公开(公告)号：US06225510B1

公开(公告)日：2001-05-01

申请号：US09459254

申请日：1999-12-10

申请人： Peter Frenkel ,  Ted M. Pettijohn ,  Lawrence R. Brecker

发明人： Peter Frenkel ,  Ted M. Pettijohn ,  Lawrence R. Brecker

IPC分类号： C07C40900

CPC分类号： C07C409/16 ,  C07C407/00 ,  C07C409/04

摘要： A process for production of a t-alkyl peroxide compound includes the steps of: a) reacting an n-alkyl t-alkyl ether with a reactant mixture comprising an acid catalyst and a compound of the formula RO2H  (I)  where R is H or t-alkyl, provided that if R is t-alkyl the t-alkyl peroxide compound product is a di-t-alkyl peroxide, and b) isolating a reaction product comprising said t-alkyl peroxide compound from the mixture resulting from step a). The process can be used to prepare t-butyl hydroperoxide or di-t-butyl peroxide from methyl t-butyl ether. Sulfuric acid may be used as the acid catalyst.

摘要翻译： 一种生产叔烷基过氧化物的方法包括以下步骤：a）使正烷基叔烷基醚与包含酸催化剂和下式化合物的反应混合物反应，其中R是H或叔烷基， 条件是如果R是叔烷基，则叔烷基过氧化物产物是二叔烷基过氧化物，和b）从由步骤a）得到的混合物中分离出包含所述叔烷基过氧化物化合物的反应产物。 用于从甲基叔丁基醚制备叔丁基过氧化氢或二叔丁基过氧化物。 硫酸可用作酸催化剂。

公开(公告)号：US06700023B1

公开(公告)日：2004-03-02

申请号：US10049409

申请日：2002-02-06

申请人： Robert Clayton Wheland ,  Ming-Hong Hung

发明人： Robert Clayton Wheland ,  Ming-Hong Hung

IPC分类号： C07C40900

CPC分类号： C07C409/34 ,  C08F4/34

摘要： A new class of low temperature initiators has been found, enabling fluoroolefin polymerizations at relatively low temperatures. These initiators are diacyl peroxides which allow improved productivity and product properties, as well as more favorable reaction conditions.

摘要翻译： 已经发现了一类新的低温引发剂，使氟烯烃在较低温度下聚合。 这些引发剂是二酰基过氧化物，其允许改进的生产率和产物性质以及更有利的反应条件。

公开(公告)号：US06541661B1

公开(公告)日：2003-04-01

申请号：US09718265

申请日：2000-11-22

申请人： Daniel Delorme ,  Rejean Ruel ,  Rico Lavoie ,  Carl Thibault ,  Elie Abou-Khalil

发明人： Daniel Delorme ,  Rejean Ruel ,  Rico Lavoie ,  Carl Thibault ,  Elie Abou-Khalil

IPC分类号： C07C40900

CPC分类号： C07D213/76 ,  C07C259/06 ,  C07C259/10 ,  C07C275/42 ,  C07C311/13 ,  C07C311/21 ,  C07C311/29 ,  C07C311/44 ,  C07C317/44 ,  C07D213/71 ,  C07D215/36 ,  C07D285/135 ,  C07D307/46 ,  C07D307/54 ,  C07D307/91 ,  C07D333/34 ,  C07D333/62

摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

公开(公告)号：US06476276B2

公开(公告)日：2002-11-05

申请号：US09907933

申请日：2001-07-19

申请人： Shigekazu Matsui ,  Hiroshi Kuroda ,  Nobuya Hirokane ,  Haruyuki Makio ,  Toshihiro Takai ,  Koji Kato ,  Terunori Fujita ,  Makoto Kamimura

发明人： Shigekazu Matsui ,  Hiroshi Kuroda ,  Nobuya Hirokane ,  Haruyuki Makio ,  Toshihiro Takai ,  Koji Kato ,  Terunori Fujita ,  Makoto Kamimura

IPC分类号： C07C40900

CPC分类号： C07C407/00 ,  C07C409/10

摘要： A process for preparing hydroperoxides which comprises oxidizing hydrocarbon by a gas containing oxygen in the presence of a specific compound and converting them selectively to corresponding hydroperoxides. The specific compound is the compound that can capture radicals. The preferable example may be a compound selected from radicals of oxygen, nitrogen, phosphorus, sulfur, carbon or silicon or a compound that forms radicals of these in the reaction system. The present invention can be applied to oxidation of hydrocarbons including arylalkylhydrocarbons such as cumene, m-diisopropylbenzene, p-diisopropylbenzene, 1,3,5-triisopropylbenzene, isopropylnaphthalene, diisopropylnaphthalene, isopropylbiphenyl, diisopropylbiphenyl, etc.

