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公开(公告)号：US11896574B2
公开(公告)日：2024-02-13
申请号：US16805795
申请日：2020-03-01
发明人： Dania Birte Reiche , Silke Haag-Diergarten , Leah Jeanette Hennings , Saskia Kley , Anne M. Traas
IPC分类号： A61K31/351 , A61P3/10 , A61K38/28 , A61K31/7034 , C07D309/10 , C07H7/04 , A61K31/7042 , C07D493/10 , C07D493/08 , A61P3/06 , A61P31/12 , A61K31/357 , A61P9/12 , A61K31/381 , A61K31/7056 , C07H17/02 , C07D335/02 , A61K31/35 , A61K47/22 , C07D333/12 , A61P5/50 , A61P3/04 , C07H17/00 , C07H5/10 , A61P3/00 , C07H15/203 , A61P29/00 , C07D333/56
CPC分类号： A61K31/351 , A61K31/35 , A61K31/357 , A61K31/381 , A61K31/7034 , A61K31/7042 , A61K31/7056 , A61K38/28 , A61K47/22 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/50 , A61P9/12 , A61P29/00 , A61P31/12 , C07D309/10 , C07D333/12 , C07D333/56 , C07D335/02 , C07D493/08 , C07D493/10 , C07H5/10 , C07H7/04 , C07H15/203 , C07H17/00 , C07H17/02
摘要： The present invention relates to one or more SGLT2 inhibitors or pharmaceutically acceptable forms thereof for use in the treatment and/or prevention of a metabolic disorder in a feline animal, preferably wherein the metabolic disorder is one or more selected from the group consisting of: ketoacidosis, pre-diabetes, diabetes mellitus type 1 or type 2, insulin resistance, obesity, hyperglycemia, impaired glucose tolerance, hyperinsulinemia, dyslipidemia, dysadipokinemia, subclinical inflammation, systemic inflammation, low grade systemic inflammation, hepatic lipidosis, atherosclerosis, inflammation of the pancreas, neuropathy and/or Syndrome X (metabolic syndrome) and/or loss of pancreatic beta cell function and/or wherein the remission of the metabolic disorder, preferably diabetic remission, is achieved and/or maintained.
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公开(公告)号：US20230121865A1
公开(公告)日：2023-04-20
申请号：US17909317
申请日：2021-02-25
申请人： National University Corporation Tokai National Higher Education and Research System , Taoka Chemical Co., Ltd.
发明人： Kenichiro ITAMI , Hideto ITO , Kaho MATSUSHIMA , Kazuo MURAKAMI , Hidefumi NAKATSUJI , Shunsuke ISHIDA
IPC分类号： C07D495/14 , C07F7/08 , C07C25/22 , C07C17/26 , C07D333/12 , C07C309/65
摘要： Provided is a method that allows for a safer production of a naphthylsilole for use as a starting material for GNR, which involves reacting a compound of formula (1): (wherein R1a and R1b are the same or different and represent a hydrogen atom, an alkyl group, a cycloalkyl group, a (poly)ether group, an ester group, a halogen atom, an aromatic hydrocarbon group, or a heterocyclic group; R1a and R1b are optionally bound to each other to form a ring; R2 represents an aromatic hydrocarbon ring or a heterocyclic ring; and X represents a bromine or iodine atom) with a lanthanide- and lithium-containing ate complex to produce a lanthanide complex of the compound of formula (1); and then reacting it with a silyl compound of formula (2): R3aR3bSiCl2 (2) (wherein R3a and R3b are the same or different and represent an optionally branched C1-C4 alkyl group or a phenyl group).
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公开(公告)号：US11124524B2
公开(公告)日：2021-09-21
申请号：US16374571
申请日：2019-04-03
申请人： Solutia Canada Inc.
