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公开(公告)号：US20180222898A1
公开(公告)日：2018-08-09
申请号：US15892229
申请日：2018-02-08
发明人： Meyyappan Muthuppalaniappan , Srikant Viswanadha , Gayatri S. Merikapudi , Swaroop K. Vakkalanka
IPC分类号： C07D417/10 , A61K31/415 , A61K31/422 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D207/327 , C07D207/337 , C07D231/12 , C07D295/195 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C12N5/078
CPC分类号： C07D417/10 , A61K31/415 , A61K31/422 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D207/327 , C07D207/337 , C07D231/12 , C07D295/195 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C12N5/0634 , C12N2500/46 , Y02A50/422
摘要： Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present disclosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to methods for identifying therapeutics for treating and of diagnosing cancer.
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公开(公告)号：US20170342089A1
公开(公告)日：2017-11-30
申请号：US15674376
申请日：2017-08-10
IPC分类号： C07D498/04 , C07D417/04 , C07D413/04 , C07D401/04 , C07D405/04 , C07D401/14 , C07D417/14 , C07D413/14
CPC分类号： C07D498/04 , C07D401/04 , C07D401/14 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to novel compounds of formula (A) and (B) as modulators of GPR-119, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of GPR-119 mediated diseases or disorders with them.
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公开(公告)号：US20170313690A1
公开(公告)日：2017-11-02
申请号：US15635268
申请日：2017-06-28
发明人： Meyyappan Muthuppalaniappan , Srikant Viswanadha , Gayatri S. Merikapudi , Swaroop K. Vakkalanka
IPC分类号： C07D417/10 , A61K31/415 , C07D417/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D413/10 , C07D403/14 , C07D403/12 , C07D403/10 , C07D403/04 , C07D401/14 , C07D401/12 , C07D401/10 , C07D401/04 , C07D295/195 , C07D231/12 , C07D207/337 , C07D207/327 , A61K45/06 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/455 , A61K31/4439 , A61K31/433 , A61K31/427 , A61K31/422 , C12N5/078
CPC分类号： C07D417/10 , A61K31/415 , A61K31/422 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D207/327 , C07D207/337 , C07D231/12 , C07D295/195 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C12N5/0634 , C12N2500/46 , Y02A50/422
摘要： Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present disclosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to methods for identifying therapeutics for treating and of diagnosing cancer.
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公开(公告)号：US10668051B2
公开(公告)日：2020-06-02
申请号：US16248528
申请日：2019-01-15
发明人： Meyyappan Muthuppalaniappan , Srikant Viswanadha , Gayatri S. Merikapudi , Swaroop K. Vakkalanka
IPC分类号： A61K31/433 , A61K31/427 , A61K31/415 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61P29/00 , A61K31/444 , A61K31/506 , C07D231/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D207/327 , C07D401/10 , C07D403/10 , C07D413/10 , C07D417/10 , A61K31/422 , A61K31/455 , A61K45/06 , C07D207/337 , C07D295/195 , C12N5/078
摘要： Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present disclosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to methods for identifying therapeutics for treating and of diagnosing cancer.
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公开(公告)号：US10246450B2
公开(公告)日：2019-04-02
申请号：US15892229
申请日：2018-02-08
发明人： Meyyappan Muthuppalaniappan , Srikant Viswanadha , Gayatri S. Merikapudi , Swaroop K. Vakkalanka
IPC分类号： C07D417/10 , A61K31/415 , A61K31/422 , A61K31/433 , A61K31/4439 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D207/327 , C07D207/337 , C07D231/12 , C07D295/195 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C12N5/078 , A61K31/427
摘要： Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present disclosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to methods for identifying therapeutics for treating and of diagnosing cancer.
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公开(公告)号：US09758514B2
公开(公告)日：2017-09-12
申请号：US14539470
申请日：2014-11-12
发明人： Meyyappan Muthuppalaniappan , Srikant Viswanadha , Gayatri S. Merikapudi , Swaroop K. Vakkalanka
IPC分类号： C07D417/10 , C07D401/10 , C07D401/12 , C07D403/10 , A61K45/06 , A61K31/427 , A61K31/422 , A61K31/415 , A61K31/433 , A61K31/5377 , C07D231/12 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D207/327 , C07D413/10 , A61K31/4439 , A61K31/455 , A61K31/496 , A61K31/506 , C07D207/337 , C07D295/195 , C12N5/078
CPC分类号： C07D417/10 , A61K31/415 , A61K31/422 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D207/327 , C07D207/337 , C07D231/12 , C07D295/195 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C12N5/0634 , C12N2500/46 , Y02A50/422
摘要： Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present disclosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to methods for identifying therapeutics for treating and of diagnosing cancer.
