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    M13 bacteriophage as a chemoaddressable nanoparticle for biological and medical applications
    2.
    发明授权
    M13 bacteriophage as a chemoaddressable nanoparticle for biological and medical applications 有权
    M13噬菌体作为用于生物和医学应用的化学可接地纳米颗粒

    公开(公告)号：US08415131B2

    公开(公告)日：2013-04-09

    申请号：US12604575

    申请日：2009-10-23

    申请人： Qian Wang ,  Kai Li ,  Charlene Mello

    发明人： Qian Wang ,  Kai Li ,  Charlene Mello

    IPC分类号： C12Q1/70 ,  C12N7/00 ,  C12N7/06 ,  C07C245/00 ,  C07D249/16

    CPC分类号： G01N21/6486 ,  C12N7/00 ,  C12N2795/14142 ,  C12N2795/14145 ,  C12N2810/10 ,  C12N2810/405

    摘要： Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding.

    摘要翻译： 通常提供活性和改良的M13噬菌体及其制备和使用方法。 反应性M13噬菌体可以包括共价连接到M13噬菌体上的炔官能团。 修饰的M13噬菌体可以包括通过1,2,3-三唑键共价连接到M13噬菌体上的取代基。 也通常提供双重修饰的M13噬菌体，并且可以包括共价连接到M13噬菌体的癌靶向取代基和共价连接到M13噬菌体的荧光基团。 修饰的M13噬菌体不仅可以用作癌症成像的荧光探针，还可以用作细胞比对和脚手架的生物材料。

    METHODS AND COMPOSITIONS RELATED TO PHAGE-NANOPARTICLE ASSEMBLIES
    3.
    发明申请
    METHODS AND COMPOSITIONS RELATED TO PHAGE-NANOPARTICLE ASSEMBLIES 审中-公开
    相关的纳米材料组合物的方法和组合物

    公开(公告)号：US20100291537A1

    公开(公告)日：2010-11-18

    申请号：US11719508

    申请日：2005-11-16

    申请人： Glauco Souza ,  Wadih Arap ,  Renata Pasqualini ,  J. Houston Miller

    发明人： Glauco Souza ,  Wadih Arap ,  Renata Pasqualini ,  J. Houston Miller

    IPC分类号： C12Q1/70 ,  C12M1/34

    CPC分类号： G01N33/587 ,  A61K35/76 ,  A61K47/6901 ,  A61K49/0065 ,  A61K49/0097 ,  C07K7/06 ,  C07K14/005 ,  C07K2319/01 ,  C07K2319/20 ,  C12N7/00 ,  C12N2795/14122 ,  C12N2795/14142 ,  C12N2810/50 ,  G01N33/569

    摘要： Embodiments of the invention include additional compositions and related methods and devices for the use of phage-nanoparticle assemblies. Embodiments of the invention include compositions, methods and devices related to phage-nanoparticle assemblies and their use in a variety of methods including detection methods, in vitro and in vivo diagnostic methods, direct and/or indirect therapeutic methods, or combinations thereof. Phage-nanoparticle assemblies of the invention comprise a plurality of nanoparticles complexed with one or more phage particles to form a phage-nanoparticle assembly. In certain aspects, the phage-nanoparticle assembly may also include other agents, including but not limited to organizing agents and/or therapeutic agents.

    摘要翻译： 本发明的实施方案包括另外的组合物和用于使用噬菌体 - 纳米颗粒组件的相关方法和装置。 本发明的实施方案包括与噬菌体 - 纳米颗粒组件相关的组合物，方法和装置及其在各种方法中的应用，包括检测方法，体外和体内诊断方法，直接和/或间接治疗方法或其组合。 本发明的噬菌体纳米颗粒组件包含与一个或多个噬菌体颗粒复合以形成噬菌体 - 纳米颗粒组件的多个纳米颗粒。 在某些方面，噬菌体 - 纳米颗粒组件还可以包括其它试剂，包括但不限于组织试剂和/或治疗剂。

