公开(公告)号：US09024043B2

公开(公告)日：2015-05-05

申请号：US14236995

申请日：2012-08-06

Applicant: Swati Pramod Joshi ,  Roshan Rajan Kulkarni

Inventor： Swati Pramod Joshi ,  Roshan Rajan Kulkarni

IPC: C07D493/08 ,  C07C35/42 ,  C07C13/60 ,  C07C409/18 ,  C07D319/14

CPC classification number: C07D493/08 ,  C07C13/60 ,  C07C35/42 ,  C07C409/18 ,  C07C2603/26 ,  C07D319/14

Abstract: This invention discloses diterpenes class of novel compounds of general formula I from a novel source. More particularly the invention relates to extracts/fractions containing pimarane diterpenes from Anisochillus (Lamiaceae), useful for prevention, treatment, inhibition or controlling growth and proliferation of mycobacterial activity in mammals. The invention further relates to extracts, fractions standardized to diterpenes class of novel compounds useful for the treatment of cancers.

Abstract translation: 本发明公开了一种新型来源的通式I的新型化合物二萜类。 更具体地，本发明涉及含有来自Anisochillus（Lamiaceae）的异丙苯二萜的提取物/级分，其可用于预防，治疗，抑制或控制哺乳动物中分枝杆菌活性的生长和增殖。 本发明还涉及标准化为二萜类的提取物，用于治疗癌症的新化合物的级分。

公开(公告)号：US20140171662A1

公开(公告)日：2014-06-19

申请号：US14236995

申请日：2012-08-06

Applicant: Swati Pramod Joshi ,  Roshan Rajan Kulkarni

Inventor： Swati Pramod Joshi ,  Roshan Rajan Kulkarni

IPC: C07D493/08 ,  C07C35/42

CPC classification number: C07D493/08 ,  C07C13/60 ,  C07C35/42 ,  C07C409/18 ,  C07C2603/26 ,  C07D319/14

Abstract: This invention discloses diterpenes class of novel compounds of general formula I from a novel source. More particularly the invention relates to extracts/fractions containing pimarane diterpenes from Anisochillus (Lamiaceae), useful for prevention, treatment, inhibition or controlling growth and proliferation of mycobacterial activity in mammals. The invention further relates to extracts, fractions standardized to diterpenes class of novel compounds useful for the treatment of cancers.

Abstract translation: 本发明公开了一种新型来源的通式I的新型化合物二萜类。 更具体地，本发明涉及含有来自Anisochillus（Lamiaceae）的异丙苯二萜的提取物/级分，其可用于预防，治疗，抑制或控制哺乳动物中分枝杆菌活性的生长和增殖。 本发明还涉及标准化为二萜类的提取物，用于治疗癌症的新化合物的级分。

公开(公告)号：US20130116473A1

公开(公告)日：2013-05-09

申请号：US13673278

申请日：2012-11-09

Applicant: BASF SE

Inventor： Hansgeorg Ernst ,  Michael Puhl ,  Stefan Benson ,  Wolfgang Siegel

IPC: C07C45/28 ,  C07F9/54 ,  C07C409/18

CPC classification number: C07C45/28 ,  C07C403/08 ,  C07C407/00 ,  C07C409/18 ,  C07C2601/16 ,  C07F9/5442 ,  Y02P20/55 ,  C07C409/14

Abstract: The present invention relates to the preparation of oxovinylionol and its O-protected derivatives of the formula I in which R is hydrogen or an OH protecting group, for example a group Si(Ra)3, by reacting a compound of the general formula II in which R has the meanings given above for formula I, i.e. β-vinyl ionol (formula II, R=hydrogen) or an O-protected derivative thereof (formula II, R═OH protecting group) with an oxidant in the presence of at least one transition metal, where the oxidant comprises at least one oxygen-containing compound which is selected from among hydrogen peroxide and organic hydroperoxides.

Abstract translation: 本发明涉及通过使通式II的化合物与式（I）的化合物反应制备式I化合物的氧代乙烯基醇及其O-保护的衍生物，其中R是氢或OH保护基，例如Si（Ra） 其中R具有上述式I的定义，即β-乙烯基离子（式II，R =氢）或其保护有机化合物（式II，R = OH保护基）与氧化剂在至少 一种过渡金属，其中氧化剂包含至少一种选自过氧化氢和有机氢过氧化物的含氧化合物。