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公开(公告)号：US20150361092A1
公开(公告)日：2015-12-17
申请号：US14832349
申请日：2015-08-21
IPC分类号： C07D498/04 , C07D401/04 , C07D417/04 , C07D413/04 , C07D405/04 , C07D401/14 , C07D413/14
CPC分类号： C07D498/04 , C07D401/04 , C07D401/14 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to novel compounds of formula (A) and (B) as modulators of GPR-119, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of GPR-119 mediated diseases or disorders with them.
摘要翻译： 本发明涉及作为GPR-119调节剂的新型式（A）和（B）化合物，其制备方法，含有它们的药物组合物和治疗，预防和/或改善GPR-119介导的疾病或病症的方法 跟他们。
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公开(公告)号：US09944631B2
公开(公告)日：2018-04-17
申请号：US15635268
申请日：2017-06-28
发明人： Meyyappan Muthuppalaniappan , Srikant Viswanadha , Gayatri S. Merikapudi , Swaroop K. Vakkalanka
IPC分类号： C07D417/10 , A61K31/415 , A61K31/496 , A61K31/422 , A61K31/506 , A61K31/455 , A61K31/427 , A61K31/433 , C07D231/12 , C07D295/195 , C12N5/078 , A61K31/4439 , A61K31/5377 , A61K45/06 , C07D413/10 , C07D403/10 , C07D401/10 , C07D207/327 , C07D417/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D403/14 , C07D403/12 , C07D403/04 , C07D401/14 , C07D401/12 , C07D401/04 , C07D207/337
CPC分类号： C07D417/10 , A61K31/415 , A61K31/422 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D207/327 , C07D207/337 , C07D231/12 , C07D295/195 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C12N5/0634 , C12N2500/46 , Y02A50/422
摘要： Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present disclosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to methods for identifying therapeutics for treating and of diagnosing cancer.
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公开(公告)号：US09777018B2
公开(公告)日：2017-10-03
申请号：US14832349
申请日：2015-08-21
IPC分类号： C07D498/04 , C07D405/04 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
CPC分类号： C07D498/04 , C07D401/04 , C07D401/14 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to novel compounds of formula (A) and (B) as modulators of GPR-119, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of GPR-119 mediated diseases or disorders with them.
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公开(公告)号：US09758474B2
公开(公告)日：2017-09-12
申请号：US14172707
申请日：2014-02-04
发明人： Meyyappan Muthuppalaniappan , Prashant K. Bhavar , Srikant Viswanadha , Swaroop K. Vakkalanka , Gayatri S. Merikapudi
IPC分类号： A01N37/18 , A01N43/40 , A01N43/32 , A01N43/38 , A61K31/50 , C07D211/72 , C07C233/00 , C12N5/00 , C07C235/56 , C07C233/65 , C07C233/66 , C07C233/75 , C07C309/59 , C07C317/32 , C07C323/42 , C07D209/14 , C07D213/75 , C07D213/81 , C07D231/56 , C07D241/24 , C07D307/79 , C07D317/58 , C07D319/18 , A61K31/167 , A61K31/185 , A61K31/196 , A61K31/343 , A61K31/357 , A61K31/405 , A61K31/416 , A61K31/44 , A61K45/06 , C07C235/84 , C07C309/52
CPC分类号： C07C235/56 , A61K31/167 , A61K31/185 , A61K31/196 , A61K31/343 , A61K31/357 , A61K31/405 , A61K31/416 , A61K31/44 , A61K45/06 , C07C233/65 , C07C233/66 , C07C233/75 , C07C235/84 , C07C309/52 , C07C309/59 , C07C317/32 , C07C323/42 , C07C2601/02 , C07C2601/08 , C07D209/14 , C07D213/75 , C07D213/81 , C07D231/56 , C07D241/24 , C07D307/79 , C07D317/58 , C07D319/18
摘要： The present invention provides dihydroorotate dehydrogenase inhibitors, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of diseases or disorders wherein the inhibition of Dihydroorotate dehydrogenase is known to show beneficial effect.
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