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    Citrullinylarginine dipeptide analogs and their dermatological uses as care and treatment agents
    1.
    发明申请
    Citrullinylarginine dipeptide analogs and their dermatological uses as care and treatment agents 有权
    柠檬酰精氨酸二肽类似物及其皮肤病学用途作为护理和治疗剂

    公开(公告)号：US20040175397A1

    公开(公告)日：2004-09-09

    申请号：US10801592

    申请日：2004-03-17

    发明人： Marie-Christine Seguin

    IPC分类号： A61K038/16 ,  A61K035/80

    CPC分类号： A61Q19/08 ,  A61K8/44 ,  A61K8/64 ,  A61K8/9706 ,  A61K36/02 ,  A61K36/04 ,  A61K38/05 ,  A61Q19/00 ,  A61Q19/06

    摘要： The present invention relates to an algal adduct of the citrullinylarginine natural dipeptide as well as to its dermatological use and the use of chemical analogs issued from the same dipeptide displaying no toxic potential, as skin and phanera care and treatment agents, the said analogs having the following general formula (I): 1 in which: R1 represents an acyl or acycloxy radical, R2 represents a hydroxyl, amine, alkylamine or alcoxy radical, R3 represents a hydrogen atom or a hydroxyl radical.

    摘要翻译： 本发明涉及瓜氨酸精氨酸天然二肽的藻类加合物以及其皮肤病学用途以及使用由不具有毒性潜力的相同二肽发出的化学类似物作为皮肤和香精护理和治疗剂，所述类似物具有 通式（I）：其中：R1表示酰基或酰基，R2表示羟基，胺，烷基胺或烷氧基，R3表示氢原子或羟基。

    Blood fluidity-improving health foods
    2.
    发明申请
    Blood fluidity-improving health foods 审中-公开
    血液流动性改善健康食品

    公开(公告)号：US20040131636A1

    公开(公告)日：2004-07-08

    申请号：US10738998

    申请日：2003-12-19

    申请人： SHIRAKO CO., LTD.

    发明人： Hiroshi Hagino ,  Masanobu Saito

    IPC分类号： A61K035/80

    CPC分类号： A61K36/04 ,  A23L17/60 ,  A23L33/105 ,  A23L33/12 ,  A23L33/16 ,  A61K36/03 ,  A61K2300/00

    摘要： This invention provides a novel health food which is effective in prevention and treatment of life-style related diseases in organs in the circulatory system, such as hypertension, cerebral infarction, myocardial infarction etc. by improving blood fluidity. Phospholipid components or mineral components are collected from seaweeds of the genus Porphyra and/or seaweeds of the genus Undaria and then formed into a health food improving blood fluidity. This health food has an improving action on blood fluidity, and is thus effective in prevention and treatment of life-style related diseases in organs in the circulatory system, such as hypertension, cerebral infarction, myocardial infarction etc.

    摘要翻译： 本发明提供了一种新颖的保健食品，通过改善血液流动性，有效预防和治疗循环系统器官中的生命方式相关疾病，如高血压，脑梗死，心肌梗死等。 磷脂成分或矿物成分从紫菜属紫菜和/或海草属的海草中收集，然后形成健康食品，改善血液流动性。 这种保健食品对血液流动性有改善的作用，因此有效预防和治疗循环系统器官中的生活方式相关疾病，如高血压，脑梗死，心肌梗死等。

    Products and methods for maintaining or increasing ceramide levels in skin
    3.
    发明申请
    Products and methods for maintaining or increasing ceramide levels in skin 失效
    用于维持或增加皮肤神经酰胺水平的产品和方法

    公开(公告)号：US20040096485A1

    公开(公告)日：2004-05-20

    申请号：US10299161

    申请日：2002-11-19

    申请人： Kimberly-Clark Worldwide, Inc.

    发明人： David W. Koenig ,  Jamie Joseph Van Gompel

    IPC分类号： A61K035/72 ,  A61K035/80 ,  A61K009/70 ,  A61K035/78

    CPC分类号： A61K8/0208 ,  A61K8/97 ,  A61K2800/70 ,  A61K2800/78 ,  A61Q19/00 ,  A61Q19/08

    摘要： Disclosed are methods and products such as wet wipes and absorbents capable of providing a skin health benefit when utilized in the intended fashion. More specifically, the products described herein comprise an agent, such as a botanical extract, which is capable of increasing the activity of sphingomyelinase according to a Sphingomyelinase Activity Screening Test and/or decreasing the activity of ceramidase according to a Ceramidase Activity Screening Test. By increasing the activity of sphingomyelinase and/or decreasing the activity of ceramidase, the agents in combination with the products described herein are able to maintain or increase the level of ceramides in the skin leading to improved skin health.

