公开(公告)号：US11708592B2

公开(公告)日：2023-07-25

申请号：US17120005

申请日：2020-12-11

申请人： Genomatica, Inc.

发明人： Anthony P. Burgard ,  Robin E. Osterhout ,  Priti Pharkya ,  Mark J. Burk

IPC分类号： C12P17/08 ,  C12N15/70 ,  C08G63/08 ,  C07D313/04 ,  C12N15/63 ,  C12P17/02 ,  C08G18/42 ,  C12N5/00 ,  C12N15/52

CPC分类号： C12P17/08 ,  C07D313/04 ,  C08G18/4277 ,  C08G63/08 ,  C12N5/0018 ,  C12N15/52 ,  C12N15/63 ,  C12N15/70 ,  C12P17/02

摘要： The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. The invention additionally provides methods of using such microbial organisms to produce caprolactone by culturing a non-naturally occurring microbial organism containing caprolactone pathways as described herein under conditions and for a sufficient period of time to produce caprolactone.

公开(公告)号：US20220037697A1

公开(公告)日：2022-02-03

申请号：US17506142

申请日：2021-10-20

申请人： CONTEMPORARY AMPEREX TECHNOLOGY CO., LIMITED

发明人： Zeli WU ,  Changlong HAN ,  Chenghua FU

IPC分类号： H01M10/0567 ,  H01M10/0569 ,  H01M4/38 ,  H01M4/505 ,  H01M4/525 ,  C07D307/60 ,  C07D309/32 ,  C07D313/04 ,  C07F9/09

摘要： This application provides a secondary battery and a device comprising the same. The secondary battery includes a negative electrode plate and an electrolyte. The negative electrode plate includes a negative electrode active material. The electrolyte includes an electrolyte salt, an organic solvent, and an additive. The negative electrode active material includes a silicon-based material. The organic solvent includes ethylene carbonate (EC) and diethyl carbonate (DEC). A mass ratio of EC in the organic solvent is less than or equal to 20%, and a mass ratio of DEC in the organic solvent is less than or equal to 20%. The additive includes an additive A and an additive B. The additive A is selected from one or more of compounds represented by Formula 1 or Formula 2, and the additive B is selected from one or more of compounds represented by Formula 3, as described in the application.

公开(公告)号：US20210230176A1

公开(公告)日：2021-07-29

申请号：US17143326

申请日：2021-01-07

申请人： ENANTA PHARMACEUTICALS, INC.

发明人： Yao-Ling Qiu ,  Xuri Gao ,  Wei Li ,  Hui Cao ,  Meizhong Jin ,  Jorden Kass ,  Xiaowen Peng ,  Yat Sun Or

IPC分类号： C07D493/08 ,  C07C317/44 ,  C07C323/62 ,  A61K31/167 ,  A61K31/18 ,  A61K31/196 ,  A61K31/215 ,  A61K31/223 ,  A61K31/277 ,  A61K31/325 ,  A61K31/335 ,  A61K31/336 ,  A61K31/341 ,  A61K31/351 ,  A61K31/357 ,  A61K31/365 ,  A61K31/39 ,  A61K31/401 ,  A61K31/41 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4164 ,  A61K31/421 ,  A61K31/426 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4409 ,  A61K31/4425 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/655 ,  C07B59/00 ,  C07C235/56 ,  C07C311/53 ,  C07C317/32 ,  C07C323/42 ,  C07D207/16 ,  C07D211/54 ,  C07D213/52 ,  C07D213/81 ,  C07D213/89 ,  C07D231/12 ,  C07D233/64 ,  C07D257/04 ,  C07D261/02 ,  C07D261/08 ,  C07D261/20 ,  C07D263/52 ,  C07D277/26 ,  C07D295/088 ,  C07D303/26 ,  C07D303/34 ,  C07D307/32 ,  C07D307/33 ,  C07D309/08 ,  C07D313/04 ,  C07D317/72 ,  C07D327/10 ,  C07D401/04 ,  C07D451/04 ,  C07D493/04

摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-L-R  (I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US10731079B2

公开(公告)日：2020-08-04

申请号：US16393499

申请日：2019-04-24

申请人： International Business Machines Corporation

发明人： Eric J. Campbell ,  Sarah K. Czaplewski ,  Brandon M. Kobilka ,  Jason T. Wertz

IPC分类号： C09K21/12 ,  C07D313/02 ,  C08K5/02 ,  C08K5/04 ,  C09K21/14 ,  C07D313/04 ,  C07F9/655 ,  C07F9/09 ,  C08G63/682 ,  C08G63/692 ,  C08F4/16 ,  C08G63/08

摘要： A process for forming a flame retardant polymer, as well as the flame retardant polymer, are disclosed. A flame retardant polymer is a polymer that can be resistant to thermal degradation and/or thermal oxidation. A flame retardant polymer can be mixed or otherwise incorporated into a standard polymer to give flame retardancy to the standard polymer. The flame retardant polymers can include polycaprolactone functionalized with flame retardant substituents. The flame retardant substituents can include halides, substituted phosphoryl, and substituted phosphonyl.

