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    Fully automatic rapid microscope slide scanner
    1.
    发明授权
    Fully automatic rapid microscope slide scanner 有权

    公开(公告)号：US08055042B2

    公开(公告)日：2011-11-08

    申请号：US12344037

    申请日：2008-12-24

    申请人： Dirk G. Soenksen

    发明人： Dirk G. Soenksen

    IPC分类号： G06K9/00

    CPC分类号： G02B21/367 ,  G02B21/002 ,  G02B21/0036 ,  G02B21/008 ,  G02B21/14 ,  G02B21/245 ,  G02B21/26 ,  G02B21/32 ,  G02B21/34 ,  G02B21/365 ,  G06F19/00 ,  H04N1/053 ,  H04N1/1903 ,  H04N1/193 ,  H04N1/19573 ,  H04N5/2256 ,  H04N5/23206 ,  H04N7/18 ,  H04N7/183 ,  H04N2201/04727 ,  H04N2201/04755

    摘要： Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging.

    Fully Automatic Rapid Microscope Slide Scanner
    3.
    发明申请
    Fully Automatic Rapid Microscope Slide Scanner 有权
    全自动快速显微镜幻灯片

    公开(公告)号：US20090141126A1

    公开(公告)日：2009-06-04

    申请号：US12344037

    申请日：2008-12-24

    申请人： Dirk G. Soenksen

    发明人： Dirk G. Soenksen

    IPC分类号： H04N7/18

    CPC分类号： G02B21/367 ,  G02B21/002 ,  G02B21/0036 ,  G02B21/008 ,  G02B21/14 ,  G02B21/245 ,  G02B21/26 ,  G02B21/32 ,  G02B21/34 ,  G02B21/365 ,  G06F19/00 ,  H04N1/053 ,  H04N1/1903 ,  H04N1/193 ,  H04N1/19573 ,  H04N5/2256 ,  H04N5/23206 ,  H04N7/18 ,  H04N7/183 ,  H04N2201/04727 ,  H04N2201/04755

    摘要： Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging.

    摘要翻译： 使用与作为计算机控制的显微镜幻灯片扫描器的一部分的定位台同步的线性阵列检测器，全自动快速扫描和数字化整个显微镜样品或显微镜样本的大部分的装置和方法。 本发明提供了一种用于组合从样本的连续扫描获得的图像条带到单个邻接数字图像中的方法。 本发明还提供了一种用于以不同放大率静态显示该大数字图像的子区域的方法，以及整个样本的缩小的放大宏图像。 本发明还提供了一种用于在或不与操作者交互的情况下动态显示邻接数字图像的部分的方法。 在本发明的一个优选实施例中，扫描器的所有元件都是具有到互联网或本地内部网的主要连接的单个外壳的一部分。 在该实施例中，优选的样品类型是显微镜载玻片，并且照明和成像光学元件与针对衍射极限数字成像优化的透射模式光学元件一致。

    Data Management in a Linear-Array-Based Microscope Slide Scanner
    4.
    发明申请
    Data Management in a Linear-Array-Based Microscope Slide Scanner 有权
    基于线性阵列的显微镜幻灯片扫描仪中的数据管理

    公开(公告)号：US20090028414A1

    公开(公告)日：2009-01-29

    申请号：US12235479

    申请日：2008-09-22

    申请人： Greg J. Crandall ,  Ole Eichhorn ,  Allen H. Olson ,  Dirk G. Soenksen

    发明人： Greg J. Crandall ,  Ole Eichhorn ,  Allen H. Olson ,  Dirk G. Soenksen

    IPC分类号： G06K9/00

    CPC分类号： G02B21/367 ,  G02B21/002 ,  G02B21/0036 ,  G02B21/008 ,  G02B21/14 ,  G02B21/245 ,  G02B21/26 ,  G02B21/32 ,  G02B21/34 ,  G02B21/365 ,  G06F19/00 ,  H04N1/053 ,  H04N1/1903 ,  H04N1/193 ,  H04N1/19573 ,  H04N5/2256 ,  H04N5/23206 ,  H04N7/18 ,  H04N7/183 ,  H04N2201/04727 ,  H04N2201/04755

    摘要： Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays.

