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    CYANINE DERIVATIVES, FLUORESCENT CONJUGATES CONTAINING SAME AND USE THEREOF
    1.
    发明申请
    CYANINE DERIVATIVES, FLUORESCENT CONJUGATES CONTAINING SAME AND USE THEREOF 审中-公开
    氰基衍生物，含有它们的荧光偶联物及其用途

    公开(公告)号：US20100143960A1

    公开(公告)日：2010-06-10

    申请号：US12530527

    申请日：2008-03-07

    申请人： Herve Bazin

    发明人： Herve Bazin

    IPC分类号： C12Q1/02 ,  C07F9/04

    CPC分类号： C07F9/65583 ,  G01N33/582

    摘要： A subject matter of the invention is cyanine derivatives of formula: in which the dotted lines represent the atoms necessary for the formation of one or two fused aromatic rings, each ring comprising 5 or 6 carbon atoms; R1, R2, R3 and R4 represent, independently of one another: H; substituted or unsubstituted C1-C15 alkyl; C1-C6 alkoxy; (C2-C12)dialkylamino; C1-C6 alkoxycarbonyl; di(C2-C12)alkylamido; a substituted or unsubstituted aryl, arylalkyl or aryloxy group; a halogen atom; a nitro; an L1-W, L2-M, L2-A or L2-G group; R5 and R6 represent, independently of one another: substituted or unsubstituted C1-C15 alkyl; a substituted or unsubstituted aryl or arylalkyl group; an L1-W, L2-M, L2-A or L2-G group; X is chosen from: O, S or CR7R8; Y is chosen from: O, S or CR9R10; R7, R8, R9 and R10 independently represent: substituted or unsubstituted C1-C15 alkyl; substituted or unsubstituted aryl, arylalkyl or aryloxy; an L1-W, L2-M, L2-A or L2-G group; R7 and R8 and/or R9 and R10 can also together form a ring comprising 5 or 6 atoms or a heterocycle comprising 4 to 5 carbon atoms and an oxygen atom; B represents a polymethine bridge comprising 1 to 5 methine groups, said groups being in particular individually unsubstituted or substituted by a substituted or unsubstituted C1-C15 alkyl; a substituted or unsubstituted aryl, arylalkyl or aryloxy group; a nitro group; an L1-W, L2-M, L2-A or L2-G group; L1 and L2 are connecting arms; G is a reactive group; A is a coupling agent; M is a conjugated molecule, W is a phosphate or phosphonate ester (preferably diester), with the proviso that the cyanine derivative comprises at least one L1-W group and at least one L2-A, L2-G or L2-M group.

    摘要翻译： 本发明的主题是下式的花青衍生物：其中虚线表示形成一个或两个稠合芳环所必需的原子，每个环包含5或6个碳原子; R 1，R 2，R 3和R 4彼此独立地表示：H; 取代或未取代的C 1 -C 15烷基; C1-C6烷氧基; （C 2 -C 12）二烷基氨基; C1-C6烷氧羰基; 二（C 2 -C 12）烷基酰胺基; 取代或未取代的芳基，芳烷基或芳氧基; 卤素原子; 硝基; L1-W，L2-M，L2-A或L2-G基团; R 5和R 6彼此独立地表示：取代或未取代的C 1 -C 15烷基; 取代或未取代的芳基或芳基烷基; L1-W，L2-M，L2-A或L2-G基团; X选自：O，S或CR7R8; Y选自：O，S或CR9R10; R 7，R 8，R 9和R 10独立地表示：取代或未取代的C 1 -C 15烷基; 取代或未取代的芳基，芳烷基或芳氧基; L1-W，L2-M，L2-A或L2-G基团; R 7和R 8和/或R 9和R 10也可以一起形成包含5或6个原子的环或包含4至5个碳原子的杂环和氧原子; B表示包含1至5个次甲基的多甲基桥，所述基团特别地单独未取代或被取代或未取代的C 1 -C 15烷基取代; 取代或未取代的芳基，芳烷基或芳氧基; 硝基; L1-W，L2-M，L2-A或L2-G基团; L1和L2是连接臂; G是反应性基团; A是偶联剂; M是共轭分子，W是磷酸酯或膦酸酯（优选二酯），条件是花青衍生物包含至少一个L1-W基团和至少一个L2-A，L2-G或L2-M基团。

    Compounds Active in Sphingosine 1-Phosphate Signaling
    2.
    发明申请
    Compounds Active in Sphingosine 1-Phosphate Signaling 有权
    在鞘氨醇1-磷酸盐信号中活跃的化合物

    公开(公告)号：US20070219163A1

    公开(公告)日：2007-09-20

    申请号：US11748296

    申请日：2007-05-14

    申请人： Kevin Lynch ,  Timothy Macdonald

    发明人： Kevin Lynch ,  Timothy Macdonald

    IPC分类号： A61K31/675 ,  C07F9/04

    CPC分类号： C07F9/65068 ,  C07F9/091 ,  C07F9/094 ,  C07F9/6506

    摘要： The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure: wherein R11 is C5-C18 alkyl or C5-C18 alkenyl; Q is C3-C6 optionally substituted cycloalkyl, C3-C6 optionally substituted heterocyclic, C3-C6 optionally substituted aryl C3-C6 optionally substituted heteroaryl or —NH(CO)—; R3 is H, C1-C4 alkyl, (C1-C4 alkyl)OH or (C1-C4 alkyl)NH2; R23 is H or C1-C4 alkyl, and R15 is hydroxy, phosphonate, or wherein X and R12 is O or S; or a pharmaceutically acceptable salt or tautomer thereof.

