公开(公告)号：US20240350467A1

公开(公告)日：2024-10-24

申请号：US18137294

申请日：2023-04-20

申请人： Isofol Medical AB

发明人： Per Lennart Lindberg ,  David Machover

IPC分类号： A61K31/4415 ,  A61K9/00 ,  A61K9/19 ,  A61K31/282 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61K31/7068 ,  A61P35/00

CPC分类号： A61K31/4415 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/282 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61K31/7068 ,  A61P35/00

摘要： The present invention relates to the treatment of pancreatic cancer, in particular KRAS-mutated pancreatic adenocarcinoma, in human populations employing a dosage regimen which includes arfolitixorin ([6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF) and a B6 vitamin in connection with 5-fluorouracil (5-FU) based chemotherapy.

公开(公告)号：US12109254B2

公开(公告)日：2024-10-08

申请号：US17945043

申请日：2022-09-14

申请人： Edgar Lee Hull, Jr.

发明人： Edgar Lee Hull, Jr. ,  Narashima Murthy ,  Sridhara Am

IPC分类号： A61K38/44 ,  A61K31/122 ,  A61K31/197 ,  A61K31/198 ,  A61K31/355 ,  A61K31/405 ,  A61K31/4172 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/525 ,  A61K31/714 ,  A61K33/00 ,  A61K33/04 ,  A61K33/30

CPC分类号： A61K38/443 ,  A61K31/122 ,  A61K31/197 ,  A61K31/198 ,  A61K31/355 ,  A61K31/405 ,  A61K31/4172 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/525 ,  A61K31/714 ,  A61K33/00 ,  A61K33/04 ,  A61K33/30 ,  A61K38/446

摘要： A low nitrogen protein food composition Albutrix™ for use by kidney patients in Stages 3, 4, 4a, 4b, and 5, who are not on dialysis, in a treatment program comprising administering daily a: low nitrogen diet; low nitrogen protein food comprising magnesium and/or calcium salts of alpha keto acids; and time released vitamin. The vitamin comprises the active ingredients of: Zinc; Selenium; Vitamins B1, B2, B6, B12, B5, E, and K2; Niacin; superoxide dismutase; catalase; glutathione and Folate; and excludes calcium, magnesium, phosphorus, sodium, manganese, fluoride, Vitamin D and K1. The low nitrogen food contains daily up to 300 mg of nitrogen; and at least five alpha keto analogues of magnesium and/or calcium salts of: leucine, isoleucine, methionine (MEMS-II), phenylalanine (PAMS-I), and valine. The treatment results in an increase of Glomerular Filtration Rate (GFR), a decrease in blood urea levels, and a decrease in creatinine levels.

公开(公告)号：US20240293348A1

公开(公告)日：2024-09-05

申请号：US18646642

申请日：2024-04-25

申请人： Rob D. Dickerman

发明人： Rob D. Dickerman

IPC分类号： A61K31/198 ,  A61K31/197 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/519 ,  A61K31/714

CPC分类号： A61K31/198 ,  A61K31/197 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/519 ,  A61K31/714

摘要： Compositions and methods are presented that, upon administration prior to trauma, are effective to prevent and/or reduce severity of sequelae of TBI upon trauma. Advantageously, the compositions presented herein can be orally administered, have an excellent safety profile, and will not require a prescription by physician or hospital admission.

公开(公告)号：US20240284941A1

公开(公告)日：2024-08-29

申请号：US18648995

申请日：2024-04-29

申请人： REQUIS PHARMACEUTICALS INC.

发明人： Lars Jacob Stray Knutsen ,  Judi Lois Knutsen

IPC分类号： A23L2/52 ,  A61K31/4045 ,  A61K31/405 ,  A61K31/4402 ,  A61K31/4415 ,  A61K31/495 ,  A61K31/56 ,  A61K45/06

CPC分类号： A23L2/52 ,  A61K31/4045 ,  A61K31/405 ,  A61K31/4402 ,  A61K31/4415 ,  A61K31/495 ,  A61K31/56 ,  A61K45/06 ,  A23V2250/065 ,  A23V2250/30

摘要： The present invention provides combinations comprising a sedating antihistamine and selected indole-based natural products such as L-tryptophan, 5-hydroxytryptophan and melatonin, along with pharmaceutically acceptable calcium and magnesium salts and selected B vitamins. These combinations are useful in providing a medicament for improving sleep in mammals, especially humans.

