公开(公告)号：US20240358730A1

公开(公告)日：2024-10-31

申请号：US18765449

申请日：2024-07-08

申请人： Optibiotix Limited

发明人： Stephen Patrick O'Hara ,  Oswaldo Hernandez ,  Sofia Kolida

IPC分类号： A61K31/702 ,  A23L27/30 ,  A23L33/21 ,  A61K9/14 ,  A61P1/00

CPC分类号： A61K31/702 ,  A23L27/30 ,  A23L33/21 ,  A61K9/14 ,  A61P1/00 ,  A23V2002/00

摘要： The present invention relates to a non-digestible prebiotic oligosaccharide modified so as to incorporate one or more monosaccharide units thereon and have a higher sweetness value than the unmodified oligosaccharide. Uses and methods of producing the non-digestible prebiotic oligosaccharides are also described.

公开(公告)号：US12129294B2

公开(公告)日：2024-10-29

申请号：US18105316

申请日：2023-02-03

申请人： AbbVie Inc.

发明人： Gregg Timony ,  Sheila Gujrathi ,  Robert Peach ,  Allan Olson

IPC分类号： C07K16/24 ,  A61K31/436 ,  A61K31/519 ,  A61K31/58 ,  A61K38/13 ,  A61K39/395 ,  A61K45/06 ,  A61P1/00 ,  A61P37/06

CPC分类号： C07K16/244 ,  A61K31/436 ,  A61K31/519 ,  A61K31/58 ,  A61K38/13 ,  A61K39/3955 ,  A61K45/06 ,  A61P1/00 ,  A61P37/06 ,  C07K2317/56

摘要： The present invention is directed to methods for treating diseases in which IL-13 activity is detrimental, including eosinophilic esophagitis (EoE) and asthma, by administering to a subject in need of such treatment, a composition containing an interleukin-13 (IL-13) antibody, or an antigen binding fragment, thereof.

公开(公告)号：US20240352067A1

公开(公告)日：2024-10-24

申请号：US18648015

申请日：2024-04-26

申请人： RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

发明人： Kwangho LEE ,  Sang Dal RHEE ,  Gildon CHOI ,  Imran ALI ,  Chong Hak CHAE ,  Moon Kook JEON ,  Seok Hee PARK ,  Youn Sook LEE

IPC分类号： C07K5/117 ,  A61K38/00 ,  A61K47/54 ,  A61P1/00 ,  C07D207/04 ,  C07D403/06 ,  C07K5/097 ,  C07K5/103 ,  C07K5/107

CPC分类号： C07K5/1024 ,  A61K47/542 ,  A61P1/00 ,  C07D207/04 ,  C07D403/06 ,  C07K5/0823 ,  C07K5/1008 ,  C07K5/1016 ,  A61K38/00

摘要： Pyrrolidine carboxamido derivatives, optical isomers thereof, and salts thereof that are able to prevent, improve, and/or treat inflammatory conditions, including inflammatory bowel disease, and methods for preparing and using the same are provided.

公开(公告)号：US20240325475A1

公开(公告)日：2024-10-03

申请号：US18575677

申请日：2022-06-30

申请人： AB Mauri (UK) Ltd

发明人： Carlos DE LECEA ,  Jordi CUÑÉ CASTELLANA ,  Maria TINTORÉ GAZULLA

IPC分类号： A61K36/064 ,  A61P1/00 ,  A61P31/14

CPC分类号： A61K36/064 ,  A61P1/00 ,  A61P31/14

摘要： A physiologically acceptable composition comprising at least one component selected from the group consisting of S. boulardii yeasts, S. boulardii lysates, S. boulardii cell wall components, and S. boulardii extracts, further comprising at least one component selected from the group consisting of K. marxianus yeasts, K. marxianus lysates, K. marxianus cell wall components and K. marxianus extracts. Optionally, the composition further comprises at least one component selected from the group of S. cerevisiae yeasts, S. cerevisiae lysates, S. cerevisiae cell wall components and S. cerevisiae extracts. The invention further relates to the composition for use as a medicament.

公开(公告)号：US20240316155A1

公开(公告)日：2024-09-26

申请号：US18275195

申请日：2022-02-17

申请人： ZEALAND PHARMA A/S

发明人： Jonathan Griffin ,  Per-Olof Eriksson ,  Wayne Shaun Russell ,  Mark Berner-Hansen

IPC分类号： A61K38/26 ,  A61P1/00

CPC分类号： A61K38/26 ,  A61P1/00

摘要： The present invention relates to a composition comprising a GLP-1/GLP-2 dual agonist for use in a method for the treatment and/or prevention of diarrhea, loose stools, urgency, incontinence, high fecal output and/or high stomal output in a patient having undergone surgical resection of the bowel.