    摘要翻译： 本发明涉及具有作为S1P受体调节剂的活性的S1P类似物以及这些化合物用于治疗与不适当S1P受体活性相关的疾病的用途。 化合物具有以下通式结构：其中R 11是C 5 -C 18烷基或C 5 -C 18 链烯基; Q是C 3 -C 6任选取代的环烷基，C 3 -C 6 -C 6任选取代的杂环，C 1 -C 6烷基， 任选取代的芳基C 3 -C 6任选取代的杂芳基或-NH（CO） - ; R 3是H，C 1 -C 4烷基，（C 1 -C 4）烷基， 烷基）OH或（C 1 -C 4烷基）NH 2; R 23是H或C 1 -C 4烷基，R 15是羟基，膦酸酯或其中R 15是氢或C 1 -C 4烷基， X和R 12是O或S; 或其药学上可接受的盐或互变异构体。

    Process for preparing dialkyl and diaryl phosphonothioic halides
    4.
    发明授权
    Process for preparing dialkyl and diaryl phosphonothioic halides 失效
    制备二烷基和二芳基膦酰基卤化物的方法

    公开(公告)号：US4076746A

    公开(公告)日：1978-02-28

    申请号：US694270

    申请日：1976-06-09

    申请人： Arthur D. F. Toy ,  Eugene H. Uhing

    发明人： Arthur D. F. Toy ,  Eugene H. Uhing

    IPC分类号： C07F9/34 ,  C07F9/04

    CPC分类号： C07F9/34

    摘要： Dialkyl or diaryl phosphonothioic halides are prepared by contacting an alkyl or aryl halide, respectively, with phosphorus sesquisulfide, P.sub.4 S.sub.3, under at least autogenous pressure at a temperature of from about 200.degree. to about 400.degree. C. The compounds obtained are useful as pesticides and as intermediates in preparation of pesticides and other organo-phosphorus compounds.

    摘要翻译： 二烷基或二芳基膦酰卤卤化物分别通过使烷基或芳基卤化物分别与二硫代二硫化物P4S3在至少自生压力下在约200至约400℃的温度下接触来制备。所得化合物可用作农药和 作为制备农药和其他有机磷化合物的中间体。

    Phosphosulfurized hydrocarbon modified N-(hydroxy and alkyl-substituted benzyl) alkylene polyamine
    5.
    发明授权
    Phosphosulfurized hydrocarbon modified N-(hydroxy and alkyl-substituted benzyl) alkylene polyamine 失效
    磷硫化烃改性的N-（羟基和烷基取代的苄基）亚烷基多胺

    公开(公告)号：US4031017A

    公开(公告)日：1977-06-21

    申请号：US674614

    申请日：1976-04-07

    申请人： Albert R. Sabol

    发明人： Albert R. Sabol

    IPC分类号： C07F9/04 ,  C10M169/00 ,  C09B49/00

    CPC分类号： C07F9/04 ,  C10M1/08 ,  C10M2209/084 ,  C10M2209/104 ,  C10M2217/042 ,  C10M2217/043 ,  C10M2219/044 ,  C10M2223/12 ,  C10M2225/041

    摘要： This invention relates to a novel lubricant oil addition agent which is a phosphosulfurized C.sub.35 to C.sub.160 hydrocarbon modified N-(hydroxy and C.sub.50 - C.sub.160 alkyl-substituted benzyl) alkylene polyamine. Such novel addition agent imparts anti-oxidant and unexpected dispersancy functions to lubricant oils commonly used as crankcase lubricants for internal combustion engines. Such novel addition agent also imparts anti-oxidant and detergency functions to the less viscous oils used to lubricate automatic transmissions and at the same time prevent failure of the rubber seals used therein from deterioration (hardening) by oxidation and distortion softening by undue swelling. The present inventive addition agent unexpectedly provides both detergency and an anti-oxidant functions for lubricant oil which are superior to the related analog addition agent derived from the reaction of one molar proportion of a phosphosulfurized 500 to 2800 (Staudinger) molecular weight hydrocarbon with from 0.5 up to 4 molar proportion of an N-(hydroxy and C.sub.4 - C.sub.24 alkyl-substituted benzyl) alkylene polyamine.

    摘要翻译： 本发明涉及一种新的润滑油添加剂，它是磷硫化C35至C160烃改性的N-（羟基和C 50 -C 16烷基取代的苄基）亚烷基多胺。 这种新型添加剂赋予通常用作内燃机用曲轴箱润滑剂的润滑油的抗氧化和意想不到的分散功能。 这种新型添加剂还对用于润滑自动变速器的较不粘稠的油赋予抗氧化和去垢功能，并且同时防止其中使用的橡胶密封件由于过度膨胀的氧化和变形软化而劣化（硬化）。 本发明的添加剂意外地提供润滑油的去污力和抗氧化功能，其优于衍生自一摩尔比例的磷硫化的500至2800（Staudinger）分子量烃与0.5的反应的相关的类似物加成剂 最多4摩尔的N-（羟基和C 4 -C 24烷基取代的苄基）亚烷基多胺。