公开(公告)号：US20240342175A1

公开(公告)日：2024-10-17

申请号：US18617800

申请日：2024-03-27

申请人： Howard Mitz

发明人： Howard Mitz

IPC分类号： A61K31/517 ,  A61K31/16 ,  A61K31/167 ,  A61K31/192 ,  A61K31/22 ,  A61K31/352 ,  A61K31/381 ,  A61K31/40 ,  A61K31/401 ,  A61K31/428 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/472 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K31/65 ,  A61K35/60 ,  A61K36/00 ,  A61K38/57 ,  A61P25/00

CPC分类号： A61K31/517 ,  A61K31/16 ,  A61K31/167 ,  A61K31/192 ,  A61K31/22 ,  A61K31/352 ,  A61K31/381 ,  A61K31/40 ,  A61K31/401 ,  A61K31/428 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/472 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K31/65 ,  A61K35/60 ,  A61K36/00 ,  A61K38/57 ,  A61P25/00

摘要： The present invention provides methods and compositions for treating synaptic dysfunction and spinal cord injuries comprising, for example, the administration of a compound that increases the level of PZP in vivo.

公开(公告)号：US12115171B2

公开(公告)日：2024-10-15

申请号：US17836836

申请日：2022-06-09

申请人： Massachusetts Institute of Technology

发明人： Michael B. Yaffe ,  Jesse C. Patterson

IPC分类号： A61K31/58 ,  A61K31/337 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/519 ,  A61K31/567 ,  A61K31/573 ,  A61K31/575 ,  A61K45/06

CPC分类号： A61K31/58 ,  A61K31/337 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/519 ,  A61K31/567 ,  A61K31/573 ,  A61K31/575 ,  A61K45/06 ,  A61K31/567 ,  A61K2300/00 ,  A61K31/575 ,  A61K2300/00 ,  A61K31/4439 ,  A61K2300/00 ,  A61K31/58 ,  A61K2300/00 ,  A61K31/496 ,  A61K2300/00 ,  A61K31/519 ,  A61K2300/00 ,  A61K31/4409 ,  A61K2300/00

摘要： Pharmaceutical compositions including an effective amount of an antiandrogen or androgen antagonist in combination with a Plk inhibitor and methods of use thereof for treating cancer are disclosed. Administration of the combination of the active agents can be effective to reduce cancer cell proliferation or viability in a subject with cancer to the same degree, or a greater degree than administering to the subject the same amount of either active agent alone. The active agents can be administered together or separately. Methods of selecting and treating subjects with cancers, particular prostate cancers including castration resistant prostate cancer, breast cancers, particularly androgen receptor positive breast cancers, and pancreatic cancers are also provided.

公开(公告)号：US20240307537A1

公开(公告)日：2024-09-19

申请号：US18451632

申请日：2023-08-17

申请人： Omeros Corporation

发明人： Michael Cicirelli ,  Neil S. Cutshall ,  Gregory A. Demopulos ,  George A. Gaitanaris ,  Marc A. Gavin ,  Alexander Gragerov ,  Thomas L. Little ,  Rene Onrust

IPC分类号： A61K39/00 ,  A61K31/17 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4409 ,  A61K31/473 ,  A61K31/495 ,  A61K31/496 ,  A61K31/502 ,  A61K31/506 ,  A61K31/519 ,  A61K31/522 ,  A61K31/53 ,  A61K31/55 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28 ,  G01N33/574

CPC分类号： A61K39/4643 ,  A61K31/17 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4409 ,  A61K31/473 ,  A61K31/495 ,  A61K31/496 ,  A61K31/502 ,  A61K31/506 ,  A61K31/519 ,  A61K31/522 ,  A61K31/53 ,  A61K31/55 ,  A61K39/39558 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28 ,  G01N33/57488 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/76

摘要： This disclosure is directed to compounds, compositions, and methods for the treatment of various diseases and/or conditions related to G protein-coupled receptor 174 (e.g., cancers).

公开(公告)号：US20240301499A1

公开(公告)日：2024-09-12

申请号：US18262102

申请日：2022-01-21

申请人： Institut Gustave Roussy

发明人： Nathalie GASPAR ,  Antonin MARCHAIS

IPC分类号： C12Q1/6886 ,  A61K31/4409 ,  A61P35/00

CPC分类号： C12Q1/6886 ,  A61K31/4409 ,  A61P35/00 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present invention provides tools for stratifying patients suffering from osteosarcoma, in order to identify patients having poor prognosis tumors. The invention also pertains to the use of an inhibitor of the PPARγ pathway as an antineoplastic treatment to improve the overall survival of patients with a poor prognosis osteosarcoma.

公开(公告)号：US20240182419A1

公开(公告)日：2024-06-06

申请号：US18441515

申请日：2024-02-14

申请人： The University of Sydney

发明人： Michael Kassiou ,  William Jorgensen ,  Lenka Munoz

IPC分类号： C07D213/75 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4965 ,  C07D213/82 ,  C07D241/24 ,  C07D307/66 ,  C07D317/66

CPC分类号： C07D213/75 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4965 ,  C07D213/82 ,  C07D241/24 ,  C07D307/66 ,  C07D317/66

摘要： The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).

