랩온어칩에 장착되는 마이크로밸브 소자의 제작방법 및 이로부터 제작되는 마이크로밸브 소자
    2.
    发明申请
    랩온어칩에 장착되는 마이크로밸브 소자의 제작방법 및 이로부터 제작되는 마이크로밸브 소자 审中-公开
    用于制造安装在片上的微型器件的方法以及由其制造的微型器件

    公开(公告)号:WO2012144794A2

    公开(公告)日:2012-10-26

    申请号:PCT/KR2012/002947

    申请日:2012-04-18

    Inventor: 손문탁

    Abstract: 본 발명은 경질 고분자 수지를 사출성형하여 제조되는 상하 기판 사이에 폴리비닐리덴클로라이드 필름을 삽입한 후 가열 가압하여 제조되는 랩온어칩의 마이크로밸브 소자를 제작하는 방법 및 이로부터 제작되는 마이크로밸브 소자에 관한 것이다. 본 발명에 따른 랩온어칩에 장착되는 마이크로밸브 소자의 제작방법은 상하 기판을 경질 고분자 소재로 사출성형이 가능하므로 짧은 시간에 대량생산이 가능하고, 폴리비닐리덴클로라이드 필름과 기판의 열융착 특성이 우수하여 경질 기판/필름 막/경질 기판의 구조를 용이하고 신뢰성 있게 구현할 수 있어서 마이크로밸브 소자의 제조에 소요되는 시간이 단축되어 랩온어칩의 대량생산이 가능하다. 또한, 폴리비닐리덴클로라이드 필름의 열수축 특성으로 인하여 열압착 접착시 필름 막이 늘어나 미세형상을 메우는 일이 발생하지 않고 필름 막의 형상이 그대로 유지되면서 진공에 의해 만곡된 형상을 가지므로 개폐가 부드럽고 민감하게 작동될 수 있으며, 유체의 투과율이 낮아서 필름 막 상하의 양 유체가 섞이지 않으므로 밸브 또는 펌프의 역할에 적합하다.

    Abstract translation: 本发明涉及一种用于制造用于芯片实验室的微型阀装置的方法,其涉及将聚偏二氯乙烯膜插入到通过注射成型刚性聚合物形成的上基板和下基板之间的间隙中 树脂,并加热和压制所得结构。 本发明还涉及通过该方法制造的微型阀装置。 根据本发明的安装在芯片实验室上的微型阀装置的制造方法的优点在于,使用刚性聚合物材料注射成型上下基板,以便能够在短时间内批量生产 的时间,聚偏二氯乙烯膜和基材之间的热固性特性优于以容易且可靠的方式形成刚性基材/薄膜/刚性基材结构,从而缩短制造微型阀装置所需的时间,并且能够批量生产 实验室上的单芯片。 此外,聚偏二氯乙烯膜具有热收缩特性,其防止膜热压粘合期间膜膜下垂并填充精细结构,从而能够保持膜膜的形状,并且能够使膜膜弯曲 真空,从而实现平稳的打开/关闭和敏感操作。 聚偏二氯乙烯膜对流体的渗透性低,从而防止膜膜上和下面的流体混合,因此可以有价值地用于阀或泵。

    MICRO-FLUIDIC SYSTEM
    3.
    发明申请
    MICRO-FLUIDIC SYSTEM 审中-公开
    微流体系统

    公开(公告)号:WO2011073784A1

    公开(公告)日:2011-06-23

    申请号:PCT/IB2010/003280

    申请日:2010-12-16

    Abstract: A micro-fluidic system (1) comprising a micro- fluidic channel (2), which has a wall (7) provided with a hole (9); a closing element (10), which is partially- housed within the hole (9) and has a membrane portion (14) adapted to deform and a side portion (15) sealingly connected with the above mentioned wall (7); and a partition (12) arranged within the micro-fluidic channel (2) between a first and a second segment (4, 5); the closing element (10) is deformable between a locked configuration in contact with the partition (12) and an open configuration spaced from the partition (12); the closing element (10) may be deformed by suction or by a rod or a piston.

    Abstract translation: 一种微流体系统(1),包括微流体通道(2),其具有设置有孔(9)的壁(7); 封闭元件(10),其部分地容纳在孔(9)内并且具有适于变形的膜部分(14)和与上述壁(7)密封连接的侧部(15); 以及在第一和第二段(4,5)之间布置在微流体通道(2)内的分隔件(12); 所述关闭元件(10)可在与所述隔板(12)接触的锁定构型和与所述隔板(12)间隔开的打开构型中变形。 关闭元件(10)可以通过抽吸或杆或活塞而变形。

    FLUID HANDLING DEVICE WITH DIRECTIONALLY-BIASED WETTING SURFACE
    4.
    发明申请
    FLUID HANDLING DEVICE WITH DIRECTIONALLY-BIASED WETTING SURFACE 审中-公开
    流体处理设备具有方向漂白的表面

    公开(公告)号:WO2007035511A3

    公开(公告)日:2007-11-29

    申请号:PCT/US2006036081

    申请日:2006-09-15

    Abstract: A fluid handling device with an anisotropic wetting surface including a substrate with a multiplicity of asymmetric substantially uniformly shaped asperities thereon. Each asperity has a first asperity rise angle and a second asperity rise angle relative to the substrate. The asperities are structured to present a desired retentive force ratio (f 1 /f 2 ) greater or less than unity caused by asymmetry between the first asperity rise angle and the second asperity rise angle according to the formula: f 3 /f 2 = sin(? 3 + 1/2?? 0 )/sin(? 2 + 1/2?? 0 ).

