公开(公告)号：US11639917B2

公开(公告)日：2023-05-02

申请号：US16959489

申请日：2019-09-23

申请人： LG Chem, Ltd.

发明人： Joon Seok Lee ,  So Yeon Kim ,  Bumgyu Choi ,  Byoung Hyoun Kim

IPC分类号： G01N30/34 ,  G01N30/36 ,  G01N30/74 ,  G01N30/64

摘要： The present invention relates to a dianhydride analysis method, which can reliably analyze a dianhydride having high reactivity and low solubility. In addition, the present invention can analyze the structure of impurities by separating the impurities on the basis of having a similar retention time in HPLC analysis, and can analyze the purity of the dianhydride with or without chromophores.

公开(公告)号：US20230089762A1

公开(公告)日：2023-03-23

申请号：US17792105

申请日：2021-01-28

申请人： DAYLIGHT SOLUTIONS, INC.

发明人： David Francis Arnone ,  Jeremy Rowlette

IPC分类号： G01N30/74

摘要： A fluid analyzer (214) that analyzes a sample (12) includes (i) an analyzer frame (236); (ii) a module (216) that includes a test cell assembly (242) that receives the sample (12) and a module frame (244) that retains the test cell assembly (242); (iii) a laser assembly (238) that generates a laser beam (239A) that is directed through the test cell assembly (242), the laser assembly (238) being coupled to the analyzer frame (236); (iv) a signal detector assembly (232) that collects a test signal light (239B) transmitted through the test cell assembly (242), the signal detector assembly (232) being coupled to the analyzer frame (236); and (v) a coupler assembly (245) that selectively couples the module frame (244) to the analyzer frame (236).

公开(公告)号：US20230021741A1

公开(公告)日：2023-01-26

申请号：US17788254

申请日：2020-12-09

申请人： INFICON GmbH

发明人： Johann Hellgren ,  Henrik Vennerberg ,  Fredrik Enquist

IPC分类号： G01N30/74 ,  G01N30/38 ,  G01N30/06

摘要： Method for adapting the concentration of a sample gas in a gas mixture to be analysed by a gas chromatograph assembly (10), the gas chromatograph assembly (10) comprising a sample gas inlet (20) for introducing a sample gas to be analysed, a secondary gas inlet (40), a gas chromatograph infrared sensor (12), a gas chromatograph column (26), and a gas chromatograph bypass (28) parallel to the column (26), characterized by a) introducing an amount of sample gas through the sample gas inlet (20), b) introducing an amount of secondary gas through the secondary gas inlet (40), c) mixing the sample gas and the secondary gas to a gas mixture and conducting the gas mixture via the gas chromatograph bypass (28), d) circulating the gas mixture in a gas conducting loop (52) comprising the gas chromatograph bypass (28), the gas chromatograph infrared sensor (12) and not comprising the gas chromatograph column (26), e) analysing the gas mixture thus obtained by means of gas chromatography employing the gas chromatograph column (26) and the gas chromatograph infrared sensor (12).

公开(公告)号：US20230016717A1

公开(公告)日：2023-01-19

申请号：US17862240

申请日：2022-07-11

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Haibo Qiu ,  Zhijie Wu ,  Hongxia Wang ,  Ning Li ,  Jonathan Wert

IPC分类号： G01N33/68 ,  G01N30/72 ,  G01N30/86 ,  G01N30/74 ,  G01N30/34

摘要： Methods for identifying viral protein constituents and quantifying the relative abundance of such viral protein constituents in a sample of viral particles are disclosed. In embodiments, the methods include first-dimension chromatography to separate intact viral capsid components of the sample, online denaturation of the viral capsid components to produce intact viral proteins, second-dimension chromatography to separate the viral proteins, and mass spectrometry to determine the masses of the viral proteins and identify the viral protein constituents of the sample.

公开(公告)号：US11519851B2

公开(公告)日：2022-12-06

申请号：US16332527

申请日：2017-09-15

申请人： C Technologies Inc.

发明人： Craig Harrison ,  Ramsey Shanbaky

IPC分类号： G01N21/33 ,  G01N21/03 ,  G01N21/05 ,  B01D15/20 ,  B01D35/02 ,  G01N30/50 ,  G01N21/27 ,  G01N30/74 ,  G01N30/88 ,  B01D65/10 ,  B01D57/02 ,  G01N27/447 ,  G01N30/46 ,  B01D61/20 ,  G01N21/17

摘要： The present invention relates to methods for determining the change in concentration of a substance in solution over time by continuously monitoring in real time. In particular, the present invention relates to methods for continuously monitoring the concentration of compounds during the manufacturing process of biomolecules.