摘要翻译： 一种制备氢过氧化物的方法，其包括在特定化合物存在下，通过含氧气体氧化烃，并将其选择性地转化成相应的氢过氧化物。具体化合物是可以捕获自由基的化合物。 优选的实例可以是选自氧，氮，磷，硫，碳或硅的基团的化合物或在反应体系中形成这些基团的化合物。本发明可以应用于包括芳基烷基烃如烃基的烃类的氧化 间二异丙基苯，对二异丙基苯，1,3,5-三异丙基苯，异丙基萘，二异丙基萘，异丙基联苯，二异丙基联苯等。

公开(公告)号：US06369278B2

公开(公告)日：2002-04-09

申请号：US09730583

申请日：2000-12-07

申请人： Tomoyuki Noritake ,  Shigeru Goto ,  Kenji Itoh

发明人： Tomoyuki Noritake ,  Shigeru Goto ,  Kenji Itoh

IPC分类号： C07C40900

CPC分类号： C07C409/08 ,  C07C407/00 ,  C07C407/003 ,  C07C409/12

摘要： There are provided: (I) a process for preparing an extract containing at least one hydroperoxide, which comprises the steps of: (1) oxidizing an aromatic hydrocarbon substituted with an alkyl group to obtain a liquid reaction mixture, and (2) extracting at least one hydroperoxide in the liquid reaction mixture to obtain an extract having a concentration of acetone of not more than 1% by weight: and (II) a process for preparing an extract containing at least one hydroperoxide, which comprises the steps of, (1) oxidizing an aromatic hydrocarbon substituted with an alkyl group to obtain a liquid reaction mixture, and (2) extracting at least one hydroperoxide with an aqueous alkali solution having an A value of not more than 10 to obtain an extract.

摘要翻译： 提供：（I）制备含有至少一种氢过氧化物的提取物的方法，其包括以下步骤：（1）氧化被烷基取代的芳烃以获得液体反应混合物，和（2）在 在液体反应混合物中至少一个氢过氧化物，以获得丙酮浓度不超过1重量％的提取物;和（II）制备含有至少一种氢过氧化物的提取物的方法，其包括以下步骤：（1 ）氧化被烷基取代的芳族烃，得到液体反应混合物，（2）用A值不大于10的碱性水溶液萃取至少一种氢过氧化物，得到提取物。

公开(公告)号：US06700024B2

公开(公告)日：2004-03-02

申请号：US10247075

申请日：2002-09-19

申请人： Gerard Du Cauze de Nazelle ,  Wan Shi Foong ,  Tjeerd Willem Garritsen ,  Raymond Lawrence June ,  Mohammad Azmi Bin Othman ,  Eduardus Petrus Simon Schouten

发明人： Gerard Du Cauze de Nazelle ,  Wan Shi Foong ,  Tjeerd Willem Garritsen ,  Raymond Lawrence June ,  Mohammad Azmi Bin Othman ,  Eduardus Petrus Simon Schouten

IPC分类号： C07C40900

CPC分类号： C07D301/19 ,  C07C15/40 ,  C07C407/00 ,  C07C407/003 ,  C07C409/08

摘要： A process for preparing organic hydroperoxides, which process comprises: (a) oxidation of an organic compound to obtain reaction product containing organic hydroperoxide, (b) contacting at least part of the organic hydroperoxide containing reaction product with a basic aqueous solution, (c) separating hydrocarbonaceous phase containing organic hydroperoxide from aqueous phase, (d) contacting at least part of the separated hydrocarbonaceous phase containing organic hydroperoxide with an aqueous solution comprising wastewater, and (e) separating the hydrocarbonaceous phase containing organic hydroperoxide from the aqueous phase. The invention further relates to a process for preparing an oxirane compounds with the help of this process, and a to a process for preparing an alkenyl aryl with the help of this process.

摘要翻译： 一种制备有机氢过氧化物的方法，该方法包括：（a）氧化有机化合物以获得含有机氢过氧化物的反应产物，（b）将至少部分含有机氢过氧化物的反应产物与碱性水溶液接触，（c） 从水相中分离含烃有机氢过氧化物，（d）使至少部分含有机氢过氧化物的分离烃相与含有废水的水溶液接触，（e）从含水相中分离含烃有机氢过氧化物。 借助于该方法，还涉及一种用于制备环氧乙烷化合物的方法，以及涉及通过该方法制备烯基芳基的方法。

公开(公告)号：US06610768B1

公开(公告)日：2003-08-26

申请号：US09424496

申请日：2000-01-28

申请人： Jernej Jelenic ,  Gerrit Frits Drost ,  Frans Johannes Van Moorsel ,  Akio Ishiwatari ,  Akihiko Tkai

发明人： Jernej Jelenic ,  Gerrit Frits Drost ,  Frans Johannes Van Moorsel ,  Akio Ishiwatari ,  Akihiko Tkai

IPC分类号： C07C40900

CPC分类号： C08K5/14

摘要： This application relates to compositions of cross-linking peroxides which have excellent storage stability, without exudation of peroxide taking place, which contain the organic peroxide in a high concentration, and which are easily blendable with a rubber to be cross-linked. The compositions are obtained by mixing a softening agent with a Brookfield viscosity of 10,000 poises or less at 60 ° C. with an organic peroxide, preferably in the presence of a filler, and optionally with further ingredients.