公开(公告)号：US20240261360A1

公开(公告)日：2024-08-08

申请号：US17999730

申请日：2021-05-21

申请人： Metaceutic APS

发明人： Ali Kazemi

IPC分类号： A61K36/81 ,  A61K9/00 ,  A61K31/4415 ,  A61K31/525 ,  A61K31/593 ,  A61K31/714 ,  A61K36/16 ,  A61K36/185 ,  A61K36/23 ,  A61K36/258 ,  A61K36/28 ,  A61K36/324 ,  A61K36/35 ,  A61K36/38 ,  A61K36/41 ,  A61K36/42 ,  A61K36/45 ,  A61K36/48 ,  A61K36/53 ,  A61K36/537 ,  A61K36/67 ,  A61K36/68 ,  A61K36/725 ,  A61K36/736 ,  A61K36/738 ,  A61K36/752 ,  A61K36/82 ,  A61K36/87 ,  A61K36/88 ,  A61K36/899 ,  A61K36/9066 ,  A61K36/9068 ,  A61P1/14

CPC分类号： A61K36/81 ,  A61K9/0053 ,  A61K31/4415 ,  A61K31/525 ,  A61K31/593 ,  A61K31/714 ,  A61K36/16 ,  A61K36/185 ,  A61K36/23 ,  A61K36/258 ,  A61K36/28 ,  A61K36/324 ,  A61K36/3486 ,  A61K36/35 ,  A61K36/38 ,  A61K36/41 ,  A61K36/42 ,  A61K36/45 ,  A61K36/48 ,  A61K36/53 ,  A61K36/537 ,  A61K36/5777 ,  A61K36/67 ,  A61K36/68 ,  A61K36/725 ,  A61K36/736 ,  A61K36/738 ,  A61K36/752 ,  A61K36/82 ,  A61K36/87 ,  A61K36/88 ,  A61K36/899 ,  A61K36/9066 ,  A61K36/9068 ,  A61P1/14

摘要： The present invention relates to a nutraceutical composition, use of a nutraceutical composition, and a method of increasing or decreasing a relative population of bacteria in the intestines of a mammal. The composition comprises an extract containing two or more plant secondary metabolites, wherein said two or more plant secondary metabolites are encapsulated in an acid resistant coating. The composition can affect the composition of bacteria in the gut of mammals.

公开(公告)号：US20240261321A1

公开(公告)日：2024-08-08

申请号：US18100563

申请日：2023-01-23

申请人： BEST PLANET SCIENCE LLC

发明人： Tatiana Svetlana LEON CAMACHO

IPC分类号： A61K33/00 ,  A23L2/54 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A61K9/00 ,  A61K31/198 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/51 ,  A61K31/519 ,  A61K31/525 ,  A61K31/714 ,  A61K33/04 ,  A61K33/06 ,  A61K33/26 ,  A61K33/30 ,  A61K33/34 ,  C02F1/68

CPC分类号： A61K33/00 ,  A23L2/54 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A61K9/0095 ,  A61K31/198 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/51 ,  A61K31/519 ,  A61K31/525 ,  A61K31/714 ,  A61K33/04 ,  A61K33/06 ,  A61K33/26 ,  A61K33/30 ,  A61K33/34 ,  C02F1/68

摘要： An aqueous formulation including a three-dimensional helical cage structure of polygonal water molecules, wherein the polygonal water molecules include two or more adjacent water molecules connected by hydrogen bridges, the helical cage structure has a central hollow lumen, and when viewed from a top, the helical cage structure has a hexagonal shape. The aqueous formulation also includes molecular hydrogen and at least one additive located within the central hollow lumen of the helical structure.

公开(公告)号：US20240226030A1

公开(公告)日：2024-07-11

申请号：US18558956

申请日：2022-05-04

申请人： SOCIÉTÉ DES PRODUITS NESTLE S.A.

发明人： CHIEH JASON CHOU ,  SHAILLAY KUMAR DOGRA ,  ADRIEN DARDINIER

IPC分类号： A61K31/047 ,  A61K31/07 ,  A61K31/197 ,  A61K31/352 ,  A61K31/366 ,  A61K31/4415 ,  A61K31/593 ,  A61K31/714

CPC分类号： A61K31/047 ,  A61K31/07 ,  A61K31/197 ,  A61K31/352 ,  A61K31/366 ,  A61K31/4415 ,  A61K31/593 ,  A61K31/714

摘要： An aspect is a composition containing at least one of inositol, erythritol or sorbitol and formulated for administration to a subject such that the at least one of inositol, erythritol or sorbitol enhance growth of Faecalibacterium prausnitzii in the microbiome of the subject. Another aspect is a method to treat, prevent, reduce a severity of, and/or reduce an incidence of a pathological condition in the subject, and the method includes enhancing growth of Faecalibacterium prausnitzii in the microbiome of the subject by administering, to the subject, at least one of inositol, erythritol or sorbitol. Yet another aspect is a method to achieve at least one of a metabolic effect, an anti-aging effect, or an anti-inflammatory effect in a subject, and the method includes enhancing growth of Faecalibacterium prausnitzii in the microbiome of the subject by administering, to the subject, at least one of inositol, erythritol or sorbitol.