    M13 Bacteriophage as A Chemoaddressable Nanoparticle for Biological and Medical Applications
    5.
    发明申请
    M13 Bacteriophage as A Chemoaddressable Nanoparticle for Biological and Medical Applications 有权
    M13噬菌体作为用于生物和医学应用的化学可接地纳米颗粒

    公开(公告)号：US20100190233A1

    公开(公告)日：2010-07-29

    申请号：US12604575

    申请日：2009-10-23

    申请人： Qian Wang ,  Kai Li ,  Charlene Mello

    发明人： Qian Wang ,  Kai Li ,  Charlene Mello

    IPC分类号： C12N7/00 ,  C12N5/09

    CPC分类号： G01N21/6486 ,  C12N7/00 ,  C12N2795/14142 ,  C12N2795/14145 ,  C12N2810/10 ,  C12N2810/405

    摘要： Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding.

    摘要翻译： 通常提供活性和改良的M13噬菌体及其制备和使用方法。 反应性M13噬菌体可以包括共价连接到M13噬菌体上的炔官能团。 修饰的M13噬菌体可以包括通过1,2,3-三唑键共价连接到M13噬菌体上的取代基。 也通常提供双重修饰的M13噬菌体，并且可以包括共价连接到M13噬菌体的癌靶向取代基和共价连接到M13噬菌体的荧光基团。 修饰的M13噬菌体不仅可以用作癌症成像的荧光探针，还可以用作细胞比对和脚手架的生物材料。

    M13 bacteriophage as a chemoaddressable nanoparticle for biological and medical applications
    6.
    发明授权
    M13 bacteriophage as a chemoaddressable nanoparticle for biological and medical applications 有权
    M13噬菌体作为用于生物和医学应用的化学可接地纳米颗粒

    公开(公告)号：US09551666B2

    公开(公告)日：2017-01-24

    申请号：US13800526

    申请日：2013-03-13

    申请人： University of South Carolina

    发明人： Qian Wang ,  Kai Li ,  Charlene Mello

    IPC分类号： C12Q1/70 ,  G01N21/64 ,  C12N7/00

    CPC分类号： G01N21/6486 ,  C12N7/00 ,  C12N2795/14142 ,  C12N2795/14145 ,  C12N2810/10 ,  C12N2810/405

    摘要： Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding.

    摘要翻译： 通常提供活性和改良的M13噬菌体及其制备和使用方法。 反应性M13噬菌体可以包括共价连接到M13噬菌体上的炔官能团。 修饰的M13噬菌体可以包括通过1,2,3-三唑键共价连接到M13噬菌体上的取代基。 也通常提供双重修饰的M13噬菌体，并且可以包括共价连接到M13噬菌体的癌靶向取代基和共价连接到M13噬菌体的荧光基团。 修饰的M13噬菌体不仅可以用作癌症成像的荧光探针，还可以用作细胞比对和脚手架的生物材料。

    M13 Bacteriophage as a Chemoaddressable Nanoparticle for Biological and Medical Applications
    7.
    发明申请
    M13 Bacteriophage as a Chemoaddressable Nanoparticle for Biological and Medical Applications 有权
    M13噬菌体作为生物和医学应用的化学可接地纳米粒子

    公开(公告)号：US20130337435A1

    公开(公告)日：2013-12-19

    申请号：US13800526

    申请日：2013-03-13

    申请人： UNIVERSITY OF SOUTH CAROLINA

    发明人： Qian Wang ,  Kai Li ,  Charlene Mello

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6486 ,  C12N7/00 ,  C12N2795/14142 ,  C12N2795/14145 ,  C12N2810/10 ,  C12N2810/405

    摘要： Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding.

    摘要翻译： 通常提供活性和改良的M13噬菌体及其制备和使用方法。 反应性M13噬菌体可以包括共价连接到M13噬菌体上的炔官能团。 修饰的M13噬菌体可以包括通过1,2,3-三唑键共价连接到M13噬菌体上的取代基。 也通常提供双重修饰的M13噬菌体，并且可以包括共价连接到M13噬菌体的癌靶向取代基和共价连接到M13噬菌体的荧光基团。 修饰的M13噬菌体不仅可以用作癌症成像的荧光探针，还可以用作细胞比对和脚手架的生物材料。