公开(公告)号：US5154912A

公开(公告)日：1992-10-13

申请号：US587176

申请日：1990-09-20

Applicant: Jean-Pierre Schirmann ,  Jean-Jacques Barieux

Inventor： Jean-Pierre Schirmann ,  Jean-Jacques Barieux

IPC: C01B15/01 ,  C01B15/023 ,  C07B59/00 ,  C07C67/00 ,  C07C407/00 ,  C07C409/00 ,  C07C409/16 ,  C07C409/18 ,  C07C409/40 ,  C07C409/42

CPC classification number: C01B15/01 ,  C07C409/18 ,  C07C409/20 ,  C07C409/24 ,  C07C409/30 ,  C07C409/32 ,  C07C409/38 ,  C07C409/42 ,  C07B2200/05 ,  C07C2101/14

Abstract: The peroxides which include the O.sup.17 isotope, especially the hydrogen peroxides and peroxides and hydroperoxides prepared therefrom, are well adapted as nonradioactive labeled compounds for use in the medicinal and biological arts.

Abstract translation: 包括O17同位素，特别是过氧化氢和由此制备的过氧化氢和氢过氧化物的过氧化物，很好地适用于药物和生物学领域中的非放射性标记化合物。

公开(公告)号：US5698648A

公开(公告)日：1997-12-16

申请号：US202473

申请日：1994-02-28

Applicant: Ezio Rizzardo ,  Gordon Francis Meijs ,  San Hoa Thang

Inventor： Ezio Rizzardo ,  Gordon Francis Meijs ,  San Hoa Thang

IPC: C07C409/04 ,  C07C409/16 ,  C07C409/18 ,  C07C409/38 ,  C07C409/40 ,  C08F2/38 ,  C08F4/34 ,  C08F124/00

CPC classification number: C07C409/04 ,  C07C409/16 ,  C07C409/18 ,  C07C409/38 ,  C07C409/40 ,  C08F2/38 ,  C08F4/34

Abstract: A process for the production of lower molecular weight polymers by free radical polymerization, characterized in that there is added to the polymerization system a compound of the general formula I ##STR1## wherein R.sup.1 is hydrogen, chlorine, an alkyl group, or a group capable of activating the vinylic carbon towards free radical addition; R.sup.2 is hydrogen or an optionally substituted alkyl, alkenyl, aryl, cycloalkenyl or cycloalkyl group or the group --COZ, where Z is R.sup.3 or OR.sup.3, where R.sup.3 is hydrogen or an optionally substituted alkyl, alkenyl or aryl group. X is a hydrogen atom, an alkyl or aryl group, or a halogen, and the two X groups may be the same or different. The invention also includes polymers or oligomers made by the process and novel compounds of the general formula I as defined above.

Abstract translation: 通过自由基聚合生产低分子量聚合物的方法，其特征在于向聚合体系中加入通式为I n烷基的化合物或能够将乙烯基碳活化成自由基添加的基团; R2是氢或任选取代的烷基，烯基，芳基，环烯基或环烷基或基团-COZ，其中Z是R3或OR3，其中R3是氢或任选取代的烷基，烯基或芳基。 X是氢原子，烷基或芳基或卤素，两个X基可以相同或不同。 本发明还包括通过该方法制备的聚合物或低聚物和如上定义的通式I的新化合物。

公开(公告)号：US5319146A

公开(公告)日：1994-06-07

申请号：US995745

申请日：1992-12-22

Applicant: Ubaldus Kragten ,  Otto E. Sielcken

Inventor： Ubaldus Kragten ,  Otto E. Sielcken

IPC: B01J31/32 ,  C07B61/00 ,  C07C45/51 ,  C07C45/62 ,  C07C407/00 ,  C07C409/18 ,  C07C409/14

CPC classification number: C07C45/51 ,  C07C409/18 ,  C07C45/62 ,  C07C2101/14 ,  C07C2101/16

Abstract: The invention relates to a compound having the Formula (I) ##STR1## in which n=1, 2, 3 or 4 and m=1, 2, 3, 4, 5, 6, 7 or 8. The invention also relates to a method for the preparation of the above-described compound by bringing a cycloalkyl hydroperoxide having 5 to 12 carbon atoms into contact with a cycloalkene having 5-8 carbon atoms, under the influence of a metal compound as catalyst, the metal being chosen from groups VIB, VIIB and VIII of the periodic system. The reaction takes place at a temperature of 0.degree.-80.degree. C.