    Abstract translation: 一种具有各向异性润湿表面的流体处理装置,包括在其上具有多个不对称的基本均匀形状的凹凸的基底。 每个粗糙度具有相对于基底的第一粗糙度上升角和第二粗糙度上升角。 凹凸被构造为呈现由第一粗糙度上升角和第二粗糙度之间的不对称性引起的大于或等于单位的期望保持力比(f 1/2/2) 上升角度根据以下公式:f 3 3 / f 2 = sin(θ3 + 1/2< 0< SUB>)/ sin(θ2 + 1/2< 0< 0>)。

    FLUIDIC FUNCTIONS BASED ON NON-WETTABLE SURFACES
    6.
    发明申请
    FLUIDIC FUNCTIONS BASED ON NON-WETTABLE SURFACES 审中-公开
    基于非湿度表面的流体功能

    公开(公告)号:WO2004103891A1

    公开(公告)日:2004-12-02

    申请号:PCT/SE2004/000795

    申请日:2004-05-19

    Abstract: A method for processing two or more liquid aliquots in a microchannnel structure of a microfluidic device. The microchannel structure comprises a hydrophilic microconduit with a fluidic function and a local non-wettable surface associated with the fluidic function/microconduit. The characterizing features are: A) said processing comprises the steps of: i) passing a liquid aliquot I that contains components selected amongst organic solvents and surface active entities through the microconduit, and ii) passing another liquid aliquot II through the microconduit, and B) said non-wettable local surface area exposes fluoro groups on its surface and/or a rough part. A method for producing the fluidic function defined above. The method comprises introducing non-wettability on a local surface area S that is associated with the microconduit. The method comprises the steps of: i) providing said local surface S; ii) contacting this surface with a fixatable fluoropolymer; and iii) fixating the fluoropolymer to this surface. The fluidic function is typically selected amongst passive valves, anti-wicking functions, vents and liquid-directing functions.

    Abstract translation: 一种用于在微流体装置的微通道结构中处理两个或更多个液体等分试样的方法。 微通道结构包括具有流体功能的亲水微管道和与流体功能/微管道相关联的局部不可润湿表面。 特征特征是:A)所述处理包括以下步骤:i)将含有选自有机溶剂和表面活性物质的成分的液体等分试样I通过微型管道通过,以及ii)将另一液体等分试样II通过微管,B )所述不可润湿的局部表面区域在其表面和/或粗糙部分上暴露氟基团。 一种制备上述定义的流体功能的方法。 该方法包括在与微型管道相关联的局部表面区域S上引入非润湿性。 该方法包括以下步骤:i)提供所述局部表面S; ii)使该表面与可固定的含氟聚合物接触; 和iii)将含氟聚合物固定在该表面上。 流体功能通常选择在被动阀,防芯吸功能,排气口和液体引导功能中。

    A MICRO VALVE APPARATUS USING MICRO BEAD AND METHOD FOR CONTROLLING THE SAME
    9.
    发明申请
    A MICRO VALVE APPARATUS USING MICRO BEAD AND METHOD FOR CONTROLLING THE SAME 审中-公开
    使用微珠的微型阀装置及其控制方法

    公开(公告)号:WO2002097422A1

    公开(公告)日:2002-12-05

    申请号:PCT/KR2002/001035

    申请日:2002-05-31

    Inventor: YOO, Jae-Chern

    Abstract: A micro (thin film type) valve apparatus for controlling fluid flow and its rate using a microbead and a method for controlling the apparatus are provided. The microbead is moved by the magnetic forge generated by upper and lower electromagnets disposed on the top and bottom surface of the body or by the electric field generated by upper and lower electrode plates disposed on the top and bottom surface of the body, thereby interconnecting or blocking flow channels in the body. The micro valve apparatus and the method for controlling the same are suitable for thin film type diagnostic assay devices, such as lab-on-chips, protein chips, or DNA chips, for detecting small quantities of analytes in fluids, and more suitable for interconnecting or blocking channels formed in thin disk type apparatus including general CD-ROMs,DVDs, bioCDs, and bio DVDs.

    Abstract translation: 提供了一种用于控制流体流动的微(薄膜型)阀装置及其使用微珠的速率和控制该装置的方法。 微珠通过设置在身体的顶部和底部表面上的上部和下部电磁体产生的磁性锻造或由设置在身体的顶部和底部表面上的上部和下部电极板产生的电场而移动,从而互连或 阻止体内的流动通道。 微阀装置及其控制方法适用于薄膜型诊断测定装置,例如片上实验室,蛋白质芯片或DNA芯片,用于检测流体中的少量分析物,更适合互连 或阻塞通道形成在包括通用CD-ROM,DVD,bioCD和生物DVD的薄盘式设备中。

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