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公开(公告)号：US11635415B2
公开(公告)日：2023-04-25
申请号：US17395909
申请日：2021-08-06
发明人： Robert Graham Cooks , Zheng Ouyang
摘要： The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
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公开(公告)号：US11635407B2
公开(公告)日：2023-04-25
申请号：US16983265
申请日：2020-08-03
摘要： Methods, systems and devices that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods, systems and devices are particularly suitable for use with a mass spectrometer.
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公开(公告)号：US11610767B2
公开(公告)日：2023-03-21
申请号：US17345070
申请日：2021-06-11
摘要： The present invention comprises novel methods of continuously monitoring the performance of an atmospheric pressure ionization (API) system. The methods of the invention allow for improved quality monitoring of the processes that leads to the formation of ions at atmospheric pressure. The methods of the invention further allow for continuously monitoring for the quality of the ion formation process in API without the addition of extraneous material (such as labelled compounds or control known compounds) to the system being monitored.
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4.发明授权公开(公告)号：US11600481B2
公开(公告)日：2023-03-07
申请号：US16927936
申请日：2020-07-13
发明人： Peng Li , Xiaojun Li , Stephen J. Valentine , Lisa Holland
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to a vibrating sharp edge spray ionization (VSSI) method suitable for coupling with a mass spectrometer, a VSSI method modified with a capillary suitable for use with continuous-flow separation methods such as liquid chromatography, and a VSSI method suitable for coupling with a capillary electrophoresis (CE) device in order to introduce the CE sample flow into a mass spectrometer. Also disclosed herein are devices for carrying out these methods and methods of making the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US20230050396A1
公开(公告)日：2023-02-16
申请号：US17975104
申请日：2022-10-27
发明人： Livia Schiavinato Eberlin , Shannon D. Green , Kyana Garza , Sydney Cordano Povilaitis , Michael Keating , Jialing Zhang , James Suliburk
IPC分类号： H01J49/04 , G01N33/483 , H01J49/00 , H01J49/16
摘要： In a general aspect, a swab sample is analyzed, for example, to test for disease. In some examples, a swab head of a swab sample is inserted through an opening into an internal reservoir of a sampling device. The sampling device includes the opening, an inlet channel, an outlet channel, and the internal reservoir. The internal reservoir is in fluid communication with the inlet channel, the outlet channel, and the opening. A liquid solvent is supplied to the swab head in the internal reservoir via the inlet channel of the sampling device. The swab head is held in the liquid solvent for a period of time to form an analyte in the internal reservoir. The analyte is extracted from the internal reservoir via the outlet channel of the sampling device. The analyte is transferred to and processed by a mass spectrometer to obtain mass spectrometry data.
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公开(公告)号：US11581178B2
公开(公告)日：2023-02-14
申请号：US17453683
申请日：2021-11-05
发明人： Robert Lang , Stefan Quint , Gabriele Punzmann
摘要： A mass spectrometry (MS) apparatus is provided. The MS apparatus includes a mass spectrometer, an ionization source coupled to the mass spectrometer, and a flow injection system (FIS) coupled to the ionization source. The ionization source is configured to provide an ionized gas flow of an analyte towards an entrance of the mass spectrometer. The ionization source is further configured to provide a second gas flow of a second gas. The MS apparatus is configured to measure a mass spectrometer (MS) signal of the analyte. The MS apparatus is further configured to analyze a dependency of the MS signal of the analyte versus a parameter of the second gas flow or a state of the second gas flow and to determine a condition of the apparatus based on the analyzed dependency.
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公开(公告)号：US20230042588A1
公开(公告)日：2023-02-09
申请号：US17792786
申请日：2020-04-07
发明人： Yasuhide NAITO , Tsuyoshi HIRAO , Minoru KONDO
摘要： An imaging unit includes a MCP, a fluorescent body, and an imager. The MCP is provided on a flight route of an ionized sample that is a component of a sample ionized and emits electrons in accordance with the ionized sample. The fluorescent body is disposed in a subsequent stage of the MCP and emits fluorescent light in accordance with the electrons emitted from the MCP. The imager is disposed in a subsequent stage of the fluorescent body and has a shutter mechanism configured to be capable of switching an open state in which the fluorescent light is imaged by allowing the fluorescent light from the fluorescent body to pass through and a close state in which the fluorescent light is not imaged by blocking the fluorescent light from the fluorescent body. An afterglow time of the fluorescent body is 12 ns or shorter.
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公开(公告)号：US11573200B2
公开(公告)日：2023-02-07
申请号：US16983293
申请日：2020-08-03
申请人： Intabio, Inc.
发明人： Erik Gentalen
IPC分类号： G01N27/447 , H01J49/04 , B01L3/00 , B01L3/02 , H01J49/16
摘要： Devices and methods for characterization of analyte mixtures are provided. Some methods described herein include performing enrichment steps on a device before expelling enriched analyte fractions from the device for subsequent analysis. Also included are devices for performing these enrichment steps.
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公开(公告)号：US11567087B2
公开(公告)日：2023-01-31
申请号：US16604947
申请日：2018-04-13
申请人： Micromass UK Limited
发明人： Steven Bajic , Jeffrey Mark Brown
摘要： A method of ionising a sample is disclosed comprising nebulising a sample which includes monoclonal antibody (“mAb”) molecules. A stream of monoclonal antibody droplets or charged droplets is directed so as to impact upon a target or electrode so as to form intact parent monoclonal antibody ions, intact minus light chain parent monoclonal antibody ions or light chain (“LC”) fragment monoclonal antibody ions.
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公开(公告)号：US20230013173A1
公开(公告)日：2023-01-19
申请号：US17781483
申请日：2020-12-16
摘要： A mass spectrometer may have an ion source region including an ion generator configured to generate ions from a sample, an ion detector configured to detect ions and produce corresponding ion detection signals, an electric field-free drift region disposed between the ion source region and the ion detector through which the generated ions drift axially toward the ion detector, a plurality of spaced-apart charge detection cylinders disposed in the drift region and through which the ions drifting axially through the drift region pass, and a plurality of charge amplifiers each coupled to a different one of the plurality of charge detection cylinders and each configured to produce a charge detection signal corresponding to a magnitude of charge of one or more of the generated ions passing through a respective one of the plurality of charge detection cylinders.
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