公开(公告)号：US09944617B2

公开(公告)日：2018-04-17

申请号：US15101277

申请日：2014-12-02

申请人： Council of Scientific and Industrial Research

发明人： Satyanarayana Vera Venkata Chilukuri ,  Narasimharao Kanna ,  Lakshmiprasad Gurrala

IPC分类号： C07C45/33 ,  C07C51/31 ,  C07D313/04 ,  B01J27/24

CPC分类号： C07D313/04 ,  B01J27/24 ,  C07C45/33 ,  C07C51/313 ,  C07C55/14 ,  C07C49/04

摘要： The present invention discloses an improved oxidation process using carbon nitride nanotubes as metal free catalyst and molecular O2 as the oxidant to obtain desired adipic acid and other oxygenated hydrocarbons with improved conversion and selectivity.

公开(公告)号：US09765048B2

公开(公告)日：2017-09-19

申请号：US15167298

申请日：2016-05-27

申请人： Council of Scientific and Industrial Research

发明人： Varun Rawat ,  Soumen Dey ,  Anil Maruti Shelke ,  Gurunath Mallappa Suryavanshi ,  Arumugam Sudalai

IPC分类号： C07D313/04 ,  C07D313/00

CPC分类号： C07D313/00 ,  C07B2200/07

摘要： The present invention discloses organocatalytic process for asymmetric synthesis of highly enantioselective decanolide compounds in high yield with >99% ee. Further, the present invention disclose cost effective, improved organocatalytic process for asymmetric synthesis of highly enantioselective decanolides compounds from non-chiral, cheap, easily available raw materials.

公开(公告)号：US09719118B2

公开(公告)日：2017-08-01

申请号：US14995069

申请日：2016-01-13

申请人： Genomatica, Inc.

发明人： Anthony P. Burgard ,  Robin E. Osterhout ,  Priti Pharkya ,  Mark J. Burk

IPC分类号： C08G63/02 ,  C12P17/08 ,  C12N15/70 ,  C07D313/04 ,  C12N15/63 ,  C12P17/02 ,  C08G18/42 ,  C12N5/00 ,  C08G63/08 ,  C12N15/52

CPC分类号： C12P17/08 ,  C07D313/04 ,  C08G18/4277 ,  C08G63/08 ,  C12N5/0018 ,  C12N15/52 ,  C12N15/63 ,  C12N15/70 ,  C12P17/02

摘要： The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. The invention additionally provides methods of using such microbial organisms to produce caprolactone by culturing a non-naturally occurring microbial organism containing caprolactone pathways as described herein under conditions and for a sufficient period of time to produce caprolactone.

公开(公告)号：US09353077B2

公开(公告)日：2016-05-31

申请号：US14426305

申请日：2013-09-06

申请人： Council of Scientific and Industrial Research

发明人： Varun Rawat ,  Soumen Dey ,  Anil Maruti Shelke ,  Gurunath Mallappa Suryavanshi ,  Arumugam Sudalai

IPC分类号： C07D313/04 ,  C07D313/00

CPC分类号： C07D313/00 ,  C07B2200/07

摘要： The present invention discloses organocatalytic process for asymmetric synthesis of highly enantioselective decanolide compounds in high yield with >99% ee. Further, the present invention disclose cost effective, improved organocatalytic process for asymmetric synthesis of highly enantioselective decanolides compounds from non-chiral, cheap, easily available raw materials.

摘要翻译： 本发明公开了以高达99％ee的高产率非对称合成高对映选择性癸内酯化合物的有机催化方法。 此外，本发明公开了从非手性的，便宜的，容易获得的原料不对称合成高度对映选择性的癸内酯化合物的成本有效的改进的有机催化方法。

公开(公告)号：US08987497B2

公开(公告)日：2015-03-24

申请号：US14072179

申请日：2013-11-05

申请人： BASF SE

发明人： Nicolas Vautravers ,  Joaquim Henrique Teles ,  Andrei-Nicolae Parvulescu ,  Ulrich Müller

IPC分类号： C07C69/74 ,  C07D313/04 ,  C07C51/285 ,  C07D309/30 ,  C07D313/00 ,  B01J23/00 ,  C07C45/54

CPC分类号： C07D313/04 ,  B01J23/00 ,  C07C45/54 ,  C07C51/285 ,  C07D309/30 ,  C07D313/00 ,  C07C47/21 ,  C07C57/03

摘要： A process for the oxidation of an organic carbonyl compound comprising reacting the organic carbonyl compound, optionally in the presence of a solvent, with hydrogen peroxide in the presence of a catalyst comprising a tin-containing zeolitic material having an MWW-type framework structure.

