公开(公告)号：US20150056231A1

公开(公告)日：2015-02-26

申请号：US14388810

申请日：2013-02-19

申请人： FOLIA BIOTECH INC.

发明人： Denis Leclerc ,  Nathalie Majeau

IPC分类号： C07K14/005 ,  A61K39/12 ,  C12N7/00 ,  A61K39/145

CPC分类号： C07K14/005 ,  A61K39/0275 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5258 ,  A61K2039/55516 ,  A61K2039/55577 ,  A61K2039/6075 ,  A61K2039/6081 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2770/26023 ,  C12N2770/26034 ,  C12N2770/26043 ,  C12N2770/40034 ,  Y02A50/482

摘要： Recombinant papaya mosaic virus (PapMV) coat proteins comprising one or more antigenic peptides derived from an influenza virus antigen, such as from the M2e peptide, fused at a position within a predicted random coil within 13 amino acids of the N-terminus of the coat protein, uses thereof to prepare virus-like particles (VLPs), and uses of the VLPs in influenza vaccines.

摘要翻译： 包含一种或多种衍生自流感病毒抗原的抗原肽（例如来自M2e肽）的重组番木瓜花叶病毒（PapMV）外壳蛋白在外壳的N末端的13个氨基酸内的预测的无规卷曲内的位置融合 蛋白质，其用于制备病毒样颗粒（VLP）的用途以及VLPs在流感疫苗中的用途。

公开(公告)号：US20130280298A1

公开(公告)日：2013-10-24

申请号：US13839630

申请日：2013-03-15

申请人： Folia Biotech Inc.

发明人： Denis LECLERC

IPC分类号： A61K39/29 ,  A61K39/145 ,  A61K39/112

CPC分类号： A61K39/29 ,  A61K39/0275 ,  A61K39/12 ,  A61K39/145 ,  A61K39/39 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/55588 ,  C12N2710/24143 ,  C12N2760/16134 ,  C12N2770/24234 ,  C12N2770/40034 ,  Y02A50/482

摘要： An affinity-conjugated antigen system (ACAS) comprising one or more antigens conjugated via a plurality of affinity moieties to a papaya mosaic virus (PapMV) or virus-like particle (VLP) derived from the coat protein of PapMV is provided. The affinity moieties are molecules or compounds that are capable of specifically binding to the antigen(s) of interest and which can be attached, for example by chemical or genetic means, to the coat protein of the PapMV or PapMV VLP. The ACAS can optionally further comprise one or more additional antigens, which may be the same as, or different to, the conjugated antigen(s) comprised by the ACAS. Also provided are immunogenic compositions, including vaccines, comprising an ACAS. The immunogenic compositions are useful in the treatment, including prevention, of various diseases and disorders for which a humoral and/or cellular response in the animal is required.

摘要翻译： 提供了包含通过多个亲和部分缀合的一种或多种抗原与来自PapMV的外壳蛋白的木瓜花叶病毒（PapMV）或病毒样颗粒（VLP））的亲和共轭抗原系统（ACAS）。 亲和部分是能够特异性结合感兴趣的抗原并且可以例如通过化学或遗传方式与PapMV或PapMV VLP的外壳蛋白连接的分子或化合物。 ACAS可以任选地进一步包含一个或多个另外的抗原，其可以与由ACAS组成的缀合的抗原相同或不同。 还提供了包含ACAS的免疫原性组合物，包括疫苗。 免疫原性组合物可用于治疗需要动物体液和/或细胞应答的各种疾病和病症，包括预防。

公开(公告)号：US20240316188A1

公开(公告)日：2024-09-26

申请号：US18734088

申请日：2024-06-05

申请人： KBIO HOLDINGS LIMITED

发明人： Leigh Burden ,  Steven D. Hume ,  Joshua Morton ,  Greg Pogue ,  Barry Bratcher ,  Hugh A. Haydon ,  Carrie A. Simpson ,  Nick Partain ,  John W. Shepherd

IPC分类号： A61K39/385 ,  A61K39/00 ,  C12N7/00

CPC分类号： A61K39/385 ,  C12N7/00 ,  A61K2039/525 ,  C12N2770/00051 ,  C12N2770/40034 ,  C12N2770/40051

摘要： Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound demonstrating enhanced stability, which in some embodiments comprises a protein and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for unrefrigerated storage for longer time periods than previous approaches, thus making feasible access to such products over a global supply chain.

公开(公告)号：US12097256B2

公开(公告)日：2024-09-24

申请号：US17966954

申请日：2022-10-17

申请人： KBIO HOLDINGS LIMITED

发明人： Leigh Burden ,  Steven D. Hume ,  Joshua Morton ,  Greg Pogue ,  Barry Bratcher ,  Hugh A. Haydon ,  Carrie A. Simpson ,  Nick Partain ,  John W. Shepherd

IPC分类号： A61K39/385 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/385 ,  C12N7/00 ,  A61K2039/525 ,  C12N2770/00051 ,  C12N2770/40034 ,  C12N2770/40051

摘要： Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound demonstrating enhanced stability, which in some embodiments comprises a protein and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for unrefrigerated storage for longer time periods than previous approaches, thus making feasible access to such products over a global supply chain.

公开(公告)号：US20160228541A1

公开(公告)日：2016-08-11

申请号：US15022907

申请日：2014-09-19

申请人： Alain LAMARRE ,  FOLIA BIOTECH INC.

发明人： Alain LAMARRE ,  Denis LECLERC

IPC分类号： A61K39/39 ,  A61K39/00 ,  C12N7/00

CPC分类号： A61K39/39 ,  A61K9/5184 ,  A61K31/7105 ,  A61K35/15 ,  A61K35/76 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/525 ,  A61K2039/5258 ,  A61K2039/572 ,  A61K2039/585 ,  C12N7/00 ,  C12N2770/40021 ,  C12N2770/40023 ,  C12N2770/40033 ,  C12N2770/40034 ,  C12N2770/40042 ,  A61K2300/00

摘要： Papaya mosaic virus and virus-like particles (VLPs) comprising ssRNA for use to inhibit cancer growth and metastasis. The PapMV and PapMV VLPs may be used alone or in combination with another cancer therapy, such as a chemotherapeutic, immunotherapeutic, or radiotherapy.

摘要翻译： 番木瓜花叶病毒和病毒样颗粒（VLP），其包含用于抑制癌症生长和转移的ssRNA。 PapMV和PapMV VLP可以单独使用或与另一种癌症治疗如化学治疗，免疫治疗或放射治疗组合使用。