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    Diagnosis and treatment of human kidney diseases
    3.
    发明申请
    Diagnosis and treatment of human kidney diseases 失效

    公开(公告)号：US20040192663A1

    公开(公告)日：2004-09-30

    申请号：US10820537

    申请日：2004-04-08

    申请人： Shiva Biomedical, LLC

    发明人： Sudhir V. Shah

    IPC分类号： A61K031/33 ,  A61K031/195

    CPC分类号： G01N33/6893 ,  A61K31/16 ,  A61K31/164 ,  A61K31/195 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/4422 ,  A61K31/444 ,  G01N33/84 ,  G01N2800/347

    摘要： Kidney disease is diagnosed by measuring urinary catalytic iron in humans. Progressive kidney disease is treated by administering an iron chelator to humans. In particular, the progression of kidney disease essentially can be halted and the severity of kidney disease can be reduced by the administration of iron chelators to humans afflicted with a progressive kidney disease. The methods include measuring catalytic iron content in urine in a human afflicted with a progressive kidney disease and administering an iron chelator to the human. The method can include measuring total urinary protein content, blood urea nitrogen or creatinine in a blood sample before, during or after the administration of an iron chelator.

    Alpha-amino-acid compounds
    8.
    发明申请
    Alpha-amino-acid compounds 失效
    α-氨基酸化合物

    公开(公告)号：US20030078247A1

    公开(公告)日：2003-04-24

    申请号：US10146272

    申请日：2002-05-15

    发明人： Guillaume De Nanteuil ,  Bernard Portevin ,  Alain Benoist ,  Nigel Levens ,  Olivier Nosjean ,  Bernadette Husson-Robert ,  Michelle Boulanger

    IPC分类号： A61K031/33 ,  C07D207/00

    CPC分类号： C07D295/185 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  Y02P20/55

    摘要： Compound selected from those of formula (I): 1 wherein 2 nullrepresents an optionally substituted 5-membered nitrogen-containing heterocycle, Ak represents an alkylene chain, X represents a single bond or phenylene, R1 and R2, which may be identical or different, each represent hydrogen or alkyl, R3 represents alkyl, nitro or cyano, Y represents NR4 or CHNO2, R4 represents hydrogen or alkyl, its tautomers when they exist, its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid, with the exclusion of compounds wherein, simultaneously, 3 represents an unsubstituted 5-membered nitrogen-containing heterocycle, Ak represents null(CH2)3null, X represents a single bond, Y represents NH and R3 represents nitro. Medicinal products containing the same which are useful as dipeptidyl peptidase IV inhibitors.

    摘要翻译： 选自式（I）的化合物：其中表示任选取代的5元含氮杂环，Ak表示亚烷基链，X表示单键或亚苯基，可以相同或不同的R 1和R 2各自表示 氢或烷基，R 3表示烷基，硝基或氰基，Y表示NR 4或CHNO 2，R 4表示氢或烷基，其互变异构体存在时，其光学异构体及其与药学上可接受的酸的加成盐， 同时代表未取代的5元含氮杂环，Ak表示 - （CH2）3-，X表示单键，Y表示NH，R3表示硝基。 含有它们的药用产品可用作二肽基肽酶IV抑制剂。

    Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same
    10.
    发明申请
    Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same 失效
    具有成骨活性的合成肽和假肽以及含有它们的药物组合物

    公开(公告)号：US20030069175A1

    公开(公告)日：2003-04-10

    申请号：US10255679

    申请日：2002-09-27

    发明人： Itai Bab ,  Dan Gazit ,  Chen Yu-Chen ,  Andras Muhlrad ,  Arie Shteyer ,  Michael Chorev

    IPC分类号： A61K038/12 ,  A61K031/33 ,  C07K005/12

    CPC分类号： C07K5/1008 ,  A61K38/00 ,  C07K5/0806 ,  C07K5/126 ,  C07K14/51

    摘要： Cyclic to Synthetic pseudopeptide derivatives of osteogenic growth polypeptide (OGP) and OGP(10-14) which are capable of enhancing bone cell proliferation and bone formation. Pharmaceutical composition comprising as active ingredient at least one pseudopeptide derivative of the invention and to the use of these pseudopeptide derivatives in the preparation of a pharmaceutical composition for stimulating the formation of osteoblastic or fibroblastic cells, enhancing bone formation in osteopenic pathological conditions, repairing fractures, healing wounds, grafting of intraosseous implants, reversing bone loss in osteoporosis and other conditions requiring enhanced bone cells formation.

    摘要翻译： 循环到成骨生长多肽（OGP）和OGP（10-14）的合成假肽衍生物，其能够增强骨细胞增殖和骨形成。 药物组合物，其包含本发明的至少一种假肽衍生物作为活性成分，以及这些假肽衍生物在制备用于刺激成骨细胞或成纤维细胞形成的药物组合物中的用途，增强骨质疏松病理状况中的骨形成，修复骨折， 愈合伤口，骨内植入物移植，逆转骨质疏松症中的骨质流失以及需要增强骨细胞形成的其他病症。