    摘要翻译： 提供了用于处理，存储和查看由基于线性阵列的显微镜幻灯片扫描仪快速生成的超大图像数据的系统和方法。 该系统接收，处理和存储由线性扫描仪产生的图像数据作为一系列重叠的图像条纹，并将数据组合成无缝和连续的基线图像。 基线图像被逻辑地映射到单独寻址的多个区域中，以便于观察和操纵基线图像。 该系统能够在扫描和捕获新的图像条纹时消除与存储未压缩图像条纹相关的开销的动态图像数据压缩。 该系统还创建中间级图像，从而将基线图像组织成称为虚拟幻灯片的可变级金字塔结构。 该系统有助于虚拟幻灯片在诸如远程医疗，远程病理学，显微镜教育等应用中的使用，以及对组织阵列等高价值标本的分析。

    Optical scanning apparatus having self-propelled light bar assembly
    5.
    发明授权
    Optical scanning apparatus having self-propelled light bar assembly 有权
    具有自走式轻钢组件的光学扫描装置

    公开(公告)号：US07440147B2

    公开(公告)日：2008-10-21

    申请号：US10053989

    申请日：2002-01-19

    申请人： Curtis Gregory Kelsay

    发明人： Curtis Gregory Kelsay

    IPC分类号： H04N1/04

    CPC分类号： H04N1/1017 ,  H04N2201/0442 ,  H04N2201/0464 ,  H04N2201/0471 ,  H04N2201/04725 ,  H04N2201/04727 ,  H04N2201/04734

    摘要： The present invention provides for an optical scanning apparatus having a scanner body and a self-propelled light bar assembly supported within the scanner body. In one example the scanning apparatus further includes a drive track supported within the scanner body, and the light bar assembly includes a drive wheel in contact with the drive track. This configuration allows the drive wheel to propel the light bar assembly with respect to the scanner body. In a second example the scanner has a scanner body and a magnet-track portion of a linear electric motor fixedly supported within the scanner body. The light bar assembly includes a slider portion of a linear electric motor, and the light bar assembly is supported in the scanner body to place the magnet-track portion in proximity to the slider portion to thereby allow the light bar assembly to be driven along the magnet-track portion.

    摘要翻译： 本发明提供了一种具有扫描器主体和支撑在扫描器主体内的自推进光条组件的光学扫描装置。 在一个示例中，扫描装置还包括支撑在扫描器主体内的驱动轨道，并且光条组件包括与驱动轨道接触的驱动轮。 这种构造允许驱动轮相对于扫描器主体推动灯条组件。 在第二示例中，扫描器具有固定地支撑在扫描器主体内的扫描器主体和线性电动机的磁道部分。 灯杆组件包括线性电动机的滑块部分，并且灯条组件被支撑在扫描器主体中，以将磁轨部分放置在靠近滑动部分的位置，从而允许光棒组件沿着 磁轨部分。

    Full-zone optical image addressing apparatus
    6.
    发明申请
    Full-zone optical image addressing apparatus 有权
    全区域光学图像寻址装置

    公开(公告)号：US20040066539A1

    公开(公告)日：2004-04-08

    申请号：US10065353

    申请日：2002-10-08

    发明人： Chin-Lin Chang ,  Chen-Ho Lee ,  Chen-Hsiang Shih

    IPC分类号： H04N001/04 ,  H04N001/46

    CPC分类号： H04N1/00013 ,  H04N1/00002 ,  H04N1/00031 ,  H04N1/00045 ,  H04N1/0005 ,  H04N1/00063 ,  H04N1/00068 ,  H04N1/00087 ,  H04N1/047 ,  H04N1/1013 ,  H04N1/1017 ,  H04N1/193 ,  H04N2201/0081 ,  H04N2201/04708 ,  H04N2201/0472 ,  H04N2201/04727 ,  H04N2201/04749

