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    METHODS AND COMPOSITIONS RELATED TO PHAGE-NANOPARTICLE ASSEMBLIES
    1.
    发明申请
    METHODS AND COMPOSITIONS RELATED TO PHAGE-NANOPARTICLE ASSEMBLIES 审中-公开
    相关的纳米材料组合物的方法和组合物

    公开(公告)号：US20100291537A1

    公开(公告)日：2010-11-18

    申请号：US11719508

    申请日：2005-11-16

    申请人： Glauco Souza ,  Wadih Arap ,  Renata Pasqualini ,  J. Houston Miller

    发明人： Glauco Souza ,  Wadih Arap ,  Renata Pasqualini ,  J. Houston Miller

    IPC分类号： C12Q1/70 ,  C12M1/34

    CPC分类号： G01N33/587 ,  A61K35/76 ,  A61K47/6901 ,  A61K49/0065 ,  A61K49/0097 ,  C07K7/06 ,  C07K14/005 ,  C07K2319/01 ,  C07K2319/20 ,  C12N7/00 ,  C12N2795/14122 ,  C12N2795/14142 ,  C12N2810/50 ,  G01N33/569

    摘要： Embodiments of the invention include additional compositions and related methods and devices for the use of phage-nanoparticle assemblies. Embodiments of the invention include compositions, methods and devices related to phage-nanoparticle assemblies and their use in a variety of methods including detection methods, in vitro and in vivo diagnostic methods, direct and/or indirect therapeutic methods, or combinations thereof. Phage-nanoparticle assemblies of the invention comprise a plurality of nanoparticles complexed with one or more phage particles to form a phage-nanoparticle assembly. In certain aspects, the phage-nanoparticle assembly may also include other agents, including but not limited to organizing agents and/or therapeutic agents.

    摘要翻译： 本发明的实施方案包括另外的组合物和用于使用噬菌体 - 纳米颗粒组件的相关方法和装置。 本发明的实施方案包括与噬菌体 - 纳米颗粒组件相关的组合物，方法和装置及其在各种方法中的应用，包括检测方法，体外和体内诊断方法，直接和/或间接治疗方法或其组合。 本发明的噬菌体纳米颗粒组件包含与一个或多个噬菌体颗粒复合以形成噬菌体 - 纳米颗粒组件的多个纳米颗粒。 在某些方面，噬菌体 - 纳米颗粒组件还可以包括其它试剂，包括但不限于组织试剂和/或治疗剂。

    COMPOSITIONS AND METHODS OF USE OF TARGETING PEPTIDES AGAINST PLACENTA AND ADIPOSE TISSUES
    2.
    发明申请
    COMPOSITIONS AND METHODS OF USE OF TARGETING PEPTIDES AGAINST PLACENTA AND ADIPOSE TISSUES 有权
    使用针对PLACENTA和ADIPOSE TISSUES的靶向肽的组合物和方法

    公开(公告)号：US20130039972A1

    公开(公告)日：2013-02-14

    申请号：US13559222

    申请日：2012-07-26

    申请人： Renata Pasqualini ,  Wadih Arap ,  Mikhail G. Kolonin

    发明人： Renata Pasqualini ,  Wadih Arap ,  Mikhail G. Kolonin

    IPC分类号： C07K1/107 ,  C12N1/20 ,  A61K38/10 ,  A61K9/127 ,  A61K38/08 ,  A61K38/16 ,  C12N7/00 ,  C12N15/63

    CPC分类号： A61K38/08 ,  A61K31/70

    摘要： The present invention concerns compositions comprising and methods of identification and use of targeting peptides for placenta or adipose tissue. In certain embodiments, the targeting peptides comprise part or all of SEQ ID NO:5-11, SEQ ID NO:13-22 or SEQ ID NO:144. The peptides may be attached to various therapeutic agents for targeted delivery. Adipose-targeting peptides may be used in methods for weight control, inducing weight loss and treating lipodystrophy syndrome. Adipose-targeting may also be accomplished using other binding moieties selectively targeted to adipose receptors, such as a prohibitin receptor protein complex. Placenta-targeting peptides may be used to interfere with pregnancy, induce labor and/or for targeted delivery of therapeutic agents to placenta and/or fetus. In other embodiments, receptors identified by binding to placenta-targeting peptides may be used to screen compounds for potential teratogenicity. An exemplary placental receptor is FcRn/β2M, and compounds that bind to FcRn/β2M are potential teratogens.

