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    Ion analyzer
    2.
    发明授权
    Ion analyzer 有权

    公开(公告)号：US10998177B2

    公开(公告)日：2021-05-04

    申请号：US16500124

    申请日：2018-03-29

    申请人： SHIMADZU CORPORATION ,  THE DOSHISHA

    发明人： Hidenori Takahashi ,  Motoi Wada

    IPC分类号： H01J49/00 ,  H01J49/04 ,  G01N27/622

    摘要： An ion analyzer that generates product ions from precursor ions derived from a sample component and analyzes the product ions includes a reaction chamber (2) into which the precursor ion is introduced, a radical generation chamber (51), a material gas supply source (52) configured to introduce material gas into the radical generation chamber (51), a vacuum evacuator (57) configured to evacuate the radical generation chamber (51), a vacuum discharge unit (53) configured to generate a vacuum discharge in the radical generation chamber (51), a radical irradiation unit (54) configured to irradiate an inside of the reaction chamber (2) with radicals generated from the material gas in the radical generation chamber (51), and a separation and detection (3) configured to separate and detect product ions generated from the precursor ion by reaction with the radicals according to at least one of a mass-to-charge ratio and ion mobility.

    ANALYTICAL DEVICE
    4.
    发明申请
    ANALYTICAL DEVICE 审中-公开

    公开(公告)号：US20190333748A1

    公开(公告)日：2019-10-31

    申请号：US16394024

    申请日：2019-04-25

    申请人： SHIMADZU CORPORATION ,  THE DOSHISHA

    发明人： Hidenori TAKAHASHI ,  Motoi WADA ,  Yuji SHIMABUKURO

    IPC分类号： H01J49/00 ,  H01J49/02 ,  H01J49/06 ,  H01J49/10 ,  G01N27/62

    摘要： An analytical device includes: a reaction unit into which an ion derived from a sample component is introduced; a radical generation unit that generates a radical by vacuum discharge and comprises a raw material introduction chamber into which a plasma raw material is introduced; a connection part that introduces the radical generated in the radical generation unit into a vacuum chamber, the vacuum chamber having a pressure lower than a pressure of the raw material introduction chamber and being connected to the reaction unit; and a separation unit that separates a generated ion generated by a reaction with the radical introduced via the connection part into the reaction unit according to m/z and/or ion mobility, wherein an inner diameter of a cross section of the connection part is equal to or less than 20 millimeters.

    ION SENSOR CATALYST, ION SENSOR USING SAME, AND QUANTIFICATION METHOD
    7.
    发明申请
    ION SENSOR CATALYST, ION SENSOR USING SAME, AND QUANTIFICATION METHOD 审中-公开
    离子传感器催化剂，使用相同的离子传感器和定量方法

    公开(公告)号：US20170074823A1

    公开(公告)日：2017-03-16

    申请号：US15118657

    申请日：2015-02-04

    申请人： The Doshisha

    发明人： Masatsugu MORIMITSU

    IPC分类号： G01N27/416 ,  G01N27/333

    CPC分类号： G01N27/4168 ,  G01N27/333 ,  G01N27/4166 ,  G01N27/4167 ,  G01N33/182

    摘要： An inexpensive ion sensor catalyst capable of detecting hydrogen phosphate ions in water and determining hydrogen phosphate ion concentration on the basis of oxidation current density for the ions, along with an ion sensor and a quantification method, the ion sensor catalyst being characterized by providing higher detection sensitivity than conventional ion sensor catalysts, being capable of maintaining high detection sensitivity over a wide range of hydrogen phosphate ion concentration, achieving a proportional relationship between concentration and oxidation current density, so that the concentration can be determined with accuracy regardless of the concentration range, and allowing oxidation current to reach a steady-state value in a short time, so that time to determine current density is short, resulting in shortened time to quantify hydrogen phosphate ions, and stable response to hydrogen phosphate ion oxidation can be made repeatedly.

    摘要翻译： 一种廉价的离子传感器催化剂，其能够检测水中的磷酸氢根离子并基于离子的氧化电流密度测定磷酸氢根离子浓度以及离子传感器和定量方法，其特征在于提供较高的检测 灵敏度高于常规离子传感器催化剂，能够在广泛的磷酸氢根离子浓度范围内保持较高的检测灵敏度，达到浓度与氧化电流密度之间的比例关系，从而可以准确测定浓度，而不考虑浓度范围， 并允许氧化电流在短时间内达到稳态值，从而确定电流密度的时间短，导致缩短磷酸氢根离子定量的时间，可以反复进行磷酸氢根离子氧化的稳定响应。

    DIFFERENTIATION MARKER AND DIFFERENTIATION CONTROL OF EYE CELL
    9.
    发明申请
    DIFFERENTIATION MARKER AND DIFFERENTIATION CONTROL OF EYE CELL 有权
    眼细胞分化标记和差异控制

    公开(公告)号：US20150202256A1

    公开(公告)日：2015-07-23

    申请号：US14413066

    申请日：2013-07-03

    申请人： Kyoto Prefectural Public University Corporation ,  The Doshisha ,  Senju Pharmaceutical Co., Ltd.

