公开(公告)号：US12012466B2

公开(公告)日：2024-06-18

申请号：US17377338

申请日：2021-07-15

申请人： Hoffmann-La Roche Inc.

发明人： Alexander Alanine ,  Julien Beignet ,  Konrad Bleicher ,  Bernhard Fasching ,  Hans Hilpert ,  Taishan Hu ,  Dwight MacDonald ,  Stephen Jackson ,  Sabine Kolczewski ,  Carsten Kroll ,  Adrian Schaeublin ,  Hong Shen ,  Theodor Stoll ,  Helmut Thomas ,  Amal Wahhab ,  Claudia Zampaloni

IPC分类号： C07K5/08 ,  C07K5/02 ,  C07K5/068 ,  C07K5/083 ,  C07K5/087 ,  C07K5/09 ,  C07K5/097 ,  A61K38/00

CPC分类号： C07K5/0827 ,  C07K5/02 ,  C07K5/06086 ,  C07K5/08 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/081 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/0821 ,  A61K38/00

摘要： The present invention provides compounds of formula (I)






wherein X1 to X8 and R1 to R8 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by Acinetobacter baumannii.

公开(公告)号：US11826387B2

公开(公告)日：2023-11-28

申请号：US17369075

申请日：2021-07-07

申请人： PROTOKINETIX INC.

发明人： Lachlan Grant Young

IPC分类号： A61K35/30 ,  A61K31/16 ,  A61K31/164 ,  C07K14/00 ,  C07K5/08 ,  C07K9/00 ,  A61K31/335 ,  A61P27/00 ,  A61K38/14 ,  C07K5/10

CPC分类号： A61K35/30 ,  A61K31/16 ,  A61K31/164 ,  A61K31/335 ,  A61K38/14 ,  A61P27/00 ,  C07K5/08 ,  C07K5/0827 ,  C07K9/001 ,  C07K14/00 ,  C07K5/1027

摘要： The present disclosure relates to an in vitro method for enhancing engraftment of neurosensory precursor cell comprising the step of contacting an isolated neurosensory precursor cell prior to a transplantation in a subject in need thereof, with a gem-difluorinated C-glycopeptide compound of general formula I, or a pharmaceutically acceptable base, addition salt with an acid, hydrate or solvate thereof:

公开(公告)号：US20230346752A1

公开(公告)日：2023-11-02

申请号：US18181487

申请日：2023-03-09

申请人： Purdue Research Foundation

发明人： Philip Stewart Low ,  Sumit A. Kularatne

IPC分类号： A61K31/426 ,  C07C323/52 ,  C07D207/416 ,  A61K47/54 ,  A61K49/00 ,  A61K51/04 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08 ,  A61K47/64

CPC分类号： A61K31/426 ,  C07C323/52 ,  C07D207/416 ,  A61K47/54 ,  A61K49/0041 ,  A61K49/0043 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0489 ,  A61K47/542 ,  A61K47/548 ,  A61K49/0056 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K49/0052 ,  A61K51/088 ,  A61K47/64 ,  A61K47/547

摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US11717514B2

公开(公告)日：2023-08-08

申请号：US17086063

申请日：2020-10-30

申请人： Purdue Research Foundation

发明人： Philip Stewart Low ,  Sumith A. Kularatne

IPC分类号： A61K31/426 ,  A61K47/54 ,  A61K49/00 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K47/64 ,  C07C323/52 ,  C07D207/416 ,  A61K51/04 ,  A61K51/08

CPC分类号： A61K31/426 ,  A61K31/475 ,  A61K31/4745 ,  A61K47/54 ,  A61K47/542 ,  A61K47/547 ,  A61K47/548 ,  A61K47/64 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0056 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0489 ,  A61K51/088 ,  C07C323/52 ,  C07D207/416 ,  C07K5/08

摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20230065900A1

公开(公告)日：2023-03-02

申请号：US17981862

申请日：2022-11-07

申请人： Alastin Skincare, Inc.

发明人： Alan David WIDGEROW ,  John A. GARRUTO

IPC分类号： C07K5/08 ,  C07K7/06 ,  A61K9/00 ,  A61K31/685 ,  A61K31/351 ,  A61P17/02

摘要： Compositions and methods for modulating inflammation and wound healing are provided.

