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    COMPOSITIONS, METHODS AND KITS FOR TREATING A CONTACT LENS
    1.
    发明申请
    COMPOSITIONS, METHODS AND KITS FOR TREATING A CONTACT LENS 有权

    公开(公告)号：US20230012411A1

    公开(公告)日：2023-01-12

    申请号：US17948376

    申请日：2022-09-20

    申请人： University of Houston System

    发明人： Guoting Qin ,  Chengzhi Cai

    IPC分类号： A61K9/00 ,  C07C271/12 ,  C07C271/14 ,  C07D215/56 ,  A61K31/496 ,  A61L12/10

    摘要： Provided herein are fluorinated compounds having chemical structures: (I) where n is 0 or greater, or (II) where m and n are 0 or greater, or an amino acid, a soluble polymer, an oligo(ethylene glycol), a poly(ethylene glycol), or a carbohydrate each fluorinated with perfluorocarbons having the chemical structure (III) where n is 0 or greater. These fluorinated compounds are utilized in contact lenses to impart lipid-resistant, protein-resistant and biofouling-resistant properties, thus reducing discomfort and infection caused by contact lens wear without changing its transmission characteristics. Also provided is an ophthalmic drug delivery system comprising at least one of the compounds described above embedded in the contact lens and a kit to incorporate the ophthalmic into a contact lens. Methods for incorporating these compounds onto a contact lens without affecting transparency and for use in treating an ophthalmologic-associated condition are provided.

    Compositions, Methods and Kits for Treating a Contact Lens
    2.
    发明申请
    Compositions, Methods and Kits for Treating a Contact Lens 审中-公开

    公开(公告)号：US20190133932A1

    公开(公告)日：2019-05-09

    申请号：US16096603

    申请日：2017-04-28

    申请人： GUOTING QIN ,  CHENGZHI CAI ,  UNIVERSITY OF HOUSTON SYSTEM

    发明人： Guoting Qin ,  Chengzhi Cai

    IPC分类号： A61K9/00 ,  A61K31/496 ,  A61L12/10

    摘要： Provided herein are fluorinated compounds having chemical structures: (I) where n is 0 or greater, or (II) where m and n are 0 or greater, or an amino acid, a soluble polymer, an oligo(ethylene glycol), a poly(ethylene glycol), or a carbohydrate each fluorinated with perfluorocarbons having the chemical structure (III) where n is 0 or greater. These fluorinated compounds are utilized in contact lenses to impart lipid-resistant, protein-resistant and biofouling-resistant properties, thus reducing discomfort and infection caused by contact lens wear without changing its transmission characteristics. Also provided is an ophthalmic drug delivery system comprising at least one of the compounds described above embedded in the contact lens and a kit to incorporate the ophthalmic into a contact lens. Methods for incorporating these compounds onto a contact lens without affecting transparency and for use in treating an ophthalmologic-associated condition are provided.

    CONTACT LENS CARE PREPARATION AND PACKAGING SOLUTION
    3.
    发明申请
    CONTACT LENS CARE PREPARATION AND PACKAGING SOLUTION 有权
    联系人眼镜护理准备和包装解决方案

    公开(公告)号：US20150024987A1

    公开(公告)日：2015-01-22

    申请号：US14381870

    申请日：2012-03-02

    申请人： Yosuke Matsuoka ,  Norio Iwakiri ,  Mao Maruhashi ,  Nobuyuki Sakamoto

    发明人： Yosuke Matsuoka ,  Norio Iwakiri ,  Mao Maruhashi ,  Nobuyuki Sakamoto

    IPC分类号： A61L12/10

    CPC分类号： A61L12/10 ,  A61L12/08 ,  A61L12/14 ,  C11D3/0078 ,  C11D3/3719 ,  C11D3/3765 ,  C11D3/3773 ,  C11D3/3784

    摘要： Provided are a contact lens care preparation capable of imparting durable surface lubricity and amebic adhesion inhibitory effect to a contact lens surface through a simple treatment, and a contact lens packaging solution utilizing the same. The contact lens care preparation is composed of a solution containing 0.01 to 2 weight/volume % of a polymer having particular monomer units with a phosphorylcholine-like group, particular (meth)acrylamide derivative units, and particular monomer units with a hydrophobic group at a particular ratio, and a weight average molecular weight of 5,000 to 2,000,000, and is useful as a contact lens packaging solution.

    摘要翻译： 提供能够通过简单的处理赋予隐形眼镜表面耐久的表面润滑性和抗坏血酸粘附抑制作用的隐形眼镜护理制剂，以及使用该隐形眼镜护理制剂的隐形眼镜包装溶液。 隐形眼镜护理制剂由含有0.01〜2重量/体积％的具有磷酸胆碱基的特定单体单元的聚合物，特定的（甲基）丙烯酰胺衍生物单元和具有疏水基团的特定单体单元的溶液组成， 特别的比例，重均分子量为5,000〜2,000,000，可用作隐形眼镜包装溶液。

    Compositions and methods for disinfecting contact lenses and preserving contact lens care products
    4.
    发明授权
    Compositions and methods for disinfecting contact lenses and preserving contact lens care products 失效
    用于消毒隐形眼镜和保护隐形眼镜护理产品的组合物和方法

    公开(公告)号：US6024954A

    公开(公告)日：2000-02-15

    申请号：US692867

    申请日：1996-08-02

    申请人： John Y. Park ,  Lin Peng ,  Daniel P. Cafaro ,  Anthony J. Dziabo

    发明人： John Y. Park ,  Lin Peng ,  Daniel P. Cafaro ,  Anthony J. Dziabo

    IPC分类号： A61K39/40 ,  A61L12/10 ,  A61K38/54

    CPC分类号： A61K39/40 ,  A61L12/102

    摘要： Compositions for disinfecting contact lenses include a liquid medium containing a chlorite component, preferably a water soluble chlorite component, in a contact lens disinfecting amount, and a polyanionic component, preferably a water soluble polyanionic component, in an amount effective to do at least one of the following: inhibit formation of protein deposit material on a contact lens immersed in the composition; reduce the toxicity of the composition to the human eye, and reduce the damage to a contact lens caused by immersing the contact lens in the composition. The composition has a viscosity of less than 50 cps at 25.degree. C., an osmolality of at least about 200 mOsmol/kg, and preferably a pH in the range of about 6 to about 9.

    摘要翻译： 用于消毒隐形眼镜的组合物包括含有接枝镜片消毒量的亚氯酸盐组分，优选水溶性亚氯酸盐组分的液体培养基和聚阴离子组分，优选水溶性聚阴离子组分，其量有效地进行至少一种 以下：抑制沉积在组合物中的隐形眼镜上形成蛋白沉积物质; 降低组合物对人眼的毒性，并减少由隐形眼镜浸入组合物而导致的隐形眼镜的损伤。 该组合物在25℃下的粘度小于50cps，至少约200mOsmol / kg的重量摩尔渗透压浓度，优选在约6至约9范围内的pH。