公开(公告)号：US20220346376A1

公开(公告)日：2022-11-03

申请号：US17852788

申请日：2022-06-29

申请人： Bayer CropScience Aktiengesellschaft ,  Bayer Aktiengesellschaft

发明人： Friedrich KERZ-MOEHLENDICK ,  Sybille LAMPRECHT ,  Klaus TIETJEN

IPC分类号： A01N43/40 ,  C07D213/79

摘要： The present invention relates to the use of compound (A) according to formula (I) having the chemical name: 3-chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid) for inducing positive growth responses in plants, a composition comprising compound (A) and a new method of plant treatment wherein is compound (A) applied to a plant, a plant part, plant propagation material or the habitat the plant is growing in to induce positive growth responses.

公开(公告)号：US11299982B2

公开(公告)日：2022-04-12

申请号：US16252133

申请日：2019-01-18

申请人： Saudi Arabian Oil Company

发明人： Hooisweng Ow ,  Rena Shi ,  Jason R. Cox ,  Sehoon Chang

IPC分类号： E21B43/16 ,  E21B47/11 ,  C09K8/03 ,  C09K11/07 ,  C07D213/55 ,  C07D213/79 ,  C07D213/89 ,  C07D401/04 ,  C07D471/04 ,  E21B49/08 ,  G01N21/64

摘要： Analyzing a fluid extracted from a reservoir includes introducing a first composition featuring a first complexing agent into a reservoir at a first location, extracting a fluid from the reservoir at a second location different from the first location, combining the fluid with a second composition featuring a concentration of a lanthanide ion to form a third composition featuring a concentration of a complex formed by the first complexing agent and the lanthanide ion, exposing a quantity of the complex to electromagnetic radiation for a first time period ending at a time t0, detecting fluorescence emission from the quantity of the complex for a second time period starting at a time t1>t0, where t1-t0 is greater than 2 microseconds, and determining information about a fluid flow path between the first location and the second location.

公开(公告)号：US20210079017A1

公开(公告)日：2021-03-18

申请号：US16947214

申请日：2020-07-23

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Roland Gendron ,  Melissa Fleury ,  Adam D. Hughes

IPC分类号： C07D498/08 ,  C07D213/81 ,  C07D231/14 ,  C07D233/26 ,  C07D233/90 ,  C07D237/24 ,  C07D239/34 ,  C07D241/24 ,  C07D249/04 ,  C07D249/10 ,  C07D249/18 ,  C07D257/04 ,  C07D261/20 ,  C07D263/34 ,  C07D271/06 ,  C07D277/56 ,  C07D307/68 ,  C07D333/70 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/12 ,  C07D409/06 ,  C07D471/04 ,  C07D498/04 ,  C07D261/18 ,  C07D207/34 ,  C07D239/36 ,  C07D413/06 ,  A61K31/42 ,  A61K31/422 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/04 ,  C07D413/12 ,  C07D213/79 ,  C07D213/80 ,  C07D237/04 ,  C07D249/08 ,  C07D249/12 ,  C07D261/12 ,  C07D263/56 ,  C07D277/46 ,  C07D333/40

摘要： In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

公开(公告)号：US20210046070A1

公开(公告)日：2021-02-18

申请号：US17075199

申请日：2020-10-20

申请人： Landos Biopharma, Inc.

发明人： Josep Bassaganya-Riera ,  Adria Carbo Barrios ,  Richard Gandour ,  Julian D. Cooper ,  Raquel Hontecillas

IPC分类号： A61K31/496 ,  C07D403/12 ,  C07D413/14 ,  C07D413/12 ,  C07D213/69 ,  C07D307/60 ,  C07D401/14 ,  C07C65/40 ,  C07D213/79 ,  C07D307/68 ,  C07D403/14 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/4439

摘要： Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including infectious disease, autoimmune disease, diabetes, and a chronic inflammatory disease.

公开(公告)号：US10807956B2

公开(公告)日：2020-10-20

申请号：US16782275

申请日：2020-02-05

申请人： CELGENE QUANTICEL RESEARCH, INC.