摘要翻译： 本申请涉及交联过氧化物的组合物，其具有优异的储存稳定性，不会发生过氧化物渗透，其含有高浓度的有机过氧化物，并且易于与要交联的橡胶共混。 组合物通过在60℃下用有机过氧化物，优选在填料存在下，任选地与其它成分混合软化剂与10,000泊泊或更小的Brookfield粘度来获得。

公开(公告)号：US06486360B1

公开(公告)日：2002-11-26

申请号：US09937725

申请日：2001-09-28

申请人： Jean-Marie Aubry ,  Veronique Rataj-Nardello ,  Paul Alsters

发明人： Jean-Marie Aubry ,  Veronique Rataj-Nardello ,  Paul Alsters

IPC分类号： C07C40900

CPC分类号： C07D493/08 ,  C07B41/14 ,  C07C407/00 ,  C07C409/04 ,  C07C409/08 ,  C07C409/18

摘要： The invention relates to a method for oxidizing organic substrate by using 1O2. According to the inventive method, organic substrates that react with 1O2 are mixed with 30-70% H2O2 in water, in an organic solvent or in a mixture thereof in the presence of a lanthanide as the catalyst. H2O2 is catalytically decomposed to water and 1O2 and is then oxidized to the corresponding oxidation products.

摘要翻译： 本发明涉及通过使用1O2氧化有机底物的方法。 根据本发明的方法，与作为催化剂的镧系元素存在下，在有机溶剂或其混合物中，与10 2反应的有机底物与30-70％H 2 O 2在水中混合。 H 2 O 2催化分解成水和1O 2，然后氧化成相应的氧化产物。

公开(公告)号：US06384287B1

公开(公告)日：2002-05-07

申请号：US09762671

申请日：2001-02-12

申请人： Anna Gerdine Van De Bovenkamp-Bouwman ,  Bernhard De Vries ,  John Meijer ,  Ejaz Ahmed Syed ,  Andreas Herman Hogt

发明人： Anna Gerdine Van De Bovenkamp-Bouwman ,  Bernhard De Vries ,  John Meijer ,  Ejaz Ahmed Syed ,  Andreas Herman Hogt

IPC分类号： C07C40900

CPC分类号： C08F4/36 ,  C07C409/22 ,  C07C2601/14 ,  C08F283/01 ,  C08F4/28

摘要： The present invention relates to a new class of peroxides and to a process for the preparation of these peroxides having the general formula (I), wherein n=1 or 2, R1, R2, R4, R5, and R6 are independently selected from the group comprising hydrogen, C1-C20 alkyl, C3-C20 cycloalkyl, C6-C20 aryl, C7-C20 aralkyl, and C7-C20 alkaryl, or R1 and R2 form a C3-C12 cycloalkyl group, which groups may include linear or branched alkyl moieties; and each of R1, R2, R4, R5, and R6 may optionally be substituted with one or more groups selected from hydroxy, alkoxy, linear or branched alkyl, aryloxy, halogen, ester, carboxy, nitrile, and amido, and R1 and R2 may form a ring, and R3 is independently selected from the group comprising C1-C20, alkyl; C3-C20 cycloalkyl, C6-C20 aryl, C7-C20, aralkyl, and C7-C20 alkaryl, which groups may include linear or branched alkyl moieties; and R3 may optionally be substituted with one or more groups selected from hydroxy, alkoxy, linear or branched alkyl, aryloxy, halogen, ester, carboxy, nitrile, and amido, and any pair of the optionally substituted R3, R4, R5, and R6 may form a ring, comprising the reaction of the corresponding ketone.

摘要翻译： 本发明涉及一类新型过氧化物，以及制备具有通式（I）的这些过氧化物的方法，其中n = 1或2，R 1，R 2，R 4，R 5和R 6独立地选自 包括氢，C 1 -C 20烷基，C 3 -C 20环烷基，C 6 -C 20芳基，C 7 -C 20芳烷基和C 7 -C 20烷芳基，或R 1和R 2形成C 3 -C 12环烷基，所述基团可包括直链或支链烷基 部分; R 1，R 2，R 4，R 5和R 6可以任选被一个或多个选自羟基，烷氧基，直链或支链烷基，芳氧基，卤素，酯，羧基，腈和酰氨基的基团取代，并且R 1和R 2 可以形成环，R 3独立地选自C 1 -C 20烷基， C 3 -C 20环烷基，C 6 -C 20芳基，C 7 -C 20，芳烷基和C 7 -C 20烷芳基，这些基团可以包括直链或支链烷基部分; 并且R 3可以任选被一个或多个选自羟基，烷氧基，直链或支链烷基，芳氧基，卤素，酯，羧基，腈和酰氨基的基团取代，以及任意一对任选取代的R 3，R 4，R 5和R 6 可形成环，包括相应酮的反应。