公开(公告)号：US20240180973A1

公开(公告)日：2024-06-06

申请号：US18433467

申请日：2024-02-06

申请人： BEIJING UNIVERSITY OF CHINESE MEDICINE

发明人： Anlong XU ,  Hongmei LI

IPC分类号： A61K35/60 ,  A61K31/343 ,  A61K31/661 ,  A61K31/704 ,  A61K31/7048 ,  A61K35/30 ,  A61K35/32 ,  A61K35/50 ,  A61K36/258 ,  A61K36/28 ,  A61K36/296 ,  A61K36/424 ,  A61K36/481 ,  A61K36/537 ,  A61K38/02 ,  A61K38/18 ,  A61P9/00

CPC分类号： A61K35/60 ,  A61K31/343 ,  A61K31/661 ,  A61K31/704 ,  A61K31/7048 ,  A61K35/30 ,  A61K35/32 ,  A61K35/50 ,  A61K36/258 ,  A61K36/28 ,  A61K36/296 ,  A61K36/424 ,  A61K36/481 ,  A61K36/537 ,  A61K38/02 ,  A61K38/18 ,  A61P9/00 ,  A61K2236/15 ,  A61K2236/19 ,  A61K2236/53

摘要： The invention discloses a traditional Chinese medicine mixture with a function of promoting directional differentiation of stem cells into cardiomyocytes, which comprises syngnathus, cornu cervi pantotrichum, hippocampus, ginseng, astragalus, epimedium, placenta hominis, salvia miltiorrhiza, gynostemma pentaphyllum and saussurea involucrata. The invention discloses a traditional Chinese medicine effective ingredient compound with a function of promoting directional differentiation of stem cells into cardiomyocytes. The invention further discloses a chemical compound with a function of promoting directional differentiation of stem cells into cardiomyocytes, which is a brand-new chemical compound from a mixture of velvet antler polypeptide, a syngnathus extract and a hippocampus extract—a new isomer of iridoid glycoside Scropolioside D. The invention further discloses uses of the mixture, the compound and the chemical compound in preparation of a drug or a kit for promoting directional differentiation of stem cells into cardiomyocytes and in scientific research.

公开(公告)号：US20240165186A1

公开(公告)日：2024-05-23

申请号：US18506182

申请日：2023-11-10

申请人： Robert E. Rockwood

发明人： Robert E. Rockwood

IPC分类号： A61K36/424 ,  A61K9/00 ,  A61K31/122 ,  A61K31/4745 ,  A61K31/706 ,  A61K31/7084 ,  A61K35/02

CPC分类号： A61K36/424 ,  A61K9/0014 ,  A61K9/0053 ,  A61K31/122 ,  A61K31/4745 ,  A61K31/706 ,  A61K31/7084 ,  A61K35/02

摘要： A synergistic composition is provided to support mitochondrial health and ATP production. The composition may be topical and/or ingestible, depending on embodiment. Consistent application of the composition has been shown to produce more healthy, youthful looking skin. The present disclosure results in a unique combination that will nutritionalize and energize skin cells in a way that no other single or multiple compound is capable of doing.

公开(公告)号：US20190201468A1

公开(公告)日：2019-07-04

申请号：US15862131

申请日：2018-01-04

申请人： BTC CORPORATION

发明人： Tae Young KIM ,  Joo Myung MOON ,  Su Hyun KYONG ,  Yoon Hee KIM

IPC分类号： A61K36/424

CPC分类号： A61K36/424 ,  A61K2236/17 ,  A61K2236/33 ,  A61K2236/331

摘要： A preparation method of Gynostemma Pentaphyllus leaves extracts with increased amount of small molecular effective saponin and decreased benzopyrene includes the steps of drying fresh Gynostemma Pentaphyllus leaves after heating, treating the dried Gynostemma Pentaphyllus leaves with steam, adding water of 1 to 100-fold volume to the above Gynostemma Pentaphyllus leaves and then preparing a hot water extract by carrying out a hot water extraction at 100-180 V, 0.5-10 atm for 1-120 hours, adding C1-C4 lower alcohol of 1 to 100-fold volume to the residual remained after the hot water extraction and then preparing an alcohol extract of the residual from the hot water extract by carrying out an alcohol extraction at 50-100° C. for 1-4 hours, and mixing the hot water extract and the alcohol extract, and then filtering and concentrating the mixture.

公开(公告)号：US10010571B2

公开(公告)日：2018-07-03

申请号：US15363931

申请日：2016-11-29

申请人： Maximum Human Performance, LLC

发明人： Shane E. Durkee ,  Gabriel Wilson

IPC分类号： A61K36/424 ,  A61K36/704 ,  A23L33/105

CPC分类号： A61K36/424 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/165 ,  A61K36/704 ,  A61K2300/00 ,  A23V2200/328 ,  A23V2200/332

摘要： The present invention includes a method of activating irisin by administering to an individual in need of such treatment a composition comprising irisin-activating ingredients, thus increasing the conversion of white fat to BAT, and consequently, increasing metabolic rate and promoting weight loss. In an embodiment, the composition includes a Gynostemma pentaphyllum extract, a Polygonum cuspidatum root extract, capsaicinoids, and grains of paradise or constituents thereof. The composition may optionally comprise additional ingredients to activate the increased BAT, thus further increasing metabolic rate and furthering weight loss.

