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    A Valve which Depressurises, and a Valve System
    1.
    发明申请
    A Valve which Depressurises, and a Valve System 审中-公开

    公开(公告)号：WO2015015178A3

    公开(公告)日：2015-02-05

    申请号：PCT/GB2014/052304

    申请日：2014-07-28

    Applicant: ATLAS GENETICS LIMITED

    Inventor： TAYLOR, Jay Kendall ,  ARLETT, Ben

    IPC: B01L3/00 ,  F16K99/00

    Abstract: A valve for a fluidic cartridge is provided. The valve comprises a valve cavity having first and second openings connected to first and second passageways, respectively; and a flexible membrane within the valve cavity, the flexible membrane having a first portion actuatable to seal against the first opening and a second portion actuatable to seal against the second opening; wherein the valve cavity is configured such that the first flexible membrane portion may be actuated independently of the second flexible membrane portion to enable the first opening to be sealed independently of the second.

    FLUID CONTROL DEVICE AND METHOD OF MANUFACTURE
    3.
    发明申请
    FLUID CONTROL DEVICE AND METHOD OF MANUFACTURE 审中-公开
    流体控制装置及其制造方法

    公开(公告)号：WO2015015176A1

    公开(公告)日：2015-02-05

    申请号：PCT/GB2014/052302

    申请日：2014-07-28

    Applicant: ATLAS GENETICS LIMITED

    Inventor： KENDALL TAYLOR, Jay ,  ARLETT, Ben

    IPC: B29C45/16 ,  F16K99/00 ,  B01L3/00

    CPC classification number: B01L3/502738 ,  B29C45/1675 ,  B29C45/1676 ,  F16K99/0015 ,  F16K2099/0078 ,  F16K2099/008

    Abstract: A fluid control device comprises a first polymer layer having a top surface, a bottom surface and a void extending through the first polymer layer and having an opening in at least the bottom surface; and a second polymer layer forming a membrane across the void in the first polymer layer. A third polymer layer having a top surface and a bottom surface may also be provided, such that the second polymer layer is disposed between the first and third polymer layers. The bottom surface of the first polymer layer and the top surface of the third polymer layer are in contacting arrangement around at least a portion of the perimeter of the second polymer layer. The fluid control device may be formed by injection-moulding a first polymer layer and subsequently injection-overmoulding a second polymer layer onto at least a portion of the first polymer layer to form a seal between the membrane and the first polymer layer.

    Abstract translation: 流体控制装置包括第一聚合物层，其具有顶表面，底表面和延伸穿过第一聚合物层并且在至少底表面中具有开口的空隙; 以及在第一聚合物层中跨越空隙形成膜的第二聚合物层。 还可以提供具有顶表面和底表面的第三聚合物层，使得第二聚合物层设置在第一和第三聚合物层之间。 第一聚合物层的底表面和第三聚合物层的顶表面围绕第二聚合物层的周边的至少一部分处于接触排列。 流体控制装置可以通过注塑成型第一聚合物层并随后将第二聚合物层注射成型至第一聚合物层的至少一部分上以在膜和第一聚合物层之间形成密封来形成。

    INSTRUMENT FOR PERFORMING A DIAGNOSTIC TEST ON A FLUIDIC CARTRIDGE
    4.
    发明申请
    INSTRUMENT FOR PERFORMING A DIAGNOSTIC TEST ON A FLUIDIC CARTRIDGE 审中-公开
    用于对流体盒进行诊断测试的仪器

    公开(公告)号：WO2016124907A1

    公开(公告)日：2016-08-11

    申请号：PCT/GB2016/050233

    申请日：2016-02-02

    Applicant: ATLAS GENETICS LIMITED

    Inventor： ARLETT, Ben ,  EDWARDS, Tom

    IPC: G01N35/00 ,  G01N35/10 ,  B01L3/00 ,  B01L7/00

    CPC classification number: B01L3/527 ,  B01L3/502738 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2200/14 ,  B01L2200/146 ,  B01L2300/021 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/1822 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0666 ,  B01L2400/0683 ,  G01N35/00029 ,  G01N35/1002 ,  G01N2035/1044

    Abstract: Instrument for performing a diagnostic test on a fluidic cartridge A cartridge reader is for carrying out a diagnostic test on a sample contained in a fluidic cartridge inserted into the reader. The fluidic cartridge comprises a fluidic layer comprising at least one sample processing region, at least one collapsible blister containing a liquid reagent, a pneumatic interface, an electrical interface and at least one mechanical valve. The reader comprises a housing; an upper clamp occupying a fixed position relative to the reader, anda lower clamp, movable relative to the first clamp, wherein the upper clamp and the lower clamp define a cartridge receiving region therebetween. The reader comprises a thermal module comprised in the lower clamp, wherein the thermal module comprises at least one thermal stack for heating the at least one sample processing region of the cartridge inserted into the reader. The reader comprises at least one mechanical actuator for actuating the mechanical valve comprised in the cartridge inserted into the reader.