摘要翻译： 一种有机羰基化合物的氧化方法，包括有机羰基化合物，任选在溶剂存在下，在含有具有MWW型骨架结构的含锡沸石材料的催化剂存在下，与过氧化氢反应。

公开(公告)号：US08946224B2

公开(公告)日：2015-02-03

申请号：US13883713

申请日：2011-11-11

申请人： Mark Craighead ,  Ronald Palin ,  Neil Murray ,  Derek Lindsay

发明人： Mark Craighead ,  Ronald Palin ,  Neil Murray ,  Derek Lindsay

IPC分类号： A61K31/4985 ,  C07D487/04 ,  C07D498/06 ,  C07D413/12 ,  C07C63/64 ,  C07D213/60 ,  C07C217/58 ,  C07D403/06 ,  C07C69/12 ,  C07C235/16 ,  C07D257/04 ,  C07D313/04 ,  C07D407/06 ,  C07C43/205 ,  C07C215/46 ,  C07C255/25 ,  C07D205/08 ,  C07D281/06 ,  C07D417/06 ,  C07D413/04 ,  C07D401/04 ,  C07C63/66 ,  C07D499/88 ,  C07D401/12 ,  C07D519/00 ,  C07D209/18 ,  C07D307/00 ,  C07D501/00 ,  C07C233/22 ,  C07D473/00 ,  C07H19/052 ,  C07C251/40 ,  C07D403/12 ,  C07D513/06 ,  C07C251/54 ,  C07C257/14 ,  C07C251/48 ,  C07C57/00 ,  C07C233/36 ,  C07H19/173 ,  C07D411/10 ,  C07C229/18 ,  C07D295/02 ,  C07H19/06 ,  C07C235/28 ,  C07D233/54 ,  C07J5/00 ,  C07D471/04 ,  C07D241/04 ,  C07D235/16 ,  C07D277/40 ,  C07D417/12 ,  C07D309/32 ,  C07C237/20 ,  C07C251/58 ,  C07D401/14 ,  C07D491/04

CPC分类号： C07D487/04 ,  C07C43/205 ,  C07C57/00 ,  C07C63/64 ,  C07C63/66 ,  C07C69/12 ,  C07C215/46 ,  C07C217/58 ,  C07C229/18 ,  C07C233/22 ,  C07C233/36 ,  C07C235/16 ,  C07C235/28 ,  C07C237/20 ,  C07C251/40 ,  C07C251/48 ,  C07C251/54 ,  C07C251/58 ,  C07C255/25 ,  C07C257/14 ,  C07C2601/16 ,  C07C2602/10 ,  C07C2603/74 ,  C07D205/08 ,  C07D209/18 ,  C07D213/60 ,  C07D233/54 ,  C07D235/16 ,  C07D241/04 ,  C07D257/04 ,  C07D277/40 ,  C07D281/06 ,  C07D295/02 ,  C07D307/00 ,  C07D309/32 ,  C07D313/04 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D407/06 ,  C07D411/10 ,  C07D413/04 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D491/04 ,  C07D498/06 ,  C07D499/88 ,  C07D501/00 ,  C07D513/06 ,  C07D519/00 ,  C07H19/052 ,  C07H19/06 ,  C07H19/173 ,  C07J5/00 ,  C07J71/0031

摘要： The present invention relates to derivatives of known active pharmaceutical compounds. These derivatives are differentiated from the parent active compound by virtue of being redox derivatives of the active compound. This means that one or more of the functional groups in the active compound has been converted to another group in one or more reactions which may be considered to represent a change of oxidation state. We refer to these compounds generally as redox derivatives. The derivatives of the invention may be related to the original parent active pharmaceutical compound by only a single step transformation, or may be related via several synthetic steps including one or more changes of oxidation state. Exemplary derivatives have the formula

摘要翻译： 本发明涉及已知的活性药物化合物的衍生物。 由于活性化合物的氧化还原衍生物，这些衍生物与母体活性化合物不同。 这意味着活性化合物中的一个或多个官能团已经在一个或多个反应中被转化为另一个基团，这可被认为代表氧化态的变化。 我们通常将这些化合物称为氧化还原衍生物。 本发明的衍生物可以仅通过单步转化与原始的母体活性药物化合物相关，或者可以通过包括氧化态的一个或多个变化的几个合成步骤相关。 示例性衍生物具有式