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公开(公告)号：US11285202B2
公开(公告)日：2022-03-29
申请号：US15416429
申请日：2017-01-26
发明人： Qian Wang , L. Andrew Lee
IPC分类号： A61K39/12 , A61K39/015 , A61K39/00
摘要： A polymer-protein core-shell nanoparticle is generally provided. In one embodiment, the polymer-protein core-shell nanoparticle includes a pyridinyl group grafted polymer assembled with a protein or a glycoprotein based antigen to form a core-shell particle. A method is also generally provided for treating an infected organism. In one embodiment, the method includes administering the polymer-protein core-shell nanoparticle to the infected organism.
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公开(公告)号：US20210372959A1
公开(公告)日：2021-12-02
申请号：US17212021
申请日：2021-03-25
摘要： The current disclosure provides a transformative concept based on nanopore technology, Sequencing-by-Hydrolysis, to identify the N-terminal amino acid and the length of each peptide fragment in a peptide ladder to reconstitute the sequence of a protein: a protein/peptide analyte will be nonspecifically hydrolyzed to generate random fragments of the analyte that are different by one amino acid with the N-terminal amino acid of each fragment modified so it generates a distinguishable fingerprint signal when tested by nanopore. The length of the fragment can be estimated by characterizing its translocation signal to back calculate the location of the amino acid in the original analyte. This approach will significantly advance the nanopore technology with single amino acid resolution for protein/peptide sequencing.
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公开(公告)号：US20170096643A9
公开(公告)日：2017-04-06
申请号：US13685122
申请日：2012-11-26
发明人： Qian Wang , Zhongwei Niu
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , B82Y5/00 , C12N2770/00023 , D01F1/10 , D01F6/76 , Y10S977/762
摘要： The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensional nanostructures formed from crosslinked viruses assembled in a single, film-like layer are generally disclosed. Porous gels having controllable pore size through the use of virus particles are also disclosed.
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4.发明授权M13 bacteriophage as a chemoaddressable nanoparticle for biological and medical applications 有权M13噬菌体作为用于生物和医学应用的化学可接地纳米颗粒公开(公告)号：US09551666B2
公开(公告)日：2017-01-24
申请号：US13800526
申请日：2013-03-13
发明人： Qian Wang , Kai Li , Charlene Mello
CPC分类号： G01N21/6486 , C12N7/00 , C12N2795/14142 , C12N2795/14145 , C12N2810/10 , C12N2810/405
摘要： Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding.
摘要翻译： 通常提供活性和改良的M13噬菌体及其制备和使用方法。 反应性M13噬菌体可以包括共价连接到M13噬菌体上的炔官能团。 修饰的M13噬菌体可以包括通过1,2,3-三唑键共价连接到M13噬菌体上的取代基。 也通常提供双重修饰的M13噬菌体，并且可以包括共价连接到M13噬菌体的癌靶向取代基和共价连接到M13噬菌体的荧光基团。 修饰的M13噬菌体不仅可以用作癌症成像的荧光探针，还可以用作细胞比对和脚手架的生物材料。
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5.发明申请M13 Bacteriophage as a Chemoaddressable Nanoparticle for Biological and Medical Applications 有权M13噬菌体作为生物和医学应用的化学可接地纳米粒子公开(公告)号：US20130337435A1
公开(公告)日：2013-12-19
申请号：US13800526
申请日：2013-03-13
发明人： Qian Wang , Kai Li , Charlene Mello
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , C12N7/00 , C12N2795/14142 , C12N2795/14145 , C12N2810/10 , C12N2810/405
摘要： Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding.
摘要翻译： 通常提供活性和改良的M13噬菌体及其制备和使用方法。 反应性M13噬菌体可以包括共价连接到M13噬菌体上的炔官能团。 修饰的M13噬菌体可以包括通过1,2,3-三唑键共价连接到M13噬菌体上的取代基。 也通常提供双重修饰的M13噬菌体，并且可以包括共价连接到M13噬菌体的癌靶向取代基和共价连接到M13噬菌体的荧光基团。 修饰的M13噬菌体不仅可以用作癌症成像的荧光探针，还可以用作细胞比对和脚手架的生物材料。
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公开(公告)号：US20130143303A1
公开(公告)日：2013-06-06
申请号：US13685122
申请日：2012-11-26
发明人： Qian Wang , Zhongwei Niu
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , B82Y5/00 , C12N2770/00023 , D01F1/10 , D01F6/76 , Y10S977/762
摘要： The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensional nanostructures formed from crosslinked viruses assembled in a single, film-like layer are generally disclosed. Porous gels having controllable pore size through the use of virus particles are also disclosed.
摘要翻译： 通常公开了使用诸如病毒和病毒样颗粒的生物材料来形成纳米结构。 例如，棒状病毒可以用于形成复合纳米纤维，它们通过聚合物以头对尾组装方式固定在一起。 此外，通常公开了由组装在单个膜状层中的交联病毒形成的二维纳米结构。 还公开了通过使用病毒颗粒具有可控孔径的多孔凝胶。
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公开(公告)号：US20190038643A1
公开(公告)日：2019-02-07
申请号：US15665862
申请日：2017-08-01
发明人： Qian Wang
CPC分类号： A61K31/664 , A61L15/26 , A61L15/28 , A61L15/425 , A61L15/44 , A61L15/64 , A61L2300/10 , A61L2300/216 , A61L2300/41 , A61L2300/412 , A61L2400/12 , A61L2430/34 , C08L5/04 , C08L5/08 , C08L67/04
摘要： A dressing for wound healing is provided, wherein the dressing includes a hydrogen sulfide (H2S) donor compound. The dressing facilitates the delivery of H2S to a wound site in a controlled manner, which results in an improved wound healing process by stimulating angiogenesis and anti-inflammatory action. In some embodiments, the wound dressing can include an electrospun nanofiber dressing, a sponge dressing, or a hydrogel dressing.
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公开(公告)号：US10066216B2
公开(公告)日：2018-09-04
申请号：US15619805
申请日：2017-06-12
发明人： Qian Wang , Zhongwei Niu
摘要： The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensional nanostructures formed from crosslinked viruses assembled in a single, film-like layer are generally disclosed. Porous gels having controllable pore size through the use of virus particles are also disclosed.
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公开(公告)号：US10456410B2
公开(公告)日：2019-10-29
申请号：US15665862
申请日：2017-08-01
发明人： Qian Wang
摘要： A dressing for wound healing is provided, wherein the dressing includes a hydrogen sulfide (H2S) donor compound. The dressing facilitates the delivery of H2S to a wound site in a controlled manner, which results in an improved wound healing process by stimulating angiogenesis and anti-inflammatory action. In some embodiments, the wound dressing can include an electrospun nanofiber dressing, a sponge dressing, or a hydrogel dressing.
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公开(公告)号：US09683218B2
公开(公告)日：2017-06-20
申请号：US13685122
申请日：2012-11-26
发明人： Qian Wang , Zhongwei Niu
CPC分类号： C12N7/00 , B82Y5/00 , C12N2770/00023 , D01F1/10 , D01F6/76 , Y10S977/762
摘要： The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensional nanostructures formed from crosslinked viruses assembled in a single, film-like layer are generally disclosed. Porous gels having controllable pore size through the use of virus particles are also disclosed.
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