公开(公告)号：US20240316084A1

公开(公告)日：2024-09-26

申请号：US18257774

申请日：2021-12-17

申请人： SOCIETE DES PRODUITS NESTLE S.A.

发明人： LAURENT FAVRE ,  FLORENCE ROCHAT ,  NORBERT SPRENGER

IPC分类号： A61K31/702 ,  A23L33/00 ,  A61P1/00 ,  A61P3/02

CPC分类号： A61K31/702 ,  A23L33/40 ,  A61P1/00 ,  A61P3/02

摘要： The present invention relates to composition comprising 2′-FL for use in promoting accelerated butyrate production in the gut thereby preventing and/or treating a health disorder, and/or promoting a health benefit in young children consuming the composition.

公开(公告)号：US20240315976A1

公开(公告)日：2024-09-26

申请号：US18672320

申请日：2024-05-23

申请人： GIE Medical, Inc.

发明人： Lixiao Wang ,  Peter Barnett

IPC分类号： A61K9/48 ,  A61K31/337 ,  A61K31/436 ,  A61M25/10 ,  A61P1/00

CPC分类号： A61K9/4816 ,  A61K9/4833 ,  A61K31/337 ,  A61K31/436 ,  A61M25/10 ,  A61M25/1029 ,  A61P1/00 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2210/105

摘要： Various embodiments disclosed relate to polymer-encapsulated drug particles and a drug-releasing coating including the same, as well as drug-coated balloon catheters for treating, preventing, or reducing the recurrence of strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes the polymer-encapsulated drug particles; or a drug-releasing coating including the polymer-encapsulated drug particles; or a therapeutic agent and a first and/or second additive; or a combination thereof.

公开(公告)号：US20240294649A1

公开(公告)日：2024-09-05

申请号：US18595973

申请日：2024-03-05

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Yuu Okura ,  Noriyuki Takahashi

IPC分类号： C07K16/28 ,  A61P1/00 ,  A61P37/06 ,  G01N33/577

CPC分类号： C07K16/2833 ,  A61P1/00 ,  A61P37/06 ,  G01N33/577 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N2800/065

摘要： The invention provides anti-HLA-DQ2.5/8 antibodies and methods of using the same. The antibodies of the present invention have binding activity to human HLA-DQ2.5/8 and monkey MHC-DQ, but substantially no binding activity to HLA-DR, HLA-DP, or a complex of the invariant chain (CD74) and HLA-DQ2.5/8. The antibodies bind to HLA-DQ2.5/8 in the presence of a gluten peptide such as gliadin, i.e., bind to HLA-DQ2.5/8 forming a complex with the gluten peptide. The antibodies have neutralizing activity against the binding between HLA-DQ2.5/8 and TCR, and thus block the interaction between HLA-DQ2.5/8 and an HLA-DQ2.5/8-restricted CD4+ T cell. The antibodies do not undergo rapid internalization mediated by the invariant chain. These characteristics are particularly useful for treating celiac disease. Thus, the present invention also provides a method of treating celiac disease using the antibodies of the present invention.

公开(公告)号：US20240277864A1

公开(公告)日：2024-08-22

申请号：US18307729

申请日：2023-04-26

申请人： SORRISO PHARMACEUTICALS, INC.

发明人： Scott CROWE ,  Kevin ROBERTS ,  Tim CARLTON ,  Luana MAGGIORE ,  Marion CUBITT ,  Mike WEST ,  Keith RAY

IPC分类号： A61K47/68 ,  A61K9/00 ,  A61K39/00 ,  A61K47/65 ,  A61P1/00 ,  C07K16/24 ,  C07K16/28

CPC分类号： A61K47/6849 ,  A61K9/0053 ,  A61K47/65 ,  A61K47/6845 ,  A61P1/00 ,  C07K16/241 ,  C07K16/2866 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/542 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： There is provided inter alia a composition comprising a TNF-alpha binding polypeptide and an IL-6R binding polypeptide.

公开(公告)号：US20240277739A1

公开(公告)日：2024-08-22

申请号：US18570652

申请日：2022-07-01

申请人： N.V. Nutricia

发明人： Selma Paulien Wiertsema ,  Saskia Adriana Overbeek ,  Ingrid Brunhilde Renes ,  Lauriane Emmanuelle Melanie Schwebel

IPC分类号： A61K31/702 ,  A23L33/00 ,  A23L33/12 ,  A61K31/201 ,  A61P1/00

CPC分类号： A61K31/702 ,  A23L33/12 ,  A23L33/40 ,  A61K31/201 ,  A61P1/00

摘要： The present invention concerns nutritional compositions for infants and young children that are high in oleic acid and low in palmitic acid and comprise galacto-oligosaccharides, in particular including beta1,3′-galactosyllactose. The nutritional compositions are particularly advantageous for improving intestinal barrier function.