公开(公告)号：US11986459B2

公开(公告)日：2024-05-21

申请号：US17713576

申请日：2022-04-05

申请人： University of South Florida

发明人： Bill J. Baker ,  Kyle Rohde ,  Bingjie Yang ,  Marisa Fuse

IPC分类号： A61K31/12 ,  A61K31/133 ,  A61K31/145 ,  A61K31/192 ,  A61K31/235 ,  A61K31/343 ,  A61K31/352 ,  A61K31/365 ,  A61K31/366 ,  A61K31/4015 ,  A61K31/4045 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/454 ,  A61K31/472 ,  A61K31/496 ,  A61K31/498 ,  A61K31/505 ,  A61K31/7036 ,  A61P31/06

CPC分类号： A61K31/366 ,  A61K31/12 ,  A61K31/133 ,  A61K31/145 ,  A61K31/192 ,  A61K31/235 ,  A61K31/343 ,  A61K31/352 ,  A61K31/365 ,  A61K31/4015 ,  A61K31/4045 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/454 ,  A61K31/472 ,  A61K31/496 ,  A61K31/498 ,  A61K31/505 ,  A61K31/7036 ,  A61P31/06

摘要： The present disclosure provides methods for the treatment of infections with Mycobacterium such as tuberculosis or leprosy.

公开(公告)号：US11974972B1

公开(公告)日：2024-05-07

申请号：US18388696

申请日：2023-11-10

申请人： Joong Ho Moon ,  Michelle Miranda

发明人： Joong Ho Moon ,  Michelle Miranda

IPC分类号： A61K8/43 ,  A61K31/133 ,  A61K31/155 ,  A61K31/17 ,  A61K31/277 ,  A61K31/4409 ,  A61K31/47 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/498 ,  A61K31/5377 ,  A61P31/04 ,  A61P31/06 ,  C07C279/12 ,  C07D295/215 ,  C08G65/00 ,  C08G71/02

CPC分类号： A61K31/17 ,  A61K31/133 ,  A61K31/277 ,  A61K31/4409 ,  A61K31/47 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/498 ,  A61K31/5377 ,  A61P31/06 ,  C07C279/12 ,  C07D295/215 ,  C08G65/00 ,  C08G71/02 ,  C07C2601/16

摘要： The subject invention provides oligo(carbamoylated guanidine)s (OCGs) having fast and selective mycobactericidal effects via disruption of the mycobacterial membrane potential. OCGs also potentiates bedaquiline, an oxidative phosphorylation-targeting anti-TB drug. The combination of OCG and anti-TB drug can be used as an effective therapy for treating tuberculosis.

公开(公告)号：US11939296B2

公开(公告)日：2024-03-26

申请号：US17899297

申请日：2022-08-30

申请人： The University of Sydney

发明人： Michael Kassiou ,  William Jorgensen ,  Lenka Munoz

IPC分类号： A61K31/4409 ,  A61K31/4406 ,  A61K31/4965 ,  C07D213/75 ,  C07D213/82 ,  C07D241/24 ,  C07D307/66 ,  C07D317/66

CPC分类号： C07D213/75 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4965 ,  C07D213/82 ,  C07D241/24 ,  C07D307/66 ,  C07D317/66

摘要： The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).

公开(公告)号：US11918630B2

公开(公告)日：2024-03-05

申请号：US15523282

申请日：2015-10-30

申请人： KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION ,  THE DOSHISHA ,  SENJU PHARMACEUTICAL CO., LTD.

发明人： Noriko Koizumi ,  Naoki Okumura ,  Shigeru Kinoshita

IPC分类号： A61K38/39 ,  A61K9/00 ,  A61K31/4409 ,  A61K35/30 ,  A61K45/00 ,  A61K45/06 ,  A61P27/02

CPC分类号： A61K38/39 ,  A61K9/0048 ,  A61K31/4409 ,  A61K35/30 ,  A61K45/00 ,  A61K45/06 ,  A61P27/02 ,  A61K38/39 ,  A61K2300/00 ,  A61K31/4409 ,  A61K2300/00 ,  A61K35/30 ,  A61K2300/00

摘要： The present invention provides a technique for treating retinal epithelium and/or nerves. More specifically, the present invention is an agent for the treatment or prevention of retinal disease or the like and/or a disease, disorder, or ophthalmological state of the nerves, the agent including at least one factor selected from the group consisting of laminin and fragments thereof, wherein the problem is solved by also providing a technique characterized in that this agent is administered together with retinal pigment epithelial cells and/or nerve cells. Specifically, the present invention can include laminin 411 (α4β1γ1), laminin 511 (α5β1γ1), laminin 521 (α5β2γ1), or fragments of these.

公开(公告)号：US20240050376A1

公开(公告)日：2024-02-15

申请号：US18488349

申请日：2023-10-17

申请人： Acorda Therapeutics, Inc.

发明人： Joseph E. Cobb, JR. ,  Thomas B. Gold ,  Rohini D'Souza ,  Susan L. Way

IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K31/4409

CPC分类号： A61K9/2027 ,  A61K9/2031 ,  A61K9/2866 ,  A61K9/2893 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2095 ,  A61K31/4409

摘要： The present invention generally relates to sustained release 4-aminopyridine tablets, which include a core and a coating. The sustained release tablets of the invention are generally suitable for once daily oral administration for the treatment of neurological disorders.