    Abstract translation: 用于对流体盒进行诊断测试的仪器盒读取器用于对包含在插入到读取器中的流体盒中的样品进行诊断测试。 流体盒包括流体层，其包含至少一个样品处理区域，至少一个含有液体试剂的可收缩泡罩，气动界面，电接口和至少一个机械阀。 读者包括一个外壳; 相对于读取器占据固定位置的上夹具，以及相对于第一夹具可移动的下夹具，其中上夹具和下夹具在其间限定盒容纳区域。 阅读器包括下部夹具中的热模块，其中热模块包括至少一个用于加热插入到读取器中的盒的至少一个样品处理区域的热叠层。 阅读器包括至少一个机械致动器，用于致动包括在插入读取器中的盒中的机械阀。

    INSTRUMENT FOR PERFORMING A DIAGNOSTIC TEST ON A FLUIDIC CARTRIDGE
    5.
    发明申请
    INSTRUMENT FOR PERFORMING A DIAGNOSTIC TEST ON A FLUIDIC CARTRIDGE 审中-公开
    用于对流体盒进行诊断测试的仪器

    公开(公告)号：WO2016124905A1

    公开(公告)日：2016-08-11

    申请号：PCT/GB2016/050231

    申请日：2016-02-02

    Applicant: ATLAS GENETICS LIMITED

    Inventor： ARLETT, Ben ,  EDWARDS, Tom

    IPC: G01N35/00 ,  B01L3/00 ,  G01N35/10

    CPC classification number: B01L3/527 ,  B01L3/502715 ,  B01L3/50273 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/025 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2200/146 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/1822 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0666 ,  B01L2400/0683 ,  C12Q1/686 ,  G01N35/00029 ,  G01N35/1002 ,  G01N35/1009 ,  G01N2035/1044

    Abstract: A cartridge reader is configured to carry out a diagnostic test on a fluid sample contained within a fluidic cartridge. The cartridge comprises first, second and third collapsible blisters containing at least one reagent for use in the diagnostic test. The cartridge reader comprises an upper clamp, occupying a fixed position relative to the reader and a lower clamp, movable relative to the upper clamp, and wherein the upper clamp and the lower clamp are configured to receive and hold a fluidic cartridge therebetween. First, second and third blister actuators are mounted on the upper clamp, for aligning with first, second and third collapsible blisters of a fluidic cartridge inserted into the reader. The first, second and third blister actuators are movable relative to the upper clamp, between a first position in which the blister actuators are spaced apart from the collapsible blisters comprised on the fluidic cartridge received between the upper and lower clamps, and a second position in which the blister actuators depress the collapsible blisters, thereby collapsing the blisters and ejecting the reagents contained therein into a channel in the microfluidic cartridge.

    Abstract translation: 盒读取器被配置为对包含在流体盒中的流体样品进行诊断测试。 该盒包括第一，第二和第三可收缩泡罩，其包含用于诊断测试中的至少一种试剂。 墨盒读取器包括相对于读取器占据固定位置的上部夹具和可相对于上部夹具移动的下部夹具，并且其中上部夹具和下部夹具构造成在其间容纳和保持流体盒。 首先，第二和第三泡罩致动器安装在上夹具上，用于与插入读取器的流体盒的第一，第二和第三可折叠泡罩对准。 第一，第二和第三泡罩致动器可相对于上夹具移动，在第一位置和第二位置之间，第一位置中，泡罩致动器与包含在上下夹具之间的流体盒上的可折叠泡罩间隔开， 其中泡囊致动器压下可折叠的水疱，从而使泡罩塌缩并将其中包含的试剂喷射到微流体盒中的通道中。

    A FLUIDIC CARTRIDGE AND METHOD FOR PROCESSING A LIQUID SAMPLE
    6.
    发明申请
    A FLUIDIC CARTRIDGE AND METHOD FOR PROCESSING A LIQUID SAMPLE 审中-公开
    一种用于处理液体样品的流体盒和方法

    公开(公告)号：WO2015015179A1

    公开(公告)日：2015-02-05

    申请号：PCT/GB2014/052306

    申请日：2014-07-28

    Applicant: ATLAS GENETICS LIMITED

    Inventor： KENDALL TAYLOR, Jay ,  ARLETT, Ben

    IPC: B01L3/00

    CPC classification number: B01L3/502 ,  B01L3/502738 ,  B01L3/567 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/123 ,  B01L2300/1883 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/06 ,  B01L2400/0622 ,  B01L2400/0638 ,  B01L2400/0655 ,  B01L2400/0683 ,  G01N1/38

