颜料微粒不动的聚合物。
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公开(公告)号：US20180353626A1
公开(公告)日：2018-12-13
申请号：US16101544
申请日：2018-08-13
申请人： NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY , NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
IPC分类号： A61K49/00 , A61B5/0205 , A61B5/20 , C09B23/08 , C09B23/01 , C08B37/16 , A61M5/00 , C09B67/00 , A61B5/00 , A61B5/026 , A61B5/0275
CPC分类号： A61K49/0054 , A61B5/0071 , A61B5/0205 , A61B5/026 , A61B5/0275 , A61B5/201 , A61B5/415 , A61B5/418 , A61B5/7275 , A61B5/7425 , A61B2576/00 , A61K49/001 , A61K49/0017 , A61K49/0032 , A61K49/0034 , A61K49/0093 , A61M5/007 , C08B37/0012 , C08B37/0015 , C09B23/0066 , C09B23/086 , C09B68/41 , C09B68/485
摘要： The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.
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公开(公告)号：US20170157273A1
公开(公告)日：2017-06-08
申请号：US15438047
申请日：2017-02-21
申请人： NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY , NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
CPC分类号： A61K49/0054 , A61B5/0071 , A61B5/0205 , A61B5/026 , A61B5/0275 , A61B5/201 , A61B5/415 , A61B5/418 , A61B5/7275 , A61B5/7425 , A61B2576/00 , A61K49/001 , A61K49/0032 , A61K49/0034 , A61K49/0093 , A61M5/007 , C08B37/0012 , C08B37/0015 , C09B23/0066 , C09B23/086 , C09B68/41 , C09B68/485
摘要： The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.
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7.发明申请NOVEL INDOCYANINE COMPOUND, SYNTHESIS METHOD AND PURIFICATION METHOD THEREOF, DIAGNOSTIC COMPOSITION USING THE INDOCYANINE COMPOUND, AND DEVICE FOR MEASURING BIOKINETICS AND DEVICE FOR VISUALIZING CIRCULATION USING THE DIAGNOSTIC COMPOSITION 审中-公开新型吲哚啉化合物，其合成方法和纯化方法，使用吲哚啉化合物的诊断组合物和用于测量生物活性的装置和用于使用诊断组合物观察循环的装置公开(公告)号：US20150152267A1
公开(公告)日：2015-06-04
申请号：US14616117
申请日：2015-02-06
申请人： NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY , NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
CPC分类号： A61K49/0054 , A61B5/0071 , A61B5/0205 , A61B5/026 , A61B5/0275 , A61B5/201 , A61B5/415 , A61B5/418 , A61B5/7275 , A61B5/7425 , A61B2576/00 , A61K49/001 , A61K49/0032 , A61K49/0034 , A61K49/0093 , A61M5/007 , C08B37/0012 , C08B37/0015 , C09B23/0066 , C09B23/086 , C09B68/41 , C09B68/485
摘要： The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.
摘要翻译： 本发明的目的在于提供一种新的吲哚菁化合物，其解决了常规使用的吲哚菁绿的问题，例如在水或生理盐水中的溶解度，其合成方法和纯化方法，以及包含新的吲哚菁化合物的诊断组合物。 此外，提供了用于评估新型吲哚菁化合物的生物动力学的方法和用于测量生物动力学的装置，以及利用诊断组合物来观察生物体中的血液等流体的循环的方法和装置。 此外，发现了一种新颖的吲哚菁化合物，其中近红外荧光靛蓝分子中的疏水部分包含在环状糖链环糊精的空腔中，以用葡萄糖覆盖靛蓝分子中的疏水部分，以及合成方法和 其纯化方法。 此外，发现了通过静脉内给药对肝脏以外的器官进行荧光成像的方法，评价新型吲哚菁化合物的生物动力学的评价方法，生物动力学测定装置以及用于使流体（例如血液）的循环可视化的方法和装置 在生物体中，利用包含新的吲哚菁化合物的诊断组合物。
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8.发明授权公开(公告)号：US07538155B2
公开(公告)日：2009-05-26
申请号：US11480401
申请日：2006-07-05
申请人： Hideki Maeta , Tadahisa Sato
发明人： Hideki Maeta , Tadahisa Sato
CPC分类号： C08K5/0041 , C09B67/0013 , C09B67/0096 , C09B68/4253 , C09B68/44 , C09B68/463 , C09B68/485
摘要： A method of producing an organic pigment dispersion liquid, which has the steps of: providing an alkaline or acidic solution with an organic pigment dissolved therein and an aqueous medium, wherein a polymerizable compound is contained in at least one of the organic pigment solution and the aqueous medium; mixing the organic pigment solution and the aqueous medium; and thereby forming the pigment as fine particles; then polymerizing the polymerizable compound to form a polymer immobile from the pigment fine particles.
摘要翻译： 一种生产有机颜料分散液的方法，其具有以下步骤：提供溶于其中的有机颜料的碱性或酸性溶液和水性介质，其中可聚合化合物包含在至少一种有机颜料溶液和 水介质; 混合有机颜料溶液和水性介质; 从而形成作为细颗粒的颜料; 然后聚合可聚合化合物以形成从颜料微粒不动的聚合物。
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