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公开(公告)号：US12097256B2
公开(公告)日：2024-09-24
申请号：US17966954
申请日：2022-10-17
发明人： Leigh Burden , Steven D. Hume , Joshua Morton , Greg Pogue , Barry Bratcher , Hugh A. Haydon , Carrie A. Simpson , Nick Partain , John W. Shepherd
IPC分类号： A61K39/385 , C12N7/00 , A61K39/00
CPC分类号： A61K39/385 , C12N7/00 , A61K2039/525 , C12N2770/00051 , C12N2770/40034 , C12N2770/40051
摘要： Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound demonstrating enhanced stability, which in some embodiments comprises a protein and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for unrefrigerated storage for longer time periods than previous approaches, thus making feasible access to such products over a global supply chain.
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公开(公告)号：US11529413B2
公开(公告)日：2022-12-20
申请号：US16709063
申请日：2019-12-10
发明人： Leigh Burden , Steven D. Hume , Joshua Morton , Greg Pogue , Barry Bratcher , Hugh A. Haydon , Carrie A. Simpson , Nick Partain , John W. Shepherd
IPC分类号： A61K39/385 , C12N7/00 , A61K39/00
摘要： Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound demonstrating enhanced stability, which in some embodiments comprises a protein and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for unrefrigerated storage for longer time periods than previous approaches, thus making feasible access to such products over a global supply chain.
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公开(公告)号：US20240316188A1
公开(公告)日：2024-09-26
申请号：US18734088
申请日：2024-06-05
发明人： Leigh Burden , Steven D. Hume , Joshua Morton , Greg Pogue , Barry Bratcher , Hugh A. Haydon , Carrie A. Simpson , Nick Partain , John W. Shepherd
IPC分类号： A61K39/385 , A61K39/00 , C12N7/00
CPC分类号： A61K39/385 , C12N7/00 , A61K2039/525 , C12N2770/00051 , C12N2770/40034 , C12N2770/40051
摘要： Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound demonstrating enhanced stability, which in some embodiments comprises a protein and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for unrefrigerated storage for longer time periods than previous approaches, thus making feasible access to such products over a global supply chain.
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公开(公告)号：US11696948B2
公开(公告)日：2023-07-11
申请号：US16919943
申请日：2020-07-02
发明人： Steven D. Hume , Leigh Burden , Joshua Morton , Greg Pogue , Barry Bratcher , Hugh A. Haydon , Carrie A. Simpson , Nick Partain , Youngjun Oh , John W. Shepherd , Michael H. Pauly
IPC分类号： A61K39/215 , A61K39/145 , A61K39/12 , A61K47/68 , C07K16/46 , A61P31/16 , A61P31/14 , A61K47/42
CPC分类号： A61K39/215 , A61K39/12 , A61K39/145 , A61K47/42 , A61K47/6811 , A61P31/14 , A61P31/16 , C07K16/46 , C07K2319/30
摘要： Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound, which in some embodiments comprises an antigen and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for use of the conjugate mixture as a vaccine, including but not limited to use as a vaccine against various pathogens including for treatment of diseases caused by novel coronaviruses (including SARS-COV 2).
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公开(公告)号：US11690907B2
公开(公告)日：2023-07-04
申请号：US17186941
申请日：2021-02-26
发明人： Steven D. Hume , Leigh Burden , Joshua Morton , Greg Pogue , Barry Bratcher , Hugh A. Haydon , Carrie A. Simpson , Nick Partain , Youngjun Oh , John W. Shepherd , Michael H. Pauly
IPC分类号： A61K39/145 , A61K39/215 , A61K47/68 , A61K39/00
CPC分类号： A61K39/215 , A61K39/145 , A61K47/6811 , A61K2039/5256 , A61K2039/627 , A61K2039/70
摘要： Disclosed herein are methods of forming compounds and exemplary stable compounds in the nature of a conjugated compound at refrigerated or room temperature, which in some embodiments comprises an antigen and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for use of the conjugate mixture as a vaccine, including but not limited to use as a vaccine against various pathogens including for treatment of diseases caused by novel coronaviruses (including SARS-COV 2).