    Abstract: A fluidic cartridge for processing a liquid sample comprises a main channel for passing the liquid sample therethrough from an upstream end to a downstream end; and one or more branch channels that join the main channel for introducing liquid and gas into the main channel after the liquid sample has passed downstream of the one or more branch channels. The one or more branch channels including a first branch channel, wherein the first branch channel comprises: a gas inlet for introducing a gas into the first branch channel; a liquid inlet for introducing a liquid into the first branch channel; and a valve configured to move between a closed position in which it prevents liquid and gas in the first branch channel from passing into the main channel and an open position in which it permits liquid and gas in the first branch channel to pass into the main channel.

    Abstract translation: 用于处理液体样品的流体盒包括用于使液体样品从上游端流到下游端的主通道; 以及一个或多个分支通道，其在液体样品已经通过一个或多个分支通道的下游之后连接主通道用于将液体和气体引入主通道。 所述一个或多个分支通道包括第一分支通道，其中所述第一分支通道包括：用于将气体引入所述第一分支通道的气体入口; 用于将液体引入到第一分支通道中的液体入口; 以及构造成在闭合位置之间移动的阀，其中其阻止第一分支通道中的液体和气体进入主通道，并且其中允许第一分支通道中的液体和气体进入主通道的打开位置 。

    VALVE WITH LATCHING MECHANISM
    7.
    发明申请
    VALVE WITH LATCHING MECHANISM 审中-公开
    阀门采用锁紧机构

    公开(公告)号：WO2015015181A1

    公开(公告)日：2015-02-05

    申请号：PCT/GB2014/052310

    申请日：2014-07-28

    Applicant: ATLAS GENETICS LIMITED

    Inventor： TAYLOR, Jay Kendall ,  MULLARKEY, Toby Charles Edward ,  ARLETT, Ben

    IPC: B01L3/00 ,  F16K99/00

    CPC classification number: B01L3/502738 ,  B01L2400/0638 ,  F16K99/0015 ,  F16K2099/0071 ,  F16K2099/0084

    Abstract: A valve for a fluidic cartridge comprises a valve chamber having first and second openings connected to first and second passageways, respectively;a flexible membrane movable between an open position, in which the flexible membrane is spaced apart from the first and second openings to permit fluid to flow between the passageways and a closed position, in which the flexible membrane seals against at least one of the first and second openings to prevent fluid flow between the passageways; and an actuator configured to act on the flexible membrane to move it from its open position to its closed position, the actuator comprising a latching mechanism configured to latch the actuator such that it maintains the flexible membrane in its closed position.

    Abstract translation: 用于流体盒的阀包括分别具有连接到第一和第二通道的第一和第二开口的阀室;可在打开位置之间移动的柔性膜，柔性膜与第一和第二开口间隔开，以允许流体 在所述通道和关闭位置之间流动，其中所述柔性膜密封所述第一和第二开口中的至少一个，以防止流体在所述通道之间流动; 以及致动器，其构造成作用在所述柔性膜上以将其从其打开位置移动到其关闭位置，所述致动器包括闩锁机构，所述闩锁机构构造成闩锁所述致动器，使得其将所述柔性膜保持在其关闭位置。

    SYSTEM AND METHOD FOR PROCESSING FLUID IN A FLUIDIC CARTRIDGE
    9.
    发明申请
    SYSTEM AND METHOD FOR PROCESSING FLUID IN A FLUIDIC CARTRIDGE 审中-公开

    公开(公告)号：WO2015015180A3

    公开(公告)日：2015-02-05

    申请号：PCT/GB2014/052307

    申请日：2014-07-28

    Applicant: ATLAS GENETICS LIMITED

    Inventor： TAYLOR, Jay Kendall ,  ARLETT, Ben

    IPC: B01L3/00 ,  G01N35/10

    Abstract: A system and method for processing fluid in a fluidic cartridge is provided. The system comprises a fluid pathway for passing a liquid sample therethrough from an upstream end to a downstream end, a sample processing chamber (C102) with in the fluid pathway having an in let valve (C101) upstream of the sample processing chamber (C102), a downstream sample processing reg ion (C104) with in the fluid pathway downstream of the outlet valve (C103) and a bypass channel (C105) coupled to the fluid pathway at a junction between the outlet valve (C103) and the downstream sample processing region (C104), the valve system configured such that surplus liquid downstream of the outlet valve (C103) may be evacuated through the bypass channel (C105) when the outlet valve (C103) is closed, thereby leaving a metered volume of liquid sample between the in let valve (C101) and the downstream sample processing region (C104).

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