公开(公告)号：US20040013658A1

公开(公告)日：2004-01-22

申请号：US10342119

申请日：2003-01-13

Applicant: Brandeis University

Inventor： Chandler Fulton ,  Elaine Y. Lai

IPC: A61K038/43 ,  A61K048/00

CPC classification number: C12N9/1085 ,  A61K38/45 ,  A61K38/50 ,  A61K48/00 ,  C07K14/4747 ,  C07K2319/00 ,  C12N9/78 ,  C12Y205/01002 ,  C12Y305/99002 ,  Y10S977/70 ,  Y10S977/902 ,  Y10S977/905 ,  Y10S977/911 ,  Y10S977/912

Abstract: The disclosure describes methods for inducing apoptosis of a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Included are methods for inducing apoptosis of cancer cells. Also described are compounds and compositions for use in methods of thiamin depletion and treating diseases such as cancer, and methods for identifying thiamin-depleting agents and for preparing pharmaceutical compositions.

Abstract translation: 本公开描述了通过降低细胞中硫胺素的水平来诱导体内选择的脊椎动物细胞群的凋亡的方法。 包括诱导癌细胞凋亡的方法。 还描述了用于硫胺消耗和治疗疾病如癌症的方法的化合物和组合物，以及鉴定硫胺消耗剂和制备药物组合物的方法。

公开(公告)号：US07803531B2

公开(公告)日：2010-09-28

申请号：US10342119

申请日：2003-01-13

Applicant: Chandler Fulton ,  Elaine Y. Lai

Inventor： Chandler Fulton ,  Elaine Y. Lai

IPC: C12Q1/68 ,  A01N43/04 ,  A01N63/00 ,  A01N25/00 ,  C12N9/00 ,  C12N5/00 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00 ,  C12Q1/00

CPC classification number: C12N9/1085 ,  A61K38/45 ,  A61K38/50 ,  A61K48/00 ,  C07K14/4747 ,  C07K2319/00 ,  C12N9/78 ,  C12Y205/01002 ,  C12Y305/99002 ,  Y10S977/70 ,  Y10S977/902 ,  Y10S977/905 ,  Y10S977/911 ,  Y10S977/912

Abstract: The disclosure describes methods for inducing apoptosis of a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Included are methods for inducing apoptosis of cancer cells. Also described are compounds and compositions for use in methods of thiamin depletion and treating diseases such as cancer, and methods for identifying thiamin-depleting agents and for preparing pharmaceutical compositions.

Abstract translation: 本公开描述了通过降低细胞中硫胺素的水平来诱导体内选择的一组脊椎动物细胞的凋亡的方法。 包括诱导癌细胞凋亡的方法。 还描述了用于硫胺消耗和治疗疾病如癌症的方法的化合物和组合物，以及鉴定硫胺消耗剂和制备药物组合物的方法。

公开(公告)号：US06506550B1

公开(公告)日：2003-01-14

申请号：US09113596

申请日：1998-07-10

Applicant: Chandler Fulton ,  Elaine Y. Lai

Inventor： Chandler Fulton ,  Elaine Y. Lai

IPC: C12Q100

CPC classification number: C12N9/1085 ,  A61K38/45 ,  A61K38/50 ,  A61K48/00 ,  C07K14/4747 ,  C07K2319/00 ,  C12N9/78 ,  C12Y205/01002 ,  C12Y305/99002 ,  Y10S977/70 ,  Y10S977/902 ,  Y10S977/905 ,  Y10S977/911 ,  Y10S977/912

Abstract: The disclosure describes methods for inducing apoptosis of a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Included are methods for inducing apoptosis of cancer cells. Also described are compounds and compositions for use in methods of thiamin depletion and treating diseases such as cancer, and methods for identifying thiamin-depleting agents and for preparing pharmaceutical compositions.

Abstract translation: 本公开描述了通过降低细胞中硫胺素的水平来诱导体内选择的一组脊椎动物细胞的凋亡的方法。 包括诱导癌细胞凋亡的方法。 还描述了用于硫胺消耗和治疗疾病如癌症的方法的化合物和组合物，以及鉴定硫胺消耗剂和制备药物组合物的方法。