发明人： Neil Robin Branda , Jeremy Graham Finden , Simon James Gauthier , Ali Hayek , Kyle Andrew Hope-Ross , James Daniel Senior , Andreea Spantulescu , Serguei Sviridov
IPC分类号： C07D495/04 , C07F7/18 , C07D409/14 , C07D493/14 , C07D333/22 , C07D333/38 , C07D495/14 , C07D519/00 , C07F7/08 , C07D493/22 , C07D333/18 , C07D513/14 , G02B5/22 , C07D493/04 , C07D513/04 , C09K9/02 , G02B1/04 , C07D333/12 , C07D277/22 , C07D307/79 , G02B5/20 , G02B5/23
摘要： A compound according to Formula IA and IB, reversibly convertible under photochromic and electrochromic conditions between a ring-open isomer A and a ring-closed isomer B is provided. For substitutent groups, Z is N, O or S; each R1 is independently selected from the group consisting of H, or halo; each R2 is independently selected from the group consisting of H, halo, a polymer backbone, alkyl or aryl; or, when both R2 together form —CH═CH— and form part of a polymer backbone; each R3 is independently selected from the group consisting of H, halo, alkyl, alkoxy, thioalkyl or aryl; each R4 is aryl; and each R5 is independently selected from the group consisting of H, halo, alkyl, alkoxy, thioalkyl or aryl.
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公开(公告)号：US10239857B2
公开(公告)日：2019-03-26
申请号：US15563008
申请日：2016-03-31
IPC分类号： C07D271/06 , C07D333/38 , C07D333/22 , C07D333/12
摘要： Provided herein are processes for the preparation of 2-thiophenecarbonyl chloride, which is useful, for example, in the preparation of 3,5-disubstituted-1,2,4-oxadiazoles, such as tioxazafen (3-phenyl-5-(2-thienyl)-1,2,4-oxadiazole).
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![FUNGICIDAL N-CYCLOALKYL-N-{[ORTHO-(1-SUBSTITUTED-CYCLOALKYL)HETEROARYL]METHYL}PYRAZOLE(THIO)CARBOXAMIDS](/abs-image/US/2018/05/24/US20180139962A1/abs.jpg.150x150.jpg)
5.发明申请公开(公告)号：US20180139962A1
公开(公告)日：2018-05-24
申请号：US15575064
申请日：2016-05-19
发明人： Pierre CRISTAU , Philippe DESBORDES , Julie GEIST , Lionel NICOLAS , Philippe RINOLFI , Jan Peter SCHMIDT , Tomoki TSUCHIYA
IPC分类号： A01N43/56 , C07D333/12 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/24 , C07D401/12 , C07D409/12 , C07D409/14
CPC分类号： A01N43/56 , C07D333/12 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/24 , C07D401/12 , C07D409/12 , C07D409/14
摘要： The invention relates to fungicidal N-cycloalkyl-N-{[ortho-(1-substituted-cycloalkyl)heteroaryl]methyl}carboxamides and their thiocarbonyl derivatives of formula (I), their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions, and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
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公开(公告)号：US09321769B2
公开(公告)日：2016-04-26
申请号：US14703004
申请日：2015-05-04
申请人： FAB PHARMA S.A.S.
发明人： Vincent Gerusz , Sonia Escaich , Mayalen Oxoby , Alexis Denis
IPC分类号： C07D487/00 , C07D498/00 , C07D487/22 , C07D471/04 , C07D211/22 , C07D205/04 , C07D207/12 , C07D413/04 , C07D333/12 , C07D409/12 , C07D277/22 , C07D417/12 , C07D239/26 , C07D403/12 , C07D213/73 , C07D401/12
CPC分类号： C07D471/04 , C07D205/04 , C07D207/12 , C07D211/22 , C07D213/73 , C07D239/26 , C07D277/22 , C07D333/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/04 , C07D417/12 , C07D471/20
摘要： The invention relates to novel heterocyclic acrylamide compounds (I), to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments and pharmaceutical compositions containing the compounds.
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公开(公告)号：US20150232466A1
公开(公告)日：2015-08-20
申请号：US14703004
申请日：2015-05-04
申请人： FAB PHARMA S.A.S.