公开(公告)号：US20230000836A1

公开(公告)日：2023-01-05

申请号：US17573304

申请日：2022-01-11

申请人： Purdue Research Foundation

发明人： Philip Steward Low ,  Sumith A. Kularatne

IPC分类号： A61K31/426 ,  C07C323/52 ,  C07D207/416 ,  A61K47/54 ,  A61K49/00 ,  A61K51/04 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08 ,  A61K47/64

摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US11426473B2

公开(公告)日：2022-08-30

申请号：US15078738

申请日：2016-03-23

申请人： FUJIFILM Corporation ,  PDRadiopharma Inc.

发明人： Hirofumi Fukunaga ,  Hiroyuki Dozono ,  Akihiro Hino ,  Shinobu Oshikiri ,  Akio Nagano

IPC分类号： A61K51/08 ,  C07K5/08 ,  C07K5/10 ,  C07D401/12 ,  A61K51/04 ,  C07D471/04 ,  C07D519/00 ,  C07D401/14 ,  C07D213/75 ,  C07D213/73 ,  C07K5/062

摘要： The present invention provides a compound represented by the formula (1) or a salt thereof, or a complex of the compound or the salt with a metal, in the formula (1), A1 represents a chelate group; R1 represents a hydrogen atom or the like; R2 represents a hydrogen atom or the like; and Z1, Z2, Z3, Z4, and Z5 are the same or different and each represent a nitrogen atom or CR3 or the like wherein R3 represents a hydrogen atom or an optionally substituted C1-6 alkyl group or the like; L1 represents a group represented by the formula (3) wherein R13, R14, R15, and R16 are the same or different and each represent a hydrogen atom or the like; L2 represents an optionally substituted C1-6 alkylene group; and L3 represents an optionally substituted C1-6 alkylene group.

公开(公告)号：US11365219B2

公开(公告)日：2022-06-21

申请号：US16908204

申请日：2020-06-22

申请人： California Institute of Technology

发明人： James R. Heath ,  Rosemary Dyane Rohde ,  Arundhati Nag ,  Samir Das ,  Aiko Umeda

IPC分类号： C07K7/64 ,  A61K49/00 ,  C07K5/06 ,  C07K5/08 ,  A61K51/08 ,  C07K5/10 ,  C07K1/04 ,  C07K7/56 ,  C07K14/00 ,  G01N33/573 ,  G01N33/68

摘要： Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R1, L1, L2, G, M, Y1Y2 and SEQ are as defined herein. Methods associated with preparation and use of such peptides, as well as pharmaceutical compositions comprising such peptides, are also disclosed.

公开(公告)号：US20220160813A1

公开(公告)日：2022-05-26

申请号：US16991534

申请日：2020-08-12

申请人： Purdue Research Foundation

发明人： Vincent Jo Davisson ,  Matthew David Bartolowits ,  Jonathon Michael Gast

IPC分类号： A61K38/06 ,  A61K38/00 ,  C07K5/08 ,  C07K5/087 ,  A61K45/06 ,  C07K5/083

摘要： The present invention relates to series of compounds as an inhibitor targeting Proliferating Cell Nuclear Antigen (PCNA). Pharmaceutical compositions of those compounds and methods of using them in the treatment of cancer are within the scope of this disclosure.

公开(公告)号：US20220144889A1

公开(公告)日：2022-05-12

申请号：US17429429

申请日：2020-02-12

申请人： Sumitomo Dainippon Pharma Co., Ltd.

发明人： Atsushi Suwa

IPC分类号： C07K5/08 ,  A61K47/68 ,  A61P35/00 ,  C07K5/10

摘要： A compound represented by formula (1): wherein b represents an integer of 1 to 5; X represents —NH— or —CO—; Z represents a group represented, for example, by formula (Z-1); R1 represents a hydrogen atom or (AB)m; AB represents a particular amino acid residue, and when there is a plurality of ABs, each AB may be the same as or different from each other and ABs are bonded to each other via an amide bond; m represents an integer of 1 to 9; R2 represents a hydroxy group or (AC)g; AC represents a particular amino acid residue, and when there is a plurality of ACs, each AC may be the same as or different from each other and ACs are bonded to each other via an amide bond; and g represents an integer of 1 to 9, or a salt thereof.