公开(公告)号：US09539275B2

公开(公告)日：2017-01-10

申请号：US14165560

申请日：2014-01-27

申请人： Hong Kong Baptist University

发明人： Wen Luan Wendy Hsiao ,  Ting Fung Tsang

IPC分类号： C07H15/256 ,  A61K31/704 ,  A61K31/706 ,  A61K36/424 ,  A61K31/00

CPC分类号： A61K31/706 ,  A61K31/00 ,  A61K31/704 ,  A61K36/424 ,  C07H15/256

摘要： The present invention provides composition and method for inducing melanogenesis. The composition comprising an effective amount of saponins extracted from herbal plants.

摘要翻译： 本发明提供了诱导黑素生成的组合物和方法。 所述组合物包含从草药植物提取的有效量的皂苷。

公开(公告)号：US09445624B2

公开(公告)日：2016-09-20

申请号：US13814129

申请日：2010-08-05

申请人： Chen Xie ,  Zhong Zhong

发明人： Chen Xie ,  Zhong Zhong

IPC分类号： A61K36/185 ,  A61K36/41 ,  A61K36/42 ,  A61K36/81 ,  A23L2/52 ,  A23L1/30 ,  A61K36/424 ,  A61K36/815

CPC分类号： A23L2/52 ,  A23L33/105 ,  A61K36/41 ,  A61K36/424 ,  A61K36/815 ,  A61K2300/00

摘要： The present invention provides a composition of a plant material with anti-fatigue activity, its preparation method, usage and related products. The said composition is manufactured from the following plant materials: 20-80% from the genus Rhodiola; 10-60% Gynostemma; 10-60% Lycium. The said composition can be used to manufacture health product, food or anti-fatigue medicine which is able to significantly reduce the fatigue symptoms of those people suffering from fatigue, improve sleeping quality with no impact on normal body physiology. It is shown that the medicine derived from the present is invention exerts its anti-fatigue effect through improving the functions of erythrocytes and thrombocytes to enhance the body's ability of supplying oxygen. The medicinal composition of the present invention is characterized by the small effective dose and good water solubility and thus suitable to be made into a variety of dosage forms for use.

摘要翻译： 本发明提供具有抗疲劳活性的植物材料的组合物，其制备方法，用途及相关产品。 所述组合物由以下植物材料制成：来自红景天属的20-80％; 绞股蓝10-60％ 10-60％枸杞子。 所述组合物可用于制造健康产品，食品或抗疲劳药物，其能够显着降低患有疲劳的人的疲劳症状，改善睡眠质量，而不影响正常身体生理。 表明本发明的药物是通过改善红细胞和血栓细胞的功能而发挥其抗疲劳作用，提高身体供氧的能力。 本发明的药物组合物的特征在于有效剂量小，水溶性好，因此适于制成各种使用剂型。

公开(公告)号：US20230134432A1

公开(公告)日：2023-05-04

申请号：US17912779

申请日：2021-03-19

申请人： NOVEL CONCEPTS MEDICAL LTD

发明人： Rachel ALKALAY

IPC分类号： A61K36/53 ,  A61K36/185 ,  A61K36/22 ,  A61K36/424 ,  A61K36/324 ,  A61K36/258 ,  A61K36/71 ,  A61K31/122 ,  A61K31/05 ,  A61K38/48 ,  A61K36/88 ,  A61K31/405 ,  A61K36/534 ,  A61K36/738 ,  A61K36/899 ,  A61K36/85 ,  A61K36/9062 ,  A61K36/54 ,  A61K36/82 ,  A61P35/00

摘要： A method of preventing or treating solid and soft tumors and proliferative diseases in a subject in need thereof is provided. The method comprising administering to the subject an effective amount of a plant species or genus thereof-derived component selected from the group consisting of a plant part, extract thereof, fraction thereof, active ingredient thereof, synthetic analog thereof, mimetic thereof or combination thereof, wherein the component is capable of treating solid and soft tumors and proliferative diseases and wherein the plant species is selected from the group consisting of Nigella sativa, Thymuscapitatus, Thymus vulgaris, Origanum syriacum, Thymbra spicata, Satujera thymbra, Sesamum indicum, Rhus coriaria, Gynostemma pentaphyllum, Boswellia sacra and Panaxginseng, preventing or treating solid and soft tumors and proliferative diseases in the subject.