发明人： Young K. Chen ,  Toufike Kanouni ,  Zhe Nie ,  Jeffrey Alan Stafford ,  James Marvin Veal ,  Michael Brennan Wallace

IPC分类号： C07D213/79 ,  C07D213/74 ,  C07D213/81 ,  C07D237/24 ,  C07D401/04 ,  C07D401/12 ,  C07D405/14 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14

摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

公开(公告)号：US10787421B2

公开(公告)日：2020-09-29

申请号：US16248110

申请日：2019-01-15

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人： Carl Wagner ,  Peter Jurutka ,  Pamela Marshall

IPC分类号： A61K31/136 ,  C07C211/48 ,  C07D239/42 ,  C07D213/79 ,  C07D237/24 ,  C07D241/28 ,  C07C229/60 ,  C07D213/80

摘要： The invention provides compounds formula (I) and salts thereof: wherein R1-R4 have any of the values defined in the specification. The compounds are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, inflammation, hyperresponsiveness, allergic conditions, asthma, and psychotic disorders such as schizophrenia. The compounds are also useful to lower IL-4, IL-5, or IL-15 levels in an animal.

公开(公告)号：US20200261447A1

公开(公告)日：2020-08-20

申请号：US16866169

申请日：2020-05-04

申请人： Landos Biopharma, Inc.

发明人： Josep Bassaganya-Riera ,  Adria Carbo Barrios ,  Richard Gandour ,  Julian D. Cooper ,  Raquel Hontecillas

IPC分类号： A61K31/496 ,  A61K31/4439 ,  A61K31/423 ,  A61K31/4184 ,  C07D403/14 ,  C07D307/68 ,  C07D213/79 ,  C07C65/40 ,  C07D401/14 ,  C07D307/60 ,  C07D213/69 ,  C07D413/12 ,  C07D413/14 ,  C07D403/12

摘要： Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including infectious disease, autoimmune disease, diabetes, and a chronic inflammatory disease.

公开(公告)号：US10682349B2

公开(公告)日：2020-06-16

申请号：US16653446

申请日：2019-10-15

申请人： Landos Biopharma, Inc.

发明人： Josep Bassaganya-Riera ,  Adria Carbo Barrios ,  Richard Gandour ,  Julian D. Cooper ,  Raquel Hontecillas

IPC分类号： C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  A61K31/496 ,  C07D213/69 ,  C07D307/60 ,  C07C65/40 ,  C07D213/79 ,  C07D307/68 ,  C07D403/14 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/4439

摘要： Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including infectious disease, autoimmune disease, diabetes, and a chronic inflammatory disease.

公开(公告)号：US20200039938A1

公开(公告)日：2020-02-06

申请号：US16498714

申请日：2018-03-27

申请人： ALBERT-LUDWIGS-UNIVERSITY FREIBURG ,  CELGENE QUANTICEL RESEARCH, INC.

发明人： Roland Schüle ,  Eric Metzger

IPC分类号： C07D213/79 ,  A61P35/00

摘要： The present disclosure relates generally to compounds and methods for inhibiting the enzymatic activity of lysine demethylase 4 (KDM4) and treating cancer. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibiting lysine demethylase 4. Furthermore, the subject compounds and compositions are useful for the treatment of breast cancer and the like.

公开(公告)号：US20190169130A1

公开(公告)日：2019-06-06

申请号：US16270981

申请日：2019-02-08

申请人： University of South Florida ,  The Regents of the University of Michigan

发明人： Michael J. Zaworotko ,  Nair Rodriguez-Hornedo ,  Brian Moulton

IPC分类号： C07D223/26 ,  C07C53/08 ,  A61K9/16 ,  C07C57/30 ,  C07C57/58 ,  C07C61/135 ,  C07C63/307 ,  C07C69/157 ,  C07C205/57 ,  C07C233/03 ,  C07C233/75 ,  C07C317/04 ,  C07D213/06 ,  C07D213/22 ,  C07D275/06 ,  C07D213/79 ,  C07D213/69 ,  C07D213/82 ,  C07C47/544 ,  C07C53/02 ,  C07D233/74 ,  C07C233/25 ,  C07C51/43 ,  C07C51/41 ,  A61K47/32 ,  A61K47/10 ,  A61K31/616 ,  A61K31/55 ,  A61K31/4166 ,  A61K31/192 ,  A61K31/167 ,  C07C53/124

摘要： The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention also pertains to multiple-component phase compositions comprising one or more pharmaceutical entities and methods for producing such compositions.