公开(公告)号：US11567087B2

公开(公告)日：2023-01-31

申请号：US16604947

申请日：2018-04-13

申请人： Micromass UK Limited

发明人： Steven Bajic ,  Jeffrey Mark Brown

IPC分类号： G01N33/68 ,  G01N30/72 ,  H01J49/00 ,  H01J49/16 ,  H01J49/06 ,  H01J49/04

摘要： A method of ionising a sample is disclosed comprising nebulising a sample which includes monoclonal antibody (“mAb”) molecules. A stream of monoclonal antibody droplets or charged droplets is directed so as to impact upon a target or electrode so as to form intact parent monoclonal antibody ions, intact minus light chain parent monoclonal antibody ions or light chain (“LC”) fragment monoclonal antibody ions.

公开(公告)号：US09105455B2

公开(公告)日：2015-08-11

申请号：US14355848

申请日：2012-11-02

申请人： Micromass UK Limited

发明人： Jeffrey Mark Brown ,  Martin Raymond Green ,  Jason Lee Wildgoose

IPC分类号： H01J49/10 ,  H01J49/04 ,  H01J49/16

CPC分类号： H01J49/107 ,  H01J49/0404 ,  H01J49/0468 ,  H01J49/10 ,  H01J49/16

摘要： A mass spectrometer is disclosed comprising a dual channel Solvent Assisted Inlet Ionisation (“SAII”) interface.

摘要翻译： 公开了一种质谱仪，其包括双通道溶剂辅助入口电离（“SAII”）界面。

公开(公告)号：US20200378989A1

公开(公告)日：2020-12-03

申请号：US16604947

申请日：2018-04-13

申请人： Micromass UK Limited

发明人： Steven Bajic ,  Jeffrey Mark Brown

IPC分类号： G01N33/68 ,  G01N30/72 ,  H01J49/00 ,  H01J49/16

摘要： A method of ionising a sample is disclosed comprising nebulising a sample which includes monoclonal antibody (“mAb”) molecules. A stream of monoclonal antibody droplets or charged droplets is directed so as to impact upon a target or electrode so as to form intact parent monoclonal antibody ions, intact minus light chain parent monoclonal antibody ions or light chain (“LC”) fragment monoclonal antibody ions.

公开(公告)号：US09947523B2

公开(公告)日：2018-04-17

申请号：US15348453

申请日：2016-11-10

申请人： MICROMASS UK LIMITED

发明人： Jeffrey Mark Brown ,  Paul Murray

IPC分类号： H01J49/40 ,  H01J49/24 ,  H01J49/06 ,  H01J49/00 ,  H01J49/04 ,  H01J49/16

CPC分类号： H01J49/061 ,  H01J49/0027 ,  H01J49/0495 ,  H01J49/06 ,  H01J49/164 ,  H01J49/40

摘要： A mass spectrometer includes: an ion source; an aperture; a flight region arranged between the ion source and aperture for separating ions according to their mass to charge ratio; and ion optics arranged and configured for causing ions to be reflected or deflected while they separate according to mass to charge ratio in the flight region and such that the ions are focussed to a geometrical focal point at the aperture so that the ions are transmitted through the aperture. The multi-reflecting or multi-deflecting ion optics provides a relatively long flight path for the ions, while naturally converging the ion beam to a focus. As this focus is arranged at the aperture, it enables the aperture to be made relatively small while still maintaining high ion transmission efficiency.