公开(公告)号：US11298372B2

公开(公告)日：2022-04-12

申请号：US16885930

申请日：2020-05-28

申请人： National University Corporation Tokyo Medical and Dental University

发明人： Emi Nishimura ,  Hiroyuki Matsumura

IPC分类号： A61K31/713 ,  A61K38/55 ,  A61K36/05 ,  A61K36/14 ,  A61K36/47 ,  A61K36/48 ,  A61K36/54 ,  A61K8/97 ,  A61K31/506 ,  A61K36/489 ,  A61K36/738 ,  A61K36/04 ,  A61K36/424 ,  A61Q5/00 ,  A61K48/00 ,  A61K31/7088 ,  C12Q1/37 ,  A61K36/30 ,  A61K36/74 ,  A61K36/23 ,  A61K36/60 ,  A61K36/185 ,  A61Q7/00 ,  A61K36/718 ,  A61K36/488 ,  A61K36/53 ,  A61K36/82 ,  A61K39/395 ,  A61K36/18 ,  A61K36/28 ,  A61K31/222 ,  A61K45/00 ,  A61P17/14 ,  A61K31/05 ,  A61K31/16 ,  A61K31/355 ,  A61K31/375 ,  A61K31/381 ,  A61K31/7048 ,  A61K31/13 ,  A61K36/00

摘要： The present invention provides novel compositions for suppressing or improving hair loss, and compositions for suppressing or improving graying. More specifically, it provides agents that stabilize type XVII collagen expression, preferably agents that suppress the degradation of type XVII collagen by ELANE inhibitors and such, and compositions comprising a DNA repair-promoting agent or a DNA damage-suppressing agent as an active ingredient. Advantageous suppressive effects of hair loss and graying can be obtained when a composition comprising as an active ingredient a suppressive agent of type XVII collagen degradation such as an ELANE inhibitor is administered to a mammal. For the ELANE inhibitors, suppressive agents of type XVII collagen degradation and DNA repair-promoting agents, low-molecular compounds, polypeptides, proteins, antibodies, or nucleic acid medicine such as antisense oligos or siRNAs may be used. A method of screening for effective substances for suppression of hair loss and graying is also provided.

公开(公告)号：US09861676B2

公开(公告)日：2018-01-09

申请号：US14662237

申请日：2015-03-18

申请人： Wei-Ming Chen ,  Bo-Cheng Guo

发明人： Wei-Ming Chen

IPC分类号： A61K36/899 ,  A61K36/28 ,  A61K36/00 ,  A61K36/8945 ,  A61K36/344 ,  A61K36/481 ,  A61K36/8984 ,  A61K36/8968 ,  A61K36/488 ,  A61K36/286 ,  A61K36/48 ,  A61K36/424 ,  A61K36/62 ,  A61K36/61

CPC分类号： A61K36/899 ,  A61K36/286 ,  A61K36/344 ,  A61K36/424 ,  A61K36/48 ,  A61K36/481 ,  A61K36/488 ,  A61K36/61 ,  A61K36/62 ,  A61K36/8945 ,  A61K36/8968 ,  A61K36/8984 ,  A61K2300/00

摘要： The present invention provides herbal compositions comprise Radix Dioscoreae, Radix Codonopsis, and Radix Astragalus Membranaceus. The herbal compositions are used to suppress intestinal glucose uptake of intestinal villus and decrease blood glucose levels. The present invention also provides methods of regulating blood glucose levels by administrating the herbal compositions.

公开(公告)号：US20160271201A1

公开(公告)日：2016-09-22

申请号：US14662237

申请日：2015-03-18

申请人： WEI-MING CHEN ,  BO-CHENG GUO

发明人： WEI-MING CHEN

IPC分类号： A61K36/899 ,  A61K36/344 ,  A61K36/481 ,  A61K36/8984 ,  A61K36/61 ,  A61K36/488 ,  A61K36/286 ,  A61K36/48 ,  A61K36/424 ,  A61K36/62 ,  A61K36/8945 ,  A61K36/8968

CPC分类号： A61K36/899 ,  A61K36/286 ,  A61K36/344 ,  A61K36/424 ,  A61K36/48 ,  A61K36/481 ,  A61K36/488 ,  A61K36/61 ,  A61K36/62 ,  A61K36/8945 ,  A61K36/8968 ,  A61K36/8984 ,  A61K2300/00

摘要： The present invention provides herbal compositions comprise Radix Dioscoreae, Radix Codonopsis, and Radix Astragalus Membranaceus. The herbal compositions are used to suppress intestinal glucose uptake of intestinal villus and decrease blood glucose levels. The present invention also provides methods of regulating blood glucose levels by administrating the herbal compositions.

摘要翻译： 本发明提供草药组合物，其包含枸杞子，党参和黄芪。 草药组合物用于抑制肠绒毛的肠葡萄糖摄取并降低血糖水平。 本发明还提供了通过施用草药组合物来调节血糖水平的方法。