公开(公告)号：US12029769B2

公开(公告)日：2024-07-09

申请号：US18079155

申请日：2022-12-12

申请人： Houn Simon Hsia

发明人： Houn Simon Hsia

IPC分类号： A61K31/00 ,  A23L33/105 ,  A23L33/115 ,  A23L33/14 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/175 ,  A61K31/015 ,  A61K31/05 ,  A61K31/122 ,  A61K31/18 ,  A61K31/198 ,  A61K31/202 ,  A61K31/24 ,  A61K31/30 ,  A61K31/32 ,  A61K31/34 ,  A61K31/4415 ,  A61K31/519 ,  A61K31/593 ,  A61K33/18 ,  A61K33/24 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K35/60 ,  A61K36/06 ,  A61K36/064

CPC分类号： A61K36/064 ,  A23L33/105 ,  A23L33/115 ,  A23L33/14 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/175 ,  A61K31/015 ,  A61K31/05 ,  A61K31/122 ,  A61K31/18 ,  A61K31/198 ,  A61K31/202 ,  A61K31/24 ,  A61K31/30 ,  A61K31/32 ,  A61K31/34 ,  A61K31/4415 ,  A61K31/519 ,  A61K31/593 ,  A61K33/18 ,  A61K33/24 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K35/60 ,  A61K36/06 ,  A23V2002/00 ,  A61K36/06 ,  A61K2300/00 ,  A61K31/202 ,  A61K2300/00 ,  A61K33/24 ,  A61K2300/00 ,  A61K33/18 ,  A61K2300/00 ,  A61K33/32 ,  A61K2300/00 ,  A61K33/34 ,  A61K2300/00 ,  A61K33/30 ,  A61K2300/00 ,  A61K31/519 ,  A61K2300/00 ,  A61K31/122 ,  A61K2300/00 ,  A61K31/593 ,  A61K2300/00 ,  A61K31/198 ,  A61K2300/00 ,  A61K31/4415 ,  A61K2300/00 ,  A61K31/05 ,  A61K2300/00 ,  A61K35/60 ,  A61K2300/00 ,  A23V2002/00 ,  A23V2200/308 ,  A23V2250/06 ,  A23V2250/1642 ,  A23V2250/1882 ,  A23V2250/21166 ,  A23V2250/2132 ,  A23V2250/314 ,  A23V2250/70

摘要： The present invention provides nutritional compositions that are employed as oral supplementation to the human diet and methods for using such nutritional compositions. The compositions of the present invention provide for supplementation to the diet of the cancer patient, as well as preventative dietary supplementation aimed at supporting the human immune system for those not currently suffering from cancer. Methods are provided that utilize specific combinations of selected forms selenium. chromium, and molybdenum in combination with fish oil.

公开(公告)号：US20240165174A1

公开(公告)日：2024-05-23

申请号：US18283424

申请日：2022-03-29

申请人： Axeen Pharma

发明人： Sossio Morra

IPC分类号： A61K35/748 ,  A61K9/00 ,  A61K9/48 ,  A61K31/355 ,  A61K31/4415 ,  A61K31/593 ,  A61K33/04 ,  A61K36/15 ,  A61K36/899 ,  A61P31/14

CPC分类号： A61K35/748 ,  A61K9/0053 ,  A61K9/4816 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/355 ,  A61K31/4415 ,  A61K31/593 ,  A61K33/04 ,  A61K36/15 ,  A61K36/899 ,  A61P31/14

摘要： The invention relates to a composition comprising spirulina. The invention is characterized in that the composition comprises an aqueous extract of pollen cytoplasm, said pollen(s) being obtained from plants belonging to the Secale, Zea, Pinus and/or Dactylis genera, and optionally: an extract of pistil(s); selenium; and/or vitamins.

公开(公告)号：US20240108678A1

公开(公告)日：2024-04-04

申请号：US18265899

申请日：2021-12-16

申请人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Lakshmi Mundkur

发明人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Lakshmi Mundkur

IPC分类号： A61K36/67 ,  A61K31/05 ,  A61K31/122 ,  A61K31/198 ,  A61K31/30 ,  A61K31/315 ,  A61K31/375 ,  A61K31/4415 ,  A61K31/4525 ,  A61K31/525 ,  A61K31/593 ,  A61K36/19 ,  A61K36/704 ,  A61K36/71 ,  A61P31/14

CPC分类号： A61K36/67 ,  A61K31/05 ,  A61K31/122 ,  A61K31/198 ,  A61K31/30 ,  A61K31/315 ,  A61K31/375 ,  A61K31/4415 ,  A61K31/4525 ,  A61K31/525 ,  A61K31/593 ,  A61K36/19 ,  A61K36/704 ,  A61K36/71 ,  A61P31/14

摘要： The present invention discloses methods and compositions comprising. Andrographis paniculata extract standardized to contain not less than 10% w/w andrographolides, Polygonum cuspidatum extract standardized to contain not less than 80% w/w resveratrol, Piper nigrum extract standardized to contain 95% w/w piperine, 95% tetrahydrocurcuminoids, vitamins for the management of viral infections, specifically COVID infection. The invention also discloses the use of the compositions in preventing proteolytic activation of viral spike protein by inhibiting the furin enzyme.