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公开(公告)号：US20230027693A1
公开(公告)日：2023-01-26
申请号：US17951674
申请日：2022-09-23
发明人： Leigh Burden , Steven D. Hume , Joshua Morton , Greg Pogue , Barry Bratcher , Hugh A. Haydon , Carrie A. Simpson , Nick Partain , John W. Shepherd
IPC分类号： C12N7/00 , B01D15/34 , B01D15/36 , B01D15/38 , A61K47/69 , A61K38/36 , A61K39/00 , A61K39/145 , C07K1/18 , C07K1/16 , C07K1/22
摘要： Disclosed herein are methods and exemplary compositions associated with virus purification, antigen purification, and conjugation of virus and proteins (e.g., antigen) to form vaccines for delivery of immunological and other therapeutic agents, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection; and a conjugation platform providing activation of the virus at a pH that increases binding rate and binding propensity between the virus and the protein, wherein embodiments related to the conjugation platform include controlling the ratio of virus to protein.
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公开(公告)号：US11655461B2
公开(公告)日：2023-05-23
申请号：US17063022
申请日：2020-10-05
发明人： Steven D. Hume , Leigh Burden , Joshua Morton , Greg Pogue , Barry Bratcher , Hugh A. Haydon , Carrie A. Simpson , Nick Partain , John W. Shepherd , Kelsi Swope
IPC分类号： A61K39/00 , B01D15/34 , B01D15/36 , B01D15/38 , C07K1/16 , C07K1/18 , C07K1/22 , C12N7/00 , A61K39/145 , A61K47/69 , A61K38/36
CPC分类号： C12N7/00 , A61K38/36 , A61K39/0001 , A61K39/145 , A61K47/6901 , B01D15/34 , B01D15/361 , B01D15/3809 , B01D15/3847 , C07K1/16 , C07K1/18 , C07K1/22 , A61K2039/5254 , C12N2770/00051 , C12N2770/00061 , C12N2770/40051 , C12N2770/40061
摘要： Disclosed herein are methods and exemplary compositions associated with antigen purification, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; and a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection.
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公开(公告)号：US20230149532A1
公开(公告)日：2023-05-18
申请号：US17851428
申请日：2022-06-28
发明人： Steven D. Hume , Leigh Burden , Joshua Morton , Greg Pogue , Barry Bratcher , Hugh A. Haydon , Carrie A. Simpson , Nick Partain , Youngjun Oh , John W. Shepherd , Michael H. Pauly
IPC分类号： A61K39/215 , A61K39/145 , A61K47/68
CPC分类号： A61K39/215 , A61K39/145 , A61K47/6811 , A61K2039/627
摘要： Disclosed herein are methods of forming compounds and exemplary stable compounds in the nature of a conjugated compound at refrigerated or room temperature, which in some embodiments comprises an antigen and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for use of the conjugate mixture as a vaccine, including but not limited to use as a vaccine against various pathogens including for treatment of diseases caused by novel coronaviruses (including SARS-COV 2).
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公开(公告)号：US20230056944A1
公开(公告)日：2023-02-23
申请号：US17966954
申请日：2022-10-17
发明人： Leigh Burden , Steven D. Hume , Joshua Morton , Greg Pogue , Barry Bratcher , Hugh A. Haydon , Carrie A. Simpson , Nick Partain , John W. Shepherd
IPC分类号： A61K39/385 , C12N7/00 , A61K39/00
摘要： Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound demonstrating enhanced stability, which in some embodiments comprises a protein and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for unrefrigerated storage for longer time periods than previous approaches, thus making feasible access to such products over a global supply chain.
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公开(公告)号：US11485956B2
公开(公告)日：2022-11-01
申请号：US16437734
申请日：2019-06-11
发明人： Leigh Burden , Steven D. Hume , Joshua Morton , Greg Pogue , Barry Bratcher , Hugh A. Haydon , Carrie A. Simpson , Nick Partain , John W. Shepherd
IPC分类号： A61K38/36 , C07K1/18 , C12N7/00 , B01D15/34 , B01D15/36 , B01D15/38 , A61K47/69 , A61K39/00 , A61K39/145 , C07K1/16 , C07K1/22
摘要： Disclosed herein are methods and exemplary compositions associated with virus purification, antigen purification, and conjugation of virus and proteins (e.g., antigen) to form vaccines for delivery of immunological and other therapeutic agents, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection; and a conjugation platform providing activation of the virus at a pH that increases binding rate and binding propensity between the virus and the protein, wherein embodiments related to the conjugation platform include controlling the ratio of virus to protein.
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