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    Sperm sorting chip and method for sorting sperm using the same
    2.
    发明授权
    Sperm sorting chip and method for sorting sperm using the same 有权

    公开(公告)号：US11491488B2

    公开(公告)日：2022-11-08

    申请号：US16881099

    申请日：2020-05-22

    申请人： NATIONAL YANG MING CHIAO TUNG UNIVERSITY

    发明人： Bor-Ran Li ,  Chung-Hsien Huang

    IPC分类号： B01L3/00 ,  C12M3/06 ,  C12M1/00 ,  C12N5/076 ,  C12N5/00

    摘要： The present invention provides a sperm sorting chip and a method for sorting sperm using the same. Said sperm sorting chip includes: a flow channel structure sequentially configured with a gradually diverging flow field region, a main flow channel, and a gradually converging main flow channel intercommunicated with each other from a first side end to a second side end; a fluid injection port, a semen injection port, and a semen extraction port separately located at the first side end and communicated with a main input channel of the gradual diverging flow field region; and a waste fluid outlet located at the second side end and communicated with the gradually converging main flow channel. The gradually diverging flow field region further includes a plurality of sub-input channels derived from the main input channel and converged into the main flow channel, and the plurality of sub-input channels have a gradually widening channel width at the junction with the main flow channel. By contrast, the gradually converging main flow channel has a gradually narrowing channel width toward the waste fluid outlet.

    A METHOD FOR INCREASING POPULATION OF SPERMATOGONIAL STEM CELLS
    6.
    发明申请
    A METHOD FOR INCREASING POPULATION OF SPERMATOGONIAL STEM CELLS 有权

    公开(公告)号：US20210386792A1

    公开(公告)日：2021-12-16

    申请号：US17416340

    申请日：2018-12-19

    申请人： Dong Ha BHANG

    发明人： Dong Ha Bhang ,  Sandra Sonsuk Ryeom

    IPC分类号： A61K35/52 ,  A61K35/44 ,  C12N5/076 ,  A61P15/00

    摘要： Maintenance of adult tissues depends on stem cell self-renewal in local niches. Spermatogonial stem cells (SSC) are germline adult stem cells necessary for spermatogenesis and fertility. The present invention relates utilization of testicular endothelial cells (TECs) in the SSC niche producing glial cell line-derived neurotrophic factor (GDNF) and other factors to support human and mammal SSCs in long-term culture. The present invention also relates to utilization of five factors sufficient for long-term maintenance of human and mammal SSC colonies in feeder-free cultures. Male cancer survivors after chemotherapy are often infertile since SSCs are highly susceptible to cytotoxic injury. Transplantation of TECs alone is used to restore spermatogenesis in mice after chemotherapy-induced depletion of SSCs.

    GENETICALLY MODIFIED SALMON WHICH PRODUCE STERILE OFFSPRING
    8.
    发明申请
    GENETICALLY MODIFIED SALMON WHICH PRODUCE STERILE OFFSPRING 有权

    公开(公告)号：US20210315188A1

    公开(公告)日：2021-10-14

    申请号：US17282097

    申请日：2019-10-01

    申请人： VESTLANDETS INNOVASJONSSELSKAP AS

    发明人： Anna TROEDSSON-WARGELIUS ,  Rolf Brudvik EDVARDSEN

    IPC分类号： A01K67/027 ,  C12N5/076 ,  C12N5/075 ,  C12N15/90

    摘要： The present invention relates, inter alia, to a process for making modified fish zygotes or early-stage fish embryos (particularly salmon zygotes and salmon embryos), wherein the process comprises (a) modifying the genome of the fish zygote or an early-stage fish embryo to eliminate functional expression of a germ cell survival factor gene (e.g. dead-end, dnd)\ and (b) introducing functional protein or RNA encoded by the germ cell survival factor gene into the zygote or early-stage embryo. The invention also provides fish zygotes, fish embryos, juvenile fish, mature fish and sterile fish which are produced by the processes of the invention.

    METHODS AND PRODUCTS FOR IMPROVING SPERM QUALITY
    9.
    发明申请
    METHODS AND PRODUCTS FOR IMPROVING SPERM QUALITY 有权

    公开(公告)号：US20210145815A1

    公开(公告)日：2021-05-20

    申请号：US16649222

    申请日：2018-09-21

    申请人： THE UNIVERSITY OF ADELAIDE

    发明人： Rebecca, Louise ROBKER ,  Macarena BERMUDEZ GONZALEZ

    IPC分类号： A61K31/4545 ,  C12N5/076 ,  A01N1/02

    摘要： Disclosed are methods and products for improving the quality of sperm, methods for treating subjects to improve sperm quality or improve fertility, and use of sperm with improved quality in assisted reproductive technologies, including exposing the sperm to BGP-15 and/or a derivative thereof, such as BGP-15, propanolol, bimoclomol, arimoclomal, NG94, iroxanadine, and/or a pharmaceutically acceptable derivative, prodrug, solvate, salt, tautomer, stereoisomer, and/or racemate thereof.

    MICROFLUIDICS SYSTEM
    10.
    发明申请
    MICROFLUIDICS SYSTEM 有权

    公开(公告)号：US20210121880A1

    公开(公告)日：2021-04-29

    申请号：US17051927

    申请日：2019-04-30

    申请人： THE UNIVERSITY OF BIRMINGHAM

    发明人： Mozafar Saadat ,  Arran James Richard Hughes ,  Amir Mohammad Hajiyavand

    IPC分类号： B01L3/00 ,  C12N5/076 ,  G01N33/68

    摘要： The disclosure relates to methods and systems for isolating individual sperm from a semen sample using microfluidics. Examples include a microfluidics system for isolating individual sperm from a semen sample, the system including: a first laminar flow channel extending between a first inlet and a first outlet; a second laminar flow channel extending between a second inlet and a second outlet; and a third laminar flow channel extending between the first and second laminar flow channels and having a restriction configured to prevent passage of a single sperm through the third laminar flow channel, wherein flow of a semen sample through the first laminar flow channel at a pressure higher than flow of a liquid medium through the second laminar flow channel results in a single sperm being trapped by the restriction in the third laminar flow channel.