    摘要： A full-zone optical image addressing apparatus, including an addressing device, an image extraction converter, a comparator, an AND gate and a counter. The addressing device is located at the enclosure of the scanner and includes a plurality of geometric patterns. Each of the geometric patterns includes a plurality of rows of pixels. While receiving an exposure signal, the image extraction converter extracts one row of pixels from the addressing device, such that a series of analog signals is obtained and output to the comparator. The comparator then compares the series of analog signals to an analog critical voltage to output a series of analog comparison signals to the AND gate. The AND gate synchronously processes the series of analog comparison signals and a pixel rate clock to output the pixel data corresponding to the extracted row of pixels to the counter. After receiving the synchronously processed pixel value from the AND gate, the counter calculates and outputs the extracted row of pixels, including the amount of pixels and the geometric patterns in the row of pixels.

    摘要翻译： 全区域光学图像寻址装置，包括寻址装置，图像提取转换器，比较器，与门和计数器。 寻址设备位于扫描仪的外壳处并且包括多个几何图案。 每个几何图案包括多行像素。 在接收到曝光信号的同时，图像提取转换器从寻址装置中提取一行像素，从而获得一系列模拟信号并将其输出到比较器。 比较器然后将一系列模拟信号与模拟临界电压进行比较，以将一系列模拟比较信号输出到与门。 与门同时处理一系列模拟比较信号和像素速率时钟，以将与提取的像素行对应的像素数据输出到计数器。 在从与门接收到同步处理的像素值之后，计数器计算并输出所提取的像素行，包括像素行中的像素数量和几何图案。

    Apparatus and method for increasing the scan accuracy and quality of the flatbed scanner by using close loop control
    7.
    发明授权
    Apparatus and method for increasing the scan accuracy and quality of the flatbed scanner by using close loop control 失效
    通过使用闭环控制来增加平板扫描仪的扫描精度和质量的装置和方法

    公开(公告)号：US06178015B1

    公开(公告)日：2001-01-23

    申请号：US09092263

    申请日：1998-06-05

    申请人： Wayne Lee ,  Jenn-Tsair Tsai

    发明人： Wayne Lee ,  Jenn-Tsair Tsai

    IPC分类号： H04N104

    CPC分类号： H04N1/0473 ,  H04N1/1013 ,  H04N1/193 ,  H04N2201/02439 ,  H04N2201/04705 ,  H04N2201/0472 ,  H04N2201/04727 ,  H04N2201/04734 ,  H04N2201/04755 ,  H04N2201/04794

    摘要： An optical ruler is provided on the back surface side of the top housing and close to the transparent window along a scanning direction for providing a calibration reference. The optical ruler is formed with black and white blocks alternately arranged in an array. An image sensor which has a width larger than the width of the transparent window is provided for reading the image information of the optical ruler along with a scanned sheet while being progressively driven by a step motor. A determining element computes the actual moving steps of the step motor by calculating the number of black and white pixels from the scanned image of the optical ruler. When the actual moving steps of the step motor are fewer than a predetermined threshold value, or when the frequency of the occurrences of the scan line losses is higher than a predetermined threshold value, the image sensor is driven by the step motor to scan the sheet again. As a result, the step motor can be operated in response to a closed loop control signal depending on the actual moving steps of the step motor.

    摘要翻译： 光学尺被设置在顶部壳体的背面侧并沿着扫描方向靠近透明窗口，以提供校准基准。 光学标尺形成有交替排列成阵列的黑白块。 提供宽度大于透明窗口宽度的图像传感器，用于通过步进电机逐步驱动来读取光学标尺的图像信息以及扫描的片材。 确定元件通过从光学标尺的扫描图像计算黑白像素的数量来计算步进电机的实际移动步长。 当步进电动机的实际移动步骤小于预定阈值时，或者当扫描线损耗的频率高于预定阈值时，图像传感器由步进电机驱动以扫描片材 再次。 结果，可以根据步进电动机的实际移动步骤响应于闭环控制信号来操作步进电动机。