发明人： Vincent GERUSZ , Sonia ESCAICH , Mayalen OXOBY , Alexis DENIS
IPC分类号： C07D471/04 , C07D205/04 , C07D207/12 , C07D413/04 , C07D333/12 , C07D401/12 , C07D277/22 , C07D417/12 , C07D239/26 , C07D403/12 , C07D213/73 , C07D211/22 , C07D409/12
CPC分类号： C07D471/04 , C07D205/04 , C07D207/12 , C07D211/22 , C07D213/73 , C07D239/26 , C07D277/22 , C07D333/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/04 , C07D417/12 , C07D471/20
摘要： The invention relates to novel heterocyclic acrylamide compounds (I), to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments and pharmaceutical compositions containing the compounds.
摘要翻译： 本发明涉及新型杂环丙烯酰胺化合物（I），用于制备其中使用的化合物和中间体，以及该化合物用作抗菌药物和含有该化合物的药物组合物。
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公开(公告)号：US09087996B2
公开(公告)日：2015-07-21
申请号：US14460177
申请日：2014-08-14
IPC分类号： H01L51/00 , C07C43/225 , C09K11/06 , C07C35/52 , C07D333/12 , H05B33/10 , C07C17/35 , C07C41/30 , C07C29/09
CPC分类号： H01L51/0055 , C07C17/35 , C07C29/09 , C07C35/52 , C07C41/30 , C07C43/225 , C07C2603/24 , C07C2603/52 , C07D333/12 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1092 , H01L51/0052 , H01L51/0068 , H05B33/10 , C07C22/08 , C07C25/22
摘要： A method of manufacturing a fluorine-containing aromatic compound represented by the following formula (2-1) or formula (2-2): R1 is a linear perfluoroalkyl group having a carbon number of 1 to 3; X2 to X5 are a halogen atom or a hydrogen atom; R2 to R5, L1 and L2 are a monovalent hydrocarbon group having a carbon number of 1 to 12, a monovalent aromatic hydrocarbon group, a monovalent hetero aromatic group, a halogen atom, or a hydrogen atom; one or more groups selected from R2 to R5 are a monovalent hydrocarbon group having a carbon number of 1 to 12, a monovalent aromatic hydrocarbon group, or a monovalent heteroaromatic group; and m is an integer of 0 or more, n is an integer of 1 or more, and m+n is an integer of 2 or more and 6 or less.
摘要翻译： 由下式（2-1）或式（2-2）表示的含氟芳香族化合物的制造方法：R1是碳数为1〜3的直链全氟烷基; X 2〜X 5为卤原子或氢原子; R 2〜R 5，L 1和L 2为碳数为1〜12的一价烃基，1价芳香族烃基，1价杂芳基，卤素原子或氢原子。 一个或多个选自R 2至R 5的基团是碳数为1至12的一价烃基，一价芳族烃基或一价杂芳基; m为0以上的整数，n为1以上的整数，m + n为2以上6以下的整数。
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公开(公告)号：US07902394B2
公开(公告)日：2011-03-08
申请号：US12518482
申请日：2007-12-18
IPC分类号： C07C229/00 , C07D333/12 , A01N37/10
CPC分类号： C07C229/34 , C07C323/32 , C07C2602/08 , C07D333/20
摘要： Novel calcilytic compounds of Formula (I), pharmaceutical compositions, methods of synthesis, and methods of using them are provided.
摘要翻译： 提供式（I）的新型钙质化合物，药物组合物，合成方法及其使用方法。
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公开(公告)号：US20110049427A1
公开(公告)日：2011-03-03
申请号：US12989220
申请日：2009-03-30
申请人： Axel Jansen , Detlef Pauluth , Harald Hirschmann , Markus Czanta
发明人： Axel Jansen , Detlef Pauluth , Harald Hirschmann , Markus Czanta
IPC分类号： C09K19/34 , C07D333/12 , C07D333/22
CPC分类号： C09K19/3491 , C07D333/12 , C07D333/38 , C09K19/42 , C09K2019/0448 , C09K2019/0466 , Y10T428/10 , Y10T428/1036
摘要： The present invention relates to thiophene derivatives, to processes and intermediates for the preparation thereof, to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, and to LC media and LC displays comprising same.
摘要翻译： 本发明涉及噻吩衍生物，其制备方法和中间体，其用于光学，电光和电子目的，特别是液晶（LC）介质和LC显示器以及LC介质和 LC显示器包括相同的。
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