    摘要翻译： 公开了当以预期的方式使用时能够提供皮肤健康益处的湿巾和吸收剂的方法和产品。 更具体地，本文所述的产品包含根据鞘磷脂酶活性筛选试验能够增加鞘磷脂酶的活性和/或根据神经酰胺酶活性筛选试验降低神经酰胺酶的活性的试剂，例如植物提取物。 通过增加鞘磷脂酶的活性和/或降低神经酰胺酶的活性，与本文所述产品组合的药剂能够维持或增加皮肤中神经酰胺的水平，从而改善皮肤健康。

    Oral delivery of a botanical
    5.
    发明申请
    Oral delivery of a botanical 失效
    口服交付植物药

    公开(公告)号：US20040081664A1

    公开(公告)日：2004-04-29

    申请号：US10273981

    申请日：2002-10-18

    发明人： Robert Gow ,  John Pierce ,  Brian Pierce ,  William Birdsall

    IPC分类号： A61K035/80 ,  A61K035/78

    CPC分类号： A61K36/67 ,  A61K31/365 ,  A61K31/366 ,  A61K36/28 ,  A61K36/48 ,  A61K45/06 ,  C07D309/32 ,  C07D309/38 ,  C07D309/40 ,  C07D407/06 ,  A61K2300/00

    摘要： A method of producing a processed kava product involves using an extraction solvent, such as liquid CO2, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping the extraction before all of the kavalactones have been extracted or allowing the extracted kavalactones to be preferentially precipitated in one or more collection environments, a processed kava product can be produced that has a kavalactone distribution profile that can differ substantially from that of the source material. As a result, roots from a less desirable kava cultivar can be used to produce a processed kava product which has a kavalactone distribution profile that is similar to that of a highly desired cultivar. The kava paste can be further processed to produce a dry flowable powder suitable for use in, e.g., a tableting formula. A rapid dissolve tablet formulation for use in the delivery of kavalactones and other botanicals is also disclosed.

    摘要翻译： 生产加工的卡瓦产品的方法涉及使用诸如液体CO 2的提取溶剂以不同的速率从源材料中优先提取不同的卡维乳糖。 通过控制提取参数并在所有的Kavalactone已被提取之前停止提取，或允许提取的kavalactones在一个或多个收集环境中优先沉淀，可以生产具有可以显着差异的Kavalactone分布分布的加工的卡瓦产品 从源材料。 结果，来自较不理想的卡拉品种的根可以用于生产加工的卡瓦产品，其具有与高度期望的品种相似的考卡内酯分布轮廓。 可以进一步处理卡瓦酱以产生适用于例如压片配方的干燥可流动粉末。 还公开了用于输送卡维内酯和其它植物药物的快速溶解片剂制剂。

    Methods of producing carbon-13 labeled biomass
    9.
    发明申请
    Methods of producing carbon-13 labeled biomass 有权
    生产碳13标记生物质的方法

    公开(公告)号：US20040208892A1

    公开(公告)日：2004-10-21

    申请号：US10417951

    申请日：2003-04-16

    发明人： Keith Darrel Evans ,  Stanley John Konopka ,  Eric Charles Henry ,  William Michael Houston

    IPC分类号： A61K035/80 ,  C12N001/12

    CPC分类号： A61K51/1296 ,  A61K35/748 ,  A61K49/0004

    摘要： A method and apparatus for preparing uniform carbon-13 labeled biomass using a water soluble carbon-13 labeled carbon source, such as a null13Cnull-bicarbonate or null13Cnull-carbonate salt, is disclosed. The biomass is prepared in one or more sterile carboys filled with growth medium, in which acidity, oxygen, and biomass density are carefully monitored and maintained. By using a solid, water-soluble null13Cnull-bicarbonate or null13Cnull-carbonate salt as the sole carbon source, a biomass is provided which is uniformly and efficiently labeled with carbon-13. This method and apparatus is particularly useful for the growth of an edible carbon-13 labeled algal mass, with Spirulina platensis being a specific alga species. The biomass may be prepared in conformance with FDA current good manufacturing practice regulations, and may be harvested and formed into lyophilized bulk drug powder which may be further processed into various drug product forms which are useful for diagnostic tests or in pharmaceutical compositions.

    摘要翻译： 公开了一种使用水溶性碳-13标记的碳源（例如[13 C] - 碳酸氢盐或[13 C] - 碳酸盐）制备均匀的碳-13标记的生物质的方法和装置。 在一个或多个填充有生长培养基的无菌碳水化合物中制备生物质，其中仔细监测和维持酸度，氧气和生物质密度。 通过使用固体的水溶性[13 C] - 碳酸氢盐或[13 C] - 碳酸盐盐作为唯一的碳源，提供了用碳-13均匀有效地标记的生物质。 该方法和装置对于可食用的碳-13标记藻类物质的生长特别有用，螺旋藻是特定的藻种。 生物质可以根据目前良好的制造实践规定制备，并且可以收获并形成冻干的散装药物粉末，其可以进一步加工成用于诊断测试或药物组合物的各种药物产品形式。