    摘要翻译： 本发明涉及包含鉴定和使用用于胎盘或脂肪组织的靶向肽的组合物。 在某些实施方案中，靶向肽包含SEQ ID NO：5-11，SEQ ID NO：13-22或SEQ ID NO：144的部分或全部。 肽可以连接到各种用于靶向递送的治疗剂。 脂肪酸靶向肽可用于体重控制，诱导体重减轻和脂肪营养不良综合症的治疗方法。 脂肪靶向也可以使用选择性靶向脂肪受体的其它结合部分来实现，例如抗蛋白受体蛋白复合物。 胎盘靶向肽可用于干扰妊娠，诱导劳动和/或用于靶向递送治疗剂至胎盘和/或胎儿。 在其它实施方案中，通过结合胎盘靶向肽鉴定的受体可用于筛选化合物以产生潜在的致畸性。 示例性的胎盘受体是FcRn / bgr; 2M，并且与FcRn / bgr2M2结合的化合物是潜在的致畸因子。

    Compositions and methods of use of targeting peptides against placenta and adipose tissues
    5.
    发明授权
    Compositions and methods of use of targeting peptides against placenta and adipose tissues 失效
    使用针对胎盘和脂肪组织的肽的组合物和方法

    公开(公告)号：US07452964B2

    公开(公告)日：2008-11-18

    申请号：US10489071

    申请日：2002-08-30

    申请人： Renata Pasqualini ,  Wadih Arap ,  Mikhail G. Kolonin

    发明人： Renata Pasqualini ,  Wadih Arap ,  Mikhail G. Kolonin

    IPC分类号： C07K5/00 ,  A61K48/00

    CPC分类号： A61K38/08 ,  A61K31/70

    摘要： The present invention concerns compositions comprising and methods of identification and use of targeting peptides for placenta or adipose tissue. In certain embodiments, the targeting peptides comprise part or all of SEQ ID NO:5-11, SEQ ID NO:13-22 OR SEQ ID NO:144. The peptides may be attached to various therapeutic agents for targeted delivery. Adipose-targeting peptides may be used in methods for weight control, inducing weight loss and treating lipodystrophy syndrome. Adipose-targeting may also be accomplished using other binding moieties selectively targeted to adipose receptors, such as a prohibitin receptor protein complex. Placenta-targeting peptides may be used to interfere with pregnancy, induce labor and/or for targeted delivery of therapeutic agents to placenta and/or fetus. In other embodiments, receptors identified by binding to placenta-targeting peptides may be used to screen compounds for potential teratogenicity. An exemplary placental receptor is FcRn/β2M, and compounds that bind to FcRn/β2M are potential teratogens.

    摘要翻译： 本发明涉及包含鉴定和使用用于胎盘或脂肪组织的靶向肽的组合物。 在某些实施方案中，靶向肽包含SEQ ID NO：5-11，SEQ ID NO：13-22或SEQ ID NO：144的部分或全部。 肽可以连接到各种用于靶向递送的治疗剂。 脂肪酸靶向肽可用于体重控制，诱导体重减轻和脂肪营养不良综合症的治疗方法。 脂肪靶向也可以使用选择性靶向脂肪受体的其它结合部分来实现，例如抗蛋白受体蛋白复合物。 胎盘靶向肽可用于干扰妊娠，诱导劳动和/或用于靶向递送治疗剂至胎盘和/或胎儿。 在其他实施方案中，通过结合胎盘靶向肽鉴定的受体可用于筛选化合物以产生潜在的致畸性。 示例性的胎盘受体是FcRn /β2M，并且结合FcRn /β2M的化合物是潜在的致畸因子。