Abstract translation: 本发明涉及具有式（I）的化合物，其中n = 1,2,3或4，m = 1,2,3,4,5,6,7或8.本发明 还涉及通过使金属化合物作为催化剂的影响使具有5〜12个碳原子的环烷基氢过氧化物与具有5-8个碳原子的环烯烃接触来制备上述化合物的方法，该金属为 选自周期性系统的VIB，VIIB和VIII组。 反应在0〜80℃的温度下进行。

公开(公告)号：US4115455A

公开(公告)日：1978-09-19

申请号：US723415

申请日：1976-09-15

Applicant: Wilbur H. McKellin ,  William A. Swarts

Inventor： Wilbur H. McKellin ,  William A. Swarts

IPC: C07B61/00 ,  B01J25/00 ,  C07C67/00 ,  C07C407/00 ,  C07C409/16 ,  C07C409/18 ,  C07C409/20 ,  C08F299/04 ,  C07C179/06

CPC classification number: C08F299/045 ,  C07C409/16 ,  C07C409/18 ,  C07C2101/14

Abstract: A method of producing hydroxy-containing dialkyl peroxides of the formula ##STR1## by either heterogeneously catalytically reducing or homogeneously, non catalytically chemically reducing carbonyl-containing dialkyl peroxides of the formula ##STR2## R, R.sub.1, R.sub.2 and R.sub.3 are aliphatics. This invention also concerns novel hydroxy-containing dialkyl peroxide compounds having the structure of formula I.

Abstract translation: 通过异构催化还原或均匀地，非催化化学还原式（II）R，R 1，R 2的含羰基的二烷基过氧化物和式（Ⅰ）的羟基含二烷基过氧化物的方法， R3是脂肪族。 本发明还涉及具有式I结构的新型羟基二烷基过氧化物。

公开(公告)号：US4082812A

公开(公告)日：1978-04-04

申请号：US790521

申请日：1977-04-25

Applicant: Donald W. Wood

Inventor： Donald W. Wood

IPC: C08F4/00 ,  C07C67/00 ,  C07C407/00 ,  C07C409/18 ,  C07C409/22 ,  C08F4/28 ,  C07C179/08 ,  A01N9/24

CPC classification number: C07C409/22 ,  C07C407/00 ,  C07C409/18 ,  C07C2101/10

Abstract: An organic peroxide of the formula ##STR1## wherein X and Y are both selected from the same one of the following two subparagraphs:(a) each of X and Y is the same and is a peroxy alkyl group of the structure --OOR in which R is a t-alkyl group of 4-8 carbon atoms;(b) X is chlorine and Y has the structure ##STR2##

公开(公告)号：US3442915A

公开(公告)日：1969-05-06

申请号：US3442915D

申请日：1965-11-24

Applicant: EXXON RESEARCH ENGINEERING CO

Inventor： STARNES WILLIAM H

IPC: C07C46/00 ,  C07C50/02 ,  C07C409/18 ,  C07C45/00 ,  C07C49/62

CPC classification number: C07C46/00 ,  C07C50/02 ,  C07C407/00 ,  C07C409/18

公开(公告)号：US09061982B2

公开(公告)日：2015-06-23

申请号：US13673278

申请日：2012-11-09

Applicant: BASF SE

Inventor： Hansgeorg Ernst ,  Michael Puhl ,  Stefan Benson ,  Wolfgang Siegel

IPC: C07C45/34 ,  C07C45/28 ,  C07C409/18 ,  C07F9/54 ,  C07C403/08 ,  C07C407/00

CPC classification number: C07C45/28 ,  C07C403/08 ,  C07C407/00 ,  C07C409/18 ,  C07C2601/16 ,  C07F9/5442 ,  Y02P20/55 ,  C07C409/14

Abstract: The present invention relates to the preparation of oxovinylionol and its O-protected derivatives of the formula I in which R is hydrogen or an OH protecting group, for example a group Si(Ra)3, by reacting a compound of the general formula II in which R has the meanings given above for formula I, i.e. β-vinyl ionol (formula II, R=hydrogen) or an O-protected derivative thereof (formula II, R═OH protecting group) with an oxidant in the presence of at least one transition metal, where the oxidant comprises at least one oxygen-containing compound which is selected from among hydrogen peroxide and organic hydroperoxides.

Abstract translation: 本发明涉及通过使通式II的化合物与式（I）的化合物反应制备式I化合物的氧代乙烯基醇及其O-保护的衍生物，其中R是氢或OH保护基，例如Si（Ra） 其中R具有上面给出的式I所示的含义，即在存在下的化合物（即，b） - 乙烯基离子（式II，R =氢）或其被保护的衍生物（式II，R = OH保护基） 至少一种过渡金属，其中氧化剂包含至少一种选自过氧化氢和有机氢过氧化物的含氧化合物。