    发明人： Takahiro Nakamura ,  Noriko Koizumi ,  Naoki Okumura ,  Shigeru Kinoshita ,  Kana Tominaga ,  Satoshi Kawasaki

    IPC分类号： A61K38/17 ,  A61K35/30 ,  C12N5/079

    CPC分类号： A61K38/1709 ,  A61K35/30 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N5/0621 ,  C12N2501/40 ,  C12N2501/415 ,  C12Q1/6881 ,  C12Q2600/158 ,  G01N33/56966 ,  G01N2333/726 ,  G01N2800/16

    摘要： The present invention relates to a differentiation marker and a differentiation controlling technique for an eye cell. More particularly, the present invention has attained an object of providing a differentiation marker for an eye cell among the aforementioned problems, by providing a marker for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, the marker comprising GPR49/LGR5, as well as a detection agent or detection method for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, comprising a substance binding to GPR49/LGR5. In addition, the present invention has attained an object of providing a differentiation controlling technique for an eye cell, by providing an agent for suppressing differentiation and/or promoting proliferation of an eye cell, comprising R-spondins.

    摘要翻译： 本发明涉及眼细胞的分化标记和分化控制技术。 更具体地，本发明通过提供用于鉴定角膜内皮细胞中具有高增殖能力的细胞和/或角膜分化能力的标记物，提供了上述问题中的眼细胞分化标记物的目的。 内皮细胞，包括GPR49 / LGR5的标记物，以及用于鉴定角膜内皮细胞中具有高增殖能力的细胞和/或角膜内皮细胞的分化能力的检测剂或检测方法，其包含与GPR49结合的物质 / LGR5。 此外，本发明通过提供用于抑制包含R-螺旋藻的眼细胞分化和/或促进增殖的试剂，已经达到了提供眼细胞分化控制技术的目的。

    ATOMIC FLUX MEASUREMENT DEVICE
    10.
    发明申请
    ATOMIC FLUX MEASUREMENT DEVICE 有权
    原子通量测量装置

    公开(公告)号：US20130124124A1

    公开(公告)日：2013-05-16

    申请号：US13733594

    申请日：2013-01-03

    申请人： THE DOSHISHA ,  ARIOS INC.

    发明人： Tadashi OHACHI ,  Motoi WADA ,  Osamu ARIYADA ,  Nobuhiko YAMABE

    IPC分类号： G01N27/70 ,  G06F17/00

    CPC分类号： G01N27/70 ,  C23C14/543 ,  C30B23/005 ,  G06F17/00 ,  H05H1/0081

    摘要： An atomic flux measurement device for measuring the amount of dissociated atomic flux produced by discharge and emitted from a plasma generation cell into a vacuum camber. The atomic flux measurement device includes a counter electrode body including a pair of first and second sheet-like electrodes that are arranged substantially parallel to each other with a predetermined spacing between them, a direct-current power supply configured to maintain the first sheet-like electrode at a negative potential so that atoms attached to the inner surface of the sheet-like electrode undergo self-ionization and to apply a direct-current voltage between the first and second sheet-like electrodes so that a current flows between the first and second sheet-like electrodes, and a direct-current ammeter configured to measure a current flowing due to electrons emitted by the self-ionization of the dissociated atoms attached to the inner surface of the first sheet-like electrode.

    摘要翻译： 一种原子通量测量装置，用于测量由等离子体发生电池放电并发射到真空弧中产生的离解原子通量的量。 原子通量测量装置包括对电极体，其包括一对第一和第二片状电极，该第一和第二片状电极以它们之间的预定间隔彼此大致平行地布置;直流电源，被配置为保持第一片状电极 电极，使得附着到片状电极的内表面的原子经历自电离并且在第一和第二片状电极之间施加直流电压，使得电流在第一和第二电极之间流动 片状电极和直流电流表，其被配置为测量由于附着到第一片状电极的内表面的解离原子的自电离而发射的电子流动的电流。