    Compositions and methods of use of targeting peptides against placenta and adipose tissues
    6.
    发明授权
    Compositions and methods of use of targeting peptides against placenta and adipose tissues 有权
    使用针对胎盘和脂肪组织的肽的组合物和方法

    公开(公告)号：US08846859B2

    公开(公告)日：2014-09-30

    申请号：US13559222

    申请日：2012-07-26

    申请人： Renata Pasqualini ,  Wadih Arap ,  Mikhail G. Kolonin

    发明人： Renata Pasqualini ,  Wadih Arap ,  Mikhail G. Kolonin

    IPC分类号： C07K5/00 ,  A61K31/70 ,  A61K38/08 ,  A61K48/00

    CPC分类号： A61K38/08 ,  A61K31/70

    摘要： The present invention concerns compositions comprising and methods of identification and use of targeting peptides for placenta or adipose tissue. In certain embodiments, the targeting peptides comprise part or all of SEQ ID NO:5-11, SEQ ID NO:13-22 or SEQ ID NO:144. The peptides may be attached to various therapeutic agents for targeted delivery. Adipose-targeting peptides may be used in methods for weight control, inducing weight loss and treating lipodystrophy syndrome. Adipose-targeting may also be accomplished using other binding moieties selectively targeted to adipose receptors, such as a prohibitin receptor protein complex. Placenta-targeting peptides may be used to interfere with pregnancy, induce labor and/or for targeted delivery of therapeutic agents to placenta and/or fetus. In other embodiments, receptors identified by binding to placenta-targeting peptides may be used to screen compounds for potential teratogenicity. An exemplary placental receptor is FcRn/β2M, and compounds that bind to FcRn/β2M are potential teratogens.

    摘要翻译： 本发明涉及包含鉴定和使用用于胎盘或脂肪组织的靶向肽的组合物。 在某些实施方案中，靶向肽包含SEQ ID NO：5-11，SEQ ID NO：13-22或SEQ ID NO：144的部分或全部。 肽可以连接到各种用于靶向递送的治疗剂。 脂肪酸靶向肽可用于体重控制，诱导体重减轻和脂肪营养不良综合症的治疗方法。 脂肪靶向也可以使用选择性靶向脂肪受体的其它结合部分来实现，例如抗蛋白受体蛋白复合物。 胎盘靶向肽可用于干扰妊娠，诱导劳动和/或用于靶向递送治疗剂至胎盘和/或胎儿。 在其它实施方案中，通过结合胎盘靶向肽鉴定的受体可用于筛选化合物以产生潜在的致畸性。 示例性的胎盘受体是FcRn / bgr; 2M，并且与FcRn / bgr2M2结合的化合物是潜在的致畸因子。

    MUC18 targeting peptides
    8.
    发明授权
    MUC18 targeting peptides 有权
    MUC18靶向肽

    公开(公告)号：US08450278B2

    公开(公告)日：2013-05-28

    申请号：US13124550

    申请日：2009-10-15

    申请人： Fernanda Staquicini ,  Renata Pasqualini ,  Wadih Arap

    发明人： Fernanda Staquicini ,  Renata Pasqualini ,  Wadih Arap

    IPC分类号： A61K38/02 ,  A61K38/08

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K14/4727 ,  C07K14/4748 ,  C07K14/70535 ,  C12N7/00 ,  G01N33/5011

    摘要： Provided are MUC 18 targeting peptides which may be used, e.g., to therapeutically target B-I lymphocytes to reduce the influence of these cells on the metastatic potential of melanoma cells and/or to target cancerous cells, including certain melanoma and leukemia cells. MUC 18 targeting peptides may be comprised in fusion constructs, imaging constructs, and/or therapeutic constructs such as fusion constructs which may be used for diagnosing or treating a cancer.

    摘要翻译： 提供了MUC18靶向肽，其可以用于例如治疗性靶向B-1淋巴细胞，以减少这些细胞对黑素瘤细胞和/或靶向癌细胞（包括某些黑素瘤和白血病细胞）的转移潜力的影响。 MUC18靶向肽可以包含在可用于诊断或治疗癌症的融合构建体，成像构建体和/或治疗构建体如融合构建体中。