公开(公告)号：US20220381748A1

公开(公告)日：2022-12-01

申请号：US17627066

申请日：2020-07-17

申请人： BioNTech SE

发明人： Heinrich HAAS ,  Tijana BACIC ,  Jens SCHUMACHER

IPC分类号： G01N30/00 ,  G01N15/02 ,  G01N30/74

摘要： The present disclosure relates generally to the field of analyzing a nucleic acid, such as RNA, in particular to the determination of at least one parameter of a sample composition comprising a nucleic acid, especially RNA, and optionally particles.

公开(公告)号：US11493449B2

公开(公告)日：2022-11-08

申请号：US16539102

申请日：2019-08-13

申请人： Shimadzu Corporation

发明人： Takuya Isoi ,  Yasuhiro Kimoto

IPC分类号： G01N21/76 ,  G01N30/74 ,  G01N30/02

摘要： When an operation receiver receives an operation for starting automatic start-up processing, a display controller causes a display to display a first direction image indicating a working order of a plurality of objects to be controlled, sequentially changes a display mode of a status image corresponding to an object that has worked to a first mode, and changes a display state of each of a plurality of operation images to an operable first state or an inoperable second state. When the operation receiver receives an operation for starting automatic stop processing, the display controller causes the display to display a second direction image indicating a stopping order of the plurality of objects in a reversed manner of the first direction image, sequentially changes a display mode of a status image corresponding to an object that has stopped to a second mode.

公开(公告)号：US20220341872A1

公开(公告)日：2022-10-27

申请号：US17852933

申请日：2022-06-29

申请人： Max-Planck-Gesellschaft zuf Foerderung der Wissenschaften e. V.

发明人： Vahid SANDOGHDAR ,  Marek PILIARIK ,  Katharina KOENIG

IPC分类号： G01N27/447 ,  G01N30/74 ,  G01N30/60 ,  G01N15/14 ,  G01N21/45 ,  G01N21/53 ,  G02B21/14

摘要： A method of detecting particles, e. g. proteins, after separation of particles based on their specific features, e.g. charge, size, shape, density, as series of single light scattering events created by the individual particles is described. The particles are separated from each other along the separation path and particles have specific arrival times at the target side depending on the particle features. The detecting step comprises an interferometric sensing of the light scattered at individual particles bound or transient in the detection volume. Parameters of the scattering light signals e.g. the interferometric contrast are analyzed for obtaining specific particle features, e.g. size, mass, shape, charge, or affinity of the particles. Furthermore, a detection apparatus being configured for detecting particles is described.

公开(公告)号：US11478524B1

公开(公告)日：2022-10-25

申请号：US16050621

申请日：2018-07-31

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： Bill J. Baker

IPC分类号： B01D15/16 ,  B01D15/24 ,  B01D15/32 ,  B01D15/42 ,  G01N30/34 ,  G01N30/72 ,  G01N30/74 ,  G01N30/82 ,  G01N30/86 ,  G01N30/02 ,  G01N30/84 ,  A61K36/82

摘要： The present disclosure relates to methods of modifying complex extracts such that components or mixtures of components are selectively removed or added, thus providing a complex mixture that does not naturally occur with a refined or a tuned therapeutic or nutraceutical effect. In various aspects, the complex extract can be an extract obtained from one or more plants, e.g., an extract obtained from green tea leaves. The present disclosure pertains to compositions obtained by the disclosed methods, nutraceutical compositions comprising same, pharmaceutical compositions comprising same, and methods of treating various conditions, including physiological dysfunctions associated with elevated reactive oxygen species and/or inflammatory molecule, e.g., TNFα, expression using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US11448625B2

公开(公告)日：2022-09-20

申请号：US16477000

申请日：2017-01-10

申请人： Shimadzu Corporation

发明人： Hidetoshi Terada ,  Hiroshi Ohashi

IPC分类号： G01N30/88 ,  G01N30/34 ,  G01N30/74 ,  G01N30/86 ,  G01N30/30

摘要： A chromatograph apparatus control device according to the present disclosure is a control device for controlling a chromatograph apparatus having the function of a liquid chromatograph and that of a supercritical fluid chromatograph. The control device includes a first-type method file creator configured to create a first-type method file describing a condition of an analysis by a liquid chromatograph; a second-type method file creator configured to create a second-type method file describing a condition of an analysis by a supercritical fluid chromatograph; and a batch file creator configured to create a single batch file including a plurality of records describing a group of method files including the first-type method file and the second-type method file, with one method file in each record.